| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Frédéric Marmigère, Laurent Givalois, Florence Rage, Sandor Arancibia, Lucia Tapia-Arancibi. Rapid induction of BDNF expression in the hippocampus during immobilization stress challenge in adult rats. Hippocampus. vol 13. issue 5. 2003-09-26. PMID:12921353. |
brain-derived neurotrophic factor (bdnf) is strongly expressed in the hippocampus, where it has been associated with memory processes. |
2003-09-26 |
2023-08-12 |
rat |
| Frédéric Marmigère, Laurent Givalois, Florence Rage, Sandor Arancibia, Lucia Tapia-Arancibi. Rapid induction of BDNF expression in the hippocampus during immobilization stress challenge in adult rats. Hippocampus. vol 13. issue 5. 2003-09-26. PMID:12921353. |
using an rnase protection assay, we demonstrated that short-time stress application induced a significant increase (at 60 min) in bdnf mrna levels in the whole rat hippocampus. |
2003-09-26 |
2023-08-12 |
rat |
| Frédéric Marmigère, Laurent Givalois, Florence Rage, Sandor Arancibia, Lucia Tapia-Arancibi. Rapid induction of BDNF expression in the hippocampus during immobilization stress challenge in adult rats. Hippocampus. vol 13. issue 5. 2003-09-26. PMID:12921353. |
in situ hybridization analysis of discrete hippocampal layers demonstrated that bdnf mrna expression increased as early as 15 min in most hippocampal regions, with no modification in the number of labeled cells. |
2003-09-26 |
2023-08-12 |
rat |
| Frédéric Marmigère, Laurent Givalois, Florence Rage, Sandor Arancibia, Lucia Tapia-Arancibi. Rapid induction of BDNF expression in the hippocampus during immobilization stress challenge in adult rats. Hippocampus. vol 13. issue 5. 2003-09-26. PMID:12921353. |
these data suggest that rapid changes in bdnf expression may be part of a compensatory response to preserve hippocampal homeostasis or a form of neuronal plasticity to cope with new stimuli. |
2003-09-26 |
2023-08-12 |
rat |
| M Mizuno, K Yamada, N Takei, M H Tran, J He, A Nakajima, H Nawa, T Nabeshim. Phosphatidylinositol 3-kinase: a molecule mediating BDNF-dependent spatial memory formation. Molecular psychiatry. vol 8. issue 2. 2003-09-23. PMID:12610654. |
we have demonstrated that radial arm maze training in rats for spatial learning and memory results in a significant increase in the bdnf mrna expression in the hippocampus. |
2003-09-23 |
2023-08-12 |
rat |
| M Mizuno, K Yamada, N Takei, M H Tran, J He, A Nakajima, H Nawa, T Nabeshim. Phosphatidylinositol 3-kinase: a molecule mediating BDNF-dependent spatial memory formation. Molecular psychiatry. vol 8. issue 2. 2003-09-23. PMID:12610654. |
here we show that phosphorylation of bdnf receptor tyrosine kinase b (trkb), phosphatidylinositol 3-kinase (pi3-k) and akt, a target of pi3-k, in the hippocampus increased in parallel with spatial memory formation. |
2003-09-23 |
2023-08-12 |
rat |
| M Mizuno, K Yamada, N Takei, M H Tran, J He, A Nakajima, H Nawa, T Nabeshim. Phosphatidylinositol 3-kinase: a molecule mediating BDNF-dependent spatial memory formation. Molecular psychiatry. vol 8. issue 2. 2003-09-23. PMID:12610654. |
our findings suggested that activation of trkb/pi3-k and protein synthesis signaling pathway by bdnf in the hippocampus is important for spatial memory. |
2003-09-23 |
2023-08-12 |
rat |
| H Okamoto, Y Shino, K Hashimoto, C Kumakiri, E Shimizu, H Shirasawa, M Iy. Dynamic changes in AP-1 transcription factor DNA binding activity in rat brain following administration of antidepressant amitriptyline and brain-derived neurotrophic factor. Neuropharmacology. vol 45. issue 2. 2003-09-16. PMID:12842131. |
however, chronic administration of amitriptyline (10 mg/kg, once daily for 3 weeks) significantly increased bdnf protein levels in the hippocampus (by 26.9%) and frontal cortex (by 24.6%). |
2003-09-16 |
2023-08-12 |
rat |
| H Okamoto, Y Shino, K Hashimoto, C Kumakiri, E Shimizu, H Shirasawa, M Iy. Dynamic changes in AP-1 transcription factor DNA binding activity in rat brain following administration of antidepressant amitriptyline and brain-derived neurotrophic factor. Neuropharmacology. vol 45. issue 2. 2003-09-16. PMID:12842131. |
direct infusion of bdnf (1 microg) into the hippocampal dentate gyrus significantly increased hippocampal ap-1 dna binding activity. |
2003-09-16 |
2023-08-12 |
rat |
| C Garcia, M J Chen, A A Garza, C W Cotman, A Russo-Neustad. The influence of specific noradrenergic and serotonergic lesions on the expression of hippocampal brain-derived neurotrophic factor transcripts following voluntary physical activity. Neuroscience. vol 119. issue 3. 2003-09-12. PMID:12809693. |
previous studies have shown that hippocampal brain-derived neurotrophic factor (bdnf) mrna levels are significantly increased in rats allowed free access to exercise wheels and/or administered antidepressant medications. |
2003-09-12 |
2023-08-12 |
