| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pedro Braga-Neto, Andre C Felicio, Marcelo Q Hoexter, José Luiz Pedroso, Lívia Almeida Dutra, Helena Alessi, Thaís Minett, Ruth F Santos-Galduroz, Antônio José da Rocha, Lucas A L Garcia, Paulo Henrique F Bertolucci, Rodrigo A Bressan, Orlando Graziani Povoas Barsottin. Cognitive and olfactory deficits in Machado-Joseph disease: a dopamine transporter study. Parkinsonism & related disorders. vol 18. issue 7. 2013-03-29. PMID:22575233. |
in this study, we investigated whether these patients had different dopamine transporter (dat) densities as compared to healthy subjects, and correlated these data with cognitive performance and sense of smell. |
2013-03-29 |
2023-08-12 |
human |
| Philippe Huot, Tom H Johnston, Michael N Gandy, M Gabriela Reyes, Susan H Fox, Matthew J Piggott, Jonathan M Brotchi. The monoamine re-uptake inhibitor UWA-101 improves motor fluctuations in the MPTP-lesioned common marmoset. PloS one. vol 7. issue 9. 2013-03-28. PMID:23029119. |
we recently described the discovery of uwa-101, a dual serotonin (sert) and dopamine (dat) transporter inhibitor, which increases the duration of "good quality" on-time provided by l-dopa in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-lesioned primate. |
2013-03-28 |
2023-08-12 |
marmoset |
| V Barth, A B Need, E T Tzavara, B Giros, C Overshiner, S D Gleason, M Wade, A M Johansson, K Perry, G G Nomikos, J M Witki. In vivo occupancy of dopamine D3 receptors by antagonists produces neurochemical and behavioral effects of potential relevance to attention-deficit-hyperactivity disorder. The Journal of pharmacology and experimental therapeutics. vol 344. issue 2. 2013-03-28. PMID:23197772. |
mice in which the dopamine transporter (dat) has been deleted exhibit hyperactivity that is normalized by compounds that are effective in the treatment of adhd. |
2013-03-28 |
2023-08-12 |
mouse |
| Saskia J Rietjens, Laura Hondebrink, Remco H S Westerink, Jan Meulenbel. Pharmacokinetics and pharmacodynamics of 3,4-methylenedioxymethamphetamine (MDMA): interindividual differences due to polymorphisms and drug-drug interactions. Critical reviews in toxicology. vol 42. issue 10. 2013-03-20. PMID:23030234. |
pretreatment with inhibitors of the dopamine or norepinephrine reuptake transporter (dat or net), 5-ht(2a) or α-β adrenergic receptor antagonists or antipsychotics prior to mdma exposure can also decrease one or more mdma-induced physiological and/or subjective effects. |
2013-03-20 |
2023-08-12 |
Not clear |
| Di Wang, Hei Kiu Wong, Li Zhang, Grainne M McAlonan, Xiao-Min Wang, Stephen Cho Wing Sze, Yi-Bin Feng, Zhang-Jin Zhan. Not only dopamine D2 receptors involved in Peony-Glycyrrhiza Decoction, an herbal preparation against antipsychotic-associated hyperprolactinemia. Progress in neuro-psychopharmacology & biological psychiatry. vol 39. issue 2. 2013-03-19. PMID:22796279. |
consistent with a d(2)-action, pgd did not affect prl in rat pituitary lactotropic tumor-derived gh3 cells that lack the d(2) receptor expression but significantly increased the expression of d(2) receptors and dopamine transporters (dat) in pc12 cells. |
2013-03-19 |
2023-08-12 |
rat |
| Takuya Hayashi, Shohei Wakao, Masaaki Kitada, Takayuki Ose, Hiroshi Watabe, Yasumasa Kuroda, Kanae Mitsunaga, Dai Matsuse, Taeko Shigemoto, Akihito Ito, Hironobu Ikeda, Hidenao Fukuyama, Hirotaka Onoe, Yasuhiko Tabata, Mari Dezaw. Autologous mesenchymal stem cell-derived dopaminergic neurons function in parkinsonian macaques. The Journal of clinical investigation. vol 123. issue 1. 2013-03-11. PMID:23202734. |
positron emission tomography (pet) using [11c]-cft, a ligand for the dopamine transporter (dat), revealed a dramatic increase in dat expression, with a subsequent exponential decline over a period of 7 months. |
2013-03-11 |
2023-08-12 |
Not clear |
