| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wen-Jing Li, Hui Yu, Jian-Min Yang, Jing Gao, Hong Jiang, Min Feng, Yu-Xia Zhao, Zhe-Yu Che. Anxiolytic effect of music exposure on BDNFMet/Met transgenic mice. Brain research. vol 1347. 2010-11-02. PMID:20515664. |
however, music treatment could not upregulate bdnf levels in the pfc, amygdala, and hippocampus in bdnf(+/)(-) mice, which suggests the essential role of bdnf in the anxiolytic effect of music. |
2010-11-02 |
2023-08-12 |
mouse |
| Shou-Sen Shi, Shu-Hong Shao, Bang-Ping Yuan, Fang Pan, Zun-Ling L. Acute stress and chronic stress change brain-derived neurotrophic factor (BDNF) and tyrosine kinase-coupled receptor (TrkB) expression in both young and aged rat hippocampus. Yonsei medical journal. vol 51. issue 5. 2010-11-01. PMID:20635439. |
acute stress and chronic stress change brain-derived neurotrophic factor (bdnf) and tyrosine kinase-coupled receptor (trkb) expression in both young and aged rat hippocampus. |
2010-11-01 |
2023-08-12 |
rat |
| Shou-Sen Shi, Shu-Hong Shao, Bang-Ping Yuan, Fang Pan, Zun-Ling L. Acute stress and chronic stress change brain-derived neurotrophic factor (BDNF) and tyrosine kinase-coupled receptor (TrkB) expression in both young and aged rat hippocampus. Yonsei medical journal. vol 51. issue 5. 2010-11-01. PMID:20635439. |
the purpose of this study is to explore the dynamic change of brainderived neurotrophic factor (bdnf) mrna, protein, and tyrosine kinase-coupled receptor (trkb) mrna of the rat hippocampus under different stress conditions and to explore the influence of senescence on the productions expression. |
2010-11-01 |
2023-08-12 |
rat |
| Fei Li, Qi-Hai Gong, Qin Wu, Yuan-Fu Lu, Jing-Shan Sh. Icariin isolated from Epimedium brevicornum Maxim attenuates learning and memory deficits induced by d-galactose in rats. Pharmacology, biochemistry, and behavior. vol 96. issue 3. 2010-10-28. PMID:20566405. |
the effects of icariin (ica), a major constituent of flavonoids from the chinese medical herb epimedium brevicornum maxim, on spatial memory performances and expressions of hippocampus brain-derived neurotrophic factor (bdnf) and tyrosine kinase trkb (tropomyosin receptor kinase b) were investigated in d-galactose (d-gal)-treated rats. |
2010-10-28 |
2023-08-12 |
rat |
| Fei Li, Qi-Hai Gong, Qin Wu, Yuan-Fu Lu, Jing-Shan Sh. Icariin isolated from Epimedium brevicornum Maxim attenuates learning and memory deficits induced by d-galactose in rats. Pharmacology, biochemistry, and behavior. vol 96. issue 3. 2010-10-28. PMID:20566405. |
subcutaneous injection of d-gal (500mg/kg/d) for four months caused memory loss as detected by the morris water maze, morphologic abnormalities of neurons in hippocampus region and the reduced expression of bdnf and trkb were observed. |
2010-10-28 |
2023-08-12 |
rat |
| Fei Li, Qi-Hai Gong, Qin Wu, Yuan-Fu Lu, Jing-Shan Sh. Icariin isolated from Epimedium brevicornum Maxim attenuates learning and memory deficits induced by d-galactose in rats. Pharmacology, biochemistry, and behavior. vol 96. issue 3. 2010-10-28. PMID:20566405. |
ica (60mg/kg/d) given orally 1h after subcutaneous injection of d-gal daily for 4months markedly attenuated d-gal-induced rats behavioral dysfunction and neurodegeneration, as evidenced by shortened escape latency and searching distance and rescued morphologic abnormalities, and also elevated the mrna levels and the protein expressions of bdnf and trkb in hippocampus, as evidenced by quantitative real-time rt-pcr and western blotting analysis. |
2010-10-28 |
2023-08-12 |
rat |
| Chunmei Guo, Yang Yang, Yun'ai Su, Tianmei S. Postnatal BDNF expression profiles in prefrontal cortex and hippocampus of a rat schizophrenia model induced by MK-801 administration. Journal of biomedicine & biotechnology. vol 2010. 2010-10-20. PMID:20625416. |
postnatal bdnf expression profiles in prefrontal cortex and hippocampus of a rat schizophrenia model induced by mk-801 administration. |
2010-10-20 |
