| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Annakaisa Haapasalo, Ilkka Sipola, Kim Larsson, Karl E O Akerman, Peter Stoilov, Stefan Stamm, Garry Wong, Eero Castre. Regulation of TRKB surface expression by brain-derived neurotrophic factor and truncated TRKB isoforms. The Journal of biological chemistry. vol 277. issue 45. 2003-02-06. PMID:12202482. |
we report here that bdnf regulates the cell surface levels of transfected or endogenously expressed full-length trkb, depending on the exposure time in neuroblastoma cells and primary hippocampal neurons. |
2003-02-06 |
2023-08-12 |
Not clear |
| Jonathan C Gewirtz, Andrew C Chen, Rose Terwilliger, Ronald C Duman, Gerard J Mare. Modulation of DOI-induced increases in cortical BDNF expression by group II mGlu receptors. Pharmacology, biochemistry, and behavior. vol 73. issue 2. 2003-02-05. PMID:12117585. |
previous studies have shown that 5-hydroxytryptamine(2a) (5-ht(2a)) receptor activation induces changes in the pattern of brain-derived neurotrophic factor (bdnf) mrna expression in the neocortex and hippocampus, and that 5-ht(2a) receptor blockade interferes with the induction of bdnf mrna by stress. |
2003-02-05 |
2023-08-12 |
Not clear |
| Paula C Ashe, Jennifer Chlan-Fourney, Augusto V Juorio, Xin-Min L. Brain-derived neurotrophic factor (BDNF) mRNA in rats with neonatal ibotenic acid lesions of the ventral hippocampus. Brain research. vol 956. issue 1. 2003-01-29. PMID:12426055. |
brain-derived neurotrophic factor (bdnf) mrna in rats with neonatal ibotenic acid lesions of the ventral hippocampus. |
2003-01-29 |
2023-08-12 |
rat |
| Paula C Ashe, Jennifer Chlan-Fourney, Augusto V Juorio, Xin-Min L. Brain-derived neurotrophic factor (BDNF) mRNA in rats with neonatal ibotenic acid lesions of the ventral hippocampus. Brain research. vol 956. issue 1. 2003-01-29. PMID:12426055. |
bdnf mrna was examined by in situ hybridization in the prefrontal cortex and hippocampus of animals with neonatal ibotenic acid lesions of the ventral hippocampus, a putative neurodevelopmental animal model of schizophrenia. |
2003-01-29 |
2023-08-12 |
rat |
| Paula C Ashe, Jennifer Chlan-Fourney, Augusto V Juorio, Xin-Min L. Brain-derived neurotrophic factor (BDNF) mRNA in rats with neonatal ibotenic acid lesions of the ventral hippocampus. Brain research. vol 956. issue 1. 2003-01-29. PMID:12426055. |
results demonstrate that animals with neonatal ibotenic acid lesions of the ventral hippocampus have reduced basal levels of bdnf mrna. |
2003-01-29 |
2023-08-12 |
rat |
| Jennifer Chlan-Fourney, Paula Ashe, Kirk Nylen, Augusto V Juorio, Xin Min L. Differential regulation of hippocampal BDNF mRNA by typical and atypical antipsychotic administration. Brain research. vol 954. issue 1. 2003-01-24. PMID:12393228. |
differential regulation of hippocampal bdnf mrna by typical and atypical antipsychotic administration. |
2003-01-24 |
2023-08-12 |
rat |
| Jennifer Chlan-Fourney, Paula Ashe, Kirk Nylen, Augusto V Juorio, Xin Min L. Differential regulation of hippocampal BDNF mRNA by typical and atypical antipsychotic administration. Brain research. vol 954. issue 1. 2003-01-24. PMID:12393228. |
chronic (19 day) but not acute (45 min) antipsychotic administration significantly altered levels of hippocampal bdnf mrna. |
2003-01-24 |
2023-08-12 |
rat |
| Jennifer Chlan-Fourney, Paula Ashe, Kirk Nylen, Augusto V Juorio, Xin Min L. Differential regulation of hippocampal BDNF mRNA by typical and atypical antipsychotic administration. Brain research. vol 954. issue 1. 2003-01-24. PMID:12393228. |
