| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yulian Miao, Jianmin Ren, Ling Jiang, Jinbo Liu, Bei Jiang, Xiaoli Zhan. α-Lipoic acid attenuates obesity-associated hippocampal neuroinflammation and increases the levels of brain-derived neurotrophic factor in ovariectomized rats fed a high-fat diet. International journal of molecular medicine. vol 32. issue 5. 2014-05-09. PMID:24008266. |
in this study, to investigate the effects of α-la on neuroinflammatory factors and the levels of hippocampal brain-derived neurotrophic factor (bdnf) in ovariectomized rats fed a high-fat diet (hfd), wistar ovariectomized rats were fed hfd alone or hfd and treated with α-la for 12 weeks. |
2014-05-09 |
2023-08-12 |
rat |
| Yulian Miao, Jianmin Ren, Ling Jiang, Jinbo Liu, Bei Jiang, Xiaoli Zhan. α-Lipoic acid attenuates obesity-associated hippocampal neuroinflammation and increases the levels of brain-derived neurotrophic factor in ovariectomized rats fed a high-fat diet. International journal of molecular medicine. vol 32. issue 5. 2014-05-09. PMID:24008266. |
metabolic parameters in serum were detected, real-time polymerase chain reaction (rt-pcr), western blot analysis and elisa were used to evaluate the levels of inflammatory factors and bdnf in the hippocampus. |
2014-05-09 |
2023-08-12 |
rat |
| Yulian Miao, Jianmin Ren, Ling Jiang, Jinbo Liu, Bei Jiang, Xiaoli Zhan. α-Lipoic acid attenuates obesity-associated hippocampal neuroinflammation and increases the levels of brain-derived neurotrophic factor in ovariectomized rats fed a high-fat diet. International journal of molecular medicine. vol 32. issue 5. 2014-05-09. PMID:24008266. |
in the hippocampal tissues of ovariectomized rats fed hfd, the protein and mrna expression of bdnf was upregulated following the administration of α-la. |
2014-05-09 |
2023-08-12 |
rat |
| Yulian Miao, Jianmin Ren, Ling Jiang, Jinbo Liu, Bei Jiang, Xiaoli Zhan. α-Lipoic acid attenuates obesity-associated hippocampal neuroinflammation and increases the levels of brain-derived neurotrophic factor in ovariectomized rats fed a high-fat diet. International journal of molecular medicine. vol 32. issue 5. 2014-05-09. PMID:24008266. |
these findings demonstrate that α-la significantly increases the expression of bdnf in the hippocampus of obese ovariectomized rats fed hfd, possibly by improving lipid metabolism, enhancing insulin sensitivity and reversing central inflammation. |
2014-05-09 |
2023-08-12 |
rat |
| Alexandre Aparecido de Almeida, Sérgio Gomes da Silva, Jansen Fernandes, Luiz Fernando Peixinho-Pena, Fulvio Alexandre Scorza, Esper Abrão Cavalheiro, Ricardo Mario Arid. Differential effects of exercise intensities in hippocampal BDNF, inflammatory cytokines and cell proliferation in rats during the postnatal brain development. Neuroscience letters. vol 553. 2014-05-08. PMID:23958502. |
differential effects of exercise intensities in hippocampal bdnf, inflammatory cytokines and cell proliferation in rats during the postnatal brain development. |
2014-05-08 |
2023-08-12 |
rat |
| Alexandre Aparecido de Almeida, Sérgio Gomes da Silva, Jansen Fernandes, Luiz Fernando Peixinho-Pena, Fulvio Alexandre Scorza, Esper Abrão Cavalheiro, Ricardo Mario Arid. Differential effects of exercise intensities in hippocampal BDNF, inflammatory cytokines and cell proliferation in rats during the postnatal brain development. Neuroscience letters. vol 553. 2014-05-08. PMID:23958502. |
