| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuanyuan Ye, Gaohua Wang, Huiling Wang, Xiaoping Wan. Brain-derived neurotrophic factor (BDNF) infusion restored astrocytic plasticity in the hippocampus of a rat model of depression. Neuroscience letters. vol 503. issue 1. 2012-01-18. PMID:21843601. |
previous studies have demonstrated that distinct alterations of astrocytes are associated with major depressive disorder, but there is a paucity of data describing whether such alterations of astrocytic plasticity are present in depressive-like rat hippocampus after bdnf administration. |
2012-01-18 |
2023-08-12 |
rat |
| Yuanyuan Ye, Gaohua Wang, Huiling Wang, Xiaoping Wan. Brain-derived neurotrophic factor (BDNF) infusion restored astrocytic plasticity in the hippocampus of a rat model of depression. Neuroscience letters. vol 503. issue 1. 2012-01-18. PMID:21843601. |
in this paper, we investigated the effects of chronic unpredictable mild stress (cums) and bdnf infusion on astrocyte immunoreactivity in rat hippocampus using sucrose preference test, open field test, and western blot analysis. |
2012-01-18 |
2023-08-12 |
rat |
| Yuanyuan Ye, Gaohua Wang, Huiling Wang, Xiaoping Wan. Brain-derived neurotrophic factor (BDNF) infusion restored astrocytic plasticity in the hippocampus of a rat model of depression. Neuroscience letters. vol 503. issue 1. 2012-01-18. PMID:21843601. |
moreover, cums produced decreased glial fibrillary acidic protein (gfap) expression and increased s100 calcium binding protein b (s100b) expression in rat hippocampus, which were partially rescued by bdnf administration. |
2012-01-18 |
2023-08-12 |
rat |
| Yuanyuan Ye, Gaohua Wang, Huiling Wang, Xiaoping Wan. Brain-derived neurotrophic factor (BDNF) infusion restored astrocytic plasticity in the hippocampus of a rat model of depression. Neuroscience letters. vol 503. issue 1. 2012-01-18. PMID:21843601. |
therefore, bdnf might restore astrocyte immunoreactivity in depressive-like rat hippocampus, providing insights into the potential pharmacological role of bdnf in stress-related disorders. |
2012-01-18 |
2023-08-12 |
rat |
| Mu-hua Dai, De-qiang Li, Yang Ha. [Effect of venlafaxine on cognitive function and hippocampal brain-derived neurotrophic factor expression in rats with post-stroke depression]. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences. vol 40. issue 5. 2012-01-12. PMID:21984156. |
to evaluate the effect of venlafaxine on the cognitive impairment of learning and memory in rats with post-stroke depression (psd) and to investigate its relationship with the expression of brain-derived neurotrophic factor (bdnf) in hippocampus. |
2012-01-12 |
2023-08-12 |
rat |
| Yonggang Cao, Xiaoyuan Mao, Chunyan Sun, Ping Zheng, Jingquan Gao, Xiaorui Wang, Dongyu Min, Hongli Sun, Ni Xie, Jiqun Ca. Baicalin attenuates global cerebral ischemia/reperfusion injury in gerbils via anti-oxidative and anti-apoptotic pathways. Brain research bulletin. vol 85. issue 6. 2012-01-11. PMID:21600966. |
the mrna and protein expressions of bdnf were determined in ischemic hippocampus by real-time rt-pcr and western blot, respectively. |
2012-01-11 |
2023-08-12 |
Not clear |
| Martin Wiener, Falk W Lohoff, H Branch Coslet. Double dissociation of dopamine genes and timing in humans. Journal of cognitive neuroscience. vol 23. issue 10. 2012-01-05. PMID:21261454. |
the bdnf val66met polymorphism affects activity-dependent secretion of bdnf and human memory and hippocampal function. |
