| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Helen E Scharfman, Neil J Maclusk. Similarities between actions of estrogen and BDNF in the hippocampus: coincidence or clue? Trends in neurosciences. vol 28. issue 2. 2005-04-25. PMID:15667930. |
furthermore, disruption of the relationship between estrogen and bdnf could contribute to neurological and psychiatric disorders that have been associated with the hippocampus, such as alzheimer's disease, depression and epilepsy. |
2005-04-25 |
2023-08-12 |
Not clear |
| Petti T Pang, Bai L. Regulation of late-phase LTP and long-term memory in normal and aging hippocampus: role of secreted proteins tPA and BDNF. Ageing research reviews. vol 3. issue 4. 2005-04-12. PMID:15541709. |
regulation of late-phase ltp and long-term memory in normal and aging hippocampus: role of secreted proteins tpa and bdnf. |
2005-04-12 |
2023-08-12 |
Not clear |
| Matthew E Szapacs, Tiffany A Mathews, Lino Tessarollo, W Ernest Lyons, Laura A Mamounas, Anne M Andrew. Exploring the relationship between serotonin and brain-derived neurotrophic factor: analysis of BDNF protein and extraneuronal 5-HT in mice with reduced serotonin transporter or BDNF expression. Journal of neuroscience methods. vol 140. issue 1-2. 2005-04-12. PMID:15589338. |
using a modified extraction procedure and a commercial enzyme-linked immunosorbant assay, 50% decreases in bdnf protein in hippocampus, frontal cortex and brain stem were confirmed in 4-month-old mice lacking one copy of the bdnf gene (bdnf(+/-)). |
2005-04-12 |
2023-08-12 |
mouse |
| Matthew E Szapacs, Tiffany A Mathews, Lino Tessarollo, W Ernest Lyons, Laura A Mamounas, Anne M Andrew. Exploring the relationship between serotonin and brain-derived neurotrophic factor: analysis of BDNF protein and extraneuronal 5-HT in mice with reduced serotonin transporter or BDNF expression. Journal of neuroscience methods. vol 140. issue 1-2. 2005-04-12. PMID:15589338. |
by contrast, 4-month-old male and female mice with partial (sert(+/-)) or complete (sert(-/-)) reductions in sert expression showed no differences in bdnf protein levels compared to sert(+/+) mice, although male sert knockout mice of all genotypes had higher bdnf levels in hippocampus, frontal cortex, and brain stem than female animals. |
2005-04-12 |
2023-08-12 |
mouse |
| T A Doucette, P B Bernard, H Husum, M A Perry, C L Ryan, R A Taske. Low doses of domoic acid during postnatal development produce permanent changes in rat behaviour and hippocampal morphology. Neurotoxicity research. vol 6. issue 7-8. 2005-04-08. PMID:15639787. |
in situ hybridization also revealed an elevation in hippocampal brain derived neurotrophic factor (bdnf) mrna in region ca1 without a corresponding increase in neuropeptide y (npy) mrna. |
2005-04-08 |
2023-08-12 |
rat |
| Shizu Ohba, Takamitsu Ikeda, Yuji Ikegaya, Nobuyoshi Nishiyama, Norio Matsuki, Maki K Yamad. BDNF locally potentiates GABAergic presynaptic machineries: target-selective circuit inhibition. Cerebral cortex (New York, N.Y. : 1991). vol 15. issue 3. 2005-04-05. PMID:15238431. |
to examine whether inhibitory neurotransmission receives target-selective modulation in the long term, we expressed the cdna of brain-derived neurotrophic factor (bdnf), which has been shown to induce the augmentation of gabaergic synapses in vivo and in vitro, in a small population of cultured hippocampal neurons. |
2005-04-05 |
2023-08-12 |
Not clear |
| Ingrid Y C Liu, W Ernest Lyons, Laura A Mamounas, Richard F Thompso. Brain-derived neurotrophic factor plays a critical role in contextual fear conditioning. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 36. 2005-04-05. PMID:15356210. |
because bdnf is involved in synaptic transmission and contextual learning is hippocampal dependent, we hypothesized that this deficit is attributable to abnormal bdnf-modulated synaptic plasticity in the hippocampus. |