rat |
| C Garcia, M J Chen, A A Garza, C W Cotman, A Russo-Neustad. The influence of specific noradrenergic and serotonergic lesions on the expression of hippocampal brain-derived neurotrophic factor transcripts following voluntary physical activity. Neuroscience. vol 119. issue 3. 2003-09-12. PMID:12809693. |
in addition, individual transcript variants of bdnf were examined, as evidence exists they are differentially regulated by discrete interventions, and are expressed in distinct sub-regions of the hippocampus. |
2003-09-12 |
2023-08-12 |
rat |
| C Garcia, M J Chen, A A Garza, C W Cotman, A Russo-Neustad. The influence of specific noradrenergic and serotonergic lesions on the expression of hippocampal brain-derived neurotrophic factor transcripts following voluntary physical activity. Neuroscience. vol 119. issue 3. 2003-09-12. PMID:12809693. |
overall, these results indicate that an intact noradrenergic system may be crucial for the observed ability of exercise to enhance full-length and exon i hippocampal bdnf mrna expression. |
2003-09-12 |
2023-08-12 |
rat |
| Nobuhiro Sugiyama, Shigenobu Kanba, Jun Arit. Temporal changes in the expression of brain-derived neurotrophic factor mRNA in the ventromedial nucleus of the hypothalamus of the developing rat brain. Brain research. Molecular brain research. vol 115. issue 1. 2003-09-05. PMID:12824057. |
at postnatal day (pnd) 4, hypothalamic structures showed only modest expression of bdnf mrna, with the exception of the ventromedial nucleus (vmn), where expression was higher than that detected in the hippocampus. |
2003-09-05 |
2023-08-12 |
rat |
| Nobuhiro Sugiyama, Shigenobu Kanba, Jun Arit. Temporal changes in the expression of brain-derived neurotrophic factor mRNA in the ventromedial nucleus of the hypothalamus of the developing rat brain. Brain research. Molecular brain research. vol 115. issue 1. 2003-09-05. PMID:12824057. |
in contrast, the low levels of bdnf mrna observed in the ca3 region of the hippocampus increased to adult levels following pnd 10. |
2003-09-05 |
2023-08-12 |
rat |
| Ahmad R Hariri, Terry E Goldberg, Venkata S Mattay, Bhaskar S Kolachana, Joseph H Callicott, Michael F Egan, Daniel R Weinberge. Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 17. 2003-09-03. PMID:12890761. |
bdnf plays a critical role in activity-dependent neuroplasticity underlying learning and memory in the hippocampus. |
2003-09-03 |
2023-08-12 |
human |
| Ahmad R Hariri, Terry E Goldberg, Venkata S Mattay, Bhaskar S Kolachana, Joseph H Callicott, Michael F Egan, Daniel R Weinberge. Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 17. 2003-09-03. PMID:12890761. |
a frequent single nucleotide polymorphism in the targeting region of the human bdnf gene (val66met) has been associated with abnormal intracellular trafficking and regulated secretion of bdnf in cultured hippocampal neurons transfected with the met allele. |
2003-09-03 |
2023-08-12 |
human |
| Ahmad R Hariri, Terry E Goldberg, Venkata S Mattay, Bhaskar S Kolachana, Joseph H Callicott, Michael F Egan, Daniel R Weinberge. Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 17. 2003-09-03. PMID:12890761. |
in addition, the met allele has been associated with abnormal hippocampal neuronal function as well as impaired episodic memory in human subjects, but a direct effect of bdnf alleles on hippocampal processing of memory has not been demonstrated. |
2003-09-03 |
2023-08-12 |
human |
| Ahmad R Hariri, Terry E Goldberg, Venkata S Mattay, Bhaskar S Kolachana, Joseph H Callicott, Michael F Egan, Daniel R Weinberge. Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 17. 2003-09-03. PMID:12890761. |
we studied the relationship of the bdnf val66met genotype and hippocampal activity during episodic memory processing using blood oxygenation level-dependent functional magnetic resonance imaging and a declarative memory task in healthy individuals. |
2003-09-03 |
2023-08-12 |
human |
| Ahmad R Hariri, Terry E Goldberg, Venkata S Mattay, Bhaskar S Kolachana, Joseph H Callicott, Michael F Egan, Daniel R Weinberge. Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 17. 2003-09-03. PMID:12890761. |
remarkably, the interaction between the bdnf val66met genotype and the hippocampal response during encoding accounted for 25% of the total variation in recognition memory performance. |
2003-09-03 |
2023-08-12 |
human |
| Ahmad R Hariri, Terry E Goldberg, Venkata S Mattay, Bhaskar S Kolachana, Joseph H Callicott, Michael F Egan, Daniel R Weinberge. Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 17. 2003-09-03. PMID:12890761. |
these data implicate a specific genetic mechanism for substantial normal variation in human declarative memory and suggest that the basic effects of bdnf signaling on hippocampal function in experimental animals are important in humans. |
2003-09-03 |
2023-08-12 |
human |