2023-08-12 |
rat |
| Chunmei Guo, Yang Yang, Yun'ai Su, Tianmei S. Postnatal BDNF expression profiles in prefrontal cortex and hippocampus of a rat schizophrenia model induced by MK-801 administration. Journal of biomedicine & biotechnology. vol 2010. 2010-10-20. PMID:20625416. |
bdnf protein levels in hippocampus and prefrontal cortex (pfc) were analyzed on pnd 15, pnd 42, and pnd 77. |
2010-10-20 |
2023-08-12 |
rat |
| Galina T Shishkina, Tatyana S Kalinina, Inna V Berezova, Veta V Bulygina, Nikolay N Dygal. Resistance to the development of stress-induced behavioral despair in the forced swim test associated with elevated hippocampal Bcl-xl expression. Behavioural brain research. vol 213. issue 2. 2010-10-19. PMID:20457187. |
brain-derived neurotrophic factor (bdnf), anti-apoptotic b cell lymphoma like x (bcl-xl) and pro-apoptotic bcl2-associated x protein (bax) expression were determined in the hippocampus and frontal cortex of rats naturally differed in despair-like behavior in the forced swim test. |
2010-10-19 |
2023-08-12 |
human |
| Galina T Shishkina, Tatyana S Kalinina, Inna V Berezova, Veta V Bulygina, Nikolay N Dygal. Resistance to the development of stress-induced behavioral despair in the forced swim test associated with elevated hippocampal Bcl-xl expression. Behavioural brain research. vol 213. issue 2. 2010-10-19. PMID:20457187. |
in the hippocampus, bdnf messenger rna (mrna) level was significantly down-regulated 2h after the forced swim test exposure, and at this time point, bcl-xl mrna and protein levels were significantly higher in stressed than in untested animals. |
2010-10-19 |
2023-08-12 |
human |
| Laura R Schaevitz, Jennifer M Moriuchi, Nupur Nag, Tiffany J Mellot, Joanne Berger-Sweene. Cognitive and social functions and growth factors in a mouse model of Rett syndrome. Physiology & behavior. vol 100. issue 3. 2010-10-12. PMID:20045424. |
we also report here that the levels of the neurotrophins brain-derived neurotrophic factor (bdnf), insulin-like growth factor-1 (igf-1), and nerve growth factor (ngf) are decreased in the hippocampus of the null mice, and discuss how this may provide an underlying mechanism for both the cognitive deficits and the increased motivation for social contact observed in the mecp2(1lox) null mice. |
2010-10-12 |
2023-08-12 |
mouse |
| Xin-Hong Zhu, Hua-Cheng Yan, Jie Zhang, Hong-Da Qu, Xing-Sheng Qiu, Liang Chen, Shu-Ji Li, Xiong Cao, Jonathan C Bean, Long-Hua Chen, Xi-He Qin, Ji-Hong Liu, Xiao-Chun Bai, Lin Mei, Tian-Ming Ga. Intermittent hypoxia promotes hippocampal neurogenesis and produces antidepressant-like effects in adult rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 38. 2010-10-08. PMID:20861371. |
furthermore, ih stably enhanced the expression of bdnf in hippocampus; both the antidepressant-like effect and the enhancement of cell proliferation induced by ih were totally blocked by pharmacological and biological inhibition of bdnf-trkb (tyrosine receptor kinase b) signaling, suggesting that the neurogenic and antidepressant-like effects of ih may involve bdnf signaling. |
2010-10-08 |
2023-08-12 |
rat |
| Anthony G Lau, Hasan A Irier, Jiaping Gu, Donghua Tian, Li Ku, Guanglu Liu, Mingjing Xia, Brita Fritsch, James Q Zheng, Raymond Dingledine, Baoji Xu, Bai Lu, Yue Fen. Distinct 3'UTRs differentially regulate activity-dependent translation of brain-derived neurotrophic factor (BDNF). Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 36. 2010-10-07. PMID:20733072. |
importantly, the endogenous long 3'utr bdnf mrna specifically undergoes markedly enhanced polyribosome association in the hippocampus in response to pilocarpine induced-seizure before transcriptional up-regulation of bdnf. |
2010-10-07 |
2023-08-12 |
Not clear |
| Anthony G Lau, Hasan A Irier, Jiaping Gu, Donghua Tian, Li Ku, Guanglu Liu, Mingjing Xia, Brita Fritsch, James Q Zheng, Raymond Dingledine, Baoji Xu, Bai Lu, Yue Fen. Distinct 3'UTRs differentially regulate activity-dependent translation of brain-derived neurotrophic factor (BDNF). Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 36. 2010-10-07. PMID:20733072. |
