| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Garcia, M J Chen, A A Garza, C W Cotman, A Russo-Neustad. The influence of specific noradrenergic and serotonergic lesions on the expression of hippocampal brain-derived neurotrophic factor transcripts following voluntary physical activity. Neuroscience. vol 119. issue 3. 2003-09-12. PMID:12809693. |
previous studies have shown that hippocampal brain-derived neurotrophic factor (bdnf) mrna levels are significantly increased in rats allowed free access to exercise wheels and/or administered antidepressant medications. |
2003-09-12 |
2023-08-12 |
rat |
| C Garcia, M J Chen, A A Garza, C W Cotman, A Russo-Neustad. The influence of specific noradrenergic and serotonergic lesions on the expression of hippocampal brain-derived neurotrophic factor transcripts following voluntary physical activity. Neuroscience. vol 119. issue 3. 2003-09-12. PMID:12809693. |
in addition, individual transcript variants of bdnf were examined, as evidence exists they are differentially regulated by discrete interventions, and are expressed in distinct sub-regions of the hippocampus. |
2003-09-12 |
2023-08-12 |
rat |
| C Garcia, M J Chen, A A Garza, C W Cotman, A Russo-Neustad. The influence of specific noradrenergic and serotonergic lesions on the expression of hippocampal brain-derived neurotrophic factor transcripts following voluntary physical activity. Neuroscience. vol 119. issue 3. 2003-09-12. PMID:12809693. |
overall, these results indicate that an intact noradrenergic system may be crucial for the observed ability of exercise to enhance full-length and exon i hippocampal bdnf mrna expression. |
2003-09-12 |
2023-08-12 |
rat |
| Nobuhiro Sugiyama, Shigenobu Kanba, Jun Arit. Temporal changes in the expression of brain-derived neurotrophic factor mRNA in the ventromedial nucleus of the hypothalamus of the developing rat brain. Brain research. Molecular brain research. vol 115. issue 1. 2003-09-05. PMID:12824057. |
at postnatal day (pnd) 4, hypothalamic structures showed only modest expression of bdnf mrna, with the exception of the ventromedial nucleus (vmn), where expression was higher than that detected in the hippocampus. |
2003-09-05 |
2023-08-12 |
rat |
| Nobuhiro Sugiyama, Shigenobu Kanba, Jun Arit. Temporal changes in the expression of brain-derived neurotrophic factor mRNA in the ventromedial nucleus of the hypothalamus of the developing rat brain. Brain research. Molecular brain research. vol 115. issue 1. 2003-09-05. PMID:12824057. |
in contrast, the low levels of bdnf mrna observed in the ca3 region of the hippocampus increased to adult levels following pnd 10. |
2003-09-05 |
2023-08-12 |
rat |
| Ahmad R Hariri, Terry E Goldberg, Venkata S Mattay, Bhaskar S Kolachana, Joseph H Callicott, Michael F Egan, Daniel R Weinberge. Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 17. 2003-09-03. PMID:12890761. |
bdnf plays a critical role in activity-dependent neuroplasticity underlying learning and memory in the hippocampus. |
2003-09-03 |
2023-08-12 |
human |
| Ahmad R Hariri, Terry E Goldberg, Venkata S Mattay, Bhaskar S Kolachana, Joseph H Callicott, Michael F Egan, Daniel R Weinberge. Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 17. 2003-09-03. PMID:12890761. |
a frequent single nucleotide polymorphism in the targeting region of the human bdnf gene (val66met) has been associated with abnormal intracellular trafficking and regulated secretion of bdnf in cultured hippocampal neurons transfected with the met allele. |
2003-09-03 |
2023-08-12 |
human |
| Ahmad R Hariri, Terry E Goldberg, Venkata S Mattay, Bhaskar S Kolachana, Joseph H Callicott, Michael F Egan, Daniel R Weinberge. Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 17. 2003-09-03. PMID:12890761. |
in addition, the met allele has been associated with abnormal hippocampal neuronal function as well as impaired episodic memory in human subjects, but a direct effect of bdnf alleles on hippocampal processing of memory has not been demonstrated. |
2003-09-03 |
2023-08-12 |
human |
| Ahmad R Hariri, Terry E Goldberg, Venkata S Mattay, Bhaskar S Kolachana, Joseph H Callicott, Michael F Egan, Daniel R Weinberge. Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 17. 2003-09-03. PMID:12890761. |
we studied the relationship of the bdnf val66met genotype and hippocampal activity during episodic memory processing using blood oxygenation level-dependent functional magnetic resonance imaging and a declarative memory task in healthy individuals. |
2003-09-03 |
2023-08-12 |
human |
| Ahmad R Hariri, Terry E Goldberg, Venkata S Mattay, Bhaskar S Kolachana, Joseph H Callicott, Michael F Egan, Daniel R Weinberge. Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 17. 2003-09-03. PMID:12890761. |
remarkably, the interaction between the bdnf val66met genotype and the hippocampal response during encoding accounted for 25% of the total variation in recognition memory performance. |
2003-09-03 |
2023-08-12 |
human |
