| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Wei, H Xu, D Xia, R Zha. Curcumin attenuates the effects of transport stress on serum cortisol concentration, hippocampal NO production, and BDNF expression in the pig. Domestic animal endocrinology. vol 39. issue 4. 2011-01-27. PMID:20920780. |
we found that 2 h of transport elevated serum cortisol concentration (p < 0.01), increased hippocampal no content, and reduced brain-derived neurotrophic factor (bdnf) mrna expression in pigs not treated with curcumin, whereas these stress responses were all reversed or attenuated in curcumin-treated pigs. |
2011-01-27 |
2023-08-12 |
Not clear |
| S Wei, H Xu, D Xia, R Zha. Curcumin attenuates the effects of transport stress on serum cortisol concentration, hippocampal NO production, and BDNF expression in the pig. Domestic animal endocrinology. vol 39. issue 4. 2011-01-27. PMID:20920780. |
these results suggest that curcumin can alleviate subacute stress response in pigs through its neuroprotective effects on modulating hippocampal no production and bdnf expression. |
2011-01-27 |
2023-08-12 |
Not clear |
| L Pietranera, A Lima, P Roig, A F De Nicol. Involvement of brain-derived neurotrophic factor and neurogenesis in oestradiol neuroprotection of the hippocampus of hypertensive rats. Journal of neuroendocrinology. vol 22. issue 10. 2011-01-26. PMID:20722975. |
the present work investigated whether e(2) treatment of shr and of hypertensive doca-salt male rats modulated the expression of brain-derived neurotrophic factor (bdnf), a neurotrophin involved in hippocampal neurogenesis. |
2011-01-26 |
2023-08-12 |
rat |
| L Pietranera, A Lima, P Roig, A F De Nicol. Involvement of brain-derived neurotrophic factor and neurogenesis in oestradiol neuroprotection of the hippocampus of hypertensive rats. Journal of neuroendocrinology. vol 22. issue 10. 2011-01-26. PMID:20722975. |
both hypertensive models showed decreased expression of bdnf mrna in the granular zone of the dentate gyrus, without changes in ca1 or ca3 pyramidal cell layers, decreased bdnf protein levels in whole hippocampal tissue, low density of doublecortin (dcx)-positive immature neurones in the subgranule zone and decreased length of dcx+ neurites in the dentate gyrus. |
2011-01-26 |
2023-08-12 |
rat |
| L Pietranera, A Lima, P Roig, A F De Nicol. Involvement of brain-derived neurotrophic factor and neurogenesis in oestradiol neuroprotection of the hippocampus of hypertensive rats. Journal of neuroendocrinology. vol 22. issue 10. 2011-01-26. PMID:20722975. |
after s.c. implantation of a single e(2) pellet for 2 weeks, bdnf mrna in the dentate gyrus, bdnf protein in whole hippocampus, dcx immunopositive cells and the length of dcx+ neurites were significantly raised in both shr and doca-salt-treated rats. |
2011-01-26 |
2023-08-12 |
rat |
| L Pietranera, A Lima, P Roig, A F De Nicol. Involvement of brain-derived neurotrophic factor and neurogenesis in oestradiol neuroprotection of the hippocampus of hypertensive rats. Journal of neuroendocrinology. vol 22. issue 10. 2011-01-26. PMID:20722975. |
these results indicate that: (i) low bdnf expression and deficient neurogenesis distinguished the hippocampus of shr and doca-salt hypertensive rats and (ii) e(2) was able to normalise these biologically important functions in the hippocampus of hypertensive animals. |
2011-01-26 |
2023-08-12 |
rat |
| Betina Elfving, Pia Høgh Plougmann, Heidi Kaastrup Müller, Aleksander A Mathé, Raben Rosenberg, Gregers Wegene. Inverse correlation of brain and blood BDNF levels in a genetic rat model of depression. The international journal of neuropsychopharmacology. vol 13. issue 5. 2011-01-25. PMID:19796445. |