to investigate the impact of exercise intensity in developing rats, we evaluated the hippocampal level of brain derived neurotrophic factor (bdnf), inflammatory cytokines (tnfα, il6 and il10) and the occurrence of hippocampal cell degeneration and proliferation at different stages of postnatal brain development of rats submitted to two physical exercise intensities. |
2014-05-08 |
2023-08-12 |
rat |
| Alexandre Aparecido de Almeida, Sérgio Gomes da Silva, Jansen Fernandes, Luiz Fernando Peixinho-Pena, Fulvio Alexandre Scorza, Esper Abrão Cavalheiro, Ricardo Mario Arid. Differential effects of exercise intensities in hippocampal BDNF, inflammatory cytokines and cell proliferation in rats during the postnatal brain development. Neuroscience letters. vol 553. 2014-05-08. PMID:23958502. |
our data show that exercise-induced neuroplastic effects on bdnf levels and cellular proliferation in the hippocampal region are dependent on exercise intensity and developmental period. |
2014-05-08 |
2023-08-12 |
rat |
| Georgina de Foubert, Ahmad A Khundakar, Tyra S Zetterströ. Effects of repeated 5-HT₆ receptor stimulation on BDNF gene expression and cell survival. Neuroscience letters. vol 553. 2014-05-08. PMID:23981663. |
the previously reported acute stimulatory action of the selective 5-ht₆ agonist ly-586713 on hippocampal bdnf expression was still present following sub-chronic (4 days), but not chronic (14 days), treatment. |
2014-05-08 |
2023-08-12 |
Not clear |
| Myoung-Hwa Lee, Niranjana D Amin, Arun Venkatesan, Tongguang Wang, Richa Tyagi, Harish C Pant, Avindra Nat. Impaired neurogenesis and neurite outgrowth in an HIV-gp120 transgenic model is reversed by exercise via BDNF production and Cdk5 regulation. Journal of neurovirology. vol 19. issue 5. 2014-05-07. PMID:23982957. |
furthermore, it increased the expression of hippocampal brain-derived neurotrophic factor (bdnf) and normalized hyperactivation of cyclin-dependent kinase 5 (cdk5). |
2014-05-07 |
2023-08-12 |
mouse |
| Tomoko Ikeno, Zachary M Weil, Randy J Nelso. Photoperiod affects the diurnal rhythm of hippocampal neuronal morphology of Siberian hamsters. Chronobiology international. vol 30. issue 9. 2014-05-02. PMID:23879697. |
in the present study, we examined diurnal and seasonal differences in hippocampal neuronal morphology, as well as mrna expression of the neurotrophic factors (i.e., brain-derived neurotrophic factor [bdnf], tropomyosin receptor kinase b [trkb; a receptor for bdnf], and vascular endothelial growth factor [vegf]) and a circadian clock gene, bmal1, in the hippocampus of siberian hamsters. |
2014-05-02 |
2023-08-12 |
Not clear |
| Thomas Andreska, Sarah Aufmkolk, Markus Sauer, Robert Blu. High abundance of BDNF within glutamatergic presynapses of cultured hippocampal neurons. Frontiers in cellular neuroscience. vol 8. 2014-04-30. PMID:24782711. |
high abundance of bdnf within glutamatergic presynapses of cultured hippocampal neurons. |
2014-04-30 |
2023-08-13 |
Not clear |
| Thomas Andreska, Sarah Aufmkolk, Markus Sauer, Robert Blu. High abundance of BDNF within glutamatergic presynapses of cultured hippocampal neurons. Frontiers in cellular neuroscience. vol 8. 2014-04-30. PMID:24782711. |
recent data provide strong evidence for an exclusive presynaptic location and anterograde secretion of endogenous bdnf at synapses of the hippocampal circuit. |
2014-04-30 |
2023-08-13 |
Not clear |
| Thomas Andreska, Sarah Aufmkolk, Markus Sauer, Robert Blu. High abundance of BDNF within glutamatergic presynapses of cultured hippocampal neurons. Frontiers in cellular neuroscience. vol 8. 2014-04-30. PMID:24782711. |
