| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Ryley Parrish, A J Albertson, S C Buckingham, J J Hablitz, K L Mascia, W Davis Haselden, F D Lubi. Status epilepticus triggers early and late alterations in brain-derived neurotrophic factor and NMDA glutamate receptor Grin2b DNA methylation levels in the hippocampus. Neuroscience. vol 248. 2015-11-03. PMID:23811393. |
status epilepticus (se) triggers abnormal expression of genes in the hippocampus, such as glutamate receptor subunit epsilon-2 (grin2b/nr2b) and brain-derived neurotrophic factor (bdnf), that is thought to occur in temporal lobe epilepsy (tle). |
2015-11-03 |
2023-08-12 |
rat |
| R Ryley Parrish, A J Albertson, S C Buckingham, J J Hablitz, K L Mascia, W Davis Haselden, F D Lubi. Status epilepticus triggers early and late alterations in brain-derived neurotrophic factor and NMDA glutamate receptor Grin2b DNA methylation levels in the hippocampus. Neuroscience. vol 248. 2015-11-03. PMID:23811393. |
bisulfite sequencing analysis revealed increased grin2b/nr2b and decreased bdnf dna methylation levels that corresponded to decreased grin2b/nr2b and increased bdnf mrna and protein expression in the epileptic hippocampus. |
2015-11-03 |
2023-08-12 |
rat |
| Jong-Seok Kan. Exercise copes with prolonged stress-induced impairment of spatial memory performance by endoplasmic reticulum stress. Journal of exercise nutrition & biochemistry. vol 19. issue 3. 2015-11-03. PMID:26527209. |
in addition, the hippocampal expression pattern of phospho-camp response element-binding protein (creb) and brain-derived neurotrophic factor (bdnf) opposed that of er stress response components. |
2015-11-03 |
2023-08-13 |
Not clear |
| C Isgor, C Pare, B McDole, P Coombs, K Guthri. Expansion of the dentate mossy fiber-CA3 projection in the brain-derived neurotrophic factor-enriched mouse hippocampus. Neuroscience. vol 288. 2015-10-29. PMID:25555929. |
these behavioral changes suggest that chronic increases in bdnf progressively disrupt hippocampal functional organization. |
2015-10-29 |
2023-08-13 |
mouse |
| Ayfer Dayi, Ferihan Cetin, Ali Riza Sisman, Ilkay Aksu, Aysegul Tas, Sevil Gönenc, Nazan Uysa. The effects of oxytocin on cognitive defect caused by chronic restraint stress applied to adolescent rats and on hippocampal VEGF and BDNF levels. Medical science monitor : international medical journal of experimental and clinical research. vol 21. 2015-10-27. PMID:25559382. |
the effects of oxytocin on cognitive defect caused by chronic restraint stress applied to adolescent rats and on hippocampal vegf and bdnf levels. |
2015-10-27 |
2023-08-13 |
rat |
| Ayfer Dayi, Ferihan Cetin, Ali Riza Sisman, Ilkay Aksu, Aysegul Tas, Sevil Gönenc, Nazan Uysa. The effects of oxytocin on cognitive defect caused by chronic restraint stress applied to adolescent rats and on hippocampal VEGF and BDNF levels. Medical science monitor : international medical journal of experimental and clinical research. vol 21. 2015-10-27. PMID:25559382. |
this study aimed to investigate chronic restraint stress on hippocampal functions, and hippocampal vascular endothelial growth factor (vegf) and brain-derived neurotrophic factor (bdnf) levels in adolescent male and female rats and the role of oxytocin in these effects. |
2015-10-27 |
2023-08-13 |
rat |
| Maira J Maturana, Cláudia Pudell, Adriano D S Targa, Laís S Rodrigues, Ana Carolina D Noseda, Mariana H Fortes, Patrícia Dos Santos, Cláudio Da Cunha, Sílvio M Zanata, Anete C Ferraz, Marcelo M S Lim. REM sleep deprivation reverses neurochemical and other depressive-like alterations induced by olfactory bulbectomy. Molecular neurobiology. vol 51. issue 1. 2015-10-20. PMID:24826915. |