moreover, in post-mortem hippocampal tissue, increased levels of bdnf immunoreactivity have been reported in subjects treated with antidepressants compared to untreated subjects. |
2011-01-25 |
2023-08-12 |
human |
| Betina Elfving, Pia Høgh Plougmann, Heidi Kaastrup Müller, Aleksander A Mathé, Raben Rosenberg, Gregers Wegene. Inverse correlation of brain and blood BDNF levels in a genetic rat model of depression. The international journal of neuropsychopharmacology. vol 13. issue 5. 2011-01-25. PMID:19796445. |
in investigations between flinders sensitive line (fsl) and flinders resistant line (frl) rats, a genetic rat model of depression, no differences were found in bdnf levels in the frontal cortex and hippocampus, areas believed to be core brain regions in depression. |
2011-01-25 |
2023-08-12 |
human |
| Betina Elfving, Pia Høgh Plougmann, Heidi Kaastrup Müller, Aleksander A Mathé, Raben Rosenberg, Gregers Wegene. Inverse correlation of brain and blood BDNF levels in a genetic rat model of depression. The international journal of neuropsychopharmacology. vol 13. issue 5. 2011-01-25. PMID:19796445. |
therefore, we examined the levels of bdnf in whole blood, serum, cerebrospinal fluid (csf), hippocampus, and frontal cortex in male fsl and frl rats. |
2011-01-25 |
2023-08-12 |
human |
| Betina Elfving, Pia Høgh Plougmann, Heidi Kaastrup Müller, Aleksander A Mathé, Raben Rosenberg, Gregers Wegene. Inverse correlation of brain and blood BDNF levels in a genetic rat model of depression. The international journal of neuropsychopharmacology. vol 13. issue 5. 2011-01-25. PMID:19796445. |
in contrast, in the hippocampus the bdnf level was significantly decreased in fsl compared to frl rats while no differences were found in the frontal cortex and csf. |
2011-01-25 |
2023-08-12 |
human |
| Betina Elfving, Pia Høgh Plougmann, Heidi Kaastrup Müller, Aleksander A Mathé, Raben Rosenberg, Gregers Wegene. Inverse correlation of brain and blood BDNF levels in a genetic rat model of depression. The international journal of neuropsychopharmacology. vol 13. issue 5. 2011-01-25. PMID:19796445. |
the differential regulation of the bdnf levels in hippocampus, serum, and whole blood in fsl/frl rats adds to the hypothesis that neurotrophic factors are related to the pathophysiology of depression. |
2011-01-25 |
2023-08-12 |
human |
| Hua-Cheng Yan, Hong-Da Qu, Li-Rong Sun, Shu-Ji Li, Xiong Cao, Ying-Ying Fang, Wei Jie, Jonathan C Bean, Wei-Kang Wu, Xin-Hong Zhu, Tian-Ming Ga. Fuzi polysaccharide-1 produces antidepressant-like effects in mice. The international journal of neuropsychopharmacology. vol 13. issue 5. 2011-01-25. PMID:19796446. |
finally, acute treatment with fps had no effect on brain monoamine levels in frontal cortex but significantly increases bdnf in the hippocampus, while the antidepressant effect and enhancement of cell proliferation induced by fps administration were totally blocked by k252a, an inhibitor of trkb in a chronic social defeat depression model, suggesting that the neurogenic and antidepressant effects of fps may involve bdnf signalling. |
2011-01-25 |
2023-08-12 |
mouse |
| Reiji Yoshimura, Atsuko Ikenouchi-Sugita, Hikaru Hori, Wakako Umene-Nakano, Kenji Hayashi, Asuka Katsuki, Nobuhisa Ueda, Jun Nakamur. [Blood levels of brain-derived neurotrophic factor (BDNF) in major depressive disorder]. Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica. vol 112. issue 10. 2011-01-25. PMID:21179660. |
depressed patients show reduced levels of hippocampal and cortical bdnf in postmortem studies. |
2011-01-25 |
2023-08-12 |
Not clear |
| Shigeru Morinobu, Manabu Fuchikami, Yosuke Yamawaki, Shigeto Yamamoto, Akiko Kurata, Shigeto Yamawak. [Epigenetic mechanism of depression]. Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica. vol 112. issue 10. 2011-01-25. PMID:21179661. |
