| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stephanie M Groman, Buyean Lee, Emanuele Seu, Alex S James, Karen Feiler, Mark A Mandelkern, Edythe D London, J David Jentsc. Dysregulation of D₂-mediated dopamine transmission in monkeys after chronic escalating methamphetamine exposure. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 17. 2012-06-25. PMID:22539846. |
exposure to methamphetamine reduced dopamine d₂-like receptor and dat availability and produced transient, selective impairments in the reversal of a stimulus-outcome association. |
2012-06-25 |
2023-08-12 |
monkey |
| Noah B Gross, Patrick C Duncker, John F Marshal. Striatal dopamine D1 and D2 receptors: widespread influences on methamphetamine-induced dopamine and serotonin neurotoxicity. Synapse (New York, N.Y.). vol 65. issue 11. 2012-06-18. PMID:21584865. |
in animals, binge mamph dosing regimens deplete markers for monoamine nerve terminals, for example, dopamine and serotonin transporters (dat and sert), in striatum and cerebral cortex. |
2012-06-18 |
2023-08-12 |
Not clear |
| Noah B Gross, Patrick C Duncker, John F Marshal. Striatal dopamine D1 and D2 receptors: widespread influences on methamphetamine-induced dopamine and serotonin neurotoxicity. Synapse (New York, N.Y.). vol 65. issue 11. 2012-06-18. PMID:21584865. |
the present study examined the contribution of dopamine d1 and d2 receptors in striatum to mamph-induced dat and sert neurotoxicities. |
2012-06-18 |
2023-08-12 |
Not clear |
| Noah B Gross, Patrick C Duncker, John F Marshal. Striatal dopamine D1 and D2 receptors: widespread influences on methamphetamine-induced dopamine and serotonin neurotoxicity. Synapse (New York, N.Y.). vol 65. issue 11. 2012-06-18. PMID:21584865. |
blockade of striatal dopamine d1 or d2 receptors during an otherwise neurotoxic binge mamph regimen produced widespread protection against mamph-induced striatal dat loss and cortical, hippocampal, and amygdalar sert loss. |
2012-06-18 |
2023-08-12 |
Not clear |
| Noah B Gross, Patrick C Duncker, John F Marshal. Striatal dopamine D1 and D2 receptors: widespread influences on methamphetamine-induced dopamine and serotonin neurotoxicity. Synapse (New York, N.Y.). vol 65. issue 11. 2012-06-18. PMID:21584865. |
this study demonstrates that (1) dopamine d1 and d2 receptors in striatum, like nigral d1 receptors, are needed for mamph-induced striatal dat reductions, (2) these same receptors are needed for mamph-induced sert loss, and (3) these widespread influences of striatal dopamine receptor antagonists are likely attributable to circuits connecting basal ganglia to thalamus and cortex. |
2012-06-18 |
2023-08-12 |
Not clear |
| Lidia Cova, Patrizia Bossolasco, Marie-Therese Armentero, Valentina Diana, Eleonora Zennaro, Manuela Mellone, Cinzia Calzarossa, Silvia Cerri, Giorgio Lambertenghi Deliliers, Elio Polli, Fabio Blandini, Vincenzo Silan. Neuroprotective effects of human mesenchymal stem cells on neural cultures exposed to 6-hydroxydopamine: implications for reparative therapy in Parkinson's disease. Apoptosis : an international journal on programmed cell death. vol 17. issue 3. 2012-06-18. PMID:22160861. |
the internalization of 6-ohda mainly relies on its uptake by the dopamine active transporter (dat), but its toxicity could also involve other pathways. |
2012-06-18 |
2023-08-12 |
human |
| Sylvie Mavel, Zoya Mincheva, Nathalie Méheux, Yvan Carcenac, Denis Guilloteau, Mohamed Abarbri, Patrick Emon. QSAR study and synthesis of new phenyltropanes as ligands of the dopamine transporter (DAT). Bioorganic & medicinal chemistry. vol 20. issue 4. 2012-06-18. PMID:22300887. |
