| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Anandhan, U Janakiraman, T Manivasaga. Theaflavin ameliorates behavioral deficits, biochemical indices and monoamine transporters expression against subacute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of Parkinson's disease. Neuroscience. vol 218. 2012-11-16. PMID:22634505. |
administration of mptp (30 mg/kg bw for four consecutive days) led to increased oxidative stress and reduced behavior patterns (open field, rotarod and hang test), nigrostriatal dopamine transporter (dat) (immunohistochemistry and western blot) and vesicular monoamine transporter 2 (vmat2) (western blot) expressions. |
2012-11-16 |
2023-08-12 |
mouse |
| Kuo-Chang Cheng, Jhen-Ni Liao, Ping-Chiang Ly. Crystal structure of the dopamine N-acetyltransferase-acetyl-CoA complex provides insights into the catalytic mechanism. The Biochemical journal. vol 446. issue 3. 2012-11-13. PMID:22716280. |
drosophila melanogaster dat (dopamine n-acetyltransferase) is an aanat. |
2012-11-13 |
2023-08-12 |
drosophila_melanogaster |
| Lisa M McFadden, Kristen A Stout, Paula L Vieira-Brock, Scott C Allen, Shannon M Nielsen, Diana G Wilkins, Glen R Hanson, Annette E Fleckenstei. Methamphetamine self-administration acutely decreases monoaminergic transporter function. Synapse (New York, N.Y.). vol 66. issue 3. 2012-11-09. PMID:22120988. |
numerous preclinical studies have demonstrated that noncontingent methamphetamine (meth) administration rapidly decreases both dopamine (da) transporter (dat) and vesicular monoamine-2 transporter (vmat-2) function. |
2012-11-09 |
2023-08-12 |
rat |
| Michael F Salvatore, Brandon S Pruett, Charles Dempsey, Victoria Field. Comprehensive profiling of dopamine regulation in substantia nigra and ventral tegmental area. Journal of visualized experiments : JoVE. issue 66. 2012-11-02. PMID:22907542. |
investigation of the proteins that regulate dopamine, such as tyrosine hydroxylase (th) protein, th phosphorylation, dopamine transporter (dat), and vesicular monoamine transporter 2 (vmat2) protein often do not include analysis of dopamine tissue content in the same sample. |
2012-11-02 |
2023-08-12 |
Not clear |
| Michael F Salvatore, Brandon S Pruett, Charles Dempsey, Victoria Field. Comprehensive profiling of dopamine regulation in substantia nigra and ventral tegmental area. Journal of visualized experiments : JoVE. issue 66. 2012-11-02. PMID:22907542. |
the ability to analyze both dopamine tissue content and its regulating proteins (including post-translational modifications) not only gives inherent power to interpreting the relationship of dopamine with the protein level and function of th, dat, or vmat2, but also extends sample economy. |
2012-11-02 |
2023-08-12 |
Not clear |
| Michael F Salvatore, Brandon S Pruett, Charles Dempsey, Victoria Field. Comprehensive profiling of dopamine regulation in substantia nigra and ventral tegmental area. Journal of visualized experiments : JoVE. issue 66. 2012-11-02. PMID:22907542. |
a comprehensive readout of dopamine tissue content and th, dat, or vmat2 can be conducted. |
2012-11-02 |
2023-08-12 |
Not clear |
| Michael F Salvatore, Brandon S Pruett, Charles Dempsey, Victoria Field. Comprehensive profiling of dopamine regulation in substantia nigra and ventral tegmental area. Journal of visualized experiments : JoVE. issue 66. 2012-11-02. PMID:22907542. |
here, a multi-step method is presented for the analyses of dopamine tissue content, the protein levels of th, dat, or vmat2, and th phosphorylation from the substantia nigra and vta from rodent midbrain. |
2012-11-02 |
2023-08-12 |
Not clear |
| Cüneyt Güzey, Per Allard, Thomas Brännström, Olav Spigse. Radioligand binding to brain dopamine and serotonin receptors and transporters in Parkinson's disease: relation to gene polymorphisms. The International journal of neuroscience. vol 122. issue 3. 2012-11-01. PMID:22004534. |
compared to control subjects, patients with pd had a significantly lowered radioligand binding to the dopamine transporter (dat) in nucleus caudatus (p = .001) and putamen (p = .008), and to the serotonin transporter in gyrus cingulatus (p = .010) and nucleus caudatus (p = .032). |
2012-11-01 |
2023-08-12 |
human |
| Epolia Ramadan, Lisa Chang, Mei Chen, Kaizong Ma, F Scott Hall, George R Uhl, Stanley I Rapoport, Mireille Basseli. Knocking out the dopamine reuptake transporter (DAT) does not change the baseline brain arachidonic acid signal in the mouse. The International journal of neuroscience. vol 122. issue 7. 2012-10-23. PMID:22376027. |
knocking out the dopamine reuptake transporter (dat) does not change the baseline brain arachidonic acid signal in the mouse. |
2012-10-23 |
2023-08-12 |
mouse |
| Epolia Ramadan, Lisa Chang, Mei Chen, Kaizong Ma, F Scott Hall, George R Uhl, Stanley I Rapoport, Mireille Basseli. Knocking out the dopamine reuptake transporter (DAT) does not change the baseline brain arachidonic acid signal in the mouse. The International journal of neuroscience. vol 122. issue 7. 2012-10-23. PMID:22376027. |
