| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ludwig Stenz, Seblewongel Zewdie, Térèse Laforge-Escarra, Julien Prados, Romano La Harpe, Alexandre Dayer, Ariane Paoloni-Giacobino, Nader Perroud, Jean-Michel Aubr. BDNF promoter I methylation correlates between post-mortem human peripheral and brain tissues. Neuroscience research. vol 91. 2015-11-20. PMID:25450314. |
in the hippocampus, bdnf promoter i and iv methylation levels were strongly correlated (pearson, n = 37, r = 0.74, p = 1.4 × 10(-7)). |
2015-11-20 |
2023-08-13 |
human |
| Klemencja Berghauzen-Maciejewska, Jadwiga Wardas, Barbara Kosmowska, Urszula Głowacka, Katarzyna Kuter, Krystyna Ossowsk. Alterations of BDNF and trkB mRNA expression in the 6-hydroxydopamine-induced model of preclinical stages of Parkinson's disease: an influence of chronic pramipexole in rats. PloS one. vol 10. issue 3. 2015-11-20. PMID:25739024. |
the lesion lowered the bdnf and trkb mrna levels in the hippocampus [ca1, ca3 and dentate gyrus (dg)] and amygdala (basolateral/lateral) as well as the bdnf mrna content in the habenula (medial/lateral). |
2015-11-20 |
2023-08-13 |
rat |
| Min-Tae Jeon, Jin Han Nam, Won-Ho Shin, Eunju Leem, Kyoung Hoon Jeong, Un Ju Jung, Young-Seuk Bae, Young-Ho Jin, Nikolai Kholodilov, Robert E Burke, Seok-Geun Lee, Byung Kwan Jin, Sang Ryong Ki. In vivo AAV1 transduction with hRheb(S16H) protects hippocampal neurons by BDNF production. Molecular therapy : the journal of the American Society of Gene Therapy. vol 23. issue 3. 2015-11-16. PMID:25502903. |
in vivo aav1 transduction with hrheb(s16h) protects hippocampal neurons by bdnf production. |
2015-11-16 |
2023-08-13 |
human |
| Min-Tae Jeon, Jin Han Nam, Won-Ho Shin, Eunju Leem, Kyoung Hoon Jeong, Un Ju Jung, Young-Seuk Bae, Young-Ho Jin, Nikolai Kholodilov, Robert E Burke, Seok-Geun Lee, Byung Kwan Jin, Sang Ryong Ki. In vivo AAV1 transduction with hRheb(S16H) protects hippocampal neurons by BDNF production. Molecular therapy : the journal of the American Society of Gene Therapy. vol 23. issue 3. 2015-11-16. PMID:25502903. |
transduction with hrheb(s16h) significantly induced neurotrophic effects in hippocampal neurons through activation of mammalian target of rapamycin complex 1 (mtorc1) without side effects such as long-term potentiation impairment and seizures from the alteration of cytoarchitecture, and the expression of hrheb(s16h) prevented thrombin-induced neurodegeneration in vivo, an effect that was diminished by treatment with specific neutralizing antibodies against brain-derived neurotrophic factor (bdnf). |
2015-11-16 |
2023-08-13 |
human |
| Min-Tae Jeon, Jin Han Nam, Won-Ho Shin, Eunju Leem, Kyoung Hoon Jeong, Un Ju Jung, Young-Seuk Bae, Young-Ho Jin, Nikolai Kholodilov, Robert E Burke, Seok-Geun Lee, Byung Kwan Jin, Sang Ryong Ki. In vivo AAV1 transduction with hRheb(S16H) protects hippocampal neurons by BDNF production. Molecular therapy : the journal of the American Society of Gene Therapy. vol 23. issue 3. 2015-11-16. PMID:25502903. |
in addition, our results showed that the basal mtorc1 activity might be insufficient to mediate the level of bdnf expression, but hrheb(s16h)-activated mtorc1 stimulated bdnf production in hippocampal neurons. |
2015-11-16 |
2023-08-13 |
human |
| Danielle Camer, Yinghua Yu, Alexander Szabo, Francesca Fernandez, Chi H L Dinh, Xu-Feng Huan. Bardoxolone methyl prevents high-fat diet-induced alterations in prefrontal cortex signalling molecules involved in recognition memory. Progress in neuro-psychopharmacology & biological psychiatry. vol 59. 2015-11-16. PMID:25584778. |
downstream brain-derived neurotrophic factor (bdnf) signalling molecules were examined in the prefrontal cortex (pfc) and hippocampus of mice via western blotting and n-methyl-d-aspartate (nmda) receptor binding. |