| Ahmad R Hariri, Terry E Goldberg, Venkata S Mattay, Bhaskar S Kolachana, Joseph H Callicott, Michael F Egan, Daniel R Weinberge. Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 17. 2003-09-03. PMID:12890761. |
these data implicate a specific genetic mechanism for substantial normal variation in human declarative memory and suggest that the basic effects of bdnf signaling on hippocampal function in experimental animals are important in humans. |
2003-09-03 |
2023-08-12 |
human |
| Idil Cavus, Ronald S Duma. Influence of estradiol, stress, and 5-HT2A agonist treatment on brain-derived neurotrophic factor expression in female rats. Biological psychiatry. vol 54. issue 1. 2003-08-22. PMID:12842309. |
we examined the effects of the estrous cycle, acute and chronic estradiol treatments on bdnf mrna expression in the hippocampus and cortex of female rats. |
2003-08-22 |
2023-08-12 |
rat |
| Eiji Shimizu, Kenji Hashimoto, Naoe Okamura, Kaori Koike, Naoya Komatsu, Chikara Kumakiri, Michiko Nakazato, Hiroyuki Watanabe, Naoyuki Shinoda, Sin-ichi Okada, Masaomi Iy. Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants. Biological psychiatry. vol 54. issue 1. 2003-08-22. PMID:12842310. |
because researchers have reported that antidepressants increase the expression of brain-derived neurotrophic factor (bdnf) in the rat hippocampus, we investigated whether serum bdnf levels may be used as a putative biological marker for major depressive disorders (mdd). |
2003-08-22 |
2023-08-12 |
rat |
| Xiaoming Jin, Hang Hu, Peter H Mathers, Ariel Agmo. Brain-derived neurotrophic factor mediates activity-dependent dendritic growth in nonpyramidal neocortical interneurons in developing organotypic cultures. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 13. 2003-08-14. PMID:12843269. |
bdnf promotes differentiation of cerebellar, hippocampal, and neostriatal inhibitory neurons, but its effects on the dendritic development of neocortical inhibitory interneurons remain unknown. |
2003-08-14 |
2023-08-12 |
mouse |
| Mariana Alonso, Monica R M Vianna, Ivan Izquierdo, Jorge H Medin. Signaling mechanisms mediating BDNF modulation of memory formation in vivo in the hippocampus. Cellular and molecular neurobiology. vol 22. issue 5-6. 2003-08-13. PMID:12585686. |
signaling mechanisms mediating bdnf modulation of memory formation in vivo in the hippocampus. |
2003-08-13 |
2023-08-12 |
human |
| Mariana Alonso, Monica R M Vianna, Ivan Izquierdo, Jorge H Medin. Signaling mechanisms mediating BDNF modulation of memory formation in vivo in the hippocampus. Cellular and molecular neurobiology. vol 22. issue 5-6. 2003-08-13. PMID:12585686. |
given that brain-derived neutrophic factor (bdnf) modulates both short-term synaptic function and activity-dependent synaptic plasticity in the adult hippocampus, here we examined signaling mechanisms in vivo in the hippocampus mediating bdnf modulation of long-term memory (ltm) formation of a one-trial fear-motivated learning task in rats. |
2003-08-13 |
2023-08-12 |
human |
| Mariana Alonso, Monica R M Vianna, Ivan Izquierdo, Jorge H Medin. Signaling mechanisms mediating BDNF modulation of memory formation in vivo in the hippocampus. Cellular and molecular neurobiology. vol 22. issue 5-6. 2003-08-13. PMID:12585686. |
thus, our results suggest that bdnf exerts its role in ltm formation in vivo in ca1 region of the hippocampus, at least in part, via creb activation. |
2003-08-13 |
2023-08-12 |
human |
| A C Hansson, W Sommer, R Rimondini, B Andbjer, I Strömberg, K Fux. c-fos reduces corticosterone-mediated effects on neurotrophic factor expression in the rat hippocampal CA1 region. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 14. 2003-08-07. PMID:12853419. |
a time course for corticosterone (10 mg/kg, s.c.) in adrenalectomized rats revealed a peak hormone effect at the 4 hr time interval for bfgf (110-204% increase), bdnf (53-67% decrease), gr (53-64% decrease), and mr (34-56% decrease) mrna levels in all hippocampal subregions using in situ hybridization. |
2003-08-07 |
2023-08-12 |
rat |
| Volkmar Lessmann, Kurt Gottmann, Marzia Malcangi. Neurotrophin secretion: current facts and future prospects. Progress in neurobiology. vol 69. issue 5. 2003-08-06. PMID:12787574. |
finally, since bdnf has been proposed to play a critical role as an intercellular synaptic messenger in long-term potentiation (ltp) in the hippocampus, we try to reconcile this possible role of bdnf in ltp with the recently described features of synaptic bdnf secretion. |
2003-08-06 |
2023-08-12 |
Not clear |
| A L Coppell, Q Pei, T S C Zetterströ. Bi-phasic change in BDNF gene expression following antidepressant drug treatment. Neuropharmacology. vol 44. issue 7. 2003-08-04. PMID:12726822. |
it was found that repeated administration of either the monoamine oxidase inhibitor tranylcypromine (tcp) or 5-hydroxytryptamine (5-ht) re-uptake inhibitors (fluoxetine, paroxetine and sertraline), evoke a bi-phasic and time-dependent effect on bdnf gene expression in the rat hippocampus (especially dentate gyrus). |
2003-08-04 |
2023-08-12 |
rat |