| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mary M Torregrossa, Ceylan Isgor, John E Folk, Kenner C Rice, Stanley J Watson, James H Wood. The delta-opioid receptor agonist (+)BW373U86 regulates BDNF mRNA expression in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 29. issue 4. 2004-05-17. PMID:14647482. |
midazolam was administered to some animals to prevent the convulsions produced by (+)bw373u86, but midazolam did not block delta-opioid receptor-mediated increases in bdnf mrna expression in frontal cortex, hippocampus, or amygdala. |
2004-05-17 |
2023-08-12 |
rat |
| Ilana S Hairston, Christelle Peyron, Daniel P Denning, Norman F Ruby, Judith Flores, Robert M Sapolsky, H Craig Heller, Bruce F O'Har. Sleep deprivation effects on growth factor expression in neonatal rats: a potential role for BDNF in the mediation of delta power. Journal of neurophysiology. vol 91. issue 4. 2004-05-17. PMID:14668298. |
bdnf was increased by sleep deprivation in the cortex at p20 and p24 and only at p24 in the hippocampus. |
2004-05-17 |
2023-08-12 |
rat |
| Tara L Spires, Helen E Grote, Neelash K Varshney, Patricia M Cordery, Anton van Dellen, Colin Blakemore, Anthony J Hanna. Environmental enrichment rescues protein deficits in a mouse model of Huntington's disease, indicating a possible disease mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 9. 2004-05-14. PMID:14999077. |
non-enriched hd mice have severe reductions in bdnf in the hippocampus and striatum at 5 months, which are entirely rescued by enrichment. |
2004-05-14 |
2023-08-12 |
mouse |
| R Molteni, A Wu, S Vaynman, Z Ying, R J Barnard, F Gómez-Pinill. Exercise reverses the harmful effects of consumption of a high-fat diet on synaptic and behavioral plasticity associated to the action of brain-derived neurotrophic factor. Neuroscience. vol 123. issue 2. 2004-05-12. PMID:14698750. |
a diet high in total fat (hf) reduces hippocampal levels of brain-derived neurotrophic factor (bdnf), a crucial modulator of synaptic plasticity, and a predictor of learning efficacy. |
2004-05-12 |
2023-08-12 |
Not clear |
| J Farmer, X Zhao, H van Praag, K Wodtke, F H Gage, B R Christi. Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male Sprague-Dawley rats in vivo. Neuroscience. vol 124. issue 1. 2004-05-10. PMID:14960340. |
in addition to changes in nr2b mrna levels, quantitative polymerase chain reaction analysis revealed that brain-derived neurotrophic factor (bdnf) and glutamate receptor 5 mrna levels were also significantly elevated in the dg of runners, but not in other areas of the hippocampus. |
2004-05-10 |
2023-08-12 |
mouse |
| Megumi Shimamura, Jeanna M Garcia, Donald S Prough, Helen L Hellmic. Laser capture microdissection and analysis of amplified antisense RNA from distinct cell populations of the young and aged rat brain: effect of traumatic brain injury on hippocampal gene expression. Brain research. Molecular brain research. vol 122. issue 1. 2004-05-10. PMID:14992815. |
northern analysis showed greater expression of two aging-associated genes, p21 and brain-derived neurotrophic factor (bdnf) in the aged hippocampus. |
2004-05-10 |
2023-08-12 |
rat |
| Thomas Roskoden, Uwe Otten, Herbert Schwegle. Early postnatal corticosterone administration regulates neurotrophins and their receptors in septum and hippocampus of the rat. Experimental brain research. vol 154. issue 2. 2004-05-03. PMID:14557907. |
the mrna and protein levels of the neurotrophins of the ngf family (ngf, bdnf, nt-3 and nt-4/5) and their receptors (trka, trkb, trkc and p75) were quantified in septum and hippocampus using rt-pcr. |
2004-05-03 |
2023-08-12 |
rat |
| Sabine Chourbaji, Rainer Hellweg, Dorothee Brandis, Björn Zörner, Christiane Zacher, Undine E Lang, Fritz A Henn, Heide Hörtnagl, Peter Gas. Mice with reduced brain-derived neurotrophic factor expression show decreased choline acetyltransferase activity, but regular brain monoamine levels and unaltered emotional behavior. Brain research. Molecular brain research. vol 121. issue 1-2. 2004-04-19. PMID:14969734. |
bndf protein levels of adult bdnf(+/-) mice were reduced to about 60% in several brain areas investigated, including the hippocampus, frontal cortex, striatum, and hypothalamus. |
2004-04-19 |
2023-08-12 |
mouse |
| Sabine Chourbaji, Rainer Hellweg, Dorothee Brandis, Björn Zörner, Christiane Zacher, Undine E Lang, Fritz A Henn, Heide Hörtnagl, Peter Gas. Mice with reduced brain-derived neurotrophic factor expression show decreased choline acetyltransferase activity, but regular brain monoamine levels and unaltered emotional behavior. Brain research. Molecular brain research. vol 121. issue 1-2. 2004-04-19. PMID:14969734. |
by contrast, choline acetyltransferase activity was significantly reduced by 19% in the hippocampus of bdnf(+/-) mice, indicating that the cholinergic system of the basal forebrain is critically dependent on sufficient endogenous bdnf levels in adulthood. |
2004-04-19 |
2023-08-12 |
mouse |