2005-04-05 |
2023-08-12 |
mouse |
| Ingrid Y C Liu, W Ernest Lyons, Laura A Mamounas, Richard F Thompso. Brain-derived neurotrophic factor plays a critical role in contextual fear conditioning. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 36. 2005-04-05. PMID:15356210. |
infusion of bdnf protein into the hippocampus appeared to partially restore contextual fear learning of bdnf(+/-) mice. |
2005-04-05 |
2023-08-12 |
mouse |
| Ingrid Y C Liu, W Ernest Lyons, Laura A Mamounas, Richard F Thompso. Brain-derived neurotrophic factor plays a critical role in contextual fear conditioning. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 36. 2005-04-05. PMID:15356210. |
this deficit can be partially rescued by infusing bdnf protein into the hippocampus. |
2005-04-05 |
2023-08-12 |
mouse |
| Ingrid Y C Liu, W Ernest Lyons, Laura A Mamounas, Richard F Thompso. Brain-derived neurotrophic factor plays a critical role in contextual fear conditioning. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 36. 2005-04-05. PMID:15356210. |
other brain regions interacting with the hippocampus in the context conditioned stimulus pathway, for example, the amygdala, may also require normal bdnf expression levels to fully rescue this impairment. |
2005-04-05 |
2023-08-12 |
mouse |
| Eija Koponen, Merja Lakso, Eero Castré. Overexpression of the full-length neurotrophin receptor trkB regulates the expression of plasticity-related genes in mouse brain. Brain research. Molecular brain research. vol 130. issue 1-2. 2005-03-30. PMID:15519679. |
significant body of evidence indicates an important role for brain-derived neurotrophic factor (bdnf) in the hippocampal synaptic plasticity; however, the exact mechanisms how the bdnf signal is converted to plastic changes during memory processes are under an intense investigation. |
2005-03-30 |
2023-08-12 |
mouse |
| Malini Sathanoori, Brian G Dias, Amrita R Nair, Sunayana B Banerjee, Shubha Tole, Vidita A Vaidy. Differential regulation of multiple brain-derived neurotrophic factor transcripts in the postnatal and adult rat hippocampus during development, and in response to kainate administration. Brain research. Molecular brain research. vol 130. issue 1-2. 2005-03-30. PMID:15519687. |
brain-derived neurotrophic factor (bdnf) is expressed at high levels in the hippocampus, where it has been implicated in physiological functions such as the modulation of synaptic strength as well as in the pathophysiology of epileptic seizures. |
2005-03-30 |
2023-08-12 |
rat |
| Malini Sathanoori, Brian G Dias, Amrita R Nair, Sunayana B Banerjee, Shubha Tole, Vidita A Vaidy. Differential regulation of multiple brain-derived neurotrophic factor transcripts in the postnatal and adult rat hippocampus during development, and in response to kainate administration. Brain research. Molecular brain research. vol 130. issue 1-2. 2005-03-30. PMID:15519687. |
to gain insight into the regulation of different bdnf transcripts in specific hippocampal subfields during postnatal development, exon-specific riboprobes were used. |
2005-03-30 |
2023-08-12 |
rat |
| Malini Sathanoori, Brian G Dias, Amrita R Nair, Sunayana B Banerjee, Shubha Tole, Vidita A Vaidy. Differential regulation of multiple brain-derived neurotrophic factor transcripts in the postnatal and adult rat hippocampus during development, and in response to kainate administration. Brain research. Molecular brain research. vol 130. issue 1-2. 2005-03-30. PMID:15519687. |
our data shows that bdnf exon i and exon ii mrnas are regulated in hippocampal subfields during postnatal development, in contrast to bdnf exon iii and exon iv mrna, which remain relatively stable through this period. |
