| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhen Liu, Fan Liu, Xiaowen Liu, Chao Ma, Jing Zha. Surgical incision induces learning impairment in mice partially through inhibition of the brain-derived neurotrophic factor signaling pathway in the hippocampus and amygdala. Molecular pain. vol 14. 2019-01-14. PMID:30232930. |
the fear conditioning test, enzyme-linked immunosorbent assay, and western blot analyses were used to confirm our hypothesis and determine the effect of a plantar incision on the fear learning and the bdnf/trkb signaling pathway in the hippocampus and amygdala. |
2019-01-14 |
2023-08-13 |
mouse |
| Yunlong Wang, Mengshi Wang, Mengjie Xu, Tongde Li, Kaiyue Fan, Tingxu Yan, Feng Xiao, Kaishun Bi, Ying Ji. Nootkatone, a neuroprotective agent from Alpiniae Oxyphyllae Fructus, improves cognitive impairment in lipopolysaccharide-induced mouse model of Alzheimer's disease. International immunopharmacology. vol 62. 2019-01-02. PMID:29990697. |
enzyme linked immunosorbent assay and western blot analysis also demonstrated that the model group had increased expression of il-1β, il-6, tnf-α, nlrp3 and nf-κb p65, especially in hippocampus relative to sham-operated group, and nkt (10 mg/kg) decreased the high expression of these inflammatory cytokines. |
2019-01-02 |
2023-08-13 |
mouse |
| Yubeen Kwon, Yulan Liao, Bokyung Koo, Hojung Bae, Jiabao Zhang, Eun Hye Han, Su Min Yun, Mi Kyung Lim, Sang Ho Lee, Seo Yun Jung, Jong Hoon Ry. Ethanolic Extract of Opuntia ficus-indica var. saboten Ameliorates Cognitive Dysfunction Induced by Cholinergic Blockade in Mice. Journal of medicinal food. vol 21. issue 10. 2019-01-02. PMID:30044674. |
we also explored its mechanism of action by conducting an acetylcholinesterase (ache) activity assay using the mouse whole brain and western blot using the mouse hippocampal tissue. |
2019-01-02 |
2023-08-13 |
mouse |
| Yubeen Kwon, Yulan Liao, Bokyung Koo, Hojung Bae, Jiabao Zhang, Eun Hye Han, Su Min Yun, Mi Kyung Lim, Sang Ho Lee, Seo Yun Jung, Jong Hoon Ry. Ethanolic Extract of Opuntia ficus-indica var. saboten Ameliorates Cognitive Dysfunction Induced by Cholinergic Blockade in Mice. Journal of medicinal food. vol 21. issue 10. 2019-01-02. PMID:30044674. |
western blot analysis and the ex vivo study revealed that eofs increased the levels of phosphorylated extracellular signal-regulated kinase and camp response element-binding protein (creb) and the levels of brain-derived neurotrophic factor (bdnf) expression in the hippocampus. |
2019-01-02 |
2023-08-13 |
mouse |
| Suku-Maran Shalini, Christabel Fung-Yih Ho, Yee-Kong Ng, Jie-Xin Tong, Eng-Shi Ong, Deron R Herr, Gavin S Dawe, Wei-Yi On. Distribution of Alox15 in the Rat Brain and Its Role in Prefrontal Cortical Resolvin D1 Formation and Spatial Working Memory. Molecular neurobiology. vol 55. issue 2. 2018-12-21. PMID:28181190. |
western blot analysis was consistent with rt-pcr data, in that the prefrontal cortex, cerebral cortex, hippocampus, and olfactory bulb had high alox15 protein expression. |
2018-12-21 |
2023-08-13 |
rat |
| Gabriela Riego, Alejandro Redondo, Sergi Leánez, Olga Po. Mechanism implicated in the anti-allodynic and anti-hyperalgesic effects induced by the activation of heme oxygenase 1/carbon monoxide signaling pathway in the central nervous system of mice with neuropathic pain. Biochemical pharmacology. vol 148. 2018-12-17. PMID:29247614. |
in male c57bl6 mice with neuropathic pain induced by the chronic constriction of sciatic nerve (cci), we evaluated the effects of corm-2 and copp on the expression of the nuclear factor erythroid 2-related factor 2 (nrf2), ho-1 and nad(p)h:quinone oxidoreductase-1 (nqo1), the microglial marker (cd11b/c), and the mitogen-activated protein kinases (mapk) (jnk, erk½ and p38) in the amygdala, prefrontal cortex, hippocampus, hypothalamus and spinal cord, by using western blot assay. |
