| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Heidi A Jurgens, Kaushik Amancherla, Rodney W Johnso. Influenza infection induces neuroinflammation, alters hippocampal neuron morphology, and impairs cognition in adult mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 12. 2012-05-18. PMID:22442063. |
at the same time point in which cognitive impairment was evident, proinflammatory cytokines (il-1β, il-6, tnf-α, ifn-α) and microglial reactivity were increased, while neurotrophic (bdnf, ngf) and immunomodulatory (cd200, cx3cl1) factors were decreased in the hippocampus of infected mice. |
2012-05-18 |
2023-08-12 |
mouse |
| João R Gomes, João T Costa, Carlos V Melo, Federico Felizzi, Patrícia Monteiro, Maria J Pinto, Ana R Inácio, Tadeusz Wieloch, Ramiro D Almeida, Mário Grãos, Carlos B Duart. Excitotoxicity downregulates TrkB.FL signaling and upregulates the neuroprotective truncated TrkB receptors in cultured hippocampal and striatal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 13. 2012-05-18. PMID:22457507. |
bdnf fully protected hippocampal neurons transduced with trkb.t when present during excitotoxic stimulation with glutamate, in contrast with the partial protection observed in cells overexpressing trkb.fl or expressing gfp. |
2012-05-18 |
2023-08-12 |
rat |
| João R Gomes, João T Costa, Carlos V Melo, Federico Felizzi, Patrícia Monteiro, Maria J Pinto, Ana R Inácio, Tadeusz Wieloch, Ramiro D Almeida, Mário Grãos, Carlos B Duart. Excitotoxicity downregulates TrkB.FL signaling and upregulates the neuroprotective truncated TrkB receptors in cultured hippocampal and striatal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 13. 2012-05-18. PMID:22457507. |
these results indicate that bdnf protects hippocampal neurons by two distinct mechanisms: through the neurotrophic effects of trkb.fl receptors and by activation of trkb.t receptors coupled to inhibition of the excitotoxic signaling. |
2012-05-18 |
2023-08-12 |
rat |
| Amy L Mahan, Liping Mou, Nirali Shah, Jia-Hua Hu, Paul F Worley, Kerry J Ressle. Epigenetic modulation of Homer1a transcription regulation in amygdala and hippocampus with pavlovian fear conditioning. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 13. 2012-05-18. PMID:22457511. |
we then demonstrated that: (1) homer1a mrna increases after fear conditioning in vivo within both amygdala and hippocampus of wild-type mice; (2) it increases after bdnf application to primary hippocampal and amygdala cultures in vitro; and (3) these increases are dependent on transcription and mapk signaling. |
2012-05-18 |
2023-08-12 |
mouse |
| Olaf Schulte-Herbrüggen, Miriam A Vogt, Heide Hörtnagl, Peter Gass, Rainer Hellwe. Pramipexole is active in depression tests and modulates monoaminergic transmission, but not brain levels of BDNF in mice. European journal of pharmacology. vol 677. issue 1-3. 2012-05-17. PMID:22206815. |
in a second experiment dosages of pramipexole shown to be effective were used and candidate brain regions including hippocampus, frontal cortex and striatum were analyzed for levels of 5-hydroxytryptamine (5-ht), noradrenaline and dopamine and their metabolites as well as brain-derived neurotrophic factor (bdnf) to investigate possible neurochemical correlates of behavioral changes. |
2012-05-17 |
2023-08-12 |
mouse |
| Tin-Tin Win-Shwe, Daisuke Nakajima, Hidekazu Fujimak. Involvement of TLR4 in diazinon-induced neurotoxicity in mice. Journal of UOEH. vol 34. issue 1. 2012-05-15. PMID:22428454. |
twenty-four hours after the final diazinon injection, the hippocampus was collected from each mouse to detect mrna expression of neurotrophins (nerve growth factor (ngf) and brain-derived neurotrophic factor (bdnf)) by the real-time rt-pcr method. |
2012-05-15 |
2023-08-12 |
mouse |
