| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G W Miller, Y M Wang, R R Gainetdinov, M G Caro. Dopamine transporter and vesicular monoamine transporter knockout mice : implications for Parkinson's disease. Methods in molecular medicine. vol 62. 2012-10-02. PMID:21318776. |
both dat and vmat2 are essential for dopamine homeostasis and are thought to participate in the pathogenesis of parkinson's disease (1-5). |
2012-10-02 |
2023-08-12 |
mouse |
| G W Miller, Y M Wang, R R Gainetdinov, M G Caro. Dopamine transporter and vesicular monoamine transporter knockout mice : implications for Parkinson's disease. Methods in molecular medicine. vol 62. 2012-10-02. PMID:21318776. |
in the homozygote dat ko mice, released dopamine remains in the extracellular space up to 300 times longer than normal. |
2012-10-02 |
2023-08-12 |
mouse |
| Keith M Erikson, Carrie E John, Sara R Jones, Michael Aschne. Manganese accumulation in striatum of mice exposed to toxic doses is dependent upon a functional dopamine transporter. Environmental toxicology and pharmacology. vol 20. issue 3. 2012-10-02. PMID:21783617. |
the objective of this study was to determine the importance of the dopamine transporter (dat) in manganese transport. |
2012-10-02 |
2023-08-12 |
mouse |
| Mari Gabrielsen, Ingebrigt Sylte, Svein G Dahl, Aina W Ravn. A short update on the structure of drug binding sites on neurotransmitter transporters. BMC research notes. vol 4. 2012-10-02. PMID:22192271. |
the dopamine (dat), noradrenalin (net) and serotonin (sert) transporters are molecular targets for different classes of psychotropic drugs. |
2012-10-02 |
2023-08-12 |
Not clear |
| Ioannis U Isaias, Alberto Marzegan, Gianni Pezzoli, Giorgio Marotta, Margherita Canesi, Gabriele E M Biella, Jens Volkmann, Paolo Cavallar. A role for locus coeruleus in Parkinson tremor. Frontiers in human neuroscience. vol 5. 2012-10-02. PMID:22287946. |
clinical diagnosis was confirmed in all subjects by reduced dopamine reuptake transporter (dat) binding values investigated by single photon computed tomography imaging (spect) with [(123)i] n-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl) tropane (fp-cit). |
2012-10-02 |
2023-08-12 |
human |
| Yan-Fen Zhang, Xiao-Yu Wang, Feng Guo, Kristin Burns, Qi-Yong Guo, Xiao-Ming Wan. Simultaneously changes in striatum dopaminergic and glutamatergic parameters following hypoxic-ischemic neuronal injury in newborn piglets. European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society. vol 16. issue 3. 2012-09-28. PMID:21723167. |
in current study, we investigated the imaging profile of glutamate (glx) levels by proton magnetic resonance spectroscopy ((1)h-mrs), and the expression of dopamine d2 receptors (d2r) and dopamine transporter (dat) by immunohistochemical staining in a newborn piglet model of h-i brain injury. |
2012-09-28 |
2023-08-12 |
Not clear |
| Yan-Fen Zhang, Xiao-Yu Wang, Feng Guo, Kristin Burns, Qi-Yong Guo, Xiao-Ming Wan. Simultaneously changes in striatum dopaminergic and glutamatergic parameters following hypoxic-ischemic neuronal injury in newborn piglets. European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society. vol 16. issue 3. 2012-09-28. PMID:21723167. |
our findings suggest that following h-i brain insult, striatal d2r positive neurons decreased due to neuron death; straital dat initially increased to compensate for dopamine uptake; and glutamatergic and dopaminergic systems in striatum may act in an interdependent way in the striatum of newborn piglets. |
2012-09-28 |
2023-08-12 |
Not clear |
