| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuri Chihara, Yuto Ueda, Taku Doi, L James Willmor. Role of endoplasmic reticulum stress in the amygdaloid kindling model of rats. Neurochemical research. vol 36. issue 10. 2012-02-08. PMID:21604154. |
protein from ipsilateral hippocampus was electrophoresed on sds-page, followed by hybridization with primary antibodies, anti-kdel (-lys-asp-glu-coo-), bcl-2, bdnf (brain-derived neurotrophic factor), chop (c/ebp-homolog protein), c/ebp (ccaat/enhancer-binding protein), nmda (n-methyl-d-aspartate; -r1 &2a), glur1 (glutamate receptor), and β-tubulin. |
2012-02-08 |
2023-08-12 |
rat |
| Éadaoin W Griffin, Sinéad Mullally, Carole Foley, Stuart A Warmington, Shane M O'Mara, Aine M Kell. Aerobic exercise improves hippocampal function and increases BDNF in the serum of young adult males. Physiology & behavior. vol 104. issue 5. 2012-02-06. PMID:21722657. |
aerobic exercise improves hippocampal function and increases bdnf in the serum of young adult males. |
2012-02-06 |
2023-08-12 |
human |
| Éadaoin W Griffin, Sinéad Mullally, Carole Foley, Stuart A Warmington, Shane M O'Mara, Aine M Kell. Aerobic exercise improves hippocampal function and increases BDNF in the serum of young adult males. Physiology & behavior. vol 104. issue 5. 2012-02-06. PMID:21722657. |
in this study of human subjects, we have assessed the effects of acute and chronic exercise on performance of a face-name matching task, which recruits the hippocampus and associated structures of the medial temporal lobe, and the stroop word-colour task, which does not, and have assessed circulating concentrations of bdnf and igf-1 in parallel. |
2012-02-06 |
2023-08-12 |
human |
| Joshua J Park, Y Peng Lo. Visualization of peptide secretory vesicles in living nerve cells. Methods in molecular biology (Clifton, N.J.). vol 789. 2012-02-06. PMID:21922405. |
e16 rat hippocampal neurons were transfected with the peptidergic vesicle markers, cpe c-terminally tagged with red or green fluorescent protein, or brain-derived neurotrophic factor (bdnf) tagged with green fluorescent protein, and grown on dishes specialized for real-time live cell visualization. |
2012-02-06 |
2023-08-12 |
rat |
| Sarah J Texel, Simonetta Camandola, Bruce Ladenheim, Sarah M Rothman, Mohamed R Mughal, Erica L Unger, Jean Lud Cadet, Mark P Mattso. Ceruloplasmin deficiency results in an anxiety phenotype involving deficits in hippocampal iron, serotonin, and BDNF. Journal of neurochemistry. vol 120. issue 1. 2012-02-06. PMID:22035068. |
ceruloplasmin deficiency results in an anxiety phenotype involving deficits in hippocampal iron, serotonin, and bdnf. |
2012-02-06 |
2023-08-12 |
mouse |
| Sarah J Texel, Simonetta Camandola, Bruce Ladenheim, Sarah M Rothman, Mohamed R Mughal, Erica L Unger, Jean Lud Cadet, Mark P Mattso. Ceruloplasmin deficiency results in an anxiety phenotype involving deficits in hippocampal iron, serotonin, and BDNF. Journal of neurochemistry. vol 120. issue 1. 2012-02-06. PMID:22035068. |
previous studies provided evidence that anxiety disorders and long-standing stress are associated with reductions in levels of serotonin (5ht) and brain-derived neurotrophic factor (bdnf) in the hippocampus. |
2012-02-06 |
2023-08-12 |
mouse |
| Sarah J Texel, Simonetta Camandola, Bruce Ladenheim, Sarah M Rothman, Mohamed R Mughal, Erica L Unger, Jean Lud Cadet, Mark P Mattso. Ceruloplasmin deficiency results in an anxiety phenotype involving deficits in hippocampal iron, serotonin, and BDNF. Journal of neurochemistry. vol 120. issue 1. 2012-02-06. PMID:22035068. |
