| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aditya Sunkaria, Aarti Yadav, Supriya Bhardwaj, Rajat Sandhi. Postnatal Proteasome Inhibition Promotes Amyloid-β Aggregation in Hippocampus and Impairs Spatial Learning in Adult Mice. Neuroscience. vol 367. 2018-07-10. PMID:29080716. |
western blot analyses showed decreased levels of pthr286-camkiiα:camkiiα and pser133-creb:creb ratio but increased pro:mature bdnf ratio in the hippocampus of mg132 mice. |
2018-07-10 |
2023-08-13 |
mouse |
| Lei Li, Wei Wang, Li-Ming Zhang, Xiang-Yun Jiang, Shu-Zheng Sun, Li-Jun Sun, Ying Guo, Jie Gong, You-Zhi Zhang, Heng-Lin Wang, Yun-Feng L. Overexpression of the 18 kDa translocator protein (TSPO) in the hippocampal dentate gyrus produced anxiolytic and antidepressant-like behavioural effects. Neuropharmacology. vol 125. 2018-06-12. PMID:28655607. |
the expression of tspo and the concentration of allopregnanolone in hippocampus tissues (3 mm in diameter around the injection site on both sides) were measured by western blot and elisa, respectively. |
2018-06-12 |
2023-08-13 |
mouse |
| Vesna Tesic, Milka Perovic, Ivan Zaletel, Mirna Jovanovic, Nela Puskas, Sabera Ruzdijic, Selma Kanazi. A single high dose of dexamethasone increases GAP-43 and synaptophysin in the hippocampus of aged rats. Experimental gerontology. vol 98. 2018-06-04. PMID:28801169. |
moreover, by introducing the gray level co-occurrence matrix method, a form of texture analysis, we were able to reveal the subtle differences in the expression pattern of both gap-43 and synaptophysin in the hippocampal subfields that were not detected by western blot analysis alone. |
2018-06-04 |
2023-08-13 |
rat |
| Ying-Li Zhu, Lin-Yuan Wang, Cheng-Long Wang, Dan-Ping Zhao, Sha Wang, Wen-Ting Fei, Jian-Jun Zhan. [Investigation of effects of albiflorin and paeoniflorin on hippocampal BDNF and NO in chronic restraint stress rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 41. issue 22. 2018-05-30. PMID:28933095. |
finally, the expressions of nnos mrna in hippocampus detected by rt-qpcr, the protein levels of nnos and bdnf in hippocampus were detected by western blot. |
2018-05-30 |
2023-08-13 |
rat |
| Seema Yousuf, Daniel J Brat, Hui-Kuo Shu, Ya Wang, Donald G Stein, Fahim Ati. Progesterone improves neurocognitive outcomes following therapeutic cranial irradiation in mice. Hormones and behavior. vol 96. 2018-05-22. PMID:28866326. |
western blot analysis of hippocampal and cortical tissue showed that ir at both doses induced astrocytic activation (glial fibrillary acidic protein), reactive macrophages/microglia (cd68) and apoptosis (cleaved caspase-3) and prog treatment inhibited these markers of brain injury. |
2018-05-22 |
2023-08-13 |
mouse |
| Yan-Na Geng, Yi-Jun Wu, Wen-Xin Zhan. [Effect of hyperforin on learning and memory abilities and Aβ₁₋₄₂, βAPP and BACE1 protein expressions in hippocampus of Alzheimer's disease model mice]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 41. issue 15. 2018-05-22. PMID:28914032. |
immunohistochemistry and western blot results showed thatas compared with the normal group, the aβ₁₋₄₂, βapp and bace1 protein expression levels in hippocampus were significantly increased in mice of model group (p<0.01);as compared with the model group, aβ₁₋₄₂, βapp and bace1 protein expression levels in hippocampus were decreased in mice of rosiglitazone group and hf high, middle and low dose groups (p<0.01 or p<0.05). |
2018-05-22 |
2023-08-13 |
mouse |
| Octavio Amancio-Belmont, Diego Pérez-Vázquez, Alejandra E Ruiz-Contreras, Miguel Pérez de la Mora, Pavel E Rueda-Orozco, Mónica Méndez-Díaz, Oscar E Prospero-Garci. Chloramphenicol decreases CB1 receptor expression in the nucleus accumbens and prefrontal cortex and prevents amphetamine-induced conditioned place preference in rats. Pharmacology, biochemistry, and behavior. vol 159. 2018-05-21. PMID:28642068. |
