| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andrew J Levine, Janet S Sinsheimer, Robert Bilder, Paul Shapshak, Elyse J Singe. Functional polymorphisms in dopamine-related genes: effect on neurocognitive functioning in HIV+ adults. Journal of clinical and experimental neuropsychology. vol 34. issue 1. 2012-05-21. PMID:22082040. |
dopamine transporter (dat), brain-derived neurotrophic factor (bdnf), and catechol-o-methyltransferase (comt) have been specifically implicated. |
2012-05-21 |
2023-08-12 |
Not clear |
| Catarina A Owesson-White, Mitchell F Roitman, Leslie A Sombers, Anna M Belle, Richard B Keithley, Jessica L Peele, Regina M Carelli, R Mark Wightma. Sources contributing to the average extracellular concentration of dopamine in the nucleus accumbens. Journal of neurochemistry. vol 121. issue 2. 2012-05-21. PMID:22296263. |
tetrabenazine almost abolished phasic dopamine release but increased extracellular dopamine to ∼500 nm, presumably by inducing reverse transport by dopamine transporter (dat). |
2012-05-21 |
2023-08-12 |
rat |
| Kristina Fischer, Vesna Sossi, Andreas von Ameln-Mayerhofer, Gerald Reischl, Bernd J Pichle. In vivo quantification of dopamine transporters in mice with unilateral 6-OHDA lesions using [11C]methylphenidate and PET. NeuroImage. vol 59. issue 3. 2012-05-17. PMID:21945469. |
quantification of the binding of [11c]methylphenidate to the dopamine transporter (dat) using positron emission tomography (pet) is often used to evaluate the integrity of dopaminergic neurons in the striatal regions of the brain. |
2012-05-17 |
2023-08-12 |
mouse |
| Eric Stice, Sonja Yokum, David Zald, Alain Daghe. Dopamine-based reward circuitry responsivity, genetics, and overeating. Current topics in behavioral neurosciences. vol 6. 2012-05-15. PMID:21243471. |
there is also growing (although mixed) evidence that genotypes that appear to lead to reduced dopamine signaling (e.g., drd2, drd4, and dat) and certain appetite-related hormones and peptides (e.g., ghrelin, orexin a, leptin) moderate the relation between dopamine signaling, overeating, and obesity. |
2012-05-15 |
2023-08-12 |
Not clear |
| Mario Mascalchi, Alessandra Vella, Roberto Ceravol. Movement disorders: role of imaging in diagnosis. Journal of magnetic resonance imaging : JMRI. vol 35. issue 2. 2012-05-10. PMID:22271273. |
however, spect using tracers of the dopamine transporter (dat) demonstrates an asymmetric decrease of the uptake in the putamen and caudate from the earliest clinical stages. |
2012-05-10 |
2023-08-12 |
Not clear |
| Teresa Femenía, Jorge Manzanare. Increased ethanol intake in prodynorphin knockout mice is associated to changes in opioid receptor function and dopamine transmission. Addiction biology. vol 17. issue 2. 2012-05-08. PMID:21966993. |
handling-induced convulsion (hic) associated to alcohol, alcohol-induced loss of righting reflex (lorr), hypothermic effects in response to acute ethanol challenge, blood ethanol levels (bels), conditioned place preference, voluntary ethanol consumption and preference, tyrosine hydroxylase (th), dopamine transporter (dat) and proenkephalin (penk) gene expression, and µ-, δ- and κ-opioid agonist-stimulated [s(35) ]- guanosine 5'-triphosphate-binding autoradiography were studied in prodynorphin knockout (pdyn ko) and wild-type (wt) mice. |
2012-05-08 |
2023-08-12 |
mouse |
| Melinda Bence, Julia Koller, Maria Sasvari-Szekely, Gergely Keszle. Transcriptional modulation of monoaminergic neurotransmission genes by the histone deacetylase inhibitor trichostatin A in neuroblastoma cells. Journal of neural transmission (Vienna, Austria : 1996). vol 119. issue 1. 2012-05-07. PMID:21785940. |