we found that levels of 5ht and norepinephrine (ne), and the expression of bdnf and its receptor trkb, are significantly reduced in the hippocampus of cpko mice. |
2012-02-06 |
2023-08-12 |
mouse |
| Sarah J Texel, Simonetta Camandola, Bruce Ladenheim, Sarah M Rothman, Mohamed R Mughal, Erica L Unger, Jean Lud Cadet, Mark P Mattso. Ceruloplasmin deficiency results in an anxiety phenotype involving deficits in hippocampal iron, serotonin, and BDNF. Journal of neurochemistry. vol 120. issue 1. 2012-02-06. PMID:22035068. |
thus, cp deficiency causes an anxiety phenotype by a mechanism that involves decreased levels of iron, 5ht, ne, and bdnf in the hippocampus. |
2012-02-06 |
2023-08-12 |
mouse |
| Anne-Laure Dinel, Caroline André, Agnès Aubert, Guillaume Ferreira, Sophie Layé, Nathalie Castano. Cognitive and emotional alterations are related to hippocampal inflammation in a mouse model of metabolic syndrome. PloS one. vol 6. issue 9. 2012-02-03. PMID:21949705. |
in agreement with the well-established role of the hippocampus in anxiety-like behavior and spatial memory, behavioral alterations of db/db mice were associated with increased inflammatory cytokines (interleukin-1β, tumor necrosis factor-α and interleukin-6) and reduced expression of brain-derived neurotrophic factor (bdnf) in the hippocampus but not the hypothalamus. |
2012-02-03 |
2023-08-12 |
mouse |
| F J Wang, C M Li, X H Hou, X R Wang, L M Zhan. Selective upregulation of brain-derived neurotrophic factor (BDNF) transcripts and BDNF direct induction of activity independent N-methyl-D-aspartate currents in temporal lobe epilepsy patients with hippocampal sclerosis. The Journal of international medical research. vol 39. issue 4. 2012-02-02. PMID:21986136. |
selective upregulation of brain-derived neurotrophic factor (bdnf) transcripts and bdnf direct induction of activity independent n-methyl-d-aspartate currents in temporal lobe epilepsy patients with hippocampal sclerosis. |
2012-02-02 |
2023-08-12 |
human |
| F J Wang, C M Li, X H Hou, X R Wang, L M Zhan. Selective upregulation of brain-derived neurotrophic factor (BDNF) transcripts and BDNF direct induction of activity independent N-methyl-D-aspartate currents in temporal lobe epilepsy patients with hippocampal sclerosis. The Journal of international medical research. vol 39. issue 4. 2012-02-02. PMID:21986136. |
brain-derived neurotrophic factor (bdnf) plays a critical role in many aspects of neuronal biology and hippocampal physiology and pathology, and has been implicated as a potential therapeutic target in temporal lobe epilepsy (tle). |
2012-02-02 |
2023-08-12 |
human |
| F J Wang, C M Li, X H Hou, X R Wang, L M Zhan. Selective upregulation of brain-derived neurotrophic factor (BDNF) transcripts and BDNF direct induction of activity independent N-methyl-D-aspartate currents in temporal lobe epilepsy patients with hippocampal sclerosis. The Journal of international medical research. vol 39. issue 4. 2012-02-02. PMID:21986136. |
bdnf total mrna and its six transcripts were compared in the hippocampal tissue of tle patients with or without hippocampal sclerosis (hs) by real-time fluorescence quantitative polymerase chain reaction. |
2012-02-02 |
2023-08-12 |
human |
| F J Wang, C M Li, X H Hou, X R Wang, L M Zhan. Selective upregulation of brain-derived neurotrophic factor (BDNF) transcripts and BDNF direct induction of activity independent N-methyl-D-aspartate currents in temporal lobe epilepsy patients with hippocampal sclerosis. The Journal of international medical research. vol 39. issue 4. 2012-02-02. PMID:21986136. |
excitatory actions induced by bdnf on hippocampal cells were investigated by whole-cell patch-clamp recordings. |
2012-02-02 |
2023-08-12 |
human |