once cpp was evaluated rats were sacrificed and the prefrontal cortex (pfc), the nucleus accumbens (nacc) and the hippocampus (hipp) were isolated and prepared for cb1r western blot analysis. |
2018-05-21 |
2023-08-13 |
rat |
| Keyan Chen, Yingjie Sun, Yugang Diao, Liu Ji, Dandan Song, Tiezheng Zhan. α7 nicotinic acetylcholine receptor agonist inhibits the damage of rat hippocampal neurons by TLR4/Myd88/NF‑κB signaling pathway during cardiopulmonary bypass. Molecular medicine reports. vol 16. issue 4. 2018-05-21. PMID:28791395. |
quantitative polymerase chain reaction and western blot assays were used to determine the expression of tlr4, myd88 and nf‑κb mrna, and protein in the hippocampus. |
2018-05-21 |
2023-08-13 |
rat |
| Tushar Deshpande, Tingsong Li, Michel K Herde, Albert Becker, Hartmut Vatter, Martin K Schwarz, Christian Henneberger, Christian Steinhäuser, Peter Bedne. Subcellular reorganization and altered phosphorylation of the astrocytic gap junction protein connexin43 in human and experimental temporal lobe epilepsy. Glia. vol 65. issue 11. 2018-05-14. PMID:28795432. |
western blot analysis showed that plasma membrane expression of connexin43 (cx43) and cx30 were not significantly different in hippocampal specimens with and without sclerosis. |
2018-05-14 |
2023-08-13 |
human |
| Lan Zhao, Chunlei Zhou, Li Li, Jianwei Liu, Huiyan Shi, Bohong Kan, Zhen Li, Yunzhu Li, Jingxian Han, Jianchun Y. Acupuncture Improves Cerebral Microenvironment in Mice with Alzheimer's Disease Treated with Hippocampal Neural Stem Cells. Molecular neurobiology. vol 54. issue 7. 2018-05-10. PMID:27558235. |
therefore, this study investigated the role of sanjiao acupuncture in the nscs-treated hippocampus of a mouse model, senescence-accelerated mouse prone 8 (samp8) using western blot, real-time fluorescent pcr, and immunofluorescence techniques. |
2018-05-10 |
2023-08-13 |
mouse |
| Ying Ren, Jin-Liang Wang, Xiang Zhang, Hao Wang, Ying Ye, Lu Song, Ying-Jie Wang, Meng-Jue Tu, Wei-Wei Wang, Lan Yang, Bo Jian. Antidepressant-like effects of ginsenoside Rg2 in a chronic mild stress model of depression. Brain research bulletin. vol 134. 2018-05-07. PMID:28842305. |
moreover, western blot analysis showed that rg2 administration significantly increased the bdnf signaling pathway in hippocampus. |
2018-05-07 |
2023-08-13 |
mouse |
| Shi-Jie Zhang, Ting-Ting Xu, Lin Li, Yu-Min Xu, Zi-Ling Qu, Xin-Chen Wang, Shui-Qing Huang, Yi Luo, Na-Chuan Luo, Ping Lu, Ya-Fei Shi, Xin Yang, Qi Wan. Bushen-Yizhi formula ameliorates cognitive dysfunction through SIRT1/ER stress pathway in SAMP8 mice. Oncotarget. vol 8. issue 30. 2018-04-23. PMID:28521305. |
in addition, western blot results (bcl-2, bax and caspase-3) and tunel staining show that bsyz prevents neuron from apoptosis, and elevates the expression of neurotrophic factors, including nerve growth factor (ngf), postsynapticdensity 95 (psd95) and synaptophysin (syn), in both hippocampus and cortex. |
2018-04-23 |
2023-08-13 |
mouse |
| Sung Min Nam, Dae Young Yoo, Hyun Jung Kwon, Jong Whi Kim, Hyo Young Jung, Dae Won Kim, Ho Jae Han, Moo-Ho Won, Je Kyung Seong, In Koo Hwang, Yeo Sung Yoo. Proteomic approach to detect changes in hippocampal protein levels in an animal model of type 2 diabetes. Neurochemistry international. vol 108. 2018-04-13. PMID:28434974. |
in addition, immunohistochemical and western blot studies demonstrated that mbp, not gfap, immunoreactivity and protein levels were significantly decreased in the hippocampus of zdf rats compared to zlc rats. |
2018-04-13 |
2023-08-13 |
rat |
| Ibanylla Kynjai Hynniewta Hadem, Ramesh Sharm. Differential Regulation of Hippocampal IGF-1-Associated Signaling Proteins by Dietary Restriction in Aging Mouse. Cellular and molecular neurobiology. vol 37. issue 6. 2018-04-10. PMID:27718093. |
