| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ling Liu, Chun-Hui Ji, Yuan Wang, Jie Zhao, Yue Liu, Wen-Qian Tang, Jiang-Hong Gu, Bo Jian. Antidepressant-like activity of L-701324 in mice: A behavioral and neurobiological characterization. Behavioural brain research. vol 399. 2021-11-15. PMID:33276033. |
repeated injection of l-701,324 not only prevented cums-induced depressive-like behaviors in mice, but also ameliorated the downregulating effects of cums on the hippocampal bdnf signaling cascade and neurogenesis. |
2021-11-15 |
2023-08-13 |
mouse |
| Ling Liu, Chun-Hui Ji, Yuan Wang, Jie Zhao, Yue Liu, Wen-Qian Tang, Jiang-Hong Gu, Bo Jian. Antidepressant-like activity of L-701324 in mice: A behavioral and neurobiological characterization. Behavioural brain research. vol 399. 2021-11-15. PMID:33276033. |
k252a administration also abolished the activating actions of l-701,324 on the hippocampal bdnf signaling cascade and neurogenesis in cums-treated mice. |
2021-11-15 |
2023-08-13 |
mouse |
| Ling Liu, Chun-Hui Ji, Yuan Wang, Jie Zhao, Yue Liu, Wen-Qian Tang, Jiang-Hong Gu, Bo Jian. Antidepressant-like activity of L-701324 in mice: A behavioral and neurobiological characterization. Behavioural brain research. vol 399. 2021-11-15. PMID:33276033. |
collectively, these data indicated that l-701,324 possesses antidepressant-like activity in mice, which was mediated, at least in part, by promoting the hippocampal bdnf system. |
2021-11-15 |
2023-08-13 |
mouse |
| Laura Martínez-Drudis, Laura Amorós-Aguilar, Meritxell Torras-Garcia, Bruna Serra-Elias, David Costa-Miserachs, Isabel Portell-Cortés, Margalida Coll-Andre. Delayed voluntary physical exercise restores "when" and "where" object recognition memory after traumatic brain injury. Behavioural brain research. vol 400. 2021-11-15. PMID:33279639. |
the aims of this work were to: 1) assess whether voluntary physical exercise can reduce the deficits associated with traumatic brain injury (tbi) in two different components of episodic-like memory based on object recognition, temporal order memory ("when"), and object location memory ("where"); and 2) determine whether changes in levels of brain-derived neurotrophic factor (bdnf) in the hippocampus and prefrontal cortex, as well as alterations in hippocampal cytokines, insulin-like growth factor-1 (igf-1) and vascular endothelial growth factor (vegf), may influence the effects exercise has on either or both tasks. |
2021-11-15 |
2023-08-13 |
rat |
| Laura Martínez-Drudis, Laura Amorós-Aguilar, Meritxell Torras-Garcia, Bruna Serra-Elias, David Costa-Miserachs, Isabel Portell-Cortés, Margalida Coll-Andre. Delayed voluntary physical exercise restores "when" and "where" object recognition memory after traumatic brain injury. Behavioural brain research. vol 400. 2021-11-15. PMID:33279639. |
physical exercise restored the "when" and "where" memories, which had been impaired by the tbi, and increased the concentration of bdnf in the hippocampus, but not the prefrontal cortex. |
2021-11-15 |
2023-08-13 |
rat |
| Mingyue Zhao, Zemeng Zhu, Haonan Li, Wei Wang, Shuyue Cheng, Xiaqing Qin, Huiran Wu, Dexiang Liu, Fang Pa. Effects of traumatic stress in adolescence on PTSD-like behaviors, dendrite development, and H3K9me2/BDNF expression in the amygdala of male rats. Journal of affective disorders. vol 296. 2021-11-15. PMID:34619155. |
in a previous experiment, we demonstrated that traumatic stress in adolescence triggers changes in the expression of the epigenetic marker h3k9me2 in the hippocampus and prefrontal cortex of adolescent and adult rats, which suppresses transcription of the brain-derived neurotrophic factor (bdnf) gene that promotes dendrite development and synaptic growth. |
2021-11-15 |
2023-08-13 |
rat |
| Izabelle Dias Benfato, Ana Carolina Silvares Quintanilha, Jessica Salles Henrique, Melyssa Alves Souza, Barbara Dos Anjos Rosário, Jose Ivo Araújo Beserra Filho, Robson Luiz Oliveira Santos, Alessandra Mussi Ribeiro, Luciana Le Sueur Maluf, Camila Aparecida Machado de Oliveir. Effects of long-term social isolation on central, behavioural and metabolic parameters in middle-aged mice. Behavioural brain research. vol 417. 2021-11-15. PMID:34656691. |
