| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Philippe Bourassa, Wael Alata, Cyntia Tremblay, Sarah Paris-Robidas, Frédéric Calo. Transferrin Receptor-Mediated Uptake at the Blood-Brain Barrier Is Not Impaired by Alzheimer's Disease Neuropathology. Molecular pharmaceutics. vol 16. issue 2. 2019-11-18. PMID:30609376. |
measurements of tfr levels using western blot analysis in whole homogenates from human post-mortem parietal cortex and hippocampus did not reveal any significant difference between individuals with or without a neuropathological diagnosis of ad (respectively, n = 19 and 22 for the parietal cortex and n = 12 and 14 for hippocampus). |
2019-11-18 |
2023-08-13 |
mouse |
| Xudong Chen, Xinyu Hua, Danhua Sun, Wenjuan Fa. [Compound porcine cerebroside and ganglioside relieves brain injury and promotes expression of cerebellin 4 in neonatal mice with intrauterine hypoxia]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 35. issue 8. 2019-11-04. PMID:31638570. |
the relative expression of cbln4 protein in the hippocampus of mice was detected by western blot analysis. |
2019-11-04 |
2023-08-13 |
mouse |
| Jiamei Lin, Shengqiang Wang, Yunlin Feng, Weihong Zhao, Weilu Zhao, Foquan Luo, Namin Fen. Propofol exposure during early gestation impairs learning and memory in rat offspring by inhibiting the acetylation of histone. Journal of cellular and molecular medicine. vol 22. issue 5. 2019-10-23. PMID:29461008. |
the protein levels of hdac2, acetylated histone 3 (h3) and 4 (h4), cyclic adenosine monophosphate (camp) response element-binding protein (creb), n-methyl-d-aspartate receptor (nmdar) 2 subunit b (nr2b), hgn and synaptophysin in offspring's hippocampus were determined by western blot or immunofluorescence test. |
2019-10-23 |
2023-08-13 |
rat |
| Peng Yao, Yong Chen, Guo-Hai X. [Effect of triptolide on cognitive dysfunction in vascular dementia rats through SIRT1/NF-κB signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 44. issue 16. 2019-10-21. PMID:31602904. |
western blot was used to detect the expression of sirt1,nf-κb,iκbα and caspase 3 in hippocampus. |
2019-10-21 |
2023-08-13 |
rat |
| Clarissa von Haefen, Marco Sifringer, Stefanie Endesfelder, Alexander Kalb, Adrián González-López, Annalena Tegethoff, Nadine Paeschke, Claudia D Spie. Physostigmine Restores Impaired Autophagy in the Rat Hippocampus after Surgery Stress and LPS Treatment. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 13. issue 3. 2019-10-02. PMID:29790105. |
activated microglia, apoptosis-, autophagy-, and anti-inflammatory-related genes and -proteins in the hippocampus were determined by real-time pcr, western blot and fluorescence microscopy after 1 h, 24 h and 3 d. surgery combined with lps-treatment led to microglia activation after 1 h and 24 h which was accompanied by apoptotic cell death after 24 h in the hippocampus. |
2019-10-02 |
2023-08-13 |
rat |
| Nihan Çarçak, Melis Yavuz, Tuğba Eryiğit Karamahmutoğlu, Akif Hakan Kurt, Meral Urhan Küçük, Filiz Yılmaz Onat, Kansu Büyükafsa. Suppressive effect of Rho-kinase inhibitors Y-27632 and fasudil on spike-and-wave discharges in genetic absence epilepsy rats from Strasbourg (GAERS). Naunyn-Schmiedeberg's archives of pharmacology. vol 391. issue 11. 2019-10-02. PMID:30073384. |
rock level and activity were measured by western blot analysis in the brain areas involved in absence seizures (i.e., cortex and thalamus) and hippocampus. |
2019-10-02 |
2023-08-13 |
rat |
| Yi-Xuan Li, Zi-He Ye, Tong Chen, Xiao-Feng Jia, Ling H. The effects of donepezil on phencyclidine-induced cognitive deficits in a mouse model of schizophrenia. Pharmacology, biochemistry, and behavior. vol 175. 2019-09-30. PMID:30218672. |
expressions of p-gsk-3β/gsk-3β, p-akt/akt, bcl-2/bax and caspase-3 in the hippocampus and cortex were detected by western blot. |
2019-09-30 |
2023-08-13 |
mouse |
| Yan Ya. [Effect of N-acetylcysteine on Cognitive Function and Nuclear Factor Erythroid 2 Related Factor 2/Heme Oxygenase-1 Pathway in Mouse Models of Postoperative Cognitive Dysfunction]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. vol 41. issue 4. 2019-09-30. PMID:31484617. |