qsar study and synthesis of new phenyltropanes as ligands of the dopamine transporter (dat). |
2012-06-18 |
2023-08-12 |
Not clear |
| Sylvie Mavel, Zoya Mincheva, Nathalie Méheux, Yvan Carcenac, Denis Guilloteau, Mohamed Abarbri, Patrick Emon. QSAR study and synthesis of new phenyltropanes as ligands of the dopamine transporter (DAT). Bioorganic & medicinal chemistry. vol 20. issue 4. 2012-06-18. PMID:22300887. |
the dopamine transporter (dat) plays a pivotal role in the regulation of dopamine neurotransmission, and is involved in a number of physiological functions and brain disorders. |
2012-06-18 |
2023-08-12 |
Not clear |
| Petroula Proitsi, Michelle K Lupton, Suzanne J Reeves, Gillian Hamilton, Nicola Archer, Belinda M Martin, Conrad Iyegbe, Paul Hollingworth, Brian Lawlor, Michael Gill, Carol Brayne, David C Rubinsztein, Michael J Owen, Julie Williams, Simon Lovestone, John F Powel. Association of serotonin and dopamine gene pathways with behavioral subphenotypes in dementia. Neurobiology of aging. vol 33. issue 4. 2012-06-15. PMID:20685009. |
significant associations were observed between the serotonin transporter gene (sert) polymorphism stin2 and "psychosis"; the dopamine transporter gene (dat) 3' variable number tandem repeats (vntr) and "agitation"; and the dopamine receptor 4 (drd4) vntr and "moods" factors. |
2012-06-15 |
2023-08-12 |
Not clear |
| Simon Vermeire, Kurt Audenaert, Rudy De Meester, Eva Vandermeulen, Tim Waelbers, Bart De Spiegeleer, Jos Eersels, André Dobbeleir, Kathelijne Pereman. Serotonin 2A receptor, serotonin transporter and dopamine transporter alterations in dogs with compulsive behaviour as a promising model for human obsessive-compulsive disorder. Psychiatry research. vol 201. issue 1. 2012-06-11. PMID:22285716. |
single photon emission computed tomography was used with (123)i-r91150 and (123)i-fp-cit, in combination with (99m)tc-ecd brain perfusion co-registration, to measure the serotonin (5-ht) 2a receptor, dopamine transporter (dat) and serotonin transporter (sert) availability. |
2012-06-11 |
2023-08-12 |
human |
| Natalie R S Goldberg, Victoria Fields, Lacey Pflibsen, Michael F Salvatore, Charles K Meshu. Social enrichment attenuates nigrostriatal lesioning and reverses motor impairment in a progressive 1-methyl-2-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease. Neurobiology of disease. vol 45. issue 3. 2012-06-07. PMID:22198503. |
cpu th and dopamine transporter (dat) protein expression, as well as dopamine tissue and th protein levels was significantly decreased compared to either vehicle group. |
2012-06-07 |
2023-08-12 |
mouse |
| Xue-Feng Tan, Guo-Hua Jin, Mei-Ling Tian, Jian-Bing Qin, Lei Zhang, Hui-Xia Zhu, Hao-Ming L. The co-transduction of Nurr1 and Brn4 genes induces the differentiation of neural stem cells into dopaminergic neurons. Cell biology international. vol 35. issue 12. 2012-06-06. PMID:21663595. |
nonetheless, these cells exhibited an immature neuronal morphology with small cell bodies and short neurite processes, and they seldom expressed dat (dopamine transporter), a late marker of mature dopaminergic neurons. |
2012-06-06 |
2023-08-12 |
Not clear |
| Kenneth L Madsen, Thor S Thorsen, Troels Rahbek-Clemmensen, Jacob Eriksen, Ulrik Gethe. Protein interacting with C kinase 1 (PICK1) reduces reinsertion rates of interaction partners sorted to Rab11-dependent slow recycling pathway. The Journal of biological chemistry. vol 287. issue 15. 2012-06-06. PMID:22303009. |
the dopamine transporter (dat), which primarily sorts to degradation upon internalization, did not form perinuclear clusters with pick1, and pick1 did not affect dat internalization/recycling. |
2012-06-06 |