2018-12-17 |
2023-08-13 |
mouse |
| R Rahimi, M M Akhavan, K Kamyab, S A Ebrahim. Maternal voluntary exercise ameliorates learning deficit in rat pups exposed, in utero, to valproic acid; role of BDNF and VEGF and their receptors. Neuropeptides. vol 71. 2018-12-11. PMID:30144942. |
also, on pnd 30, hippocampal bdnf and vegf were measured by elisa and western blot analysis respectively. |
2018-12-11 |
2023-08-13 |
rat |
| Pamela V Martino Adami, Pablo Galeano, Marina L Wallinger, Celia Quijano, Alejandro Rabossi, Eleonora S Pagano, Natividad Olivar, Carlos Reyes Toso, Daniel Cardinali, Luis I Brusco, Sonia Do Carmo, Rafael Radi, Goar Gevorkian, Eduardo M Castaño, A Claudio Cuello, Laura Morell. Worsening of memory deficit induced by energy-dense diet in a rat model of early-Alzheimer's disease is associated to neurotoxic Aβ species and independent of neuroinflammation. Biochimica et biophysica acta. Molecular basis of disease. vol 1863. issue 3. 2018-11-26. PMID:28039031. |
cognitive tests, elisa multiplex, western blot, immunohistochemistry and rt-qpcr indicated that wd worsened cognition in tg(+/-) rats, increased hippocampal levels of monomeric aβ isoforms and oligomeric species, promoted deposits of n-terminal pyroglutamate-aβ (aβn3(pe)) in ca1 pyramidal neurons and interneurons, decreased transcript levels of genes involved in neuroprotective pathways such as sirtuin-1 and increased nitrated proteins. |
2018-11-26 |
2023-08-13 |
rat |
| Wei Han, Xiangjun Dong, Xiaojie Song, Li Cheng, Lingling Xie, Hengsheng Chen, Li Jian. Effects of advanced maternal age on cognitive and emotional development in offspring rats. Behavioural brain research. vol 353. 2018-11-26. PMID:29626499. |
moreover, hematoxylin-eosin (he) staining and nissl staining were conducted to detect differences in the hippocampal morphology of the offspring, and western blot analysis was conducted to detect the protein expression of brain-derived neurotrophic factor (bdnf), camp response element binding protein (creb) and phosphorylated creb (pcreb). |
2018-11-26 |
2023-08-13 |
rat |
| Marissa Giovanna Schamne, Josiel Mileno Mack, Morgana Moretti, Filipe Carvalho Matheus, Roger Walz, Laurence Lanfumey, Rui Daniel Predige. The Gender-Biased Effects of Intranasal MPTP Administration on Anhedonic- and Depressive-Like Behaviors in C57BL/6 Mice: the Role of Neurotrophic Factors. Neurotoxicity research. vol 34. issue 4. 2018-11-26. PMID:29808370. |
we also investigated the immunocontent of neurotrophins (bdnf, gdnf, and vegf) in the hippocampus and prefrontal cortex by western blot. |
2018-11-26 |
2023-08-13 |
mouse |
| Efrat Shavit Stein, Marina Ben Shimon, Avital Artan Furman, Valery Golderman, Joab Chapman, Nicola Maggi. Thrombin Inhibition Reduces the Expression of Brain Inflammation Markers upon Systemic LPS Treatment. Neural plasticity. vol 2018. 2018-11-26. PMID:30018633. |
a panel of coagulation factors and effectors (such as thrombin, fx, par1, epcr, and pc) was tested in the hippocampus, isolated microglia, and n9 microglia cell by western blot and real-time pcr and found to be modulated by lps. |
2018-11-26 |
2023-08-13 |
Not clear |
| Hong-Ying Li, Xin-Chen Wang, Yu-Min Xu, Na-Chuan Luo, Si Luo, Xu-Yi Hao, Shu-Yi Cheng, Jian-Song Fang, Qi Wang, Shi-Jie Zhang, Yun-Bo Che. Berberine Improves Diabetic Encephalopathy Through the SIRT1/ER Stress Pathway in db/db Mice. Rejuvenation research. vol 21. issue 3. 2018-11-15. PMID:28782427. |
moreover, western blot analysis revealed that bbr increased the synapse- and nerve-related protein expression (psd95, syn, and ngf) and decreased the protein expression of inflammatory factors (tnf-α and nf-κb) in the hippocampus of db/db mice. |
2018-11-15 |
2023-08-13 |
mouse |