methods fifty-four male c57bl/6j mice(3-4 months old)were randomly divided into control group,surgery group,and surgery+nac group by block randomization.the intramedullary fixation for left tibial fracture surgery was performed to establish postoperative cognitive dysfunction models.nac(150 mg/kg)was administered intraperitoneally in group surgery+nac 30 minutes before and 3 hours,6 hours after surgery,while saline was given in control group and surgery group.six mice in each group were selected randomly underwent morris water maze test on the third day after surgery.animals were sacrificed at the first and third postoperative days,and the hippocampus was harvested.enzyme-linked immunosorbent assay was used to quantify the levels of interleukin-6(il-6)and malondialdehyde(mda)in hippocampus.western blot and real-time polymerase chain reaction were used to measure the expressions of nrf2 and ho-1 in hippocampus. |
2019-09-30 |
2023-08-13 |
mouse |
| Fu-Sheng Ding, Xiang Cheng, Tong Zhao, Yong-Qi Zhao, Guang-Bo Zhang, Hai-Tao Wu, Ling-Ling Zhu, Kui-Wu W. [Intermittent hypoxic preconditioning relieves fear and anxiety behavior in post-traumatic stress model mice]. Sheng li xue bao : [Acta physiologica Sinica]. vol 71. issue 4. 2019-09-26. PMID:31440750. |
the levels of fear and anxiety were valued by the open field, the elevated plus maze (epm) and the fear conditioning tests; the level of spatial memory was valued by y maze test; the number of fos positive neurons in hippocampus, amygdala and medial prefrontal cortex was valued by immunohistochemical staining; and the protein expressions of hypoxia inducible factor-1α (hif-1α), vascular endothelial growth factor (vegf) and brain derived neurotrophic factor (bdnf) in these brain area were valued by western blot. |
2019-09-26 |
2023-08-13 |
mouse |
| Patricia Sampedro-Piquero, Román D Moreno-Fernández, M Carmen Mañas-Padilla, Sara Gil-Rodríguez, Ana Luisa Gavito, Francisco J Pavón, Carmen Pedraza, María García-Fernández, David Ladrón de Guevara-Miranda, Luis J Santín, Estela Castilla-Orteg. Training memory without aversion: Appetitive hole-board spatial learning increases adult hippocampal neurogenesis. Neurobiology of learning and memory. vol 151. 2019-09-18. PMID:29608953. |
furthermore, the trained animals increased the hippocampal protein expression of all the neuroplasticity markers analyzed by western blot. |
2019-09-18 |
2023-08-13 |
mouse |
| Huiling Fu, Li Liu, Yue Tong, Yuanjie Li, Xia Zhang, Xiaojuan Gao, Jingjiao Yong, Jianjun Zhao, Dong Xiao, Kuishen Wen, Hanqing Wan. The antidepressant effects of hesperidin on chronic unpredictable mild stress-induced mice. European journal of pharmacology. vol 853. 2019-09-03. PMID:30928632. |
furthermore, the protein expression levels of high-mobility group box 1 protein (hmgb1), receptor for advanced glycation end-products (rage)/nf-κb and brain-derived neurotrophic factor (bdnf)/tropomyosin-related kinase b (trkb) pathway in the hippocampus and corticosterone-induced pc12 cells were detected by western blot. |
2019-09-03 |
2023-08-13 |
mouse |
| Mariane C Vicente, Maria C Almeida, Kênia C Bícego, Daniel C Carrettiero, Luciane H Gargaglion. Hypercapnic and Hypoxic Respiratory Response During Wakefulness and Sleep in a Streptozotocin Model of Alzheimer's Disease in Rats. Journal of Alzheimer's disease : JAD. vol 65. issue 4. 2019-08-26. PMID:30124447. |
in addition, we performed western blot analyses for phosphorylated tau, total tau, and amyloid-β (aβ) peptide in the locus coeruleus (lc), retrotrapezoid nucleus, medullary raphe, pre-bötzinger/bötzinger complex, and hippocampus, and evaluated memory and learning acquisition using the barnes maze. |
2019-08-26 |
2023-08-13 |
rat |
| Durairaj Ragu-Varman, Mayra Macedo-Mendoza, Francisco Emmanuel Labrada-Moncada, Pamela Reyes-Ortega, Teresa Morales, Ataúlfo Martínez-Torres, Daniel Reyes-Har. Anorexia increases microglial density and cytokine expression in the hippocampus of young female rats. Behavioural brain research. vol 363. 2019-08-26. PMID:30690107. |
finally, western blot analysis showed increased expression of iba1, tnf-α, il-6 and il-1β in the hippocampus of both experimental groups. |