remsd triggered antidepressant mechanisms such as the increment of brain-derived neurotrophic factor (bdnf) levels, within the substantia nigra pars compacta (snpc), which were strongly correlated to the swimming time (r = 0.83; p < 0.0001) and hippocampal serotonin (5-ht) content (r = 0.66; p = 0.004). |
2015-10-20 |
2023-08-13 |
rat |
| Maira J Maturana, Cláudia Pudell, Adriano D S Targa, Laís S Rodrigues, Ana Carolina D Noseda, Mariana H Fortes, Patrícia Dos Santos, Cláudio Da Cunha, Sílvio M Zanata, Anete C Ferraz, Marcelo M S Lim. REM sleep deprivation reverses neurochemical and other depressive-like alterations induced by olfactory bulbectomy. Molecular neurobiology. vol 51. issue 1. 2015-10-20. PMID:24826915. |
we suggested that the neurochemical complexity inflicted by the obx model, counteracted by remsd, is directly correlated to the nigral bdnf expression and hippocampal 5-ht levels. |
2015-10-20 |
2023-08-13 |
rat |
| Indira Mendez-David, Laurent Tritschler, Zeina El Ali, Marie-Hélène Damiens, Marc Pallardy, Denis J David, Saadia Kerdine-Römer, Alain M Gardie. Nrf2-signaling and BDNF: A new target for the antidepressant-like activity of chronic fluoxetine treatment in a mouse model of anxiety/depression. Neuroscience letters. vol 597. 2015-10-19. PMID:25916883. |
furthermore, we found that chronic fluoxetine also increased brain derived neurotrophic factor (bdnf) protein levels in cortex and hippocampus of cort-treated nrf2 knockout mice (ko, nrf2(-/-)). |
2015-10-19 |
2023-08-13 |
mouse |
| Túlio Cezar de Souza Bernardino, Antonio Lúcio Teixeira, Aline Silva Miranda, Patrícia Maia Guidine, Gustavo Rezende, Maria Carolina Doretto, Gabriel Perfeito Castro, Luciana Drummond, Márcio Flávio Dutra Moraes, Pedro Augusto Lopes Tito, Antonio Carlos Pinheiro de Oliveira, Helton José Rei. Wistar Audiogenic Rats (WAR) exhibit altered levels of cytokines and brain-derived neurotrophic factor following audiogenic seizures. Neuroscience letters. vol 597. 2015-10-19. PMID:25936592. |
four hours after stimulation, animals were decapitated and the hippocampus, inferior colliculus, striatum and cortex were removed for evaluation of the levels of interleukin (il)-1β, il-6, tumor necrosis factor (tnf)-α and brain derived neurotrophic factor (bdnf). |
2015-10-19 |
2023-08-13 |
rat |
| Ataç Sönmez, Oya Sayın, Seren Gülşen Gürgen, Meryem Çalişi. Neuroprotective effects of MK-801 against traumatic brain injury in immature rats. Neuroscience letters. vol 597. 2015-10-19. PMID:25943283. |
the aims of the present study were to determine: (i) the short term effects of mk-801 on hippocampal bdnf, ngf and nmda receptor immunoreactivity and neuron density in hippocampus (ii) long term effects of mk-801 on cognitive dysfunction following tbi in the immature rats. |
2015-10-19 |
2023-08-13 |
rat |
| Ataç Sönmez, Oya Sayın, Seren Gülşen Gürgen, Meryem Çalişi. Neuroprotective effects of MK-801 against traumatic brain injury in immature rats. Neuroscience letters. vol 597. 2015-10-19. PMID:25943283. |
hippocampal damage was examined by cresyl violet staining, bdnf, ngf and nmdar receptor immunohistochemistry on p10 day and behavioral alterations were evaluated using elevated plus maze and novel object recognition tests two months after the trauma. |
2015-10-19 |
2023-08-13 |
rat |
| Ataç Sönmez, Oya Sayın, Seren Gülşen Gürgen, Meryem Çalişi. Neuroprotective effects of MK-801 against traumatic brain injury in immature rats. Neuroscience letters. vol 597. 2015-10-19. PMID:25943283. |
significantly ameliorated the trauma induced hippocampal neuron loss and decreased bdnf, ngf and nmdar expressions in ca1, ca3 and dg hippocampal brain regions. |
2015-10-19 |
2023-08-13 |
rat |
