| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Madhuparna Banerjee, Rekha R Sheno. Emphasizing roles of BDNF promoters and inducers in Alzheimer's disease for improving impaired cognition and memory. Journal of basic and clinical physiology and pharmacology. 2021-11-09. PMID:34751526. |
drugs and herbals promote neuroprotection by increasing the hippocampus' bdnf level in various disease-induced animal models for neurodegeneration. |
2021-11-09 |
2023-08-13 |
Not clear |
| Francisco J Flores-Ramirez, Anapaula Themann, Jorge A Sierra-Fonseca, Israel Garcia-Carachure, Samuel A Castillo, Minerva Rodriguez, Omar Lira, Joshua Preciado-Piña, Brandon L Warren, Alfred J Robison, Sergio D Iñigue. Adolescent fluoxetine treatment mediates a persistent anxiety-like outcome in female C57BL/6 mice that is ameliorated by fluoxetine re-exposure in adulthood. Scientific reports. vol 11. issue 1. 2021-11-08. PMID:33833356. |
an additional goal was to assess the impact of adolescent flx pretreatment, and its re-exposure in adulthood, on serotonin transporters (5-htt) and brain-derived-neurotrophic-factor (bdnf)-related signaling markers (trkb-erk1/2-creb-probdnf-mbdnf) within the hippocampus and prefrontal cortex. |
2021-11-08 |
2023-08-13 |
mouse |
| Shanshan Liu, Qing Liu, Yanjie Ju, Lei Li. Downregulation of miR-383 reduces depression-like behavior through targeting Wnt family member 2 (Wnt2) in rats. Scientific reports. vol 11. issue 1. 2021-11-08. PMID:33927285. |
downregulation of mir-383 significantly inhibited the apoptosis and inflammatory response of hippocampal neurons, and increased the expression levels of gfap, bdnf and creb which were impacted in depression, as well as neurotransmitters, then attenuated neural injury in rats induced by cums. |
2021-11-08 |
2023-08-13 |
rat |
| Haidar Tafner Curi, Clarissa Tavares Dias, Maria Laura Monteiro da Luz Camargo, Paula Dos Santos Gomez, Moisés Felipe Pereira Gomes, José Ivo Araujo Beserra-Filho, Alessandra Medeiros, Alessandra Mussi Ribeiro, Fernando Moreira Simabuco, Rafael Herling Lambertucci, Cristiano Mendes-da-Silv. Maternal high-fat diet increases anhedonic behavior and modulates hippocampal Mash1 and BDNF expression in adult offspring. Neuroscience letters. vol 764. 2021-11-08. PMID:34509569. |
maternal high-fat diet increases anhedonic behavior and modulates hippocampal mash1 and bdnf expression in adult offspring. |
2021-11-08 |
2023-08-13 |
Not clear |
| Ke-Zhuo Chen, Shi Chen, Jie-Yi Ren, Shi Lin, Ming-Jun Xiao, Li Cheng, Xiao-Chuan Y. [Antidepressant effect of acidic polysaccharides from Poria and their regulation of neurotransmitters and NLRP3 pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 19. 2021-11-08. PMID:34738405. |
the results showed that compared with the model group, acidic polysaccharides from poria at the low-, medium-, and high-doses(0.1, 0.3 and 0.5 g·kg~(-1)·d~(-1)) all improved the depression-like behavior of rats, increased the number of neurons and the levels of bdnf, 5-ht, 5-hiaa, da, and ne in the hippocampus, and reduced glu and serum il-1β, il-18, and tnf-α levels. |
2021-11-08 |
2023-08-13 |
rat |
| Ping Zheng, He Bin, Wei Che. Inhibition of microRNA-103a inhibits the activation of astrocytes in hippocampus tissues and improves the pathological injury of neurons of epilepsy rats by regulating BDNF. Cancer cell international. vol 19. issue 1. 2021-11-05. PMID:31049031. |
inhibition of microrna-103a inhibits the activation of astrocytes in hippocampus tissues and improves the pathological injury of neurons of epilepsy rats by regulating bdnf. |