2005-03-30 |
2023-08-12 |
rat |
| Malini Sathanoori, Brian G Dias, Amrita R Nair, Sunayana B Banerjee, Shubha Tole, Vidita A Vaidy. Differential regulation of multiple brain-derived neurotrophic factor transcripts in the postnatal and adult rat hippocampus during development, and in response to kainate administration. Brain research. Molecular brain research. vol 130. issue 1-2. 2005-03-30. PMID:15519687. |
further, exons i and ii show distinct temporal patterns of expression in the hippocampus: bdnf i mrna peaks in adulthood in contrast to bdnf ii mrna which peaks at postnatal day 14 (p14). |
2005-03-30 |
2023-08-12 |
rat |
| Malini Sathanoori, Brian G Dias, Amrita R Nair, Sunayana B Banerjee, Shubha Tole, Vidita A Vaidy. Differential regulation of multiple brain-derived neurotrophic factor transcripts in the postnatal and adult rat hippocampus during development, and in response to kainate administration. Brain research. Molecular brain research. vol 130. issue 1-2. 2005-03-30. PMID:15519687. |
our data indicates that kainate-induced seizures induce strikingly different expression of distinct bdnf transcripts, both in magnitude as well as spatial patterns in the hippocampal subfields, of pups as compared to adults. |
2005-03-30 |
2023-08-12 |
rat |
| Malini Sathanoori, Brian G Dias, Amrita R Nair, Sunayana B Banerjee, Shubha Tole, Vidita A Vaidy. Differential regulation of multiple brain-derived neurotrophic factor transcripts in the postnatal and adult rat hippocampus during development, and in response to kainate administration. Brain research. Molecular brain research. vol 130. issue 1-2. 2005-03-30. PMID:15519687. |
these results suggest that kainate-mediated seizures differentially recruit bdnf promoters in the developing postnatal hippocampus in contrast to the adult hippocampus to achieve a hippocampal subfield specific regulation of exon-specific bdnf mrnas. |
2005-03-30 |
2023-08-12 |
rat |
| Kuo Wu, Guo-Wei Len, Geoff McAuliffe, Chia Ma, Jessica P Tai, Fei Xu, Ira B Blac. Brain-derived neurotrophic factor acutely enhances tyrosine phosphorylation of the AMPA receptor subunit GluR1 via NMDA receptor-dependent mechanisms. Brain research. Molecular brain research. vol 130. issue 1-2. 2005-03-30. PMID:15519688. |
brain-derived growth factor (bdnf) acutely regulates synaptic transmission and modulates hippocampal long-term potentiation (ltp) and long-term depression (ltd), cellular models of plasticity associated with learning and memory. |
2005-03-30 |
2023-08-12 |
Not clear |
| E Palma, G Torchia, C Limatola, F Trettel, A Arcella, G Cantore, G Di Gennaro, M Manfredi, V Esposito, P P Quarato, R Miledi, F Euseb. BDNF modulates GABAA receptors microtransplanted from the human epileptic brain to Xenopus oocytes. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 5. 2005-03-28. PMID:15665077. |
in contrast, the gabaa receptors transplanted from the nonepileptic human hippocampal uncus (obtained during surgical resection as part of the nontumoral tissue from the oligodendroglioma margins) or receptors expressed by injecting rat recombinant alpha1beta2gamma2 gabaa receptor subunit cdnas generated gaba currents whose time-course and run-down were not altered by bdnf. |
2005-03-28 |
2023-08-12 |
human |
| Xin-Fu Zhou, Xing-Yun Song, Jin-Hua Zhong, Shahram Barati, Fiona H-H Zhou, Stephen M Johnso. Distribution and localization of pro-brain-derived neurotrophic factor-like immunoreactivity in the peripheral and central nervous system of the adult rat. Journal of neurochemistry. vol 91. issue 3. 2005-03-24. PMID:15485500. |
mutation in val66met of brain-derived neurotrophic factor (bdnf) results in reduction in hippocampal function in learning and in the dysfunction of intracellular bdnf sorting and secretion. |
2005-03-24 |
2023-08-12 |
rat |