| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hyo Young Jung, Dae Young Yoo, Jong Whi Kim, Hyun Jung Kwon, Kwon Young Lee, Jung Hoon Choi, Dae Won Kim, Jin Young Chung, Yeo Sung Yoon, In Koo Hwan. Age-associated alterations in constitutively expressed cyclooxygenase-2 immunoreactivity and protein levels in the hippocampus. Molecular medicine reports. vol 15. issue 6. 2018-02-23. PMID:28487938. |
the present study investigated the age‑associated alterations in white blood cell counts and hippocampal cox‑2 expression in healthy mice using immunohistochemical and western blot analyses at 1 month postnatal (pm1), pm3, pm6, pm12 and pm24. |
2018-02-23 |
2023-08-13 |
mouse |
| Qian Xu, Xue-Fei Ji, Tian-Yan Chi, Peng Liu, Ge Jin, Ling Chen, Li-Bo Zo. Sigma-1 receptor in brain ischemia/reperfusion: Possible role in the NR2A-induced pathway to regulate brain-derived neurotrophic factor. Journal of the neurological sciences. vol 376. 2018-02-21. PMID:28431607. |
on day 22 after brain ischemia/reperfusion, mice were sacrificed and brains were immediately collected and the injured and the hippocampus was isolated and stored at -80°c for western blot analysis. |
2018-02-21 |
2023-08-13 |
mouse |
| G Wu, L Li, H-M Li, Y Zeng, W-C W. Electroacupuncture ameliorates spatial learning and memory impairment via attenuating NOX2-related oxidative stress in a rat model of Alzheimer's disease induced by Aβ1-42. Cellular and molecular biology (Noisy-le-Grand, France). vol 63. issue 4. 2018-02-16. PMID:28478802. |
meanwhile, the neun expression was examined in the hippocampus, the expression levels of nicotinamide adenine dinucleotide phosphate (nadph)-oxidase2(nox2) was detected by immunofluorescence staining and western blot. |
2018-02-16 |
2023-08-13 |
rat |
| J Marit Arp, Judith P Ter Horst, Manila Loi, Jan den Blaauwen, Eline Bangert, Guillén Fernández, Marian Joëls, Melly S Oitzl, Harm J Kruger. Blocking glucocorticoid receptors at adolescent age prevents enhanced freezing between repeated cue-exposures after conditioned fear in adult mice raised under chronic early life stress. Neurobiology of learning and memory. vol 133. 2018-02-15. PMID:27246249. |
western blot analysis revealed no effects of els on hippocampal expression of glucocorticoid receptors, neither at postnatal day 28 nor at adult age, when mice were behaviorally tested. |
2018-02-15 |
2023-08-13 |
mouse |
| Yun Li, Wei Sun, Song Han, Jianing Li, Shu Ding, Wei Wang, Yanling Yi. IGF-1-Involved Negative Feedback of NR2B NMDA Subunits Protects Cultured Hippocampal Neurons Against NMDA-Induced Excitotoxicity. Molecular neurobiology. vol 54. issue 1. 2018-02-08. PMID:26758454. |
in this study, we observed that igf-1 can salvage the hippocampal neurons in an autophagy-independent manner after 150-μm nmda exposure using thiazolyl blue tetrazolium bromide (mtt), lactate dehydrogenase (ldh), western blot assay, and transmission electron microscopy. |
2018-02-08 |
2023-08-13 |
Not clear |
| Shan Jiang, Bei Miao, Ying Che. Prolonged duration of isoflurane anesthesia impairs spatial recognition memory through the activation of JNK1/2 in the hippocampus of mice. Neuroreport. vol 28. issue 7. 2018-01-15. PMID:28240723. |
the activation of jnk1/2 in the hippocampus was tested using western blot. |
2018-01-15 |
2023-08-13 |
mouse |
| Yun-Qi An, Chun Teng Zhang, Yong Du, Ming Zhang, Su Su Tang, Mei Hu, Yan Long, Hong Bing Sun, Hao Hon. PPARδ agonist GW0742 ameliorates Aβ1-42-induced hippocampal neurotoxicity in mice. Metabolic brain disease. vol 31. issue 3. 2018-01-12. PMID:26864581. |