furthermore, bdnf protein level is quickly increased in the hippocampus upon seizure-induced neuronal activation, accompanied by a robust activation of the tropomyosin-related receptor tyrosine kinase b. |
2010-10-07 |
2023-08-12 |
Not clear |
| Eleni Païzanis, Thibault Renoir, Vincent Lelievre, Françoise Saurini, Maxette Melfort, Cecilia Gabriel, Nicholas Barden, Elisabeth Mocaër, Michel Hamon, Laurence Lanfume. Behavioural and neuroplastic effects of the new-generation antidepressant agomelatine compared to fluoxetine in glucocorticoid receptor-impaired mice. The international journal of neuropsychopharmacology. vol 13. issue 6. 2010-09-29. PMID:19775499. |
glucocorticoid receptor-impaired (gr-i) mice, a transgenic model for affective disorders with hypothalamic-pituitary-adrenal (hpa) axis feedback control deficit, were used to assess the antidepressant-like effects of the mixed melatonin receptor agonist/5-ht(2c) receptor antagonist, agomelatine, compared to the selective 5-ht reuptake inhibitor (ssri), fluoxetine, on hippocampal neurogenesis, gr and bdnf expression and antidepressant-responsive behaviour (tail suspension test, tst). |
2010-09-29 |
2023-08-12 |
mouse |
| Eleni Païzanis, Thibault Renoir, Vincent Lelievre, Françoise Saurini, Maxette Melfort, Cecilia Gabriel, Nicholas Barden, Elisabeth Mocaër, Michel Hamon, Laurence Lanfume. Behavioural and neuroplastic effects of the new-generation antidepressant agomelatine compared to fluoxetine in glucocorticoid receptor-impaired mice. The international journal of neuropsychopharmacology. vol 13. issue 6. 2010-09-29. PMID:19775499. |
both hippocampal cell proliferation and bdnf mrna expression were down-regulated in gr-i mice, and these alterations were reversed by chronic agomelatine and fluoxetine treatments, whereas gr mrna down-regulation was reversed only by agomelatine. |
2010-09-29 |
2023-08-12 |
mouse |
| Xiang Gao, Jinhui Che. Conditional knockout of brain-derived neurotrophic factor in the hippocampus increases death of adult-born immature neurons following traumatic brain injury. Journal of neurotrauma. vol 26. issue 8. 2010-09-22. PMID:19203227. |
here, we conditionally knocked out brain-derived neurotrophic factor (bdnf) in the hippocampal dentate gyrus and examined the death of adult-born immature neurons following moderate tbi. |
2010-09-22 |
2023-08-12 |
mouse |
| Xiang Gao, Jinhui Che. Conditional knockout of brain-derived neurotrophic factor in the hippocampus increases death of adult-born immature neurons following traumatic brain injury. Journal of neurotrauma. vol 26. issue 8. 2010-09-22. PMID:19203227. |
the results showed that the amount of adult-born immature neuron death in the hippocampal dentate gyrus significantly increased in the bdnf conditional knockout mice. |
2010-09-22 |
2023-08-12 |
mouse |
| Xiang Gao, Jinhui Che. Conditional knockout of brain-derived neurotrophic factor in the hippocampus increases death of adult-born immature neurons following traumatic brain injury. Journal of neurotrauma. vol 26. issue 8. 2010-09-22. PMID:19203227. |
this result suggests that bdnf is involved in regulating the survival of adult-born immature neurons in the hippocampus following tbi, and potentially might be a useful target for preventing the adult-born immature neurons from death following tbi. |
2010-09-22 |
2023-08-12 |
mouse |
| Darrick T Bal. Enhanced sensitivity of the MRL/MpJ mouse to the neuroplastic and behavioral effects of acute and chronic antidepressant treatments. Experimental and clinical psychopharmacology. vol 18. issue 1. 2010-09-20. PMID:20158296. |
chronic administration of the antidepressant drugs fluoxetine and desipramine produced robust elevations in hippocampal cell proliferation and brain-derived neurotrophic factor (bdnf) protein levels in mrl/mpj mice. |
2010-09-20 |
2023-08-12 |
mouse |