| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| William J Tyler, Lucas Pozzo-Mille. Miniature synaptic transmission and BDNF modulate dendritic spine growth and form in rat CA1 neurones. The Journal of physiology. vol 553. issue Pt 2. 2004-09-23. PMID:14500767. |
we show here that brain-derived neurotrophic factor (bdnf) increased spine density in apical dendrites of ca1 pyramidal neurones in organotypic slice cultures prepared from postnatal rat hippocampal slices. |
2004-09-23 |
2023-08-12 |
rat |
| Bin Jiang, Akihiko Kitamura, Hiroki Yasuda, Kazuhiro Sohya, Atsushi Maruyama, Yuchio Yanagawa, Kunihiko Obata, Tadaharu Tsumot. Brain-derived neurotrophic factor acutely depresses excitatory synaptic transmission to GABAergic neurons in visual cortical slices. The European journal of neuroscience. vol 20. issue 3. 2004-09-21. PMID:15255981. |
brain-derived neurotrophic factor (bdnf) acutely modulates synaptic transmission to excitatory neurons in hippocampus and neocortex. |
2004-09-21 |
2023-08-12 |
mouse |
| F R Poulsen, J Lauterborn, J Zimmer, C M Gal. Differential expression of brain-derived neurotrophic factor transcripts after pilocarpine-induced seizure-like activity is related to mode of Ca2+ entry. Neuroscience. vol 126. issue 3. 2004-09-14. PMID:15183516. |
here, effects of pilocarpine-induced seizure activity on total bdnf expression and on the individual sensitivity of bdnf transcripts to glutamate receptor and ca2+ channel blockers were evaluated using hippocampal slice cultures and in situ hybridization of transcript-specific crna probes directed against mrnas for the four 5' exons (i-iv) of the bdnf gene. |
2004-09-14 |
2023-08-12 |
Not clear |
| F R Poulsen, J Lauterborn, J Zimmer, C M Gal. Differential expression of brain-derived neurotrophic factor transcripts after pilocarpine-induced seizure-like activity is related to mode of Ca2+ entry. Neuroscience. vol 126. issue 3. 2004-09-14. PMID:15183516. |
these results indicate that transcript ii makes the greatest contribution to pilocarpine effects on total bdnf mrna content in this model and provides evidence for regional and ca2+ channel-specific differences in activity-dependent regulation of the different bdnf transcripts in hippocampus. |
2004-09-14 |
2023-08-12 |
Not clear |
| Zhe-Yu Chen, Paresh D Patel, Gayatree Sant, Chui-Xiang Meng, Kenneth K Teng, Barbara L Hempstead, Francis S Le. Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 18. 2004-09-03. PMID:15128854. |
when expressed by itself in hippocampal neurons, less bdnf(met) is secreted in an activity-dependent manner. |
2004-09-03 |
2023-08-12 |
Not clear |
| Xiao-Ping He, Robert Kotloski, Serge Nef, Bryan W Luikart, Luis F Parada, James O McNamar. Conditional deletion of TrkB but not BDNF prevents epileptogenesis in the kindling model. Neuron. vol 43. issue 1. 2004-08-26. PMID:15233915. |
we hypothesized that the neurotrophin brain-derived neurotrophic factor (bdnf) activates its receptor, trkb, in the hippocampus during epileptogenesis and that bdnf-mediated activation of trkb is required for epileptogenesis. |
2004-08-26 |
2023-08-12 |
mouse |
| Xiao-Ping He, Robert Kotloski, Serge Nef, Bryan W Luikart, Luis F Parada, James O McNamar. Conditional deletion of TrkB but not BDNF prevents epileptogenesis in the kindling model. Neuron. vol 43. issue 1. 2004-08-26. PMID:15233915. |
despite marked reductions of bdnf expression, only a modest impairment of epileptogenesis and increased hippocampal trkb activation were detected in bdnf(-/-) mice. |
2004-08-26 |
2023-08-12 |
mouse |
| Yoshifumi Irie, Nanae Itokazu, Naoko Anjiki, Atsushi Ishige, Kenji Watanabe, Wing Ming Keun. Eugenol exhibits antidepressant-like activity in mice and induces expression of metallothionein-III in the hippocampus. Brain research. vol 1011. issue 2. 2004-08-25. PMID:15157811. |
furthermore, we show that both eugenol and imipramine induce brain-derived neurotrophic factor (bdnf) in the hippocampus with and without induction of metallothionein-iii (mt-iii), respectively. |
2004-08-25 |
2023-08-12 |
mouse |
| Yoshito Mizoguchi, Hitoshi Ishibashi, Junichi Nabekur. The action of BDNF on GABA(A) currents changes from potentiating to suppressing during maturation of rat hippocampal CA1 pyramidal neurons. The Journal of physiology. vol 548. issue Pt 3. 2004-08-19. PMID:12640007. |
during the development of the hippocampus, the action of gaba shifts from depolarizing to hyperpolarizing, and brain-derived neurotrophic factor (bdnf) has important roles in gabaergic transmission. |
2004-08-19 |
2023-08-12 |
rat |
| Kenji Hashimoto, Eiji Shimizu, Masaomi Iy. Critical role of brain-derived neurotrophic factor in mood disorders. Brain research. Brain research reviews. vol 45. issue 2. 2004-08-18. PMID:15145621. |
furthermore, bdnf protects against stress-induced neuronal damage, and it might affect neurogenesis in the hippocampus, which is thought to be involved in the pathogenesis of mood disorders. |
2004-08-18 |
2023-08-12 |
Not clear |
