| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiang Jin, Peng Liu, Fengchi Yang, Ya-Hong Zhang, Danmin Mia. Rosmarinic acid ameliorates depressive-like behaviors in a rat model of CUS and Up-regulates BDNF levels in the hippocampus and hippocampal-derived astrocytes. Neurochemical research. vol 38. issue 9. 2014-03-10. PMID:23756732. |
rosmarinic acid ameliorates depressive-like behaviors in a rat model of cus and up-regulates bdnf levels in the hippocampus and hippocampal-derived astrocytes. |
2014-03-10 |
2023-08-12 |
rat |
| Xiang Jin, Peng Liu, Fengchi Yang, Ya-Hong Zhang, Danmin Mia. Rosmarinic acid ameliorates depressive-like behaviors in a rat model of CUS and Up-regulates BDNF levels in the hippocampus and hippocampal-derived astrocytes. Neurochemical research. vol 38. issue 9. 2014-03-10. PMID:23756732. |
sprague-dawley rats were exposed to chronic unpredictable stress (cus) for 21 days, and received ra for 14 days from the last week of cus, then the behavioral changes, hippocampal perk1/2 and bdnf levels were observed. |
2014-03-10 |
2023-08-12 |
rat |
| Xiang Jin, Peng Liu, Fengchi Yang, Ya-Hong Zhang, Danmin Mia. Rosmarinic acid ameliorates depressive-like behaviors in a rat model of CUS and Up-regulates BDNF levels in the hippocampus and hippocampal-derived astrocytes. Neurochemical research. vol 38. issue 9. 2014-03-10. PMID:23756732. |
rats were further treated with u0126 (an erk1/2 phosphorylation inhibitor) 30 min before ra treatment to assess the effects of ra and erk1/2 signaling in depressive-like behavior and hippocampal bdnf levels. |
2014-03-10 |
2023-08-12 |
rat |
| Xiang Jin, Peng Liu, Fengchi Yang, Ya-Hong Zhang, Danmin Mia. Rosmarinic acid ameliorates depressive-like behaviors in a rat model of CUS and Up-regulates BDNF levels in the hippocampus and hippocampal-derived astrocytes. Neurochemical research. vol 38. issue 9. 2014-03-10. PMID:23756732. |
ra administration (10 mg/kg daily) reversed depressive-like behaviors in rats exposed to a chronic unpredictable stress paradigm and restored perk1/2 protein expression and hippocampal brain-derived neurotrophic factor (bdnf). |
2014-03-10 |
2023-08-12 |
rat |
| Jian-feng Ji, Sheng-jun Ji, Rui Sun, Kun Li, Yuan Zhang, Li-yuan Zhang, Ye Tia. Forced running exercise attenuates hippocampal neurogenesis impairment and the neurocognitive deficits induced by whole-brain irradiation via the BDNF-mediated pathway. Biochemical and biophysical research communications. vol 443. issue 2. 2014-03-10. PMID:24333433. |
immunofluorescence was used to evaluate the changes in hippocampal neurogenesis and western blotting was used to assess changes in the levels of mature brain-derived neurotrophic factor (bdnf), phosphorylated tyrosine receptor kinase b (trkb) receptor, protein kinase b (akt), extracellular signal-regulated kinase (erk), calcium-calmodulin dependent kinase (camkii), camp-calcium response element binding protein (creb) in the bdnf-pcreb signaling. |
2014-03-10 |
2023-08-12 |
rat |
| Jiping Liu, Liang Feng, Dongying Ma, Minghua Zhang, Junfei Gu, Shuyuan Wang, Qiang Fu, Yu Song, Zhou Lan, Rong Qu, Shiping M. Neuroprotective effect of paeonol on cognition deficits of diabetic encephalopathy in streptozotocin-induced diabetic rat. Neuroscience letters. vol 549. 2014-03-06. PMID:23791853. |
immunohistochemistry and tunel staining showed that paeonol could attenuate apoptosis of neurons and caspase 3 expression, improve two neurotrophic factors bdnf and igf expressions, and also ameliorate aβ deposition in the hippocampus and cerebral cortex. |
2014-03-06 |
2023-08-12 |
rat |
