| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hyo Young Jung, Dae Young Yoo, Joon Ha Park, Jong Whi Kim, Jin Young Chung, Dae Won Kim, Moo-Ho Won, Yeo Sung Yoon, In Koo Hwan. Age-dependent changes in vesicular glutamate transporter 1 and 2 expression in the gerbil hippocampus. Molecular medicine reports. vol 17. issue 5. 2018-09-13. PMID:29532891. |
in the present study, the age‑associated changes of the major vgluts, vglut1 and vglut2, in the hippocampus were investigated, based on immunohistochemistry and western blot analysis at postnatal month 1 (pm1; adolescent), pm6, pm12 (adult group), pm18 and pm24 (the aged groups). |
2018-09-13 |
2023-08-13 |
Not clear |
| Yong-Hyun Ko, Sun Yeou Kim, Seok-Yong Lee, Choon-Gon Jan. 6,7,4'-Trihydroxyisoflavone, a major metabolite of daidzein, improves learning and memory via the cholinergic system and the p-CREB/BDNF signaling pathway in mice. European journal of pharmacology. vol 826. 2018-09-10. PMID:29510125. |
in addition, immunohistochemistry and western blot results revealed that 6,7,4'-thif significantly increased brain-derived neurotrophic factor (bdnf) and phosphor camp response element binding (creb) in the hippocampus of mice. |
2018-09-10 |
2023-08-13 |
mouse |
| Honghua Song, Yuqin Zheng, Fuying Cai, Yanyan Ma, Jingyue Yang, Youjia W. c-Fos downregulation positively regulates EphA5 expression in a congenital hypothyroidism rat model. Journal of molecular histology. vol 49. issue 2. 2018-09-05. PMID:29330744. |
q-pcr and western blot showed that c-fos overexpression could upregulate epha5 expression in hippocampal neurons of rats with ch. |
2018-09-05 |
2023-08-13 |
rat |
| Athira Kv, Rajaram Mohanrao Madhana, Indu Chandran Js, Mangala Lahkar, Swapnil Sinha, V G M Naid. Antidepressant activity of vorinostat is associated with amelioration of oxidative stress and inflammation in a corticosterone-induced chronic stress model in mice. Behavioural brain research. vol 344. 2018-09-04. PMID:29452193. |
at the end of dosing schedule, neurobehavioral tests were conducted; followed by mechanistic evaluation through biochemical analysis, rtpcr and western blot in serum and hippocampus. |
2018-09-04 |
2023-08-13 |
mouse |
| Natalia A Stefanova, Kseniya Yi Maksimova, Ekaterina A Rudnitskaya, Natalia A Muraleva, Nataliya G Kolosov. Association of cerebrovascular dysfunction with the development of Alzheimer's disease-like pathology in OXYS rats. BMC genomics. vol 19. issue Suppl 3. 2018-09-03. PMID:29504901. |
at preclinical, early, and advanced stages of ad-like pathology, in the hippocampus of oxys and wistar (control) rats, we evaluated (i) the blood vessel state by histological and electron-microscopic analyses; (ii) differences in gene expression according to rna sequencing (rna-seq) to identify the metabolic processes and pathways associated with blood vessel function; (iii) the amount of vascular endothelial growth factor (vegf) by western blot and immunohistochemical analysis. |
2018-09-03 |
2023-08-13 |
rat |
| Qisen Li, Jiacheng Zeng, Meiling Su, Yu He, Banghao Zh. Acetylshikonin from Zicao attenuates cognitive impairment and hippocampus senescence in d-galactose-induced aging mouse model via upregulating the expression of SIRT1. Brain research bulletin. vol 137. 2018-08-31. PMID:29325995. |
moreover, western blot results showed that as can up-regulate the expression of sirtuin 1 (sirt1) and inhibit d-gal-induced activation of p53/p21 signaling pathway in the hippocampus of mice. |
2018-08-31 |
2023-08-13 |
mouse |
| Gabor G Kovacs, Linda K Kwong, Murray Grossman, David J Irwin, Edward B Lee, John L Robinson, Eunran Suh, Vivianna M Van Deerlin, Virginia M Lee, John Q Trojanowsk. Tauopathy with hippocampal 4-repeat tau immunoreactive spherical inclusions: a report of three cases. Brain pathology (Zurich, Switzerland). vol 28. issue 2. 2018-08-30. PMID:28019685. |