| Shao-dan Li, Ming-hui Yang, Yi Li. [Effect of bushen huoxue granule on dopamine neurotransmitter and dopamine transporter in the brain of patients with Parkinson's disease]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. vol 31. issue 5. 2013-03-07. PMID:21812261. |
to observe the effect of bushen huoxue granule (bhg) on dopamine (da) neurotransmitter and dopamine transporter (dat) in the brain of patients with parkinson's disease (pd) as an adjunctive therapy. |
2013-03-07 |
2023-08-12 |
Not clear |
| Bernard Ravina, Kenneth Marek, Shirley Eberly, David Oakes, Roger Kurlan, Alberto Ascherio, Flint Beal, James Beck, Emily Flagg, Wendy R Galpern, Jennifer Harman, Anthony E Lang, Michael Schwarzschild, Caroline Tanner, Ira Shoulso. Dopamine transporter imaging is associated with long-term outcomes in Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 27. issue 11. 2013-03-06. PMID:22976926. |
dopamine (da) transporter (dat) imaging has been studied as a diagnostic tool for degenerative parkinsonism. |
2013-03-06 |
2023-08-12 |
human |
| Amy E Moritz, James D Foster, Balachandra K Gorentla, Michelle S Mazei-Robison, Jae-Won Yang, Harald H Sitte, Randy D Blakely, Roxanne A Vaugha. Phosphorylation of dopamine transporter serine 7 modulates cocaine analog binding. The Journal of biological chemistry. vol 288. issue 1. 2013-02-28. PMID:23161550. |
as an approach to elucidating dopamine transporter (dat) phosphorylation characteristics, we examined in vitro phosphorylation of a recombinant rat dat n-terminal peptide (ndat) using purified protein kinases. |
2013-02-28 |
2023-08-12 |
human |
| Yosefu Arime, Yoshiyuki Kasahara, F Scott Hall, George R Uhl, Ichiro Sor. Cortico-subcortical neuromodulation involved in the amelioration of prepulse inhibition deficits in dopamine transporter knockout mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 11. 2013-02-26. PMID:22781838. |
we recently reported that nisoxetine, a selective norepinephrine transporter (net) inhibitor, reversed the ppi deficits that have been identified in dopamine transporter (dat) knockout (ko) mice. |
2013-02-26 |
2023-08-12 |
mouse |
| Michal Kirshner, Ronit Galron, Dan Frenkel, Gil Mandelbaum, Yosef Shiloh, Zhao-Qi Wang, Ari Barzila. Malfunctioning DNA damage response (DDR) leads to the degeneration of nigro-striatal pathway in mouse brain. Journal of molecular neuroscience : MN. vol 46. issue 3. 2013-02-25. PMID:21922345. |
this cell loss is accompanied by a large reduction in immunoreactivity for the dopamine transporter protein (dat) in the striatum. |
2013-02-25 |
2023-08-12 |
mouse |
| Jeffrey B Eells, Josiah Wilcots, Scott Sisk, Shirley X Guo-Ros. NR4A gene expression is dynamically regulated in the ventral tegmental area dopamine neurons and is related to expression of dopamine neurotransmission genes. Journal of molecular neuroscience : MN. vol 46. issue 3. 2013-02-25. PMID:21932041. |
in a separate group of mice, haloperidol injection significantly elevated nur77 and nor1, but not nurr1 mrna in the vta within 1 h and significantly increased tyrosine hydroxylase (th) and dopamine transporter (dat) mrna expression by 4 h. these data demonstrate that the nr4a genes are dynamically regulated in dopamine neurons with maintenance of nurr1 expression requiring dopamine neuron activity while both attenuation of dopamine autoreceptors activation and dopamine neuronal activity combining to induce nur77 expression. |
2013-02-25 |
2023-08-12 |
mouse |
| Jeffrey B Eells, Josiah Wilcots, Scott Sisk, Shirley X Guo-Ros. NR4A gene expression is dynamically regulated in the ventral tegmental area dopamine neurons and is related to expression of dopamine neurotransmission genes. Journal of molecular neuroscience : MN. vol 46. issue 3. 2013-02-25. PMID:21932041. |
additionally, these data suggest that induction of nr4a genes could regulate th and dat expression and ultimately regulate dopamine neurotransmission. |
2013-02-25 |
2023-08-12 |
mouse |
