| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vishnudutt Purohit, Rao Rapaka, David Shurtlef. Drugs of abuse, dopamine, and HIV-associated neurocognitive disorders/HIV-associated dementia. Molecular neurobiology. vol 44. issue 1. 2011-11-04. PMID:21717292. |
in the brain, multiplication of hiv in infected macrophages/microglia could result in the release of hiv proteins such as gp120 and tat, which can bind to and impair dopamine transporter (dat) functions, leading to elevated levels of dopamine in the dopaminergic synapses in the early asymptomatic stage of hiv infection. |
2011-11-04 |
2023-08-12 |
Not clear |
| Vishnudutt Purohit, Rao Rapaka, David Shurtlef. Drugs of abuse, dopamine, and HIV-associated neurocognitive disorders/HIV-associated dementia. Molecular neurobiology. vol 44. issue 1. 2011-11-04. PMID:21717292. |
exposure of hiv-infected patients to drugs of abuse, especially cocaine and methamphetamine, can further increase synaptic levels of dopamine via binding to and subsequently impairing the function of dat. |
2011-11-04 |
2023-08-12 |
Not clear |
| Hongxia Zhou, Cao Huang, Jianbin Tong, Weimin C Hong, Yong-Jian Liu, Xu-Gang Xi. Temporal expression of mutant LRRK2 in adult rats impairs dopamine reuptake. International journal of biological sciences. vol 7. issue 6. 2011-11-01. PMID:21698001. |
temporal overexpression of lrrk2(g2019s) in adult rats impaired dopamine reuptake by dopamine transporter (dat) and thus enhanced locomotor activity, the phenotypes that were not observed in transgenic rats constitutively expressing the gene throughout life time. |
2011-11-01 |
2023-08-12 |
mouse |
| Jacqueline A Gleave, Troy H Farncombe, Chantal Saab, Laurie C Doerin. Correlative single photon emission computed tomography imaging of [123I]altropane binding in the rat model of Parkinson's. Nuclear medicine and biology. vol 38. issue 5. 2011-10-31. PMID:21718949. |
this study used the dopamine transporter (dat) probe, [(123)i]-2β-carbomethoxy-3β-(4-fluorophenyl)-n-(3-iodo-e-allyl)nortropane ([(123)i]altropane), to assess the dat levels in the 6-hydroxydopamine rat model of parkinson's disease. |
2011-10-31 |
2023-08-12 |
rat |
| Neivo da Silva, Claudia M Szobot, Carlos E Anselmi, Andrea P Jackowski, Shih M Chi, Marcelo Q Hoexter, Osvaldo E Anselmi, Flavio Pechansky, Rodrigo A Bressan, Luis A Rohd. Attention deficit/hyperactivity disorder: is there a correlation between dopamine transporter density and cerebral blood flow? Clinical nuclear medicine. vol 36. issue 8. 2011-10-21. PMID:21716015. |
although the etiology remains unclear, the involvement of the dopaminergic system has been suggested by genetic studies that report an overexpression of the dopamine transporter (dat) gene. |
2011-10-21 |
2023-08-12 |
Not clear |
| Morten Ziebel. Evaluation of the superselective radioligand [123I]PE2I for imaging of the dopamine transporter in SPECT. Danish medical bulletin. vol 58. issue 5. 2011-10-19. PMID:21535991. |
imaging of the dopamine transporter (dat) with single photon emission computer tomography (spect) has increasingly been used as a biomarker for the integrity of presynaptic dopaminergic nerve cells in patients with movement disorders. |
2011-10-19 |
2023-08-12 |
human |
| Thi-Lien Nguyen, Yu-Hua Tian, In-Jee You, Seok-Yong Lee, Choon-Gon Jan. Modafinil-induced conditioned place preference via dopaminergic system in mice. Synapse (New York, N.Y.). vol 65. issue 8. 2011-10-18. PMID:21157933. |
dopamine transporter (dat) binding was increased in the prefrontal cortex, the caudate putamen, and the nucleus accumbens. |
2011-10-18 |
2023-08-12 |
mouse |