common neuropathological features included neuronal loss in the hippocampus and dentate gyrus associated with spherical basophilic pick body-like inclusions showing 4r tau immunoreactivity, which was supported by the detection of predominantly 4r tau species by western blot examination. |
2018-08-30 |
2023-08-13 |
human |
| Guo-Shuai Yang, Xiao-Yan Zhou, Xue-Fang An, Xuan-Jun Liu, Yan-Jun Zhang, Dan Y. mTOR is involved in stroke-induced seizures and the anti-seizure effect of mild hypothermia. Molecular medicine reports. vol 17. issue 4. 2018-08-30. PMID:29484389. |
expression of phosphor (p)‑mtor and glut‑1 were upregulated in the cerebral cortex and hippocampus, as evidenced by immunohistochemistry and western blot analyses. |
2018-08-30 |
2023-08-13 |
rat |
| Ya-Bo Feng, You-Ting Lin, Yu-Xiang Han, Yue-Jiu Pang, Jing-Jing Xu, Yuan Xue, Hong Ya. 2R,4R-APDC, a Metabotropic Glutamate Receptor Agonist, Reduced Neuronal Apoptosis by Upregulating MicroRNA-128 in a Rat Model After Seizures. Neurochemical research. vol 43. issue 3. 2018-08-30. PMID:29497903. |
western blot was conducted to evaluate changes in the levels of caspase-3 and caspase-9 in hippocampus. |
2018-08-30 |
2023-08-13 |
rat |
| Ya-Bo Feng, You-Ting Lin, Yu-Xiang Han, Yue-Jiu Pang, Jing-Jing Xu, Yuan Xue, Hong Ya. 2R,4R-APDC, a Metabotropic Glutamate Receptor Agonist, Reduced Neuronal Apoptosis by Upregulating MicroRNA-128 in a Rat Model After Seizures. Neurochemical research. vol 43. issue 3. 2018-08-30. PMID:29497903. |
the western blot confirmed this finding, demonstrating that the levels of cleaved caspase-3 and cleaved caspase-9 were potently decreased by 2r,4r-apdc in rat hippocampus after seizures. |
2018-08-30 |
2023-08-13 |
rat |
| Lingxing Wang, Honghong Huang, Hongchao Cai, Yafang Che. Maternal hypoxia increases hippocampal cell susceptibility to ischemia after middle cerebral artery occlusion in rat offspring. Folia neuropathologica. vol 55. issue 4. 2018-08-23. PMID:29363906. |
caspase-3, cytochrome c, bax, and bcl-2 expression in the hippocampus was detected by western blot. |
2018-08-23 |
2023-08-13 |
rat |
| Anubha Mudawal, Ankita Srivastava, Anshuman Singh, Jai Shankar, Sanjay Yadav, Manisha Mishra, Pradhyumna K Singh, Vinay K Khanna, Devendra Parma. Proteomic approaches to investigate age related vulnerability to lindane induced neurodegenerative effects in rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 115. 2018-08-16. PMID:29614384. |
2-d and western blot analysis of protein extracts of hippocampus and substantia-nigra isolated from lindane treated rats (2.5 mg/kg; p.o. |
2018-08-16 |
2023-08-13 |
rat |
| Hyang-Ah Lee, Joon Ha Park, Dae Won Kim, Choong-Hyun Lee, In Koo Hwang, Hyeyoung Kim, Myoung Cheol Shin, Jun Hwi Cho, Jae-Chul Lee, Yoohun Noh, Sung-Su Kim, Moo-Ho Won, Ji Hyeon Ah. Age‑dependent alteration in the expression of oligodendrocyte‑specific protein in the gerbil hippocampus. Molecular medicine reports. vol 17. issue 3. 2018-08-14. PMID:29286168. |
the present study aimed to determine the alterations in oligodendrocyte‑specific protein (osp) expression in the gerbil hippocampus at 1, 2, 3, 4, 6 and 24 months of age with western blot and immunohistochemistry analyses. |
2018-08-14 |
2023-08-13 |
Not clear |
| Lingjie Wang, Junlong Du, Fangyu Zhao, Zonghai Chen, Jingru Chang, Furong Qin, Zili Wang, Fengjie Wang, Xianbing Chen, Ning Che. Trillium tschonoskii maxim saponin mitigates D-galactose-induced brain aging of rats through rescuing dysfunctional autophagy mediated by Rheb-mTOR signal pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 98. 2018-08-13. PMID:29287199. |