| Shiho Arakawa, Yukihiko Shirayama, Yuko Fujita, Tamaki Ishima, Mao Horio, Katsumasa Muneoka, Masaomi Iyo, Kenji Hashimot. Minocycline produced antidepressant-like effects on the learned helplessness rats with alterations in levels of monoamine in the amygdala and no changes in BDNF levels in the hippocampus at baseline. Pharmacology, biochemistry, and behavior. vol 100. issue 3. 2012-05-04. PMID:21967886. |
minocycline produced antidepressant-like effects on the learned helplessness rats with alterations in levels of monoamine in the amygdala and no changes in bdnf levels in the hippocampus at baseline. |
2012-05-04 |
2023-08-12 |
rat |
| Shiho Arakawa, Yukihiko Shirayama, Yuko Fujita, Tamaki Ishima, Mao Horio, Katsumasa Muneoka, Masaomi Iyo, Kenji Hashimot. Minocycline produced antidepressant-like effects on the learned helplessness rats with alterations in levels of monoamine in the amygdala and no changes in BDNF levels in the hippocampus at baseline. Pharmacology, biochemistry, and behavior. vol 100. issue 3. 2012-05-04. PMID:21967886. |
lh rats showed significantly higher serotonin turnover in the orbitofrontal cortex and lower levels of brain-derived neurotrophic factor (bdnf) in the hippocampus than control rats. |
2012-05-04 |
2023-08-12 |
rat |
| Neda Assareh, Maha M ElBatsh, Charles A Marsden, David A Kendal. The effects of chronic administration of tranylcypromine and rimonabant on behaviour and protein expression in brain regions of the rat. Pharmacology, biochemistry, and behavior. vol 100. issue 3. 2012-05-04. PMID:22037406. |
locomotor activity (lma) and a conditional emotional response (cer) were measured in addition to levels of bdnf and creb/phospho-creb, using immunoblotting, in the frontal cortex, hippocampus, striatum and cerebellum. |
2012-05-04 |
2023-08-12 |
rat |
| Fabiano R Agostinho, Gislaine Z Réus, Roberto B Stringari, Karine F Ribeiro, Bianca Pfaffenseller, Laura Stertz, Bruna S Panizzutti, Flávio Kapczinski, João Queved. Olanzapine plus fluoxetine treatment increases Nt-3 protein levels in the rat prefrontal cortex. Neuroscience letters. vol 497. issue 2. 2012-05-01. PMID:21545827. |
wistar rats received daily injections of olanzapine (3 or 6 mg/kg) and/or fluoxetine (12.5 or 25mg/kg) for 28 days, and we evaluated for bdnf, ngf and nt-3 protein levels in the prefrontal cortex, hippocampus and amygdala. |
2012-05-01 |
2023-08-12 |
rat |
| Fabiano R Agostinho, Gislaine Z Réus, Roberto B Stringari, Karine F Ribeiro, Bianca Pfaffenseller, Laura Stertz, Bruna S Panizzutti, Flávio Kapczinski, João Queved. Olanzapine plus fluoxetine treatment increases Nt-3 protein levels in the rat prefrontal cortex. Neuroscience letters. vol 497. issue 2. 2012-05-01. PMID:21545827. |
our results showed that treatment with fluoxetine and olanzapine alone or in combination did not alter bdnf in the prefrontal cortex (p=0.37), hippocampus (p=0.98) and amygdala (p=0.57) or ngf protein levels in the prefrontal cortex (p=0.72), hippocampus (p=0.23) and amygdala (p=0.64), but nt-3 protein levels were increased by olanzapine 6 mg/kg/fluoxetine 25mg/kg combination in the prefrontal cortex (p=0.03), in the hippocampus (p=0.83) and amygdala (p=0.88) nt-3 protein levels did not alter. |
2012-05-01 |
2023-08-12 |
rat |
| Aderbal S Aguiar, Adalberto A Castro, Eduardo L Moreira, Viviane Glaser, Adair R S Santos, Carla I Tasca, Alexandra Latini, Rui D S Predige. Short bouts of mild-intensity physical exercise improve spatial learning and memory in aging rats: involvement of hippocampal plasticity via AKT, CREB and BDNF signaling. Mechanisms of ageing and development. vol 132. issue 11-12. 2012-04-30. PMID:21983475. |
short bouts of mild-intensity physical exercise improve spatial learning and memory in aging rats: involvement of hippocampal plasticity via akt, creb and bdnf signaling. |
2012-04-30 |
2023-08-12 |
human |
| Aderbal S Aguiar, Adalberto A Castro, Eduardo L Moreira, Viviane Glaser, Adair R S Santos, Carla I Tasca, Alexandra Latini, Rui D S Predige. Short bouts of mild-intensity physical exercise improve spatial learning and memory in aging rats: involvement of hippocampal plasticity via AKT, CREB and BDNF signaling. Mechanisms of ageing and development. vol 132. issue 11-12. 2012-04-30. PMID:21983475. |