immunohistochemistry in the hippocampus (Δfosb, bdnf, and 8ohdg) and hypothalamus (Δfosb) was also performed. |
2021-11-15 |
2023-08-13 |
mouse |
| Izabelle Dias Benfato, Ana Carolina Silvares Quintanilha, Jessica Salles Henrique, Melyssa Alves Souza, Barbara Dos Anjos Rosário, Jose Ivo Araújo Beserra Filho, Robson Luiz Oliveira Santos, Alessandra Mussi Ribeiro, Luciana Le Sueur Maluf, Camila Aparecida Machado de Oliveir. Effects of long-term social isolation on central, behavioural and metabolic parameters in middle-aged mice. Behavioural brain research. vol 417. 2021-11-15. PMID:34656691. |
the isolated group showed impaired memory along with a decrease in hippocampal Δfosb at dentate gyrus and in bdnf at ca3. |
2021-11-15 |
2023-08-13 |
mouse |
| Izabelle Dias Benfato, Ana Carolina Silvares Quintanilha, Jessica Salles Henrique, Melyssa Alves Souza, Barbara Dos Anjos Rosário, Jose Ivo Araújo Beserra Filho, Robson Luiz Oliveira Santos, Alessandra Mussi Ribeiro, Luciana Le Sueur Maluf, Camila Aparecida Machado de Oliveir. Effects of long-term social isolation on central, behavioural and metabolic parameters in middle-aged mice. Behavioural brain research. vol 417. 2021-11-15. PMID:34656691. |
moreover, short-term memory deficit was associated with lower levels of hippocampal Δfosb and bdnf in middle age. |
2021-11-15 |
2023-08-13 |
mouse |
| Isabella A Heinrich, Andiara E Freitas, Ingrid A V Wolin, Ana Paula M Nascimento, Roger Walz, Ana Lúcia S Rodrigues, Rodrigo B Lea. Neuronal activity regulated pentraxin (narp) and GluA4 subunit of AMPA receptor may be targets for fluoxetine modulation. Metabolic brain disease. vol 36. issue 4. 2021-11-12. PMID:33528752. |
fluoxetine 10 mg/kg increased creb phosphorylation and bdnf expression in the prefrontal cortex and hippocampus. |
2021-11-12 |
2023-08-13 |
mouse |
| Hossein Bakhtiari-Dovvombaygi, Saeed Izadi, Mostafa Zare, Elham Asgari Hassanlouei, Hossein Dinpanah, S Mohammad Ahmadi-Soleimani, Farimah Behesht. Vitamin D3 administration prevents memory deficit and alteration of biochemical parameters induced by unpredictable chronic mild stress in rats. Scientific reports. vol 11. issue 1. 2021-11-12. PMID:34381124. |
the present study aimed to investigate the effects of vitamin d3 (vit d) administration on memory function, hippocampal level of amyloid-beta (aβ), brain-derived neurotrophic factor (bdnf) and oxidative stress status in a rat model of unpredictable chronic mild stress (ucms). |
2021-11-12 |
2023-08-13 |
human |
| Hossein Bakhtiari-Dovvombaygi, Saeed Izadi, Mostafa Zare, Elham Asgari Hassanlouei, Hossein Dinpanah, S Mohammad Ahmadi-Soleimani, Farimah Behesht. Vitamin D3 administration prevents memory deficit and alteration of biochemical parameters induced by unpredictable chronic mild stress in rats. Scientific reports. vol 11. issue 1. 2021-11-12. PMID:34381124. |
in addition, the levels of aβ and bdnf were measured in hippocampal region. |
2021-11-12 |
2023-08-13 |
human |
| Hossein Bakhtiari-Dovvombaygi, Saeed Izadi, Mostafa Zare, Elham Asgari Hassanlouei, Hossein Dinpanah, S Mohammad Ahmadi-Soleimani, Farimah Behesht. Vitamin D3 administration prevents memory deficit and alteration of biochemical parameters induced by unpredictable chronic mild stress in rats. Scientific reports. vol 11. issue 1. 2021-11-12. PMID:34381124. |
hippocampal level of thiol and bdnf plus the activities of catalase and superoxide dismutase (sod) were reduced in ucms group compared to the control subjects (i.e. |
2021-11-12 |
2023-08-13 |
human |
| Silvia Cursano, Chiara R Battaglia, Carolina Urrutia-Ruiz, Stefanie Grabrucker, Michael Schön, Jürgen Bockmann, Sonja Braumüller, Peter Radermacher, Francesco Roselli, Markus Huber-Lang, Tobias M Boecker. A CRHR1 antagonist prevents synaptic loss and memory deficits in a trauma-induced delirium-like syndrome. Molecular psychiatry. vol 26. issue 8. 2021-11-11. PMID:32051550. |
in parallel, hippocampal corticotropin-releasing hormone (crh) expression was highly upregulated, and brain-derived neurotrophic factor (bdnf) levels were significantly reduced. |