| Yen Ying Lim, Victor L Villemagne, Simon M Laws, David Ames, Robert H Pietrzak, Kathryn A Ellis, Karra D Harrington, Pierrick Bourgeat, Olivier Salvado, David Darby, Peter J Snyder, Ashley I Bush, Ralph N Martins, Colin L Masters, Christopher C Rowe, Pradeep J Nathan, Paul Maruf. BDNF Val66Met, Aβ amyloid, and cognitive decline in preclinical Alzheimer's disease. Neurobiology of aging. vol 34. issue 11. 2014-03-05. PMID:23769397. |
we aimed to determine the relationship between bdnf val66met and beta-amyloid (aβ) on cognitive decline, hippocampal atrophy, and aβ accumulation over 36 months in 165 healthy adults enrolled in the australian imaging, biomarkers and lifestyle study. |
2014-03-05 |
2023-08-12 |
Not clear |
| Yen Ying Lim, Victor L Villemagne, Simon M Laws, David Ames, Robert H Pietrzak, Kathryn A Ellis, Karra D Harrington, Pierrick Bourgeat, Olivier Salvado, David Darby, Peter J Snyder, Ashley I Bush, Ralph N Martins, Colin L Masters, Christopher C Rowe, Pradeep J Nathan, Paul Maruf. BDNF Val66Met, Aβ amyloid, and cognitive decline in preclinical Alzheimer's disease. Neurobiology of aging. vol 34. issue 11. 2014-03-05. PMID:23769397. |
bdnf val66met was not found to be related to rates of change in cognition or hippocampal volume in healthy adults with low aβ. |
2014-03-05 |
2023-08-12 |
Not clear |
| Emilia Romano, Andrea Fuso, Giovanni Laviol. Nicotine restores Wt-like levels of reelin and GAD67 gene expression in brain of heterozygous reeler mice. Neurotoxicity research. vol 24. issue 2. 2014-03-03. PMID:23385624. |
nicotine treatment selectively reversed the hrm-related phenotype in most brain areas and increased bdnf gene expression in cortex and hippocampus of both genotypes. |
2014-03-03 |
2023-08-12 |
mouse |
| Alja Videtič Paska, Tomaž Zupanc, Peter Pregel. The role of brain-derived neurotrophic factor in the pathophysiology of suicidal behavior. Psychiatria Danubina. vol 25 Suppl 2. 2014-02-25. PMID:23995205. |
it was also found that the mrna and protein level of bdnf was significantly lower in both the prefrontal cortex and the hippocampus of suicide subjects. |
2014-02-25 |
2023-08-12 |
human |
| P F Jiang, T Zhu, J D Gao, F Gao, S S Mao, W T Zhao, W Z Gu, H M Y. The effect of maternal infection on cognitive development and hippocampus neuronal apoptosis, proliferation and differentiation in the neonatal rats. Neuroscience. vol 246. 2014-02-24. PMID:23597829. |
terminal deoxynucleotidyl transferase dutp nick end labeling assay was used to determine neuronal apoptosis, immunostaining was conducted to assess neurogenesis, and western blot for extracellular signal-regulated kinase (erk), cyclic amp responsive element-binding protein (creb) and brain-derived neurotrophic factor (bdnf) expression in the hippocampus. |
2014-02-24 |
2023-08-12 |
rat |
| Faezeh Vahdati Hassani, Vahideh Naseri, Bibi Marjan Razavi, Soghra Mehri, Khalil Abnous, Hossein Hosseinzade. Antidepressant effects of crocin and its effects on transcript and protein levels of CREB, BDNF, and VGF in rat hippocampus. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences. vol 22. issue 1. 2014-02-19. PMID:24401376. |
antidepressant effects of crocin and its effects on transcript and protein levels of creb, bdnf, and vgf in rat hippocampus. |
2014-02-19 |
2023-08-12 |
rat |
| Faezeh Vahdati Hassani, Vahideh Naseri, Bibi Marjan Razavi, Soghra Mehri, Khalil Abnous, Hossein Hosseinzade. Antidepressant effects of crocin and its effects on transcript and protein levels of CREB, BDNF, and VGF in rat hippocampus. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences. vol 22. issue 1. 2014-02-19. PMID:24401376. |
the aim of this study was to verify the subacute antidepressant effects of crocin, an active constituent of saffron (crocus sativus l.), and its effects on creb, bdnf, and vgf proteins, transcript levels and amount of active, phosphorylated creb (p-creb) protein in rat hippocampus. |
2014-02-19 |
2023-08-12 |
rat |