it is well known that the levels of bdnf mrna and protein in the rat brain, such as frontal cortex and hippocampus, was decreased in response to stress, but the precise mechanism of stress-induced downregulation of bdnf has yet to be characterized. |
2011-01-25 |
2023-08-12 |
rat |
| Shigeru Morinobu, Manabu Fuchikami, Yosuke Yamawaki, Shigeto Yamamoto, Akiko Kurata, Shigeto Yamawak. [Epigenetic mechanism of depression]. Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica. vol 112. issue 10. 2011-01-25. PMID:21179661. |
in this context, we examined the influence of a single immobilization stress (sis) on the levels of total bdnf mrna with each exon mrna by real-time pcr and acetylated histone at the promoters of the bdnf gene by chromatin immunoprecipitaion assay in the rat hippocampus. |
2011-01-25 |
2023-08-12 |
rat |
| Synphen H Wu, Juan Carlos Arévalo, Veronika E Neubrand, Hong Zhang, Ottavio Arancio, Moses V Cha. The ankyrin repeat-rich membrane spanning (ARMS)/Kidins220 scaffold protein is regulated by activity-dependent calpain proteolysis and modulates synaptic plasticity. The Journal of biological chemistry. vol 285. issue 52. 2011-01-24. PMID:20943655. |
here we show that arms (ankyrin repeat-rich membrane spanning protein)/kidins220, a transmembrane scaffold molecule and bdnf trkb substrate, is significantly reduced in hippocampal neurons after potassium chloride depolarization. |
2011-01-24 |
2023-08-12 |
mouse |
| Lorna C Gleeson, Katie J Ryan, Eadaoin W Griffin, Thomas J Connor, Andrew Harki. The β2-adrenoceptor agonist clenbuterol elicits neuroprotective, anti-inflammatory and neurotrophic actions in the kainic acid model of excitotoxicity. Brain, behavior, and immunity. vol 24. issue 8. 2011-01-21. PMID:20599496. |
in addition, expression of inflammatory cytokines (il-1β and ifn-γ), inducible nitric oxide synthase (inos), kynurenine pathway enzymes indolamine 2,3-dioxygenase (ido) and kynurenine monooxygenase (kmo), the microglial activation marker cd11b, and the neurotrophins bdnf and ngf were quantified in the hippocampus using real-time pcr. |
2011-01-21 |
2023-08-12 |
rat |
| Yu Fukuda, Thomas L Berry, Matthew Nelson, Christopher L Hunter, Koki Fukuhara, Hideki Imai, Shinji Ito, Ann-Charlotte Granholm-Bentley, Allen P Kaplan, Tatsuro Muto. Stimulated neuronal expression of brain-derived neurotrophic factor by Neurotropin. Molecular and cellular neurosciences. vol 45. issue 3. 2011-01-21. PMID:20600926. |
repetitive oral administration of neurotropin (200nu/kg/day, 3months) prevented the age-dependent decline in hippocampal bdnf expression in ts65dn mice, a model of down's syndrome. |
2011-01-21 |
2023-08-12 |
mouse |
| Min Kyoo Shin, Hong Gi Kim, Kil Lyong Ki. A novel trimeric peptide, Neuropep-1-stimulating brain-derived neurotrophic factor expression in rat brain improves spatial learning and memory as measured by the Y-maze and Morris water maze. Journal of neurochemistry. vol 116. issue 2. 2011-01-20. PMID:21044076. |
in the present study, a positional scanning-synthetic peptide combinatorial library was utilized to identify a peptide modulator of bdnf expression in the hippocampal neuronal cell line, h19-7. |
2011-01-20 |
2023-08-12 |
rat |
| Min Kyoo Shin, Hong Gi Kim, Kil Lyong Ki. A novel trimeric peptide, Neuropep-1-stimulating brain-derived neurotrophic factor expression in rat brain improves spatial learning and memory as measured by the Y-maze and Morris water maze. Journal of neurochemistry. vol 116. issue 2. 2011-01-20. PMID:21044076. |
tail vein injection of neuropep-1 significantly up-regulated bdnf expression, trkb phosphorylation, and its downstream signals including activation of akt, erk, and camp response element binding in the rat hippocampus. |
2011-01-20 |
2023-08-12 |
rat |