2021-11-11 |
2023-08-13 |
mouse |
| Chen Li, Fantao Meng, Yun Lei, Jing Liu, Jing Liu, Jingyan Zhang, Fang Liu, Cuilan Liu, Ming Guo, Xin-Yun L. Leptin regulates exon-specific transcription of the Bdnf gene via epigenetic modifications mediated by an AKT/p300 HAT cascade. Molecular psychiatry. vol 26. issue 8. 2021-11-11. PMID:33106599. |
here, we show that the leptin receptor (leprb) colocalizes with brain-derived neurotrophic factor (bdnf), a key player in the pathophysiology of major depression and the action of antidepressants, in the dentate gyrus of the hippocampus. |
2021-11-11 |
2023-08-13 |
Not clear |
| Chen Li, Fantao Meng, Yun Lei, Jing Liu, Jing Liu, Jingyan Zhang, Fang Liu, Cuilan Liu, Ming Guo, Xin-Yun L. Leptin regulates exon-specific transcription of the Bdnf gene via epigenetic modifications mediated by an AKT/p300 HAT cascade. Molecular psychiatry. vol 26. issue 8. 2021-11-11. PMID:33106599. |
leptin treatment increases, whereas deficiency of leptin or leptin receptors decreases, total bdnf mrna levels, with distinct expression profiles of specific exons, in the hippocampus. |
2021-11-11 |
2023-08-13 |
Not clear |
| Fernanda Yvelize Ramos de Araújo, Adriano José Maia Chaves Filho, Adriana Mary Nunes, Gersilene Valente de Oliveira, Patrícia Xavier Lima Gomes, Germana Silva Vasconcelos, Jaqueline Carletti, Manoel Odorico de Moraes, Maria Elisabete de Moraes, Silvânia Maria Mendes Vasconcelos, Francisca Cléa Florenço de Sousa, David Freitas de Lucena, Danielle S Maced. Involvement of anti-inflammatory, antioxidant, and BDNF up-regulating properties in the antipsychotic-like effect of the essential oil of Alpinia zerumbet in mice: a comparative study with olanzapine. Metabolic brain disease. vol 36. issue 8. 2021-11-11. PMID:34491479. |
we conducted the behavioral evaluations of prepulse inhibition of the startle reflex (ppi), social interaction, and working memory (y-maze task), and verified antioxidant (gsh, nitrite levels), anti-inflammatory [interleukin (il)-6], and neurotrophic [brain-derived neurotrophic factor (bdnf)] effects of this oil in hippocampal tissue. |
2021-11-11 |
2023-08-13 |
mouse |
| Fernanda Yvelize Ramos de Araújo, Adriano José Maia Chaves Filho, Adriana Mary Nunes, Gersilene Valente de Oliveira, Patrícia Xavier Lima Gomes, Germana Silva Vasconcelos, Jaqueline Carletti, Manoel Odorico de Moraes, Maria Elisabete de Moraes, Silvânia Maria Mendes Vasconcelos, Francisca Cléa Florenço de Sousa, David Freitas de Lucena, Danielle S Maced. Involvement of anti-inflammatory, antioxidant, and BDNF up-regulating properties in the antipsychotic-like effect of the essential oil of Alpinia zerumbet in mice: a comparative study with olanzapine. Metabolic brain disease. vol 36. issue 8. 2021-11-11. PMID:34491479. |
eoaz efficiently protected the hippocampus against ket-induced oxidative imbalance, il-6 increments, and bdnf impairment. |
2021-11-11 |
2023-08-13 |
mouse |
| Yin-Qiong Huang, Yaofeng Wang, Keyue Hu, Shu Lin, Xia-Hong Li. Hippocampal Glycerol-3-Phosphate Acyltransferases 4 and BDNF in the Progress of Obesity-Induced Depression. Frontiers in endocrinology. vol 12. 2021-11-10. PMID:34054732. |
hippocampal glycerol-3-phosphate acyltransferases 4 and bdnf in the progress of obesity-induced depression. |
2021-11-10 |
2023-08-13 |
Not clear |
| Naeem Erfani Majd, Mohammad Reza Tabandeh, Shima Hosseinifar, Sara Rahimi Zarne. Chemical and Green ZnO nanoparticles ameliorated adverse effects of cisplatin on histological structure, antioxidant defense system and neurotrophins expression in rat hippocampus. Journal of chemical neuroanatomy. vol 116. 2021-11-10. PMID:34146667. |
at the end of the experiment, the activities of superoxide dismutase (sod), catalase (cat), glutathione peroxidase (gpx), malondialdehyde (mda), changes of reduced glutathione (gsh), oxidized glutathione (gssg) and gsh/gssg ratio, histological changes, expression of brain-derived neurotrophic factor (bdnf) and nerve growth factor (ngf) genes were assessed in the hippocampus. |
2021-11-10 |
2023-08-13 |
rat |