hence in the present investigation, the igf-1 gene expression and the normal endogenous levels of igf1r (igf-1 receptor), pi3k, akt, pakt, and pfoxo in the hippocampus of young, adult, and old mice were determined using real-time pcr and western blot analyses. |
2018-04-10 |
2023-08-13 |
mouse |
| Yanan Li, Xinran Li, Cen Guo, Lina Li, Yuxin Wang, Yiming Zhang, Yu Chen, Wenhan Liu, Li Ga. Long-term neurocognitive dysfunction in offspring via NGF/ ERK/CREB signaling pathway caused by ketamine exposure during the second trimester of pregnancy in rats. Oncotarget. vol 8. issue 19. 2018-03-26. PMID:28415680. |
the hippocampal protein levels of nerve growth factor (ngf), extracellular signal-regulated kinase (erk), phosphorylated-erk (p-erk), cyclic adenosine monophosphate response element-binding (creb), p-creb, synaptophysin (syp), synapsin (syn), and postsynaptic density-95 (psd95) were measured via western blot. |
2018-03-26 |
2023-08-13 |
rat |
| Yuan Du, Haiyue Liang, Leiming Zhang, Fenghua F. Administration of Huperzine A exerts antidepressant-like activity in a rat model of post-stroke depression. Pharmacology, biochemistry, and behavior. vol 158. 2018-03-26. PMID:28583576. |
western blot analysis was used to evaluate hippocampal expression of the 5-hydroxytryptamine 1a receptor (5-ht |
2018-03-26 |
2023-08-13 |
rat |
| A Knezovic, A Loncar, J Homolak, U Smailovic, J Osmanovic Barilar, L Ganoci, N Bozina, P Riederer, Melita Salkovic-Petrisi. Rat brain glucose transporter-2, insulin receptor and glial expression are acute targets of intracerebroventricular streptozotocin: risk factors for sporadic Alzheimer's disease? Journal of neural transmission (Vienna, Austria : 1996). vol 124. issue 6. 2018-03-20. PMID:28470423. |
the expression of ir, glut2 and glial fibrillary acidic protein (gfap) was measured by immunofluorescence and western blot analysis in the parietal (pc) and the temporal (tc) cortex, in the hippocampus (hpc) and the hypothalamus. |
2018-03-20 |
2023-08-13 |
rat |
| Khayelihle B Makhathini, Oualid Abboussi, Dan J Stein, Musa V Mabandla, William M U Daniel. Repetitive stress leads to impaired cognitive function that is associated with DNA hypomethylation, reduced BDNF and a dysregulated HPA axis. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 60. 2018-03-19. PMID:28465238. |
hippocampal bdnf levels, glucocorticoid (gr) and mineralocorticoid (mr) receptor mrna were assessed using real-time pcr and confirmed with western blot, while elisas were used to determine plasma corticosterone levels and the global methylation status of the hippocampus. |
2018-03-19 |
2023-08-13 |
rat |
| Ce Zhang, Yiying Zhang, Yuan Shen, Guoqing Zhao, Zhongcong Xie, Yuanlin Don. Anesthesia/Surgery Induces Cognitive Impairment in Female Alzheimer's Disease Transgenic Mice. Journal of Alzheimer's disease : JAD. vol 57. issue 2. 2018-02-26. PMID:28269788. |
hippocampal levels of synaptic marker postsynaptic density 95 (psd-95) and synaptophysin (svp) were measured using western blot analysis. |
2018-02-26 |
2023-08-13 |
mouse |
| Yanke Zhang, Baobing Gao, Yan Xiong, Fangshuo Zheng, Xin Xu, Yong Yang, Yida Hu, Xuefeng Wan. Expression of SHANK3 in the Temporal Neocortex of Patients with Intractable Temporal Epilepsy and Epilepsy Rat Models. Cellular and molecular neurobiology. vol 37. issue 5. 2018-02-23. PMID:27592227. |
immunofluorescence, immunohistochemistry, and western blot analysis were used to locate and determine the expression of shank3 in the temporal neocortex of patients with epilepsy, and in the hippocampus and temporal lobe cortex of rats in a pilocarpine-induced epilepsy model. |
2018-02-23 |
2023-08-13 |
rat |