| Warren H Meck, Ruey-Kuang Cheng, Christopher J MacDonald, Raul R Gainetdinov, Marc G Caron, Münire Özlem Cevi. Gene-dose dependent effects of methamphetamine on interval timing in dopamine-transporter knockout mice. Neuropharmacology. vol 62. issue 3. 2012-09-27. PMID:21296093. |
the dopamine transporter (dat) is the major regulator of the spatial and temporal resolution of dopaminergic neurotransmission in the brain. |
2012-09-27 |
2023-08-12 |
mouse |
| Francesco Papaleo, Barbara K Lipska, Daniel R Weinberge. Mouse models of genetic effects on cognition: relevance to schizophrenia. Neuropharmacology. vol 62. issue 3. 2012-09-27. PMID:21557953. |
based on functional hypotheses, gene modifications within five model systems are described: 1) dopamine (d1, d2, d3, d4, d5, dat, comt, mao); 2) glutamate (glur-a, nr1, nr2a, nr2b, grm2, grm3, glast); 3) gaba (α(5), γ(2), α(4), δgaba(a), gaba(b(1)), gat1); 4) acetylcholine (nachrβ2, α7, chrm1); and 5) calcium (camkii-α, neurogranin, camkkβ, camkiv). |
2012-09-27 |
2023-08-12 |
mouse |
| Eun-Joo Shin, Chu Xuan Duong, Xuan-Khanh Thi Nguyen, Zhengyi Li, Guoying Bing, Jae-Hyung Bach, Dae Hun Park, Keiichi Nakayama, Syed F Ali, Anumantha G Kanthasamy, Jean Lud Cadet, Toshitaka Nabeshima, Hyoung-Chun Ki. Role of oxidative stress in methamphetamine-induced dopaminergic toxicity mediated by protein kinase Cδ. Behavioural brain research. vol 232. issue 1. 2012-09-27. PMID:22512859. |
furthermore, ma-induced increases in the dopamine (da) turnover rate and decreases in tyrosine hydroxylase (th) activity and the expression of th, dopamine transporter (dat), and vesicular monoamine transporter 2 (vmat2) were not significantly observed in rottlerin-treated or pkcδ (-/-) mice. |
2012-09-27 |
2023-08-12 |
mouse |
| Xue Y Zhu, Jagan R Etukala, Suresh V K Eyunni, Vincent Setola, Bryan L Roth, Seth Y Ablordeppe. Benzothiazoles as probes for the 5HT1A receptor and the serotonin transporter (SERT): a search for new dual-acting agents as potential antidepressants. European journal of medicinal chemistry. vol 53. 2012-09-25. PMID:22520153. |
in addition, compound 20 binds with low affinity to the dopamine transporter (dat), the norepinephrine transporter (net) and 5ht(2c) receptor, which are desirable properties as selectivity for sert (and not dat or net) is associated with an absence of cardiovascular side effects. |
2012-09-25 |
2023-08-12 |
Not clear |
| Jacqueline S Womersley, Jennifer H Hsieh, Lauriston A Kellaway, Greg A Gerhardt, Vivienne A Russel. Maternal separation affects dopamine transporter function in the spontaneously hypertensive rat: an in vivo electrochemical study. Behavioral and brain functions : BBF. vol 7. 2012-09-21. PMID:22133315. |
it was hypothesized that maternal separation would alter dopamine regulation by the transporter (dat) in ways that distinguish shr from control rat strains. |
2012-09-21 |
2023-08-12 |
rat |
| Mark J Ferris, Erin S Calipari, Yolanda Mateo, James R Melchior, David C S Roberts, Sara R Jone. Cocaine self-administration produces pharmacodynamic tolerance: differential effects on the potency of dopamine transporter blockers, releasers, and methylphenidate. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 7. 2012-09-21. PMID:22395730. |
the dopamine transporter (dat) is the primary site of action for psychostimulant drugs such as cocaine, methylphenidate, and amphetamine. |
2012-09-21 |
2023-08-12 |
rat |
| Mark J Ferris, Erin S Calipari, Yolanda Mateo, James R Melchior, David C S Roberts, Sara R Jone. Cocaine self-administration produces pharmacodynamic tolerance: differential effects on the potency of dopamine transporter blockers, releasers, and methylphenidate. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 7. 2012-09-21. PMID:22395730. |