to this end, short-term parallel cultures of sk-nf-i neuroblastoma cells were treated with tsa either alone or in combination with hypoxia, and mrna levels of dopamine receptor d3 (drd3) and d4 (drd4), dopamine transporter (dat), dopamine hydroxylase (dbh), dopamine receptor regulating factor (drrf), catechol-o-methyltransferase (comt), serotonin receptor 1a (htr1a), monoamino oxidase a (mao-a), serotonin transporter (slc6a4) and tryptophan hydroxylase 2 (tph2) were determined by quantitative pcr. |
2012-05-07 |
2023-08-12 |
human |
| Hae-Won Shin, Sun Ju Chun. Drug-induced parkinsonism. Journal of clinical neurology (Seoul, Korea). vol 8. issue 1. 2012-05-03. PMID:22523509. |
dopamine transporter (dat) imaging is useful for diagnosing presynaptic parkinsonism. |
2012-05-03 |
2023-08-12 |
Not clear |
| Xiaohong Li, Heng Li, Jianfen Bi, Yana Chen, Sumit Jain, Yong Zha. Human cord blood-derived multipotent stem cells (CB-SCs) treated with all-trans-retinoic acid (ATRA) give rise to dopamine neurons. Biochemical and biophysical research communications. vol 419. issue 1. 2012-04-23. PMID:22330803. |
immunocytochemistry revealed that 48 ± 11% of atra-treated cells were positive for tyrosine hydroxylase (th), and 36 ± 9% of cells were positive for dopamine transporter (dat). |
2012-04-23 |
2023-08-12 |
human |
| Ofelia M Littrell, Francois Pomerleau, Peter Huettl, Stewart Surgener, Jacqueline F McGinty, Lawrence D Middaugh, Ann-Charlotte Granholm, Greg A Gerhardt, Heather A Boge. Enhanced dopamine transporter activity in middle-aged Gdnf heterozygous mice. Neurobiology of aging. vol 33. issue 2. 2012-04-19. PMID:21144620. |
in this study, dopamine transporter (dat) function in middle-aged, 12 month old gdnf(+/-) mice was more thoroughly investigated using in vivo electrochemistry. |
2012-04-19 |
2023-08-12 |
mouse |
| Morten Ziebell, Usman Khalid, Anders B Klein, Susana Aznar, Gerda Thomsen, Peter Jensen, Gitte M Knudse. Striatal dopamine transporter binding correlates with serum BDNF levels in patients with striatal dopaminergic neurodegeneration. Neurobiology of aging. vol 33. issue 2. 2012-04-19. PMID:21176997. |
twenty-one patients with abnormal in vivo striatal dopamine transporter (dat) binding as evidenced with [(123)i]pe2i spect brain scanning were included. |
2012-04-19 |
2023-08-12 |
Not clear |
| Peter S Jensen, Morten Ziebell, Glenna Skouboe, Usman Khalid, Robin de Nijs, Gerda Thomsen, Gitte M Knudsen, Claus Svare. Validation of a method for accurate and highly reproducible quantification of brain dopamine transporter SPECT studies. Journal of nuclear medicine technology. vol 39. issue 4. 2012-04-18. PMID:22072699. |
the purpose of this study was to validate a new time-saving algorithm (datquan) for accurate and reproducible quantification of the striatal dopamine transporter (dat) with appropriate radioligands and spect and without the need for structural brain scanning. |
2012-04-18 |
2023-08-12 |
Not clear |
| Erik R Hill, Xiaoqin Huang, Chang-Guo Zhan, F Ivy Carroll, Howard H G. Interaction of tyrosine 151 in norepinephrine transporter with the 2β group of cocaine analog RTI-113. Neuropharmacology. vol 61. issue 1-2. 2012-04-17. PMID:21420984. |
cocaine binds and inhibits dopamine transporter (dat), norepinephrine transporter (net) and serotonin transporter. |
2012-04-17 |
2023-08-12 |
Not clear |
| Laura Hondebrink, Jan Meulenbelt, Marieke Meijer, Martin van den Berg, Remco H S Westerin. High concentrations of MDMA ('ecstasy') and its metabolite MDA inhibit calcium influx and depolarization-evoked vesicular dopamine release in PC12 cells. Neuropharmacology. vol 61. issue 1-2. 2012-04-17. PMID:21497613. |