| Dao-Han Wang, Wei Li, Xiao-Fang Liu, Jin-Ming Zhang, Su-Mei Wan. Chinese Medicine Formula "Jian-Pi-Zhi-Dong Decoction" Attenuates Tourette Syndrome via Downregulating the Expression of Dopamine Transporter in Mice. Evidence-based complementary and alternative medicine : eCAM. vol 2013. 2013-02-25. PMID:23431337. |
this study aims to investigate the expression of dopamine transporter (dat) in the striatum and stereotyped behavior of ts mice model by intervention of jpzdd. |
2013-02-25 |
2023-08-12 |
mouse |
| Alex C Carpenter, Tommy P Saborido, Gregg D Stanwoo. Development of hyperactivity and anxiety responses in dopamine transporter-deficient mice. Developmental neuroscience. vol 34. issue 2-3. 2013-02-22. PMID:22572477. |
extracellular da is highly regulated by the presynaptic high-affinity dopamine transporter (dat), and drug- or genetically induced deficiencies in dat function result in loss of da reuptake. |
2013-02-22 |
2023-08-12 |
mouse |
| Enrique Garea-Rodríguez, Christina Schlumbohm, Boldizsár Czéh, Jessica König, Gunther Helms, Cornelia Heckmann, Birgit Meller, Johannes Meller, Eberhard Fuch. Visualizing dopamine transporter integrity with iodine-123-FP-CIT SPECT in combination with high resolution MRI in the brain of the common marmoset monkey. Journal of neuroscience methods. vol 210. issue 2. 2013-02-22. PMID:22827895. |
here, we report the first protocol for dopamine transporter (dat) spect in common marmosets using the radioligand ¹²³i-n-ω-fluoropropyl-2β-carbomethoxy-3β-{4-iodophenyl}nortropane (¹²³i-fp-cit). |
2013-02-22 |
2023-08-12 |
monkey |
| Rachel W S Li, Cui Yang, Y W Kwan, S W Chan, Simon M Y Lee, George P H Leun. Involvement of organic cation transporter-3 and plasma membrane monoamine transporter in serotonin uptake in human brain vascular smooth muscle cells. Frontiers in pharmacology. vol 4. 2013-02-15. PMID:23407616. |
the specific serotonin re-uptake transporter (sert) inhibitor citalopram, the specific norepinephrine transporter (net) inhibitor desipramine, and the dopamine transporter (dat) inhibitor gbr12935 inhibited 5-ht uptake in hbvsmcs with ic(50) values of 97.03 ± 40.10, 10.49 ± 5.98, and 2.80 ± 1.04 μm, respectively. |
2013-02-15 |
2023-08-12 |
human |
| Osamu Uchiumi, Yoshiyuki Kasahara, Asami Fukui, F Scott Hall, George R Uhl, Ichiro Sor. Serotonergic involvement in the amelioration of behavioral abnormalities in dopamine transporter knockout mice by nicotine. Neuropharmacology. vol 64. 2013-02-11. PMID:22809709. |
dopamine transporter knockout (dat ko) mice exhibit elevated extracellular dopamine levels in brain regions that include the striatum and the nucleus accumbens, but not the prefrontal cortex. |
2013-02-11 |
2023-08-12 |
mouse |
| Yuji Nagai, Takafumi Minamimoto, Kiyoshi Ando, Shigeru Obayashi, Hiroshi Ito, Nobuhiko Ito, Tetsuya Suhar. Correlation between decreased motor activity and dopaminergic degeneration in the ventrolateral putamen in monkeys receiving repeated MPTP administrations: a positron emission tomography study. Neuroscience research. vol 73. issue 1. 2013-01-31. PMID:22374309. |
binding of dopamine transporters (dat) and d(2) receptors were measured by positron emission tomography (pet) using [(11)c]pe2i and [(11)c]raclopride, respectively. |
2013-01-31 |
2023-08-12 |
monkey |
| Dario Arnaldi, Claudio Campus, Michela Ferrara, Francesco Famà, Agnese Picco, Fabrizio De Carli, Jennifer Accardo, Andrea Brugnolo, Gianmario Sambuceti, Silvia Morbelli, Flavio Nobil. What predicts cognitive decline in de novo Parkinson's disease? Neurobiology of aging. vol 33. issue 6. 2013-01-24. PMID:22226489. |
in a consecutive series of de novo, drug-naive pd patients, we applied stepwise regression analysis to assess which clinical, neuropsychological, and functional neuroimaging (dopamine transporter [dat] and perfusion single photon emission computed tomography [spect]) characteristics at baseline was predictive of cognitive decline during an average follow-up time of about 4 years. |
2013-01-24 |
2023-08-12 |
Not clear |