our previous work demonstrated a reduced ability of cocaine to inhibit the dat following high-dose cocaine self-administration (sa), corresponding to a reduced ability of cocaine to increase extracellular dopamine. |
2012-09-21 |
2023-08-12 |
rat |
| Mark J Ferris, Erin S Calipari, Yolanda Mateo, James R Melchior, David C S Roberts, Sara R Jone. Cocaine self-administration produces pharmacodynamic tolerance: differential effects on the potency of dopamine transporter blockers, releasers, and methylphenidate. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 7. 2012-09-21. PMID:22395730. |
we demonstrated that, similar to cocaine, the dat blockers nomifensine and bupropion were less effective at inhibiting dopamine uptake following cocaine sa. |
2012-09-21 |
2023-08-12 |
rat |
| Mark J Ferris, Erin S Calipari, Yolanda Mateo, James R Melchior, David C S Roberts, Sara R Jone. Cocaine self-administration produces pharmacodynamic tolerance: differential effects on the potency of dopamine transporter blockers, releasers, and methylphenidate. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 7. 2012-09-21. PMID:22395730. |
the reduced ability of psychostimulants to inhibit dopamine uptake following cocaine sa appears to be contingent upon their functional interaction with the dat as a pure blocker or releaser rather than their structural similarity to cocaine. |
2012-09-21 |
2023-08-12 |
rat |
| Auxiliadora Aracil-Fernández, José M Trigo, María S García-Gutiérrez, Antonio Ortega-Álvaro, Alexander Ternianov, Daniela Navarro, Patricia Robledo, Pere Berbel, Rafael Maldonado, Jorge Manzanare. Decreased cocaine motor sensitization and self-administration in mice overexpressing cannabinoid CB₂ receptors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 7. 2012-09-21. PMID:22414816. |
dopamine (da) extracellular levels in the nucleus accumbens (nacc), and gene expression of tyrosine hydroxylase (th) and da transporter (dat) in the ventral tegmental area (vta), and μ-opioid and cannabinoid cb₁ receptors in the nacc were also studied in both genotypes. |
2012-09-21 |
2023-08-12 |
mouse |
| Matthew Benskey, Bahareh Behrouz, Johan Sunryd, Samuel S Pappas, Seung-Hoon Baek, Marianne Huebner, Keith J Lookingland, John L Goudrea. Recovery of hypothalamic tuberoinfundibular dopamine neurons from acute toxicant exposure is dependent upon protein synthesis and associated with an increase in parkin and ubiquitin carboxy-terminal hydrolase-L1 expression. Neurotoxicology. vol 33. issue 3. 2012-09-18. PMID:22342763. |
initial loss of da from axon terminals was dependent on a functional dopamine transporter (dat) in nsda neurons but dat-independent in tida neurons. |
2012-09-18 |
2023-08-12 |
mouse |
| Lane J Wallac. Effects of amphetamine on subcellular distribution of dopamine and DOPAC. Synapse (New York, N.Y.). vol 66. issue 7. 2012-09-17. PMID:22314940. |
in addition, contribution to overall effects of amphetamine by each of five actions--transport by dopamine transporter (dat), transport by vesicular monoamine transporter, stimulation of reverse transport, inhibition of monoamine oxidase (mao), and slowing of dopamine cell firing rate--were evaluated. |
2012-09-17 |
2023-08-12 |
Not clear |
| Lane J Wallac. Effects of amphetamine on subcellular distribution of dopamine and DOPAC. Synapse (New York, N.Y.). vol 66. issue 7. 2012-09-17. PMID:22314940. |
a very small fraction of cytosolic dopamine is moved to extracellular compartment via reverse transport by dat. |
2012-09-17 |
2023-08-12 |
Not clear |