| Beth Levan. N-3 (omega-3) polyunsaturated Fatty acids in the pathophysiology and treatment of depression: pre-clinical evidence. CNS & neurological disorders drug targets. vol 12. issue 4. 2014-02-18. PMID:23574159. |
in addition, these pre-clinical findings indicate neurobiological mechanisms whereby n-3 pufas may contribute to the disease including control of serotonergic and dopaminergic function, modulation of brain-derived neurotrophic factor (bdnf) in the hippocampus, regulation of the hypothalamic-pituitary-adrenal axis, and effects on neuroinflammation. |
2014-02-18 |
2023-08-12 |
Not clear |
| Undine E Lang, Stefan Borgward. Molecular mechanisms of depression: perspectives on new treatment strategies. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 31. issue 6. 2014-02-18. PMID:23735822. |
the neurodegenerative hypothesis of depression explains decreased hippocampal volumes in depressed patients and changes of neurotrophic support by bdnf, erythropoietin, gdnf, fgf-2, nt3, ngf and growth hormone. |
2014-02-18 |
2023-08-12 |
Not clear |
| Katsunori Yamaura, Yuanyuan Bi, Makiko Ishiwatari, Nobuo Oishi, Hideki Fukata, Koichi Uen. Sex differences in stress reactivity of hippocampal BDNF in mice are associated with the female preponderance of decreased locomotor activity in response to restraint stress. Zoological science. vol 30. issue 12. 2014-02-18. PMID:24320179. |
sex differences in stress reactivity of hippocampal bdnf in mice are associated with the female preponderance of decreased locomotor activity in response to restraint stress. |
2014-02-18 |
2023-08-12 |
mouse |
| Katsunori Yamaura, Yuanyuan Bi, Makiko Ishiwatari, Nobuo Oishi, Hideki Fukata, Koichi Uen. Sex differences in stress reactivity of hippocampal BDNF in mice are associated with the female preponderance of decreased locomotor activity in response to restraint stress. Zoological science. vol 30. issue 12. 2014-02-18. PMID:24320179. |
the purpose of this study was to investigate the female preponderance in behavioral responsivity to restraint stress focusing on the stress reactivity of bdnf in the hippocampus. |
2014-02-18 |
2023-08-12 |
mouse |
| Katsunori Yamaura, Yuanyuan Bi, Makiko Ishiwatari, Nobuo Oishi, Hideki Fukata, Koichi Uen. Sex differences in stress reactivity of hippocampal BDNF in mice are associated with the female preponderance of decreased locomotor activity in response to restraint stress. Zoological science. vol 30. issue 12. 2014-02-18. PMID:24320179. |
bdnf mrna expression in the whole hippocampus was measured by quantitative real-time reverse transcription-polymerase chain reaction. |
2014-02-18 |
2023-08-12 |
mouse |
| Katsunori Yamaura, Yuanyuan Bi, Makiko Ishiwatari, Nobuo Oishi, Hideki Fukata, Koichi Uen. Sex differences in stress reactivity of hippocampal BDNF in mice are associated with the female preponderance of decreased locomotor activity in response to restraint stress. Zoological science. vol 30. issue 12. 2014-02-18. PMID:24320179. |
in addition to these sex differences in stress reactivity, we found a significant sex difference in bdnf levels in the hippocampus of restraint-stressed mice; total bdnf levels significantly decreased in female mice, but not in male mice in response to the stress. |
2014-02-18 |
2023-08-12 |
mouse |
| Katsunori Yamaura, Yuanyuan Bi, Makiko Ishiwatari, Nobuo Oishi, Hideki Fukata, Koichi Uen. Sex differences in stress reactivity of hippocampal BDNF in mice are associated with the female preponderance of decreased locomotor activity in response to restraint stress. Zoological science. vol 30. issue 12. 2014-02-18. PMID:24320179. |
moreover, our findings suggest a link between the sex differences in this behavioral response to stress and differential stress reactivity in the production of bdnf in the hippocampus. |
2014-02-18 |
2023-08-12 |
mouse |