| Yan Zeng, Miao Tan, Jun Kohyama, Marissa Sneddon, Joseph B Watson, Yi E Sun, Cui-Wei Xi. Epigenetic enhancement of BDNF signaling rescues synaptic plasticity in aging. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 49. 2012-02-02. PMID:22159096. |
age-dependent reductions in h3 and h4 acetylation were detected within multiple promoter regions of the bdnf gene, leading to a significant decrease in bdnf expression and impairment of downstream signaling in the aged hippocampus. |
2012-02-02 |
2023-08-12 |
rat |
| Nanxin Li, Xiaolu He, Yu Zhang, Xiaoli Qi, Huijie Li, Xinhong Zhu, Shuchang H. Brain-derived neurotrophic factor signalling mediates antidepressant effects of lamotrigine. The international journal of neuropsychopharmacology. vol 14. issue 8. 2012-02-01. PMID:20846461. |
in parallel, chronic lamotrigine treatment up-regulates frontal and hippocampal bdnf protein expression in both naive and stressed animals, and restores the stress-induced down-regulation of bdnf levels. |
2012-02-01 |
2023-08-12 |
rat |
| Lihong Wan, Yizhou Xie, Lan Su, Yanyou Liu, Yuhui Wang, Zhengrong Wan. RACK1 affects morphine reward via BDNF. Brain research. vol 1416. 2012-01-27. PMID:21885037. |
the present study was designed to investigate if shrack1 (a short hairpin rna of rack1) could reverse the mice's behavioral responses to morphine and bdnf expression in hippocampus and prefrontal cortex. |
2012-01-27 |
2023-08-12 |
mouse |
| Lihong Wan, Yizhou Xie, Lan Su, Yanyou Liu, Yuhui Wang, Zhengrong Wan. RACK1 affects morphine reward via BDNF. Brain research. vol 1416. 2012-01-27. PMID:21885037. |
no significant changes were observed in vehicle-infused mice which received no morphine treatment (conc) and shrack1-infused mice which received no morphine treatment (conr), whereas vehicle-infused mice preceded the morphine injection (mic) showed increased bdnf expression in hippocampus and prefrontal cortex, as compared to vehicle-infused mice which received no morphine treatment (conc). |
2012-01-27 |
2023-08-12 |
mouse |
| Lihong Wan, Yizhou Xie, Lan Su, Yanyou Liu, Yuhui Wang, Zhengrong Wan. RACK1 affects morphine reward via BDNF. Brain research. vol 1416. 2012-01-27. PMID:21885037. |
intracerebroventricular shrack1 treatment reversed these, and in fact, shrack1-infused mice preceded the morphine injection (mir) showed reduced bdnf expression in hippocampus and prefrontal cortex, as compared to mic. |
2012-01-27 |
2023-08-12 |
mouse |
| Simona Keller, Marco Sarchiapone, Federica Zarrilli, Rossella Tomaiuolo, Vladimir Carli, Tiziana Angrisano, Alja Videtic, Felice Amato, Raffaela Pero, Massimo di Giannantonio, Miriam Iosue, Francesca Lembo, Giuseppe Castaldo, Lorenzo Chiariott. TrkB gene expression and DNA methylation state in Wernicke area does not associate with suicidal behavior. Journal of affective disorders. vol 135. issue 1-3. 2012-01-25. PMID:21802740. |
in the bdnf pathway, trkb gene in frontal cortex and hippocampus, and bdnf gene in wernicke area have been found hypermethylated and down-regulated in suicide subjects as compared to controls. |
2012-01-25 |
2023-08-12 |
human |
| Pei-Lin Cheng, Ai-Hong Song, Yu-Hui Wong, Sheng Wang, Xiang Zhang, Mu-Ming Po. Self-amplifying autocrine actions of BDNF in axon development. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 45. 2012-01-25. PMID:22025720. |
we here report that bdnf, a secreted neurotrophin essential for the survival and differentiation of many neuronal populations, serves as a self-amplifying autocrine factor in promoting axon formation in embryonic hippocampal neurons by triggering two nested positive-feedback mechanisms. |
2012-01-25 |
2023-08-12 |
Not clear |