2019-08-26 |
2023-08-13 |
rat |
| Katarina Klacanova, Maria Kovalska, Maria Chomova, Ivana Pilchova, Zuzana Tatarkova, Peter Kaplan, Peter Raca. Global brain ischemia in rats is associated with mitochondrial release and downregulation of Mfn2 in the cerebral cortex, but not the hippocampus. International journal of molecular medicine. vol 43. issue 6. 2019-08-19. PMID:31017259. |
western blot analysis of total cell extracts and mitochondria isolated from either the cerebral cortex or hippocampus of experimental animals was performed. |
2019-08-19 |
2023-08-13 |
human |
| Bo-Yu Shi, Zhi-Li Rao, Jie Luo, Xiao-Bo Liu, Yang Fang, Hai-Juan Cao, Nan Zen. [Protective effect and mechanism of Xiaoyao San on lipopolysaccharide-induced hippocampal neurons injury]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 44. issue 4. 2019-08-14. PMID:30989892. |
western blot was used to detect the expressions of trk b,creb,p-creb and syp protein in cell lysate of hippocampal neuron,and to reveal the neuroprotective effect and mechanism of xiaoyao san. |
2019-08-14 |
2023-08-13 |
Not clear |
| Xin Wu, Shao-Hua Su, Ning-Ning Sun, Ming-Hui Lyu, Song-Jiang Zhang, Jian-Feng Ga. [Effects and mechanisms of electro-acupuncture on proliferation and differentiation of neural stem cells in C57 mice exposed to different doses of X-ray radiation]. Sheng li xue bao : [Acta physiologica Sinica]. vol 71. issue 3. 2019-08-14. PMID:31218334. |
rt-pcr and western blot were used to detect mrna and protein expressions of notch1 and mash1 in the hippocampus, respectively. |
2019-08-14 |
2023-08-13 |
mouse |
| Wenchang Chang, Dawei Huang, Y Martin Lo, Qinqiao Tee, Poling Kuo, James Swibea Wu, Wenchung Huang, Szuchuan She. Protective Effect of Caffeic Acid against Alzheimer's Disease Pathogenesis via Modulating Cerebral Insulin Signaling, β-Amyloid Accumulation, and Synaptic Plasticity in Hyperinsulinemic Rats. Journal of agricultural and food chemistry. vol 67. issue 27. 2019-08-12. PMID:31203623. |
the western blot data further confirmed that protein expressions of phosphorylated-glycogen synthase kinase 3β (gsk3β) were significantly increased, whereas the expression of phosphorylated-tau protein decreased in the hippocampus of rats administered with ca in comparison with the hf group. |
2019-08-12 |
2023-08-13 |
rat |
| Jie Zheng, Su Min, Bin Hu, Qin Liu, Yunqiang Wa. Nrdp1 is involved in hippocampus apoptosis in cardiopulmonary bypass-induced cognitive dysfunction via the regulation of ErbB3 protein levels. International journal of molecular medicine. vol 43. issue 4. 2019-07-30. PMID:30720051. |
apoptosis in the hippocampus regions were measured using a terminal deoxynucleotidyl‑transferase‑mediated dutp nick end labelling assay, the viability and apoptosis level of the cells were measured via an mtt assay and flow cytometry, respectively, and the expression levels of nrdp1, erb‑b2 receptor tyrosine kinase 3 (erbb3), phosphorylated‑protein kinase b (p‑akt) and cleaved (c‑) caspase‑3 were detected using western blot analysis. |
2019-07-30 |
2023-08-13 |
rat |
| Lulu Mana, Huili Feng, Yunfang Dong, Yahan Wang, Jing Shi, Jinzhou Tian, Pengwen Wan. Effect of Chinese herbal compound GAPT on the early brain glucose metabolism of APP/PS1 transgenic mice. International journal of immunopathology and pharmacology. vol 33. 2019-07-29. PMID:30957587. |
immunohistochemistry, western blot analysis and polymerase chain reaction (pcr) were used to detect the expression of the pi3k/akt-mtor signalling pathway-related proteins and messenger rnas (mrnas) in hippocampus of app/ps1 transgenic mice after 3 months of drug administration. |
2019-07-29 |
2023-08-13 |
mouse |
| Lulu Mana, Huili Feng, Yunfang Dong, Yahan Wang, Jing Shi, Jinzhou Tian, Pengwen Wan. Effect of Chinese herbal compound GAPT on the early brain glucose metabolism of APP/PS1 transgenic mice. International journal of immunopathology and pharmacology. vol 33. 2019-07-29. PMID:30957587. |
the immunohistochemistry, western blot analysis and pcr results indicated that gapt can increase the expression of pi3k, akt, glut1 and glut3 in the hippocampus of app/ps1 transgenic mice. |
2019-07-29 |
2023-08-13 |
mouse |