2012-01-05 |
2023-08-12 |
human |
| Noriaki Hidaka, Katsuya Suemaru, Kenshi Takechi, Bingjin Li, Hiroaki Arak. Inhibitory effects of valproate on impairment of Y-maze alternation behavior induced by repeated electroconvulsive seizures and c-Fos protein levels in rat brains. Acta medica Okayama. vol 65. issue 4. 2012-01-05. PMID:21860534. |
to clarify the precise mechanism(s), we investigated the effect of valproate on such impairment and examined the levels of brain-derived neurotrophic factor (bdnf) and c-fos protein in the prefrontal cortex and the hippocampus 24h after the last administration of ecs. |
2012-01-05 |
2023-08-12 |
rat |
| Noriaki Hidaka, Katsuya Suemaru, Kenshi Takechi, Bingjin Li, Hiroaki Arak. Inhibitory effects of valproate on impairment of Y-maze alternation behavior induced by repeated electroconvulsive seizures and c-Fos protein levels in rat brains. Acta medica Okayama. vol 65. issue 4. 2012-01-05. PMID:21860534. |
repeated ecs increased the bdnf protein levels in the hippocampus and prefrontal cortex in the presence or absence of valproate, indicating that the increase in bdnf protein levels resulted from electrical stimulation. |
2012-01-05 |
2023-08-12 |
rat |
| Daisuke Miyazawa, Yuko Yasui, Kazuyo Yamada, Naoki Ohara, Harumi Okuyam. Biochemical responses to dietary α-linolenic acid restriction proceed differently among brain regions in mice. Biomedical research (Tokyo, Japan). vol 32. issue 4. 2012-01-05. PMID:21878731. |
the bdnf contents and protein kinase c (pkc) activities in the cerebral cortex as well as in the striatum, but not in the hippocampus, were significantly lower in the saf group. |
2012-01-05 |
2023-08-12 |
mouse |
| Sheng Peng, Yan Zhang, Hua Wang, Bingxu Ren, Jiannan Zhan. Anesthetic ketamine counteracts repetitive mechanical stress-induced learning and memory impairment in developing mice. Molecular biology reports. vol 38. issue 7. 2011-12-27. PMID:21116850. |
additionally, the expression of brain-derived neurotrophic factor (bdnf) in the hippocampus was determined. |
2011-12-27 |
2023-08-12 |
mouse |
| Pauline Obiang, Eric Maubert, Isabelle Bardou, Olivier Nicole, Séverine Launay, Laurent Bezin, Denis Vivien, Véronique Agi. Enriched housing reverses age-associated impairment of cognitive functions and tPA-dependent maturation of BDNF. Neurobiology of learning and memory. vol 96. issue 2. 2011-12-27. PMID:21440650. |
in the present study, we investigated whether maintenance of mice in different environmental conditions could influence age-associated changes in hippocampal tpa expression and bdnf maturation in relation with modifications of their cognitive performances. |
2011-12-27 |
2023-08-12 |
mouse |
| Christophe Heinrich, Sari Lähteinen, Fumio Suzuki, Laharie Anne-Marie, Susanne Huber, Ute Häussler, Carola Haas, Yves Larmet, Eero Castren, Antoine Depauli. Increase in BDNF-mediated TrkB signaling promotes epileptogenesis in a mouse model of mesial temporal lobe epilepsy. Neurobiology of disease. vol 42. issue 1. 2011-12-23. PMID:21220014. |
we show that hippocampal seizures progressively developed in the injected hippocampus during the first two weeks following kainate treatment, within the same time-frame as a long-lasting and significant increase of bdnf expression in dentate granule cells. |
2011-12-23 |
2023-08-12 |
mouse |