| Padmanabh Singh, Arpita Konar, Ashish Kumar, Sweta Srivas, Mahendra K Thaku. Hippocampal chromatin-modifying enzymes are pivotal for scopolamine-induced synaptic plasticity gene expression changes and memory impairment. Journal of neurochemistry. vol 134. issue 4. 2015-10-19. PMID:25982413. |
we propose the following putative pathway for scopolamine-mediated memory impairment; scopolamine up-regulates hippocampal dnmt1 and hdac2 expression, induces methylation and deacetylation of bdnf and arc promoter, represses gene expression and eventually impairs memory consolidation. |
2015-10-19 |
2023-08-13 |
Not clear |
| Shawn Hayley, Lisheng Du, Darcy Litteljohn, Miklós Palkovits, Gábor Faludi, Zul Merali, Michael O Poulter, Hymie Anisma. Gender and brain regions specific differences in brain derived neurotrophic factor protein levels of depressed individuals who died through suicide. Neuroscience letters. vol 600. 2015-10-19. PMID:26033186. |
using postmortem samples from non-psychiatric controls and depressed individuals who died by suicide, bdnf protein levels were assessed within the hippocampus and frontopolar prefrontal cortex using western blot. |
2015-10-19 |
2023-08-13 |
Not clear |
| Shawn Hayley, Lisheng Du, Darcy Litteljohn, Miklós Palkovits, Gábor Faludi, Zul Merali, Michael O Poulter, Hymie Anisma. Gender and brain regions specific differences in brain derived neurotrophic factor protein levels of depressed individuals who died through suicide. Neuroscience letters. vol 600. 2015-10-19. PMID:26033186. |
contrastingly, within the hippocampus, depressed male but not female suicides displayed significant reductions of bdnf protein levels. |
2015-10-19 |
2023-08-13 |
Not clear |
| Chuang Wang, Jianrui Zhang, Yang Lu, Peipei Lin, Tonghe Pan, Xin Zhao, Aiming Liu, Qinwen Wang, Wenhua Zhou, Han-Ting Zhan. Antidepressant-like effects of the phosphodiesterase-4 inhibitor etazolate and phosphodiesterase-5 inhibitor sildenafil via cyclic AMP or cyclic GMP signaling in mice. Metabolic brain disease. vol 29. issue 3. 2015-10-16. PMID:24705918. |
the levels of camp, cgmp and expression of pcreb, creb, bdnf and vgf in both the hippocampus and prefrontal cortex were determined. |
2015-10-16 |
2023-08-13 |
mouse |
| Xiaolin Yang, Qinyan Yang, Xiaobin Wang, Chunqiong Luo, Yunqiang Wan, Jiali Li, Kezhi Liu, Min Zhou, Chunxiang Zhan. MicroRNA expression profile and functional analysis reveal that miR-206 is a critical novel gene for the expression of BDNF induced by ketamine. Neuromolecular medicine. vol 16. issue 3. 2015-10-15. PMID:24839168. |
in both cultured neuronal cells in vitro and hippocampus in vivo, we identified that the brain-derived neurotrophic factor (bdnf) was a direct target gene of mir-206. |
2015-10-15 |
2023-08-13 |
rat |
| Q-S Wang, J-S Tian, Y-L Cui, S Ga. Genipin is active via modulating monoaminergic transmission and levels of brain-derived neurotrophic factor (BDNF) in rat model of depression. Neuroscience. vol 275. 2015-10-15. PMID:24972301. |
these results suggest that the possible mechanism of antidepressant-like effects on genipin, at least in one part, resulted from monoaminergic neurotransmitter system and the potential dysfunctional regulation of the post-receptor signaling pathway, which particularly affected the 5-ht(1a)r, 5-ht(2a)r and bdnf levels in the hippocampus. |
2015-10-15 |
2023-08-13 |
rat |
| Anne L Lardne. Vitamin D and hippocampal development-the story so far. Frontiers in molecular neuroscience. vol 8. 2015-10-15. PMID:26468295. |
further avenues of future research are outlined including animal studies on the effects of vitamin d deprivation and inadequacy on early hippocampal biochemistry and function, e.g., measurement of bdnf levels, gabaergic activity, long-term potentiation (ltp) and spatial navigation. |
2015-10-15 |
2023-08-13 |
rat |