2015-11-16 |
2023-08-13 |
mouse |
| Danielle Camer, Yinghua Yu, Alexander Szabo, Francesca Fernandez, Chi H L Dinh, Xu-Feng Huan. Bardoxolone methyl prevents high-fat diet-induced alterations in prefrontal cortex signalling molecules involved in recognition memory. Progress in neuro-psychopharmacology & biological psychiatry. vol 59. 2015-11-16. PMID:25584778. |
in the pfc and hippocampus of the hf diet fed mice, bm administration improved downstream bdnf signalling as indicated by increased protein levels of bdnf, phosphorylated tropomyosin related kinase b (ptrkb) and phosphorylated protein kinase b (pakt), and increased phosphorylated amp-activated protein kinase (pampk) (p<0.05). |
2015-11-16 |
2023-08-13 |
mouse |
| Danielle Camer, Yinghua Yu, Alexander Szabo, Francesca Fernandez, Chi H L Dinh, Xu-Feng Huan. Bardoxolone methyl prevents high-fat diet-induced alterations in prefrontal cortex signalling molecules involved in recognition memory. Progress in neuro-psychopharmacology & biological psychiatry. vol 59. 2015-11-16. PMID:25584778. |
in summary, these findings suggest that bm prevents hf diet-induced impairments in recognition memory by improving downstream bdnf signal transduction, increasing pampk, and reducing inflammation in the pfc and hippocampus. |
2015-11-16 |
2023-08-13 |
mouse |
| Luana M Manosso, Morgana Moretti, Camille M Ribeiro, Filipe M Gonçalves, Rodrigo B Leal, Ana Lúcia S Rodrigue. Antidepressant-like effect of zinc is dependent on signaling pathways implicated in BDNF modulation. Progress in neuro-psychopharmacology & biological psychiatry. vol 59. 2015-11-16. PMID:25600102. |
the occurrence of changes in creb phosphorylation and bdnf immunocontent in the hippocampus and prefrontal cortex of mice following zncl2 treatment was also investigated. |
2015-11-16 |
2023-08-13 |
mouse |
| Luana M Manosso, Morgana Moretti, Camille M Ribeiro, Filipe M Gonçalves, Rodrigo B Leal, Ana Lúcia S Rodrigue. Antidepressant-like effect of zinc is dependent on signaling pathways implicated in BDNF modulation. Progress in neuro-psychopharmacology & biological psychiatry. vol 59. 2015-11-16. PMID:25600102. |
however, zinc is not able to acutely increase bdnf in the hippocampus and prefrontal cortex. |
2015-11-16 |
2023-08-13 |
mouse |
| Filip Vanevski, Baoji X. HuD interacts with Bdnf mRNA and is essential for activity-induced BDNF synthesis in dendrites. PloS one. vol 10. issue 2. 2015-11-16. PMID:25692578. |
we demonstrate that the neuronal elav family of rna binding proteins associates in vivo with several bdnf mrna isoforms present in the adult brain in an activity-dependent manner, and that one member, hud, interacts directly with sequences in the long bdnf 3' untranslated region (3'utr) and co-localizes with bdnf mrna in dendrites of hippocampal neurons. |
2015-11-16 |
2023-08-13 |
Not clear |
| Oliver Takach, Trevor B Gill, Michael A Silverma. Modulation of insulin signaling rescues BDNF transport defects independent of tau in amyloid-β oligomer-treated hippocampal neurons. Neurobiology of aging. vol 36. issue 3. 2015-11-12. PMID:25543463. |
modulation of insulin signaling rescues bdnf transport defects independent of tau in amyloid-β oligomer-treated hippocampal neurons. |
2015-11-12 |
2023-08-13 |
mouse |
| Sandra Dieni, Sigrun Nestel, Mirjam Sibbe, Michael Frotscher, Sabine Hellwi. Distinct synaptic and neurochemical changes to the granule cell-CA3 projection in Bassoon mutant mice. Frontiers in synaptic neuroscience. vol 7. 2015-11-11. PMID:26557085. |