in contrast, various studies using bdnf overexpression in cultured hippocampal neurons support the idea that postsynaptic elements and other dendritic structures are the preferential sites of bdnf localization and release. |
2014-04-30 |
2023-08-13 |
Not clear |
| Thomas Andreska, Sarah Aufmkolk, Markus Sauer, Robert Blu. High abundance of BDNF within glutamatergic presynapses of cultured hippocampal neurons. Frontiers in cellular neuroscience. vol 8. 2014-04-30. PMID:24782711. |
our data proof that hippocampal neurons are able to enrich and store high amounts of bdnf in small granules within the mature glutamatergic presynapse, at a principle site of synaptic plasticity. |
2014-04-30 |
2023-08-13 |
Not clear |
| Marta Nowacka, Ewa Obuchowic. BDNF and VEGF in the pathogenesis of stress-induced affective diseases: an insight from experimental studies. Pharmacological reports : PR. vol 65. issue 3. 2014-04-24. PMID:23950576. |
experimental studies indicate that a well-known brain-derived neurotrophic factor (bdnf) and vascular endothelial growth factor (vegf) which have recently focused increasing attention of neuroscientists, promote cell survival, positively modulate neuroplasticity and hippocampal neurogenesis. |
2014-04-24 |
2023-08-12 |
Not clear |
| P Ambrogini, D Lattanzi, S Ciuffoli, M Betti, M Fanelli, R Cuppin. Physical exercise and environment exploration affect synaptogenesis in adult-generated neurons in the rat dentate gyrus: possible role of BDNF. Brain research. vol 1534. 2014-04-22. PMID:23973748. |
considering that neurotrophic factors increase after exercise or environment exploration, hippocampal bdnf levels and trkb receptor activation were evaluated. |
2014-04-22 |
2023-08-12 |
rat |
| P Ambrogini, D Lattanzi, S Ciuffoli, M Betti, M Fanelli, R Cuppin. Physical exercise and environment exploration affect synaptogenesis in adult-generated neurons in the rat dentate gyrus: possible role of BDNF. Brain research. vol 1534. 2014-04-22. PMID:23973748. |
hippocampal bdnf levels and trkb receptor activation were determined to be increasing following physical activity and exploration. |
2014-04-22 |
2023-08-12 |
rat |
| Ryoko Suzuki, Masahito Matsumoto, Akihiro Fujikawa, Akira Kato, Kazuya Kuboyama, Keisuke Yonehara, Takafumi Shintani, Hiraki Sakuta, Masaharu Nod. SPIG1 negatively regulates BDNF maturation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 9. 2014-04-22. PMID:24573299. |
the amount of mature bdnf proteins as well as the tyrosine phosphorylation level of the bdnf receptor, tropomyosin-related kinase b (trkb), in the hippocampus were significantly higher in spig1-knockout mice than in wild-type mice. |
2014-04-22 |
2023-08-12 |
mouse |
| Agustin Anastasia, Katrin Deinhardt, Moses V Chao, Nathan E Will, Krithi Irmady, Francis S Lee, Barbara L Hempstead, Clay Bracke. Val66Met polymorphism of BDNF alters prodomain structure to induce neuronal growth cone retraction. Nature communications. vol 4. 2014-04-21. PMID:24048383. |
here we show that the isolated bdnf prodomain is detected in the hippocampus and that it can be secreted from neurons in an activity-dependent manner. |
2014-04-21 |
2023-08-12 |
human |
| Agustin Anastasia, Katrin Deinhardt, Moses V Chao, Nathan E Will, Krithi Irmady, Francis S Lee, Barbara L Hempstead, Clay Bracke. Val66Met polymorphism of BDNF alters prodomain structure to induce neuronal growth cone retraction. Nature communications. vol 4. 2014-04-21. PMID:24048383. |
surprisingly, application of met66 (but not val66) bdnf prodomain induces acute growth cone retraction and a decrease in rac activity in hippocampal neurons. |
2014-04-21 |
2023-08-12 |
human |