| Antonio Simeone, Michela Di Salvio, Luca Giovanni Di Giovannantonio, Dario Acampora, Daniela Omodei, Carmine Tomasett. The role of otx2 in adult mesencephalic-diencephalic dopaminergic neurons. Molecular neurobiology. vol 43. issue 2. 2011-10-14. PMID:21086067. |
in particular, otx2 is prevalently excluded from neurons of the dorsal-lateral vta, which expressed girk2 and high level of the dopamine transporter (dat). |
2011-10-14 |
2023-08-12 |
mouse |
| Melissa A Stouffer, Solav Ali, Maarten E A Reith, Jyoti C Patel, Federica Sarti, Kenneth D Carr, Margaret E Ric. SKF-83566, a D1-dopamine receptor antagonist, inhibits the dopamine transporter. Journal of neurochemistry. vol 118. issue 5. 2011-10-14. PMID:21689106. |
both effects were occluded by nomifensine (1 μm), a dopamine transporter (dat) inhibitor, suggesting that skf-83566 acted via the dat. |
2011-10-14 |
2023-08-12 |
rat |
| Alex Iranzo, Francesc Valldeoriola, Francisco Lomeña, José Luis Molinuevo, Mónica Serradell, Manel Salamero, Albert Cot, Domènec Ros, Javier Pavía, Joan Santamaria, Eduardo Tolos. Serial dopamine transporter imaging of nigrostriatal function in patients with idiopathic rapid-eye-movement sleep behaviour disorder: a prospective study. The Lancet. Neurology. vol 10. issue 9. 2011-10-13. PMID:21802993. |
serial dopamine transporter (dat) imaging in patients with parkinson's disease (pd) and other synucleinopathies shows progressive nigrostriatal dopaminergic dysfunction. |
2011-10-13 |
2023-08-12 |
Not clear |
| K B Reynolds, L MacGillivray, M Zettler, P I Rosebush, M F Mazure. Role of the dopamine transporter in mediating the neuroleptic-induced reduction of tyrosine hydroxylase-immunoreactive midbrain neurons. Brain research. vol 1394. 2011-10-11. PMID:21396352. |
the dopamine transporter (dat) has been shown to play a role in the behavioural and biochemical action of neurotoxins such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp). |
2011-10-11 |
2023-08-12 |
rat |
| Liming Shao, Michael C Hewitt, Scott C Malcolm, Fengjiang Wang, Jianguo Ma, Una C Campbell, Nancy A Spicer, Sharon R Engel, Larry W Hardy, Zhi-Dong Jiang, Rudy Schreiber, Kerry L Spear, Mark A Varne. Synthesis and pharmacological characterization of bicyclic triple reuptake inhibitor 3-aryl octahydrocyclopenta[c]pyrrole analogues. Journal of medicinal chemistry. vol 54. issue 15. 2011-10-07. PMID:21739935. |
the present work expands the chemical space known to offer potent inhibition of the serotonin transporter (sert), norepinephrine transporter (net), and dopamine transporter (dat) and discloses novel bicyclic octahydrocyclopenta[c]pyrrole and octahydro-1h-isoindole scaffolds as potent triple reuptake inhibitors (tris) for the potential treatment of depression. |
2011-10-07 |
2023-08-12 |
mouse |
| Andrea Varrone, Vladimir Stepanov, Ryuji Nakao, Miklós Tóth, Balázs Gulyás, Patrik Emond, Jean Bernard Deloye, Johnny Vercouillie, Michael G Stabin, Cathrine Jonsson, Denis Guilloteau, Christer Halldi. Imaging of the striatal and extrastriatal dopamine transporter with (18)F-LBT-999: quantification, biodistribution, and radiation dosimetry in nonhuman primates. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 52. issue 8. 2011-10-07. PMID:21764797. |
the aim of this study was to evaluate the quantification, biodistribution, and radiation dosimetry of the novel dopamine transporter (dat) radioligand (18)f-(2s,3s)-methyl 8-((e)-4-fluorobut-2-en-1-yl)-3-(p-tolyl)-8-azabicyclo[3.2.1]octane-2-carboxylate ((18)f-lbt-999) in nonhuman primates. |
2011-10-07 |
2023-08-12 |
Not clear |