in addition, whereas chronic treatment with the strong d2 receptor-blocker haloperidol significantly downregulated hippocampal bdnf mrna, the selective 5-ht2 receptor-blocker ritanserin significantly upregulated ca1 hippocampal bdnf mrna in comparison to controls. |
2003-01-24 |
2023-08-12 |
rat |
| Jennifer Chlan-Fourney, Paula Ashe, Kirk Nylen, Augusto V Juorio, Xin Min L. Differential regulation of hippocampal BDNF mRNA by typical and atypical antipsychotic administration. Brain research. vol 954. issue 1. 2003-01-24. PMID:12393228. |
since high doses of risperidone and clozapine produce potent inhibition of both 5-ht2 and d2 receptors, while lower doses produce significantly greater 5-ht2 vs. d2 receptor blockade, a dose-response study was employed to determine whether low doses of these atypical antipsychotics would also upregulate hippocampal bdnf mrna in the absence of significant d2 receptor blockade. |
2003-01-24 |
2023-08-12 |
rat |
| Jennifer Chlan-Fourney, Paula Ashe, Kirk Nylen, Augusto V Juorio, Xin Min L. Differential regulation of hippocampal BDNF mRNA by typical and atypical antipsychotic administration. Brain research. vol 954. issue 1. 2003-01-24. PMID:12393228. |
whereas chronic haloperidol and high-dose risperidone significantly downregulated hippocampal bdnf mrna, intermediate and lower doses of risperidone and clozapine were, unlike ritanserin, without effect when compared to controls. |
2003-01-24 |
2023-08-12 |
rat |
| Jennifer Chlan-Fourney, Paula Ashe, Kirk Nylen, Augusto V Juorio, Xin Min L. Differential regulation of hippocampal BDNF mRNA by typical and atypical antipsychotic administration. Brain research. vol 954. issue 1. 2003-01-24. PMID:12393228. |
thus, although the long-term downregulation of hippocampal bdnf mrna may underlie the different clinical profiles of certain antipsychotics, this effect seems to be associated with antipsychotic doses that not only cause significant d2 receptor inhibition, but are usually associated with side effects rather than therapeutic efficacies. |
2003-01-24 |
2023-08-12 |
rat |
| Maija Castrén, Katariina E Lampinen, Riitta Miettinen, Eija Koponen, Ilkka Sipola, Cathy E Bakker, Ben A Oostra, Eero Castré. BDNF regulates the expression of fragile X mental retardation protein mRNA in the hippocampus. Neurobiology of disease. vol 11. issue 1. 2003-01-23. PMID:12460560. |
bdnf regulates the expression of fragile x mental retardation protein mrna in the hippocampus. |
2003-01-23 |
2023-08-12 |
mouse |
| Maija Castrén, Katariina E Lampinen, Riitta Miettinen, Eija Koponen, Ilkka Sipola, Cathy E Bakker, Ben A Oostra, Eero Castré. BDNF regulates the expression of fragile X mental retardation protein mRNA in the hippocampus. Neurobiology of disease. vol 11. issue 1. 2003-01-23. PMID:12460560. |
exposure of cultured hippocampal neurons to bdnf, but not to nt-3, reduced fmr1 mrna levels to 84.8% of control at 4 h and the levels were back to baseline by 24 h or 4 days. |
2003-01-23 |
2023-08-12 |
mouse |
| Claudio Rivera, Hong Li, Judith Thomas-Crusells, Hannele Lahtinen, Tero Viitanen, Avtandil Nanobashvili, Zaal Kokaia, Matti S Airaksinen, Juha Voipio, Kai Kaila, Mart Saarm. BDNF-induced TrkB activation down-regulates the K+-Cl- cotransporter KCC2 and impairs neuronal Cl- extrusion. The Journal of cell biology. vol 159. issue 5. 2003-01-23. PMID:12473684. |