2021-11-05 |
2023-08-13 |
rat |
| Ping Zheng, He Bin, Wei Che. Inhibition of microRNA-103a inhibits the activation of astrocytes in hippocampus tissues and improves the pathological injury of neurons of epilepsy rats by regulating BDNF. Cancer cell international. vol 19. issue 1. 2021-11-05. PMID:31049031. |
the aim of this study is to explore the effect of microrna-103a (mir-103a) on astrocytes activation and hippocampal neuron injury in epilepsy rats by targeting brain-derived neurotrophic factor (bdnf). |
2021-11-05 |
2023-08-13 |
rat |
| Simon Couly, Allison Carles, Morgane Denus, Lorraine Benigno-Anton, Florence Maschat, Tangui Mauric. Exposure of R6/2 mice in an enriched environment augments P42 therapy efficacy on Huntington's disease progression. Neuropharmacology. vol 186. 2021-11-05. PMID:33516737. |
the p42 + ee combination also significantly decreased aggregated htt levels in the hippocampus, striatum and cortex, and increased bdnf levels in the cortex and striatum. |
2021-11-05 |
2023-08-13 |
mouse |
| Gwo-Ching Sun, Yi-Ju Lee, Yi-Ching Lee, Hsien-Fu Yu, Dean-Chuan Wan. Exercise prevents the impairment of learning and memory in prenatally phthalate-exposed male rats by improving the expression of plasticity-related proteins. Behavioural brain research. vol 413. 2021-11-04. PMID:34245761. |
the activity-regulated cytoskeleton associated protein (arc) is induced by bdnf and n-methyl-d-aspartic acid receptor (nmdar), contributing to functional modification of neuroplasticity in the hippocampus. |
2021-11-04 |
2023-08-13 |
rat |
| Sheng Wang, Guilan Huang, Jie Yan, Changxi Li, Jianwen Feng, Qi Chen, Xiaomeng Zheng, Haobin Li, Jiangchao Li, Lijing Wang, Huimin L. Influence of aging on chronic unpredictable mild stress-induced depression-like behavior in male C57BL/6J mice. Behavioural brain research. vol 414. 2021-11-04. PMID:34302872. |
moreover, lessening and impairment of hippocampal neurons was found in stressed mice at the age of 18 weeks, which was correlated with increased relative mrna expression levels of inflammatory cytokines bdnf, htr1a, and il-6 in the hippocampus. |
2021-11-04 |
2023-08-13 |
mouse |
| Samantha T Reyes, Robert M J Deacon, Scarlett G Guo, Francisco J Altimiras, Jessa B Castillo, Berend van der Wildt, Aimara P Morales, Jun Hyung Park, Daniel Klamer, Jarrett Rosenberg, Lindsay M Oberman, Nell Rebowe, Jeffrey Sprouse, Christopher U Missling, Christopher R McCurdy, Patricia Cogram, Walter E Kaufmann, Frederick T Chi. Effects of the sigma-1 receptor agonist blarcamesine in a murine model of fragile X syndrome: neurobehavioral phenotypes and receptor occupancy. Scientific reports. vol 11. issue 1. 2021-11-04. PMID:34433831. |
it also restored levels of bdnf, a converging point of many synaptic regulators, in the hippocampus. |
2021-11-04 |
2023-08-13 |
mouse |
| Xiaolan Xie, Zhiwen Shen, Chuwen Hu, Kun Zhang, Mingyan Guo, Fei Wang, Kai Qi. Dexmedetomidine Ameliorates Postoperative Cognitive Dysfunction in Aged Mice. Neurochemical research. vol 46. issue 9. 2021-11-03. PMID:34159456. |
furthermore, dex decreased mda levels, enhanced sod activity, modulated cdk5 activity and increased bdnf expression in the hippocampus. |
2021-11-03 |
2023-08-13 |
mouse |
| Jian-Feng Fan, Zhen-Hui Tang, Shi-Yi Wang, Si Lei, Bo Zhang, Shao-Wen Tia. Ketamine enhances novel object recognition memory reconsolidation via the BDNF/TrkB pathway in mice. Physiology & behavior. vol 242. 2021-11-03. PMID:34673052. |
however, this blockage had no significant effect on the ketamine-induced hippocampal bdnf level increase. |
2021-11-03 |