remarkably, the observed cognitive-enhancing properties of short bouts of exercise were accompanied by the activation of serine/threonine protein kinase (akt) and camp response element binding (creb) pro-survival signaling that culminates in the marked increase on the brain-derived neurotrophic factor (bdnf) mrna expression and bdnf protein levels on the hippocampus of aging rats. |
2012-04-30 |
2023-08-12 |
human |
| Agata Kiss, Ana Márcia Delattre, Sofia I R Pereira, Ruither G Carolino, Raphael E Szawka, Janete A Anselmo-Franci, Sílvio M Zanata, Anete C Ferra. 17β-estradiol replacement in young, adult and middle-aged female ovariectomized rats promotes improvement of spatial reference memory and an antidepressant effect and alters monoamines and BDNF levels in memory- and depression-related brain areas. Behavioural brain research. vol 227. issue 1. 2012-04-23. PMID:22085882. |
these functions were also correlated with alterations in the serotonergic system, as well as hippocampal bdnf. |
2012-04-23 |
2023-08-12 |
rat |
| Qing-Qiu Mao, Zhen Huang, Siu-Po Ip, Yan-Fang Xian, Chun-Tao Ch. Peony glycosides reverse the effects of corticosterone on behavior and brain BDNF expression in rats. Behavioural brain research. vol 227. issue 1. 2012-04-23. PMID:22119711. |
moreover, it was found that brain-derived neurotrophic factor (bdnf) protein levels in the hippocampus and frontal cortex were significantly decreased in cort-treated rats. |
2012-04-23 |
2023-08-12 |
rat |
| Qing-Qiu Mao, Zhen Huang, Siu-Po Ip, Yan-Fang Xian, Chun-Tao Ch. Peony glycosides reverse the effects of corticosterone on behavior and brain BDNF expression in rats. Behavioural brain research. vol 227. issue 1. 2012-04-23. PMID:22119711. |
the results suggest that tgp produces an antidepressant-like effect in cort-treated rats, which is possibly mediated by increasing bdnf expression in the hippocampus and frontal cortex. |
2012-04-23 |
2023-08-12 |
rat |
| Plinio C Casarotto, Valquiria C de Bortoli, Hélio Zangross. Intrahippocampal injection of brain-derived neurotrophic factor increases anxiety-related, but not panic-related defensive responses: involvement of serotonin. Behavioural pharmacology. vol 23. issue 1. 2012-04-23. PMID:22139606. |
changes in brain-derived neurotrophic factor (bdnf)-mediated signaling in the hippocampus have been implicated in the etiology of depression and in the mode of action of antidepressant drugs. |
2012-04-23 |
2023-08-12 |
rat |
| Plinio C Casarotto, Valquiria C de Bortoli, Hélio Zangross. Intrahippocampal injection of brain-derived neurotrophic factor increases anxiety-related, but not panic-related defensive responses: involvement of serotonin. Behavioural pharmacology. vol 23. issue 1. 2012-04-23. PMID:22139606. |
in the present study, we investigated the effect of an acute bdnf injection into the rat dorsal hippocampus (dh) on inhibitory avoidance acquisition and escape expression measured in the elevated t-maze (etm). |
2012-04-23 |
2023-08-12 |
rat |
| Caixia Bi, Xin Yue, Renping Zhou, Mark R Plumme. EphA activation overrides the presynaptic actions of BDNF. Journal of neurophysiology. vol 105. issue 5. 2012-04-17. PMID:21411563. |
to address this question, we examined the effects of sequential or coapplication of brain-derived neurotrophic factor (bdnf) and fc-conjugated ephrin-a5 or epha5 in cultured embryonic hippocampal neurons. |
2012-04-17 |
2023-08-12 |
Not clear |
| Latha Devi, Masuo Ohn. 7,8-dihydroxyflavone, a small-molecule TrkB agonist, reverses memory deficits and BACE1 elevation in a mouse model of Alzheimer's disease. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 2. 2012-04-17. PMID:21900882. |
5xfad mice showed impairments in the hippocampal bdnf-trkb pathway, as evidenced by significant reductions in bdnf, trkb receptors, and phosphorylated trkb. |
2012-04-17 |
2023-08-12 |
mouse |