| Christophe Heinrich, Sari Lähteinen, Fumio Suzuki, Laharie Anne-Marie, Susanne Huber, Ute Häussler, Carola Haas, Yves Larmet, Eero Castren, Antoine Depauli. Increase in BDNF-mediated TrkB signaling promotes epileptogenesis in a mouse model of mesial temporal lobe epilepsy. Neurobiology of disease. vol 42. issue 1. 2011-12-23. PMID:21220014. |
to determine whether such a bdnf increase could influence hippocampal epileptogenesis via its trkb receptors, we examined the consequences of (i) increased or (ii) decreased trkb signaling on epileptogenesis, in transgenic mice overexpressing the (i) trkb full-length or (ii) truncated trkb-t1 receptors of bdnf. |
2011-12-23 |
2023-08-12 |
mouse |
| Christophe Heinrich, Sari Lähteinen, Fumio Suzuki, Laharie Anne-Marie, Susanne Huber, Ute Häussler, Carola Haas, Yves Larmet, Eero Castren, Antoine Depauli. Increase in BDNF-mediated TrkB signaling promotes epileptogenesis in a mouse model of mesial temporal lobe epilepsy. Neurobiology of disease. vol 42. issue 1. 2011-12-23. PMID:21220014. |
these results suggest that an increase in trkb signaling, mediated by a long-lasting bdnf overexpression in the hippocampus, promotes epileptogenesis in mtle. |
2011-12-23 |
2023-08-12 |
mouse |
| Tali Kobilo, Qing-Rong Liu, Kriti Gandhi, Mohammed Mughal, Yavin Shaham, Henriette van Praa. Running is the neurogenic and neurotrophic stimulus in environmental enrichment. Learning & memory (Cold Spring Harbor, N.Y.). vol 18. issue 9. 2011-12-23. PMID:21878528. |
to dissociate effects of physical activity and enrichment on hippocampal neurogenesis and bdnf levels, young female c57bl/6 mice were housed under control, running, enrichment, or enrichment plus running conditions, and injected with bromodeoxyuridine. |
2011-12-23 |
2023-08-12 |
mouse |
| Tali Kobilo, Qing-Rong Liu, Kriti Gandhi, Mohammed Mughal, Yavin Shaham, Henriette van Praa. Running is the neurogenic and neurotrophic stimulus in environmental enrichment. Learning & memory (Cold Spring Harbor, N.Y.). vol 18. issue 9. 2011-12-23. PMID:21878528. |
in addition, locomotor activity in the open field and hippocampal mature bdnf peptide levels were measured. |
2011-12-23 |
2023-08-12 |
mouse |
| Tali Kobilo, Qing-Rong Liu, Kriti Gandhi, Mohammed Mughal, Yavin Shaham, Henriette van Praa. Running is the neurogenic and neurotrophic stimulus in environmental enrichment. Learning & memory (Cold Spring Harbor, N.Y.). vol 18. issue 9. 2011-12-23. PMID:21878528. |
we conclude that exercise is the critical factor mediating increased bdnf levels and adult hippocampal neurogenesis. |
2011-12-23 |
2023-08-12 |
mouse |
| Tatsuo Watanabe, Miho Fujihara, Eri Murakami, Michio Miyoshi, Yuki Tanaka, Satoshi Koba, Hiroto Tachiban. Green odor and depressive-like state in rats: toward an evidence-based alternative medicine? Behavioural brain research. vol 224. issue 2. 2011-12-21. PMID:21684308. |
inhaling green odor, but not vehicle, thereafter for 10 days (without swimming) led to the prolonged immobility time being significantly reduced and the hippocampal level of brain-derived neurotrophic factor (bdnf) being significantly increased. |
2011-12-21 |
2023-08-12 |
rat |
| Tatsuo Watanabe, Miho Fujihara, Eri Murakami, Michio Miyoshi, Yuki Tanaka, Satoshi Koba, Hiroto Tachiban. Green odor and depressive-like state in rats: toward an evidence-based alternative medicine? Behavioural brain research. vol 224. issue 2. 2011-12-21. PMID:21684308. |
these effects may be at least in part due to a green odor-induced upregulation of bdnf in the hippocampus. |
2011-12-21 |
2023-08-12 |
rat |