2023-08-12 |
Not clear |
| Diana Armbruster, Anett Mueller, Alexander Strobel, Klaus-Peter Lesch, Clemens Kirschbaum, Burkhard Brock. Variation in genes involved in dopamine clearance influence the startle response in older adults. Journal of neural transmission (Vienna, Austria : 1996). vol 118. issue 9. 2012-06-01. PMID:21445667. |
the dopamine transporter (dat) and the enzyme catechol-o-methyltransferase (comt) both terminate synaptic dopamine action. |
2012-06-01 |
2023-08-12 |
human |
| Zivjena Vucetic, Jesse Lea Carlin, Kathy Totoki, Teresa M Reye. Epigenetic dysregulation of the dopamine system in diet-induced obesity. Journal of neurochemistry. vol 120. issue 6. 2012-06-01. PMID:22220805. |
differential dna methylation was identified within the promoter regions of tyrosine hydroxylase (th) and dopamine transporter (dat), and the pattern of this response was consistent with the pattern of gene expression. |
2012-06-01 |
2023-08-12 |
mouse |
| J T Yorgason, S R Jones, R A Españ. Low and high affinity dopamine transporter inhibitors block dopamine uptake within 5 sec of intravenous injection. Neuroscience. vol 182. 2012-05-31. PMID:21402130. |
extensive evidence suggests that the reinforcing effects of cocaine involve inhibition of dopamine transporters (dat) and subsequent increases in dopamine (da) levels in the striatum. |
2012-05-31 |
2023-08-12 |
Not clear |
| Anna Costa, Michael Riedel, Ulrich Müller, Hans-Jürge Möller, Ulrich Ettinge. Relationship between SLC6A3 genotype and striatal dopamine transporter availability: a meta-analysis of human single photon emission computed tomography studies. Synapse (New York, N.Y.). vol 65. issue 10. 2012-05-30. PMID:21404331. |
the human dopamine transporter (dat) gene (slc6a3) contains a 40-bp variable number of tandem repeats (vntr) polymorphism. |
2012-05-30 |
2023-08-12 |
human |
| Yu-Hua Tian, Seung Hwan Kim, Seok-Yong Lee, Choon-Gon Jan. Lactational and postnatal exposure to polychlorinated biphenyls induces sex-specific anxiolytic behavior and cognitive deficit in mice offspring. Synapse (New York, N.Y.). vol 65. issue 10. 2012-05-30. PMID:21425352. |
finally, we performed autoradiographic receptor binding assays for dopamine (da) d₁ and d₂ receptors, dopamine transporter (dat), and the n-methyl-d-aspartic acid (nmda) receptor after behavioral tests to examine whether alterations occurred in the dopaminergic and nmdaergic systems of the brain. |
2012-05-30 |
2023-08-12 |
mouse |
| Sara Al-Sweidi, Marc Morissette, Mélanie Bourque, Thérèse Di Paol. Estrogen receptors and gonadal steroids in vulnerability and protection of dopamine neurons in a mouse model of Parkinson's disease. Neuropharmacology. vol 61. issue 4. 2012-05-25. PMID:21586296. |
we investigated the neuroprotective contribution of estrogen receptors (erα and erβ) against mptp toxicity by examining the membrane dopamine (da) transporter (dat), the vesicular monoamine transporter 2 (vmat2) and tyrosine hydroxylase (th) in er knock out (erko) c57bl/6 male mice compared to their plasma steroid levels. |
2012-05-25 |
2023-08-12 |
mouse |
| A C Meyer, D B Horton, N M Neugebauer, T E Wooters, J R Nickell, L P Dwoskin, M T Bard. Tetrabenazine inhibition of monoamine uptake and methamphetamine behavioral effects: locomotor activity, drug discrimination and self-administration. Neuropharmacology. vol 61. issue 4. 2012-05-25. PMID:21669212. |
effects of tbz on function of the dopamine transporter (dat) and serotonin transporter (sert) in striatal and hippocampal synaptosomes, respectively, and on vmat2 function in isolated striatal synaptic vesicles were determined. |
2012-05-25 |
2023-08-12 |
rat |