| Eiji Shimizu, Kenji Hashimoto, Masaomi Iy. [Major depressive disorders and BDNF (brain-derived neurotrophic factor)]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 24. issue 3. 2004-08-16. PMID:15291244. |
furthermore, bdnf may protect neurons against stress-induced damage, and affect neurogenesis in the adult hippocampus. |
2004-08-16 |
2023-08-12 |
Not clear |
| Shoshanna Vaynman, Zhe Ying, Fernando Gómez-Pinill. Exercise induces BDNF and synapsin I to specific hippocampal subfields. Journal of neuroscience research. vol 76. issue 3. 2004-07-29. PMID:15079864. |
exercise induces bdnf and synapsin i to specific hippocampal subfields. |
2004-07-29 |
2023-08-12 |
Not clear |
| Shoshanna Vaynman, Zhe Ying, Fernando Gómez-Pinill. Exercise induces BDNF and synapsin I to specific hippocampal subfields. Journal of neuroscience research. vol 76. issue 3. 2004-07-29. PMID:15079864. |
to assess the relationship between brain-derived neurotrophic factor (bdnf) and synapsin i in the hippocampus during exercise, we employed a novel microsphere injection method to block the action of bdnf through its tyrosine kinase (trk) receptor and subsequently measure the mrna levels of synapsin i, using real-time taqman rt-pcr for rna quantification. |
2004-07-29 |
2023-08-12 |
Not clear |
| Shoshanna Vaynman, Zhe Ying, Fernando Gómez-Pinill. Exercise induces BDNF and synapsin I to specific hippocampal subfields. Journal of neuroscience research. vol 76. issue 3. 2004-07-29. PMID:15079864. |
after establishing a causal link between bdnf and exercise-induced synapsin i mrna levels, we studied the exercise-induced distribution of bdnf and synapsin i in the rodent hippocampus. |
2004-07-29 |
2023-08-12 |
Not clear |
| Shoshanna Vaynman, Zhe Ying, Fernando Gómez-Pinill. Exercise induces BDNF and synapsin I to specific hippocampal subfields. Journal of neuroscience research. vol 76. issue 3. 2004-07-29. PMID:15079864. |
these results indicate that exercise induces plasticity of select hippocampal transsynaptic circuitry, possibly comprising a spatial restriction on synapsin i regulation by bdnf. |
2004-07-29 |
2023-08-12 |
Not clear |
| Onofre Combarros, Jon Infante, Javier Llorca, José Bercian. Polymorphism at codon 66 of the brain-derived neurotrophic factor gene is not associated with sporadic Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 18. issue 1. 2004-07-28. PMID:15084795. |
memory acquisition and consolidation are associated with an increase in brain-derived neurotrophic factor (bdnf) in synapses, particularly those innervating the hippocampus and cerebral cortex. |
2004-07-28 |
2023-08-12 |
human |
| Onofre Combarros, Jon Infante, Javier Llorca, José Bercian. Polymorphism at codon 66 of the brain-derived neurotrophic factor gene is not associated with sporadic Alzheimer's disease. Dementia and geriatric cognitive disorders. vol 18. issue 1. 2004-07-28. PMID:15084795. |
a polymorphism producing an amino acid substitution (valine to methionine) at codon 66 of the bdnf gene could affect intracellular processing and secretion of bdnf and lead to impairments in hippocampal function. |
2004-07-28 |
2023-08-12 |
human |
| H Husum, T G Bolwig, C Sánchez, A A Mathé, S L Hanse. Levetiracetam prevents changes in levels of brain-derived neurotrophic factor and neuropeptide Y mRNA and of Y1- and Y5-like receptors in the hippocampus of rats undergoing amygdala kindling: implications for antiepileptogenic and mood-stabilizing properties. Epilepsy & behavior : E&B. vol 5. issue 2. 2004-07-19. PMID:15123022. |
consequently, we investigated the regulation of bdnf and npy mrna and y1-, y2-, and y5-like receptor binding in the hippocampus of vehicle-pretreated, partially and fully amygdala-kindled rats and corresponding levetiracetam-pretreated rats (40 mg/kg i.p.). |
2004-07-19 |
2023-08-12 |
rat |
| H Husum, T G Bolwig, C Sánchez, A A Mathé, S L Hanse. Levetiracetam prevents changes in levels of brain-derived neurotrophic factor and neuropeptide Y mRNA and of Y1- and Y5-like receptors in the hippocampus of rats undergoing amygdala kindling: implications for antiepileptogenic and mood-stabilizing properties. Epilepsy & behavior : E&B. vol 5. issue 2. 2004-07-19. PMID:15123022. |
the present data indicate that the process of kindling is associated with an upregulation of hippocampal bdnf and npy mrna levels and downregulation of y1- and particularly y5-like receptors. |
2004-07-19 |
2023-08-12 |
rat |
| H Husum, T G Bolwig, C Sánchez, A A Mathé, S L Hanse. Levetiracetam prevents changes in levels of brain-derived neurotrophic factor and neuropeptide Y mRNA and of Y1- and Y5-like receptors in the hippocampus of rats undergoing amygdala kindling: implications for antiepileptogenic and mood-stabilizing properties. Epilepsy & behavior : E&B. vol 5. issue 2. 2004-07-19. PMID:15123022. |
these effects are associated with abolition of the kindling-induced rise in bdnf and npy mrna and increasing levels of y1- and particularly y5-like receptors in all hippocampal subfields. |
2004-07-19 |
2023-08-12 |
rat |