| Jun Go, Tae-Shin Park, Geun-Hee Han, Hye-Yeon Park, Young-Kyoung Ryu, Yong-Hoon Kim, Jung Hwan Hwang, Dong-Hee Choi, Jung-Ran Noh, Dae Youn Hwang, Sanghee Kim, Won Keun Oh, Chul-Ho Lee, Kyoung-Shim Ki. Piperlongumine decreases cognitive impairment and improves hippocampal function in aged mice. International journal of molecular medicine. vol 42. issue 4. 2018-11-08. PMID:30066827. |
additionally, immunohistochemistry and western blot analysis were performed to examine the effects of pl on the hippocampus. |
2018-11-08 |
2023-08-13 |
mouse |
| Fang Chen, Yingkun He, Pengwen Wang, Peng Wei, Huili Feng, Yingxue Rao, Jing Shi, Jinzhou Tia. Banxia Xiexin decoction ameliorated cognition via the regulation of insulin pathways and glucose transporters in the hippocampus of APPswe/PS1dE9 mice. International journal of immunopathology and pharmacology. vol 32. 2018-10-31. PMID:29873261. |
proteins involved in insulin signalling pathways and glucose transports in the hippocampus were assessed through immunohistochemical staining and western blot. |
2018-10-31 |
2023-08-13 |
mouse |
| Juan-Juan Jiao, Christian Hölscher, Tian Li, Xue-Fan Dong, Xue-Song Qu, Yue Cao, Mei-Na Wu, Zhao-Jun Wang, Jin-Shun Q. [GLP-1/GIP/Gcg receptor Triagonist improves the cognitive behaviors in triple-transgenic mice of Alzheimer's disease]. Sheng li xue bao : [Acta physiologica Sinica]. vol 69. issue 2. 2018-10-30. PMID:28435972. |
elisa and western blot experiments showed that the triagonist up-regulated the levels of camp, pka and p-creb in the hippocampus of 3xtg-ad mice. |
2018-10-30 |
2023-08-13 |
mouse |
| E H Chang, K Fernando, L W E Yeung, K Barbari, T-S S Chandon, A K Malhotr. Single point mutation on the gene encoding dysbindin results in recognition deficits. Genes, brain, and behavior. vol 17. issue 5. 2018-10-30. PMID:29227583. |
by western blot analysis, we found that spp homozygous (spp -/-) mutants had reduced dysbindin and synaptosomal-associated protein 25 (snap-25) in the prefrontal cortex, but unaltered levels in hippocampus. |
2018-10-30 |
2023-08-13 |
mouse |
| Guo-Shuai Yang, Xiao-Yan Zhou, Xue-Fang An, Xuan-Jun Liu, Yan-Jun Zhang, Dan Y. Mild hypothermia inhibits the Notch 3 and Notch 4 activation and seizure after stroke in the rat model. Pathology, research and practice. vol 214. issue 7. 2018-10-23. PMID:29754932. |
immunohistochemistry and western blot assays revealed the up-regulation of notch intracellular domain (nicd) 3 and 4 in the cerebral cortex and hippocampus following gci, but mild hypothermia and dapt inhibited the up-regulation of nicd 3 and 4. |
2018-10-23 |
2023-08-13 |
rat |
| Man-He Zhang, Xiu-Min Zhou, Jian-Zhong Cui, Kai-Jie Wang, Yan Feng, Hong-Ao Zhan. Neuroprotective effects of dexmedetomidine on traumatic brain injury: Involvement of neuronal apoptosis and HSP70 expression. Molecular medicine reports. vol 17. issue 6. 2018-09-26. PMID:29693126. |
the expression levels of b‑cell lymphoma‑2 (bcl‑2) and bcl‑2‑associated x protein (bax) in the rat hippocampus were evaluated using immunohistochemical staining and western blot analysis. |
2018-09-26 |
2023-08-13 |
rat |
| Man-He Zhang, Xiu-Min Zhou, Jian-Zhong Cui, Kai-Jie Wang, Yan Feng, Hong-Ao Zhan. Neuroprotective effects of dexmedetomidine on traumatic brain injury: Involvement of neuronal apoptosis and HSP70 expression. Molecular medicine reports. vol 17. issue 6. 2018-09-26. PMID:29693126. |
the protein levels of hsp70 in the hippocampal region were analyzed using western blot analysis. |
2018-09-26 |
2023-08-13 |
rat |
| Xu Chu, Shuhu Zhou, Ran Sun, Lin Wang, Chunye Xing, Ruqing Liang, Qingxia Kon. Chrysophanol Relieves Cognition Deficits and Neuronal Loss Through Inhibition of Inflammation in Diabetic Mice. Neurochemical research. vol 43. issue 4. 2018-09-24. PMID:29497904. |
elisa and western blot assay were used to determine the levels of pro-inflammation cytokines (il-1β, il-4, il-6, tnf-α) in hippocampus. |
2018-09-24 |
2023-08-13 |
mouse |