| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R J Tolwani, P S Buckmaster, S Varma, J M Cosgaya, Y Wu, C Suri, E M Shoote. BDNF overexpression increases dendrite complexity in hippocampal dentate gyrus. Neuroscience. vol 114. issue 3. 2002-12-20. PMID:12220579. |
this is the first study to evaluate the effects of bdnf overexpression on dendrite morphology in the intact hippocampus and extends previous in vitro observations that bdnf influences synaptic plasticity by increasing complexity of dendritic arbors. |
2002-12-20 |
2023-08-12 |
mouse |
| b' Francesco Angelucci, Luigi Aloe, Patricia Jim\\xc3\\xa9nez-Vasquez, Aleksander A Math\\xc3\\xa. Electroconvulsive stimuli alter the regional concentrations of nerve growth factor, brain-derived neurotrophic factor, and glial cell line-derived neurotrophic factor in adult rat brain. The journal of ECT. vol 18. issue 3. 2002-12-20. PMID:12394532.' |
electroconvulsive stimuli increased the concentrations of ngf in the frontal cortex and concentrations of bdnf in the hippocampus, the striatum, and the occipital cortex. |
2002-12-20 |
2023-08-12 |
rat |
| Mary Eve McCutchen, Clive R Bramham, Lucas D Pozzo-Mille. Modulation of neuronal calcium signaling by neurotrophic factors. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 20. issue 3-5. 2002-12-17. PMID:12175855. |
simultaneous whole-cell recording and microfluorometric ca(2+) imaging were performed in ca1 pyramidal neurons from hippocampal organotypic slice cultures treated with bdnf for 2-4 days in vitro. |
2002-12-17 |
2023-08-12 |
Not clear |
| Mary Eve McCutchen, Clive R Bramham, Lucas D Pozzo-Mille. Modulation of neuronal calcium signaling by neurotrophic factors. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 20. issue 3-5. 2002-12-17. PMID:12175855. |
these results suggest that, despite bdnf's profound effects on hippocampal synaptic plasticity, and of l-type ca(2+) channels on neuronal gene transcription, the role of bdnf in cellular models of hippocampus-dependent learning and memory does not involve modulation of voltage-gated dendritic ca(2+) signaling mediated by l-type channels in apical dendrites of ca1 pyramidal neurons. |
2002-12-17 |
2023-08-12 |
Not clear |
| Marzena Mackowiak, Michael J O'Neill, Caroline A Hicks, David Bleakman, Phil Skolnic. An AMPA receptor potentiator modulates hippocampal expression of BDNF: an in vivo study. Neuropharmacology. vol 43. issue 1. 2002-11-21. PMID:12213254. |
an ampa receptor potentiator modulates hippocampal expression of bdnf: an in vivo study. |
2002-11-21 |
2023-08-12 |
rat |
| Marzena Mackowiak, Michael J O'Neill, Caroline A Hicks, David Bleakman, Phil Skolnic. An AMPA receptor potentiator modulates hippocampal expression of BDNF: an in vivo study. Neuropharmacology. vol 43. issue 1. 2002-11-21. PMID:12213254. |
in the present study, we investigated the effect of a novel ampa receptor potentiator (ly404187) and its active isomer (ly451646) on the expression of bdnf protein and mrna, as well as trkb mrna in rat hippocampus. |
2002-11-21 |
2023-08-12 |
rat |
| Marzena Mackowiak, Michael J O'Neill, Caroline A Hicks, David Bleakman, Phil Skolnic. An AMPA receptor potentiator modulates hippocampal expression of BDNF: an in vivo study. Neuropharmacology. vol 43. issue 1. 2002-11-21. PMID:12213254. |
ly404187 administered for 7 days (1 mg/kg) significantly increased the number of bdnf immunopositive cells in the dentate gyrus, but not other hippocampal subfields. |
2002-11-21 |
2023-08-12 |
rat |
| Marzena Mackowiak, Michael J O'Neill, Caroline A Hicks, David Bleakman, Phil Skolnic. An AMPA receptor potentiator modulates hippocampal expression of BDNF: an in vivo study. Neuropharmacology. vol 43. issue 1. 2002-11-21. PMID:12213254. |
chronic treatment (7 days) with ly451646 (0.5 mg/kg, comparable to 1 mg/kg of ly404187) increased the level of both bdnf and trkb mrna expression in the dentate gyrus, ca3 and ca4 of the hippocampus. |
2002-11-21 |
2023-08-12 |
rat |
| Marzena Mackowiak, Michael J O'Neill, Caroline A Hicks, David Bleakman, Phil Skolnic. An AMPA receptor potentiator modulates hippocampal expression of BDNF: an in vivo study. Neuropharmacology. vol 43. issue 1. 2002-11-21. PMID:12213254. |
however, chronic treatment with lower doses of ly451646 (0.125 and 0.25 mg/kg) decreased the level of bdnf and trkb mrna in hippocampus, whilst the highest used dose of ly451646 (1 mg/kg) had no effect on bdnf and trkb mrna in hippocampus. |
2002-11-21 |
2023-08-12 |
rat |
| Marzena Mackowiak, Michael J O'Neill, Caroline A Hicks, David Bleakman, Phil Skolnic. An AMPA receptor potentiator modulates hippocampal expression of BDNF: an in vivo study. Neuropharmacology. vol 43. issue 1. 2002-11-21. PMID:12213254. |