| Ji Young Yun, Woong-Woo Lee, Hee Jin Kim, Ji Seon Kim, Jong-Min Kim, Han-Joon Kim, Sung Yeun Kim, Ji Yeon Kim, Sung Sup Park, Yu Kyeong Kim, Sang Eun Kim, Beom S Jeo. Relative contribution of SCA2, SCA3 and SCA17 in Korean patients with parkinsonism and ataxia. Parkinsonism & related disorders. vol 17. issue 5. 2011-09-30. PMID:21334959. |
dopamine transporter (dat) imaging was performed in a subset of ataxic or parkinsonian sca2 or sca17, all of whom showed decreased dat binding. |
2011-09-30 |
2023-08-12 |
Not clear |
| Z Y Ong, B S Muhlhausle. Maternal "junk-food" feeding of rat dams alters food choices and development of the mesolimbic reward pathway in the offspring. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 25. issue 7. 2011-09-28. PMID:21427213. |
mrna expression of μ-opioid receptor (mu) was 1.6-fold higher (p<0.01) and dopamine active transporter (dat) was 2-fold lower (p<0.05) in jf offspring at 6 wk of age. |
2011-09-28 |
2023-08-12 |
rat |
| Mohammad Reza Safarineja. Relationship between premature ejaculation and genetic polymorphisms of the dopamine transporter gene (SLC6A3). BJU international. vol 108. issue 2. 2011-09-20. PMID:21050355. |
• to investigate the possible relationships between premature ejaculation (pe) polymorphisms in the dopamine transporter (dat) gene (slc6a3, dat1), which has a polymorphic 40 base pair (40 bp) variable number of tandem repeats (vntr) sequence in the 3'-untranslated region (3' vntr). |
2011-09-20 |
2023-08-12 |
Not clear |
| P T Meyer, O H Winz, M Dafotakis, C J Werner, T Krohn, W M Schäfe. Improved visual [(123)I]FP-CIT SPECT interpretation for evaluation of parkinsonism by visual rating of parametric distribution volume ratio images. The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of.... vol 55. issue 3. 2011-09-20. PMID:21532542. |
imaging of presynaptic dopamine transporters (dat) by single-photon emission computed tomography (spect) and [(123)i]fp-cit is an established method for differentiating between neurodegenerative and non-neurodegenerative parkinsonism. |
2011-09-20 |
2023-08-12 |
Not clear |
| Bastian Zimmer, Stefan Schildknecht, Philipp B Kuegler, Vivek Tanavde, Suzanne Kadereit, Marcel Leis. Sensitivity of dopaminergic neuron differentiation from stem cells to chronic low-dose methylmercury exposure. Toxicological sciences : an official journal of the Society of Toxicology. vol 121. issue 2. 2011-09-19. PMID:21385734. |
the mixed neuronal cultures that formed within 20 days contained a small subpopulation of tyrosine hydroxylase (th)-positive neurons with specific dopaminergic functions such as dopamine transport (dat) activity. |
2011-09-19 |
2023-08-12 |
Not clear |
| Mitchell F Roitman, Seth Wescott, Jackson J Cone, Michael P McLane, Henry R Wolf. MSI-1436 reduces acute food intake without affecting dopamine transporter activity. Pharmacology, biochemistry, and behavior. vol 97. issue 1. 2011-09-15. PMID:20478327. |
many therapies designed to reduce food intake and body weight act, in part, by blocking the dopamine transporter (dat) - a protein responsible for clearing extracellular dopamine (da) after release thereby terminating its action. |
2011-09-15 |
2023-08-12 |
rat |
| Wei Sun, Kenji Sugiyama, Tetsuya Asakawa, Hiroshi Yamaguchi, Soichi Akamine, Yasuomi Ouchi, Yasuhiro Magata, Hiroki Namb. Dynamic changes of striatal dopamine D2 receptor binding at later stages after unilateral lesions of the medial forebrain bundle in Parkinsonian rat models. Neuroscience letters. vol 496. issue 3. 2011-09-07. PMID:21514359. |
in the present study, we further examined binding of d(2) receptor as well as pre-synaptic dopamine transporter (dat) at later stages (6 months after lesion) both in the striatal and mfb lesion models. |
2011-09-07 |
2023-08-12 |
rat |