| Oliver G Rössler, Klaus M Giehl, Gerald Thie. Neuroprotection of immortalized hippocampal neurones by brain-derived neurotrophic factor and Raf-1 protein kinase: role of extracellular signal-regulated protein kinase and phosphatidylinositol 3-kinase. Journal of neurochemistry. vol 88. issue 5. 2004-03-30. PMID:15009680. |
we have investigated the molecular mechanisms of neurotrophin-mediated cell survival in ht22 cells, a murine cell line of hippocampal origin, expressing the brain-derived neurotrophic factor (bdnf) receptor trkb as well as the trkb.t1 splice variant. |
2004-03-30 |
2023-08-12 |
Not clear |
| M Blurton-Jones, P N Kuan, M H Tuszynsk. Anatomical evidence for transsynaptic influences of estrogen on brain-derived neurotrophic factor expression. The Journal of comparative neurology. vol 468. issue 3. 2004-03-26. PMID:14681930. |
several studies have demonstrated that estrogen modulates brain-derived neurotrophic factor (bdnf) mrna and protein within the adult hippocampus and cortex. |
2004-03-26 |
2023-08-12 |
Not clear |
| M Blurton-Jones, P N Kuan, M H Tuszynsk. Anatomical evidence for transsynaptic influences of estrogen on brain-derived neurotrophic factor expression. The Journal of comparative neurology. vol 468. issue 3. 2004-03-26. PMID:14681930. |
by utilizing double-label immunohistochemistry for bdnf, estrogen receptor-alpha (er-alpha), and estrogen receptor-beta (er-beta), we found only sparse colocalization between er-alpha and bdnf in the hypothalamus, amygdala, prelimbic cortex, and ventral hippocampus. |
2004-03-26 |
2023-08-12 |
Not clear |
| Vinay Parikh, Mohammad M Khan, Sahebarao P Mahadi. Olanzapine counteracts reduction of brain-derived neurotrophic factor and TrkB receptors in rat hippocampus produced by haloperidol. Neuroscience letters. vol 356. issue 2. 2004-03-10. PMID:14746882. |
we compared the effect of 45 day chronic exposure of hal (2 mg/kg per day) to olz (10 mg/kg per day) on brain-derived neurotrophic factor (bdnf)) and its high affinity receptor trkb in rat hippocampus. |
2004-03-10 |
2023-08-12 |
rat |
| Vinay Parikh, Mohammad M Khan, Sahebarao P Mahadi. Olanzapine counteracts reduction of brain-derived neurotrophic factor and TrkB receptors in rat hippocampus produced by haloperidol. Neuroscience letters. vol 356. issue 2. 2004-03-10. PMID:14746882. |
hal, but not olz, significantly reduced the levels of bdnf in hippocampus. |
2004-03-10 |
2023-08-12 |
rat |
| Vinay Parikh, Mohammad M Khan, Sahebarao P Mahadi. Olanzapine counteracts reduction of brain-derived neurotrophic factor and TrkB receptors in rat hippocampus produced by haloperidol. Neuroscience letters. vol 356. issue 2. 2004-03-10. PMID:14746882. |
furthermore, post-treatment with olz markedly restored the hal treatment associated reductions in both bdnf and trkb receptors in hippocampus. |
2004-03-10 |
2023-08-12 |
rat |
| S Scaccianoce, P Del Bianco, A Caricasole, F Nicoletti, A Catalan. Relationship between learning, stress and hippocampal brain-derived neurotrophic factor. Neuroscience. vol 121. issue 4. 2004-03-01. PMID:14580931. |
brain-derived neurotrophic factor (bdnf) expression in the hippocampus is reduced in response to acute, as well as repeated immobilization stress. |
2004-03-01 |
2023-08-12 |
rat |
| S Scaccianoce, P Del Bianco, A Caricasole, F Nicoletti, A Catalan. Relationship between learning, stress and hippocampal brain-derived neurotrophic factor. Neuroscience. vol 121. issue 4. 2004-03-01. PMID:14580931. |
this effect might be mediated by corticosterone, because corticosterone administration is known to reduce hippocampal bdnf. |
2004-03-01 |
2023-08-12 |
rat |
| S Scaccianoce, P Del Bianco, A Caricasole, F Nicoletti, A Catalan. Relationship between learning, stress and hippocampal brain-derived neurotrophic factor. Neuroscience. vol 121. issue 4. 2004-03-01. PMID:14580931. |
however, rats subjected to a learning paradigm showed an increased bdnf expression in the hippocampus despite the high corticosterone levels found during the test. |
2004-03-01 |
2023-08-12 |
rat |
| S Scaccianoce, P Del Bianco, A Caricasole, F Nicoletti, A Catalan. Relationship between learning, stress and hippocampal brain-derived neurotrophic factor. Neuroscience. vol 121. issue 4. 2004-03-01. PMID:14580931. |
using this model, we now report that learning and stress exert an opposite modulation on bdnf levels in the hippocampus, and that the increasing effect of learning predominates over the decreasing effect of stress. |
2004-03-01 |
2023-08-12 |
rat |
| R M Barrientos, D B Sprunger, S Campeau, E A Higgins, L R Watkins, J W Rudy, S F Maie. Brain-derived neurotrophic factor mRNA downregulation produced by social isolation is blocked by intrahippocampal interleukin-1 receptor antagonist. Neuroscience. vol 121. issue 4. 2004-03-01. PMID:14580934. |
a 6 h period of social isolation immediately after contextual fear conditioning impaired memory for context fear measured 48 h later, and decreased bdnf mrna in the dentate gyrus and the ca3 region of the hippocampus assessed immediately after the isolation. |
2004-03-01 |
2023-08-12 |
Not clear |