dopamine transporter (dat) homozygous knockout (dat(-/-)) mice have a 10-fold higher extracellular (da) concentration in the caudate-putamen and nucleus accumbens than do wildtype (dat(+/+)) mice, but show reduced presynaptic da synthesis and fewer postsynaptic d(2) receptors. |
2012-10-23 |
2023-08-12 |
mouse |
| A Antonini, C Vitale, P Barone, R Cilia, A Righini, U Bonuccelli, G Abbruzzese, S Ramat, A Petrone, R Quatrale, R Marconi, R Ceravolo, A Stefani, L Lopiano, M Zappia, L Capus, L Morgante, F Tamma, M Tinazzi, C Colosimo, U P Guerr. The relationship between cerebral vascular disease and parkinsonism: The VADO study. Parkinsonism & related disorders. vol 18. issue 6. 2012-10-23. PMID:22531611. |
however the status of striatal dopamine transporter (dat) and the effects of brain vascular lesions on motor features and levodopa responsiveness are poorly defined. |
2012-10-23 |
2023-08-12 |
Not clear |
| Hongwen Qiao, Lin Zhu, Brian P Lieberman, Zhihao Zha, Karl Plössl, Hank F Kun. Synthesis and evaluation of novel tropane derivatives as potential PET imaging agents for the dopamine transporter. Bioorganic & medicinal chemistry letters. vol 22. issue 13. 2012-10-19. PMID:22658558. |
a novel series of tropane derivatives containing a fluorinated tertiary amino or amide at the 2β position was synthesized, labeled with the positron-emitter fluorine-18 (t(1/2)=109.8 min), and tested as potential in vivo dopamine transporter (dat) imaging agents. |
2012-10-19 |
2023-08-12 |
rat |
| Dimitra Giannakopoulou, Véronique Daguin-Nerrière, Adamantia Mitsacos, Elias D Kouvelas, Isabelle Neveu, Panagiotis Giompres, Philippe Brache. Ectopic expression of TrKA in the adult rat basal ganglia induces both nerve growth factor-dependent and -independent neuronal responses. Journal of neuroscience research. vol 90. issue 8. 2012-10-05. PMID:22419059. |
nine weeks after transfer, tyrosine hydroxylase (th) and dopamine transporter (dat) mrnas were slightly decreased in the ipsilateral sn. |
2012-10-05 |
2023-08-12 |
rat |
| Dimitra Giannakopoulou, Véronique Daguin-Nerrière, Adamantia Mitsacos, Elias D Kouvelas, Isabelle Neveu, Panagiotis Giompres, Philippe Brache. Ectopic expression of TrKA in the adult rat basal ganglia induces both nerve growth factor-dependent and -independent neuronal responses. Journal of neuroscience research. vol 90. issue 8. 2012-10-05. PMID:22419059. |
there was no change of dat binding sites or d1 or d2 receptor mrnas and binding sites in the striatum, suggesting that ectopic trka exerts a limited effect on the pool of th and dat transcripts, without affecting overall dopamine signaling. |
2012-10-05 |
2023-08-12 |
rat |
| Sun Xiao-Mian, Yue Jing, Zheng Chongxuna, Liu Min, Deng Hui-Xin. Study of 99mTc-TRODAT-1 imaging on human brain with children autism by single photon emission computed tomography. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference. vol 2005. 2012-10-02. PMID:17281454. |
to evaluate the application values of99mtc-2 β [n, n′ , - bis (2-mercaptoethy1) ethylenediamino] methyl, 3 β -(4-chlorophenyl) tropane (trodat-1) dopamine transporter (dat) spect imaging in children autism, and offer the academic foundation to etiology, mechanism and clinical therapy of autism. |
2012-10-02 |
2023-08-12 |
human |
| Joel G Anderson, Paula T Cooney, Keith M Erikso. Inhibition of DAT function attenuates manganese accumulation in the globus pallidus. Environmental toxicology and pharmacology. vol 23. issue 2. 2012-10-02. PMID:17387379. |
our primary goal of this study was to examine the potential roles of the monoamine transporters, dopamine transporter (dat), serotonin transporter (sert) and norepinephrine transporter (net), in neuronal mn transport. |
2012-10-02 |
2023-08-12 |
rat |
| S F Ali, P Haung, Y Itzha. Role of peroxynitrite in methamphetamine-induced dopaminergic neurotoxicity and sensitization in mice. Addiction biology. vol 5. issue 3. 2012-10-02. PMID:20575850. |
dopamine (da) and dopamine transporter (dat) binding sites were determined in striatum from saline and meth-treated animals. |
2012-10-02 |
2023-08-12 |
mouse |
| G W Miller, A I Leve. Immunochemical analysis of dopamine transporters in Parkinson's disease. Methods in molecular medicine. vol 62. 2012-10-02. PMID:21318775. |
recently, considerable attention has been given to the plasma membrane dopamine tranporter (dat) and the vesicular monoamine transporter (vmat2), which are responsible for the transport, packaging, and release of dopamine (2). |
2012-10-02 |
2023-08-12 |
human |
| G W Miller, A I Leve. Immunochemical analysis of dopamine transporters in Parkinson's disease. Methods in molecular medicine. vol 62. 2012-10-02. PMID:21318775. |
dat acts to terminate dopamine transmission by rapid reuptake of dopamine from the synapse, and vmat2 packages cytoplasmic dopamine into vesicles for storage and subsequent release. |
2012-10-02 |
2023-08-12 |
human |
| G W Miller, Y M Wang, R R Gainetdinov, M G Caro. Dopamine transporter and vesicular monoamine transporter knockout mice : implications for Parkinson's disease. Methods in molecular medicine. vol 62. 2012-10-02. PMID:21318776. |
this procedure has been used to generate animals lacking either the plasma membrane dopamine transporter (dat; fig. |
2012-10-02 |
2023-08-12 |
mouse |