intra-hippocampal infusion of aggregated aβ1-42 oligomer (410pmol/mouse) remarkably damaged learning and memory in the morris water maze (mwm) and y-maze tests, accompanied by decreased expression of pparδ in the hippocampus as confirmed by western blot. |
2018-01-12 |
2023-08-13 |
mouse |
| Dongsheng Zhou, Huaxia Liu, Chenli Li, Fangyan Wang, Yaosheng Shi, Lingjiang Liu, Xin Zhao, Aiming Liu, Junfang Zhang, Chuang Wang, Zhongming Che. Atorvastatin ameliorates cognitive impairment, Aβ1-42 production and Tau hyperphosphorylation in APP/PS1 transgenic mice. Metabolic brain disease. vol 31. issue 3. 2018-01-12. PMID:26883430. |
on the memory deficit by behavioral tests and changes of akt/gsk3β signaling in hippocampus and prefrontal cortex by western blot test in tg app/ps1 mice. |
2018-01-12 |
2023-08-13 |
mouse |
| Ana Carolina Cossa, Daiana Correia Lima, Tiago Gurgel do Vale, Anna Karynna Alves de Alencar Rocha, Maria da Graça Naffah-Mazzacoratti, Maria José da Silva Fernandes, Debora Amad. Maternal seizures can affect the brain developing of offspring. Metabolic brain disease. vol 31. issue 4. 2018-01-12. PMID:27085526. |
(14)c-leucine [(14)c-leu] incorporation was used to analyze protein synthesis at pn1, and western blot method was used to analyze protein levels of bax, bcl-2 and poly(adp-ribose) polymerase-1 (parp-1) in the hippocampus (pn3-pn21). |
2018-01-12 |
2023-08-13 |
rat |
| Soner Bitiktaş, Başak Kandemir, Burak Tan, Şehrazat Kavraal, Narin Liman, Nurcan Dursun, Hamiyet Dönmez-Altuntaş, Işil Aksan-Kurnaz, Cem Sue. Adult-onset hyperthyroidism impairs spatial learning: possible involvement of mitogen-activated protein kinase signaling pathways. Neuroreport. vol 27. issue 11. 2018-01-09. PMID:27258653. |
western blot analyses of the hippocampus showed that hyperthyroidism increased phosphorylated p38-mapk levels in untrained rats. |
2018-01-09 |
2023-08-13 |
rat |
| Ashish P Bharne, Chandrashekhar D Borkar, Satish Bodakuntla, Mayurika Lahiri, Nishikant K Subhedar, Dadasaheb M Kokar. Pro-cognitive action of CART is mediated via ERK in the hippocampus. Hippocampus. vol 26. issue 10. 2018-01-08. PMID:27258934. |
western blot analysis revealed that cart treatment significantly up-regulated the expression of phospo-erk1/2 in hippocampus, ent and prh. |
2018-01-08 |
2023-08-13 |
rat |
| Sarawut Lapmanee, Jantarima Charoenphandhu, Jarinthorn Teerapornpuntakit, Nateetip Krishnamra, Narattaphol Charoenphandh. Agomelatine, venlafaxine, and running exercise effectively prevent anxiety- and depression-like behaviors and memory impairment in restraint stressed rats. PloS one. vol 12. issue 11. 2017-12-29. PMID:29099859. |
moreover, western blot analysis demonstrated that venlafaxine and running exercise upregulated brain-derived neurotrophic factor (bdnf) expression in the hippocampus. |
2017-12-29 |
2023-08-13 |
rat |
| Aurélie Ledreux, Xiuzhe Wang, Marianne Schultzberg, Ann-Charlotte Granholm, Linnea R Freema. Detrimental effects of a high fat/high cholesterol diet on memory and hippocampal markers in aged rats. Behavioural brain research. vol 312. 2017-12-13. PMID:27343935. |
hippocampal tissue was analyzed by immunohistochemistry for structural changes and inflammation, and western blot analysis. |
2017-12-13 |
2023-08-13 |
rat |
| Aurélie Ledreux, Xiuzhe Wang, Marianne Schultzberg, Ann-Charlotte Granholm, Linnea R Freema. Detrimental effects of a high fat/high cholesterol diet on memory and hippocampal markers in aged rats. Behavioural brain research. vol 312. 2017-12-13. PMID:27343935. |