the popular synthetic drug of abuse 3,4-methylenedioxymethampetamine (mdma) and its metabolite 3,4-methylenedioxyamphetamine (mda) act mainly on the serotonergic system, though they also increase the amount of extracellular dopamine (da) in the brain, presumably via reversal of the membrane dopamine transporter (dat). |
2012-04-17 |
2023-08-12 |
Not clear |
| Maarten van den Buuse, Emma Ruimschotel, Sally Martin, Victoria B Risbrough, Adam L Halberstad. Enhanced effects of amphetamine but reduced effects of the hallucinogen, 5-MeO-DMT, on locomotor activity in 5-HT(1A) receptor knockout mice: implications for schizophrenia. Neuropharmacology. vol 61. issue 1-2. 2012-04-17. PMID:21501627. |
similarly, there were no major changes in density of dopamine transporters (dat) or dopamine d(1) or d(2) receptors which could explain the behavioural changes observed in 5-ht(1a) receptor knockout mice. |
2012-04-17 |
2023-08-12 |
mouse |
| W Anthony Owens, Jason M Williams, Christine Saunders, Malcolm J Avison, Aurelio Galli, Lynette C Daw. Rescue of dopamine transporter function in hypoinsulinemic rats by a D2 receptor-ERK-dependent mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 8. 2012-04-16. PMID:22357848. |
the dopamine (da) transporter (dat) is a major target for abused drugs and a key regulator of extracellular da. |
2012-04-16 |
2023-08-12 |
rat |
| Yan-Fen Zhang, Xiao-Yu Wang, Li Cao, Qi-Yong Guo, Xiao-Ming Wan. Effects of hypoxic-ischemic brain injury on striatal dopamine transporter in newborn piglets: evaluation of 11C-CFT PET/CT for DAT quantification. Nuclear medicine and biology. vol 38. issue 8. 2012-04-06. PMID:21741256. |
effects of hypoxic-ischemic brain injury on striatal dopamine transporter in newborn piglets: evaluation of 11c-cft pet/ct for dat quantification. |
2012-04-06 |
2023-08-12 |
Not clear |
| N B Gross, P C Duncker, J F Marshal. Cortical ionotropic glutamate receptor antagonism protects against methamphetamine-induced striatal neurotoxicity. Neuroscience. vol 199. 2012-04-06. PMID:21946008. |
in a separate experiment we applied ap5 or dnqx epidurally in the same cortical location of rats during a binge regimen of mamph and assessed mamph-induced striatal dopamine transporter (dat) depletions 1 week later. |
2012-04-06 |
2023-08-12 |
rat |
| Lisa M McFadden, Greg C Hadlock, Scott C Allen, Paula L Vieira-Brock, Kristen A Stout, Jonathan D Ellis, Amanda J Hoonakker, David M Andrenyak, Shannon M Nielsen, Diana G Wilkins, Glen R Hanson, Annette E Fleckenstei. Methamphetamine self-administration causes persistent striatal dopaminergic alterations and mitigates the deficits caused by a subsequent methamphetamine exposure. The Journal of pharmacology and experimental therapeutics. vol 340. issue 2. 2012-04-06. PMID:22034657. |
results revealed that self-administration of meth, given according to a regimen that produces brain meth levels comparable with those reported postmortem in human meth abusers (0.06 mg/infusion; 8-h sessions for 7 days), decreased striatal dopamine transporter (dat) uptake and/or immunoreactivity as assessed 8 or 30 days after the last self-administration session. |
2012-04-06 |
2023-08-12 |
human |
| Kyle C Schmitt, Maarten E A Reit. The atypical stimulant and nootropic modafinil interacts with the dopamine transporter in a different manner than classical cocaine-like inhibitors. PloS one. vol 6. issue 10. 2012-04-06. PMID:22043293. |
the chief molecular target of modafinil is the dopamine transporter (dat); however, the mechanistic details underlying modafinil's unique effects remain unknown. |
2012-04-06 |
2023-08-12 |
Not clear |