2023-08-13 |
mouse |
| Jian-Feng Fan, Zhen-Hui Tang, Shi-Yi Wang, Si Lei, Bo Zhang, Shao-Wen Tia. Ketamine enhances novel object recognition memory reconsolidation via the BDNF/TrkB pathway in mice. Physiology & behavior. vol 242. 2021-11-03. PMID:34673052. |
in conclusion, acute low-dose ketamine administration improves nor memory reconsolidation by increasing hippocampal bdnf levels and subsequent bdnf binding to the trkb receptor. |
2021-11-03 |
2023-08-13 |
mouse |
| Jili Zhao, Jinyu Ren, Shuang Liu, Yanan Gong, Ping Meng, Haitao Tan, Yonggang Che. Repeated exposure to sevoflurane in neonatal rats impairs cognition in adulthood via the PKA-CREB-BDNF signaling pathway. Experimental and therapeutic medicine. vol 22. issue 6. 2021-11-02. PMID:34721684. |
hippocampal brain-derived neurotrophic factor (bdnf) levels were measured by elisa. |
2021-11-02 |
2023-08-13 |
rat |
| Jili Zhao, Jinyu Ren, Shuang Liu, Yanan Gong, Ping Meng, Haitao Tan, Yonggang Che. Repeated exposure to sevoflurane in neonatal rats impairs cognition in adulthood via the PKA-CREB-BDNF signaling pathway. Experimental and therapeutic medicine. vol 22. issue 6. 2021-11-02. PMID:34721684. |
the protein expression of protein kinase a (pka), camp response element binding protein (creb), phosphorylated-creb (p-creb) and bdnf in hippocampus were assessed by western blotting. |
2021-11-02 |
2023-08-13 |
rat |
| Jili Zhao, Jinyu Ren, Shuang Liu, Yanan Gong, Ping Meng, Haitao Tan, Yonggang Che. Repeated exposure to sevoflurane in neonatal rats impairs cognition in adulthood via the PKA-CREB-BDNF signaling pathway. Experimental and therapeutic medicine. vol 22. issue 6. 2021-11-02. PMID:34721684. |
furthermore, compared with the control group, neonatal exposure to sev reduced the number of neurons and the concentration of bdnf in the hippocampus, a brain region important for learning and memory. |
2021-11-02 |
2023-08-13 |
rat |
| Tih-Shih Lee, Alexander Y Li, Amedeo Rapuano, John Mantis, Tore Eid, Thomas N Seyfried, Nihal C de Laneroll. Gene expression in the epileptic (EL) mouse hippocampus. Neurobiology of disease. vol 147. 2021-11-01. PMID:33153970. |
the increased expression of bdnf along with immediate early gene expression (fosb, junb, erg4, nr4a1, nr4a2, fbxo3) and the down regulation of gabrd, dbp and malat1 it is hypothesized may contribute to the hyperexcitability of the hippocampal neurons in this model. |
2021-11-01 |
2023-08-13 |
mouse |
| Jeremy S Lum, Katrina M Bird, Jennifer Wilkie, Samuel J Millard, Sachie Pallimulla, Kelly A Newell, Ian M Wrigh. Prenatal methadone exposure impairs adolescent cognition and GABAergic neurodevelopment in a novel rat model of maternal methadone treatment. Progress in neuro-psychopharmacology & biological psychiatry. vol 110. 2021-11-01. PMID:33571606. |
immunoblots of the adolescent prefrontal cortex and hippocampus showed methadone-exposed offspring displayed reduced levels of mature bdnf, in addition to the gabaergic proteins, gad67 and parvalbumin, in a sex- and brain region-specific fashion. |
2021-11-01 |
2023-08-13 |
rat |
| Greg L West, Kyoko Konishi, Kathleen MacDonald, Anjie Ni, Ridha Joober, Veronique D Bohbo. The BDNF val66met polymorphism is associated with decreased use of landmarks and decreased fMRI activity in the hippocampus during virtual navigation. The European journal of neuroscience. vol 54. issue 7. 2021-11-01. PMID:34467592. |
the bdnf val66met polymorphism is associated with decreased use of landmarks and decreased fmri activity in the hippocampus during virtual navigation. |
2021-11-01 |
2023-08-13 |
human |