to this end, we used a mutant mouse model harboring a mutated form of the presynaptic scaffolding protein bassoon (bsn), which is phenotypically characterized by: (i) spontaneous generalized epileptic seizure activity, representing a chronically-imbalanced neuronal network; and (ii) a dramatic increase in hippocampal brain-derived neurotrophic factor (bdnf) protein concentration, a key player in synaptic plasticity. |
2015-11-11 |
2023-08-13 |
mouse |
| Tzu-Wei Lin, Yao-Hsiang Shih, Shean-Jen Chen, Chi-Hsiang Lien, Chia-Yuan Chang, Tung-Yi Huang, Shun-Hua Chen, Chauying J Jen, Yu-Min Ku. Running exercise delays neurodegeneration in amygdala and hippocampus of Alzheimer's disease (APP/PS1) transgenic mice. Neurobiology of learning and memory. vol 118. 2015-11-10. PMID:25543023. |
long-term exercise protects neurons in the amygdala and hippocampus against ad-related degeneration, probably via enhancements of bdnf signaling pathways and aβ clearance. |
2015-11-10 |
2023-08-13 |
mouse |
| Yu-Hui Wong, Chia-Ming Lee, Wenjun Xie, Bianxiao Cui, Mu-ming Po. Activity-dependent BDNF release via endocytic pathways is regulated by synaptotagmin-6 and complexin. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 32. 2015-11-10. PMID:26216953. |
using exogenous bdnf tagged with quantum dots (bdnf-qds), we found that endocytosed bdnf-qds were preferentially localized to postsynaptic sites in the dendrite of cultured hippocampal neurons. |
2015-11-10 |
2023-08-13 |
Not clear |
| Bei-Yun Wang, Yuan Zhong, Zhe Zhao, Ya Mia. Epigenetic suppression of hippocampal BDNF mediates the memory deficiency induced by amyloid fibrils. Pharmacology, biochemistry, and behavior. vol 126. 2015-11-09. PMID:25242807. |
epigenetic suppression of hippocampal bdnf mediates the memory deficiency induced by amyloid fibrils. |
2015-11-09 |
2023-08-13 |
rat |
| Bei-Yun Wang, Yuan Zhong, Zhe Zhao, Ya Mia. Epigenetic suppression of hippocampal BDNF mediates the memory deficiency induced by amyloid fibrils. Pharmacology, biochemistry, and behavior. vol 126. 2015-11-09. PMID:25242807. |
emerging reports also found the reduction of hippocampal brain-derived neurotrophic factor (bdnf) in the patients and rodent models of ad, while the mechanism and functional significance remain debated. |
2015-11-09 |
2023-08-13 |
rat |
| Bei-Yun Wang, Yuan Zhong, Zhe Zhao, Ya Mia. Epigenetic suppression of hippocampal BDNF mediates the memory deficiency induced by amyloid fibrils. Pharmacology, biochemistry, and behavior. vol 126. 2015-11-09. PMID:25242807. |
the present study aims to study the epigenetic mechanism underlying the bdnf reduction and its functional significance in the rats with hippocampal infusion of amyloid fibrils. |
2015-11-09 |
2023-08-13 |
rat |
| Bei-Yun Wang, Yuan Zhong, Zhe Zhao, Ya Mia. Epigenetic suppression of hippocampal BDNF mediates the memory deficiency induced by amyloid fibrils. Pharmacology, biochemistry, and behavior. vol 126. 2015-11-09. PMID:25242807. |
significantly increased hippocampal hdac2 expression and its occupancy in the promoter region of bdnf exon vi were also observed, thus contributing to the histone h3 deacetylation and bdnf suppression in the hippocampal ca1 in the rats injected with amyloid fibrils. |
2015-11-09 |
2023-08-13 |
rat |
| Bombi Lee, Bongjun Sur, Seong-Guk Cho, Mijung Yeom, Insop Shim, Hyejung Lee, Dae-Hyun Hah. Effect of Beta-Asarone on Impairment of Spatial Working Memory and Apoptosis in the Hippocampus of Rats Exposed to Chronic Corticosterone Administration. Biomolecules & therapeutics. vol 23. issue 6. 2015-11-04. PMID:26535083. |
additionally, as assessed by immunohistochemistry and rt-pcr analysis, the administration of bas significantly alleviated memory-associated decreases in the expression levels of brain-derived neurotrophic factor (bdnf) and camp-response element-binding protein (creb) proteins and mrnas in the hippocampus. |
2015-11-04 |
2023-08-13 |
rat |