upon the intervention of trillium tschonoskii maxim (ttm) saponin, one of bioactive components from local natural herbs in china, the learning and memory capacity of d-gal-induced aging rats was evaluated through morris water maze test, and the regulation of rheb-mtor signal pathway and functional status of autophagy in hippocampal tissues of d-gal-induced aging rats was explored by western blot. |
2018-08-13 |
2023-08-13 |
rat |
| Shuiqiao Liu, Qingqing Dai, Rongrong Hua, Ting Liu, Song Han, Shujuan Li, Junfa L. Determination of Brain-Regional Blood Perfusion and Endogenous cPKCγ Impact on Ischemic Vulnerability of Mice with Global Ischemia. Neurochemical research. vol 42. issue 10. 2018-08-07. PMID:28597398. |
nissl staining and western blot results indicated that hypothalamus and midbrain had more severe neural cell loss than prefrontal cortex, striatum and hippocampus, which negatively coincided with endogenous cpkcγ protein levels but not blood perfusion loss and cpkcγ membrane translocation levels. |
2018-08-07 |
2023-08-13 |
mouse |
| Ling Wang, Jingyu Wang, Faqi Wang, Chunhua Liu, Xuening Yang, Jiajia Yang, Dong Min. VEGF-Mediated Cognitive and Synaptic Improvement in Chronic Cerebral Hypoperfusion Rats Involves Autophagy Process. Neuromolecular medicine. vol 19. issue 2-3. 2018-08-06. PMID:28766254. |
we further found that vegf mitigated impaired hippocampal synaptic function including basal synaptic transmission, paired-pulse facilitation, short-term, long-term plasticity, depotentiation, and the level of synaptic proteins as assessed by electrophysiological examination and western blot assay. |
2018-08-06 |
2023-08-13 |
rat |
| Maryam Moosavi, Roksana SoukhakLari, Leila Moezi, Fatema Pirsalam. Scopolamine-induced passive avoidance memory retrieval deficit is accompanied with hippocampal MMP2, MMP-9 and MAPKs alteration. European journal of pharmacology. vol 819. 2018-08-06. PMID:29225190. |
the hippocampal tissue was isolated and western blot analysis was done for mmp-2, mmp-9 and mapks (erk, p38 and jnk). |
2018-08-06 |
2023-08-13 |
mouse |
| Alessia Luoni, Peter Gass, Paolo Brambilla, Mirella Ruggeri, Marco A Riva, Dragos Int. Altered expression of schizophrenia-related genes in mice lacking mGlu5 receptors. European archives of psychiatry and clinical neuroscience. vol 268. issue 1. 2018-08-03. PMID:27581816. |
here, we investigated, using qrt-pcr and western blot, consequences in the hippocampus and prefrontal/frontal cortex (pfc/fc) of mice with a genetic deletion of the metabotropic glutamate receptor 5 (mglu5), addressing key components of the gabaergic and glutamatergic systems. |
2018-08-03 |
2023-08-13 |
mouse |
| Yong Lu, Junli Zhang, Lin Zhang, Shaokang Dang, Qian Su, Huiping Zhang, Tianwei Lin, Xiaoxiao Zhang, Yurong Zhang, Hongli Sun, Zhongliang Zhu, Hui L. Hippocampal Acetylation may Improve Prenatal-Stress-Induced Depression-Like Behavior of Male Offspring Rats Through Regulating AMPARs Expression. Neurochemical research. vol 42. issue 12. 2018-08-02. PMID:29019029. |
quantitative real-time pcr and western blot were used to determine the changes of ampars in acetylated hippocampus. |
2018-08-02 |
2023-08-13 |
rat |
| Ming Tu, Penglei Zhu, Shaobo Hu, Wei Wang, Zhipeng Su, Jiaqing Guan, Chongran Sun, Weiming Zhen. Notch1 Signaling Activation Contributes to Adult Hippocampal Neurogenesis Following Traumatic Brain Injury. Medical science monitor : international medical journal of experimental and clinical research. vol 23. 2018-07-13. PMID:29150595. |
then, the hippocampus was collected to detect the expression of notch1 markers and stem cell markers (dcx) by western blot analysis, immunohistochemistry, and immunofluorescence. |
2018-07-13 |
2023-08-13 |
rat |