here, we show that exposure of rat hippocampal slice cultures and acute slices to exogenous bdnf or neurotrophin-4 produces a trkb-mediated fall in the neuron-specific k+-cl- cotransporter kcc2 mrna and protein, as well as a consequent impairment in neuronal cl- extrusion capacity. |
2003-01-23 |
2023-08-12 |
mouse |
| Claudio Rivera, Hong Li, Judith Thomas-Crusells, Hannele Lahtinen, Tero Viitanen, Avtandil Nanobashvili, Zaal Kokaia, Matti S Airaksinen, Juha Voipio, Kai Kaila, Mart Saarm. BDNF-induced TrkB activation down-regulates the K+-Cl- cotransporter KCC2 and impairs neuronal Cl- extrusion. The Journal of cell biology. vol 159. issue 5. 2003-01-23. PMID:12473684. |
after kindling-induced seizures in vivo, the expression of kcc2 is down-regulated in the mouse hippocampus with a spatiotemporal profile complementary to the up-regulation of trkb and bdnf. |
2003-01-23 |
2023-08-12 |
mouse |
| Weiming Fu, Chengbiao Lu, Mark P Mattso. Telomerase mediates the cell survival-promoting actions of brain-derived neurotrophic factor and secreted amyloid precursor protein in developing hippocampal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 24. 2003-01-23. PMID:12486164. |
we now report that telomerase activity and levels of its catalytic subunit telomerase reverse transcriptase (tert) are increased in embryonic hippocampal neurons by brain-derived neurotrophic factor (bdnf) and a secreted form of beta-amyloid precursor protein (sapp). |
2003-01-23 |
2023-08-12 |
Not clear |
| Weiming Fu, Chengbiao Lu, Mark P Mattso. Telomerase mediates the cell survival-promoting actions of brain-derived neurotrophic factor and secreted amyloid precursor protein in developing hippocampal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 24. 2003-01-23. PMID:12486164. |
our findings demonstrate a requirement for telomerase in the cell survival-promoting actions of bdnf and sapp in early postmitotic hippocampal neurons, suggesting a previously unknown role for telomerase in mediating the biological actions of neurotrophic factors during brain development. |
2003-01-23 |
2023-08-12 |
Not clear |
| S V Vellucci, R F Parrott, M L Mimmac. Chronic dexamethasone-treatment alters mineralocorticoid receptor, truncated trkB and selected glutamate receptor subunit mRNA expression in the porcine hippocampus. Neuropeptides. vol 36. issue 4. 2003-01-10. PMID:12372704. |
the objective was to determine whether chronic glucocorticoid treatment would alter the expression of mrnas for gluco- and mineralocorticoid receptors (gr and mr), brain-derived neurotrophic factor (bdnf), its receptor, trkb, and selected ionotropic glutamate receptor (iglur) subunits in the hippocampus. |
2003-01-10 |
2023-08-12 |
Not clear |
| M Fahnestock, D Garzon, R M D Holsinger, B Michalsk. Neurotrophic factors and Alzheimer's disease: are we focusing on the wrong molecule? Journal of neural transmission. Supplementum. issue 62. 2003-01-10. PMID:12456067. |
in alzheimer's disease, bdnf mrna and protein are decreased in basal forebrain cholinergic neuron target tissues such as cortex and hippocampus. |
2003-01-10 |
2023-08-12 |
human |
| Gemma Calamandrei, Angela Valanzano, Maria Puopolo, Luigi Alo. Developmental exposure to the antiretroviral drug zidovudine increases brain levels of brain-derived neurotrophic factor in mice. Neuroscience letters. vol 333. issue 2. 2002-12-30. PMID:12419493. |
in azt-exposed females, bdnf levels were significantly increased in the hippocampus (days 7 and 21), in the cortex (day 60) and in the hypothalamus (day 21), while in males azt exposure increased bdnf in the cortex on day 21. |
2002-12-30 |
2023-08-12 |
mouse |