western blot analysis of the hippocampus showed higher levels of p-tau s202/t205 and t231 in aged hfhc rats, suggesting abnormal phosphorylation of tau protein following the hfhc diet exposure. |
2017-12-13 |
2023-08-13 |
rat |
| Xinyu Xu, Chen Zheng, Nan Li, Hui Shen, Guolin Wan. The decrease of NMDAR subunit expression and NMDAR EPSC in hippocampus by neonatal exposure to desflurane in mice. Behavioural brain research. vol 317. 2017-12-05. PMID:27639321. |
levels of nmdar subunits nr1, nr2a, and nr2b expression in hippocampus were evaluated by western blot. |
2017-12-05 |
2023-08-13 |
mouse |
| Yu-Peng Zhu, Shu-Hua Xi, Ming-Yan Li, Ting-Ting Ding, Nan Liu, Fu-Yuan Cao, Yang Zeng, Xiao-Jing Liu, Jun-Wang Tong, Shou-Fang Jian. Fluoride and arsenic exposure affects spatial memory and activates the ERK/CREB signaling pathway in offspring rats. Neurotoxicology. vol 59. 2017-11-22. PMID:28099871. |
erk, phospho-erk (p-erk), creb and phospho-creb (p-creb) protein expression in the hippocampus and cerebral cortex was detected using western blot. |
2017-11-22 |
2023-08-13 |
rat |
| Xiong Li, Chunmei Wang, Wen Wang, Chengwei Yue, Yan Tan. Neonatal exposure to BDE 209 impaired learning and memory, decreased expression of hippocampal core SNAREs and synaptophysin in adult rats. Neurotoxicology. vol 59. 2017-11-22. PMID:28104350. |
furthermore, we detected the mrna and protein expressions of hippocampal synaptobrevin 2, syntaxin 1a, synaptosome associated protein 25 (snap-25), and synaptophysin using quantitative reverse transcription-polymerase chain reaction (qrt-pcr) and western blot methods. |
2017-11-22 |
2023-08-13 |
rat |
| Linjie Yang, Ting Xu, Ke Zhang, Zhisheng Wei, Xuran Li, Mingfa Huang, Gregory M Rose, Xiang Ca. The essential role of hippocampal alpha6 subunit-containing GABAA receptors in maternal separation stress-induced adolescent depressive behaviors. Behavioural brain research. vol 313. 2017-11-21. PMID:27388150. |
using immunohistochemistry, quantitative pcr and western blot approaches, we found that alpha6 subunit-containing gabaa receptors (gabra6-containing gabaa rs) were expressed on hippocampal interneurons of adolescent rats. |
2017-11-21 |
2023-08-13 |
rat |
| E M Meylan, L Breuillaud, T Seredenina, P J Magistretti, O Halfon, R Luthi-Carter, J-R Cardinau. Involvement of the agmatinergic system in the depressive-like phenotype of the Crtc1 knockout mouse model of depression. Translational psychiatry. vol 6. issue 7. 2017-11-07. PMID:27404284. |
quantitative polymerase chain reaction and western blot analyses confirmed agmat upregulation in the crtc1(-/-) prefrontal cortex (pfc) and hippocampus, which were further demonstrated by confocal immunofluorescence microscopy to comprise an increased number of agmat-expressing cells, notably parvalbumin- and somatostatin-positive interneurons. |
2017-11-07 |
2023-08-13 |
mouse |
| Shanshan Qin, Qiang Chen, Hui Wu, Chenglong Liu, Jing Hu, Dalei Zhang, Changshui X. Effects of naringin on learning and memory dysfunction induced by gp120 in rats. Brain research bulletin. vol 124. 2017-10-26. PMID:27154619. |
learning and memory ability was evaluated via morris water maze test, p2x7 receptor and p65 protein expressions in the rat hippocampus were detected by western blot analysis, and p2x7 mrna expression in the hippocampus was measured by rt-pcr. |
2017-10-26 |
2023-08-13 |
rat |