in contrast, acute treatment with ly451646 produced an increase in bdnf mrna levels at doses of 0.125 and 0.25 mg/kg in the hippocampus (ca4, ca3 and dentate gyrus, but not in ca1). |
2002-11-21 |
2023-08-12 |
rat |
| Marzena Mackowiak, Michael J O'Neill, Caroline A Hicks, David Bleakman, Phil Skolnic. An AMPA receptor potentiator modulates hippocampal expression of BDNF: an in vivo study. Neuropharmacology. vol 43. issue 1. 2002-11-21. PMID:12213254. |
ly451646 at 0.5 mg/kg had no effect, but at 1.0 mg/kg decreased the level of bdnf mrna in hippocampus. |
2002-11-21 |
2023-08-12 |
rat |
| Marzena Mackowiak, Michael J O'Neill, Caroline A Hicks, David Bleakman, Phil Skolnic. An AMPA receptor potentiator modulates hippocampal expression of BDNF: an in vivo study. Neuropharmacology. vol 43. issue 1. 2002-11-21. PMID:12213254. |
the increase in both bdnf protein and mrna expression in the dentate gyrus but not in ca1 indicates a specific role of ampa receptors in the regulation of bdnf expression in this hippocampal subfield. |
2002-11-21 |
2023-08-12 |
rat |
| Steve C Danzer, Kristy R C Crooks, Donald C Lo, James O McNamar. Increased expression of brain-derived neurotrophic factor induces formation of basal dendrites and axonal branching in dentate granule cells in hippocampal explant cultures. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 22. 2002-11-18. PMID:12427830. |
to test this hypothesis, we transfected dgcs in rat hippocampal slice cultures with bdnf or nerve growth factor (ngf) via particle-mediated gene transfer, and we visualized the neuronal processes with cotransfected green fluorescent protein. |
2002-11-18 |
2023-08-12 |
rat |
| Jessie Truettner, Raul Busto, Weizhao Zhao, Myron D Ginsberg, Miguel A Pérez-Pinzó. Effect of ischemic preconditioning on the expression of putative neuroprotective genes in the rat brain. Brain research. Molecular brain research. vol 103. issue 1-2. 2002-11-06. PMID:12106696. |
bdnf, ngf, and c-jun were significantly upregulated in the hippocampus. |
2002-11-06 |
2023-08-12 |
rat |
| Anette Risedal, Bengt Mattsson, Per Dahlqvist, Claes Nordborg, Tommy Olsson, Barbro B Johansso. Environmental influences on functional outcome after a cortical infarct in the rat. Brain research bulletin. vol 58. issue 3. 2002-11-06. PMID:12128159. |
the bdnf gene expression in the ipsi- and contralateral cortex, thalamus, hippocampus and cerebellum did not significantly differ between the groups. |
2002-11-06 |
2023-08-12 |
rat |
| Félicien Karege, Michèle Schwald, Mbaye Ciss. Postnatal developmental profile of brain-derived neurotrophic factor in rat brain and platelets. Neuroscience letters. vol 328. issue 3. 2002-10-28. PMID:12147321. |
by using immunoassay and reverse transcription-polymerase chain reaction methods, bdnf protein and mrna levels were determined in serum and platelets, respectively, and in two brain structures (hippocampus and frontal cortex) of postnatal rats (one and three weeks old), young adults (two months old) and in aged animals (two years old). |
2002-10-28 |
2023-08-12 |
human |
| Félicien Karege, Michèle Schwald, Mbaye Ciss. Postnatal developmental profile of brain-derived neurotrophic factor in rat brain and platelets. Neuroscience letters. vol 328. issue 3. 2002-10-28. PMID:12147321. |
the results showed that brain and serum bdnf levels underwent similar changes during maturation and aging processes (analysis of variance (anova): p<0.001, p<0.001, for hippocampus and serum, respectively). |
2002-10-28 |
2023-08-12 |
human |
| Félicien Karege, Michèle Schwald, Mbaye Ciss. Postnatal developmental profile of brain-derived neurotrophic factor in rat brain and platelets. Neuroscience letters. vol 328. issue 3. 2002-10-28. PMID:12147321. |
during the same investigation period, the measure of bdnf mrna indicated gradual changes in the hippocampus but not in platelets (anova: p<0.001 and not significant, for hippocampus and platelets, respectively). |
2002-10-28 |
2023-08-12 |
human |
| Jaewon Lee, Wenzhen Duan, Mark P Mattso. Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice. Journal of neurochemistry. vol 82. issue 6. 2002-10-22. PMID:12354284. |
to determine the role of brain-derived neurotrophic factor (bdnf) in the enhancement of hippocampal neurogenesis resulting from dietary restriction (dr), heterozygous bdnf knockout (bdnf +/-) mice and wild-type mice were maintained for 3 months on dr or ad libitum (al) diets. |
2002-10-22 |
2023-08-12 |
mouse |
| Jaewon Lee, Wenzhen Duan, Mark P Mattso. Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice. Journal of neurochemistry. vol 82. issue 6. 2002-10-22. PMID:12354284. |
levels of bdnf protein in neurons throughout the hippocampus were decreased in bdnf +/- mice, but were increased by dr in wild-type mice and to a lesser amount in bdnf +/- mice. |
2002-10-22 |
2023-08-12 |
mouse |