| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rungpiyada Tipyasang, Sarun Kunwittaya, Sujira Mukda, Nittaya J Kotchabhakdi, Naiphinich Kotchabhakd. Enriched environment attenuates changes in water-maze performance and BDNF level caused by prenatal alcohol exposure. EXCLI journal. vol 13. 2015-09-29. PMID:26417281. |
moreover, the reverse-transcriptase polymerase chain reaction (rt-pcr) technique was also used in order to study the expression of brain-derived neurotrophic factor (bdnf) level in both the hippocampus and striatum of mice. |
2015-09-29 |
2023-08-13 |
mouse |
| Rungpiyada Tipyasang, Sarun Kunwittaya, Sujira Mukda, Nittaya J Kotchabhakdi, Naiphinich Kotchabhakd. Enriched environment attenuates changes in water-maze performance and BDNF level caused by prenatal alcohol exposure. EXCLI journal. vol 13. 2015-09-29. PMID:26417281. |
moreover, the levels of bdnf expression both in the hippocampus and striatum of mice were also decreased. |
2015-09-29 |
2023-08-13 |
mouse |
| Xin Guo, Zheng-Hua Chen, Hui-Ling Wang, Zhong-Chun Liu, Xiao-Ping Wang, Ben-Hong Zhou, Can Yang, Xue-Ping Zhang, Ling Xiao, Chang Shu, Jian-Xin Chen, Gao-Hua Wan. WSKY, a traditional Chinese decoction, rescues cognitive impairment associated with NMDA receptor antagonism by enhancing BDNF/ERK/CREB signaling. Molecular medicine reports. vol 11. issue 4. 2015-09-28. PMID:25503442. |
the expression of brain‑derived neurotrophic factor (bdnf), activation of camp response element binding protein (pcreb/creb) and activation of extracellular signal‑regulated kinase (perk/erk) in the hippocampus was detected using western blot analysis. |
2015-09-28 |
2023-08-13 |
rat |
| Xin Guo, Zheng-Hua Chen, Hui-Ling Wang, Zhong-Chun Liu, Xiao-Ping Wang, Ben-Hong Zhou, Can Yang, Xue-Ping Zhang, Ling Xiao, Chang Shu, Jian-Xin Chen, Gao-Hua Wan. WSKY, a traditional Chinese decoction, rescues cognitive impairment associated with NMDA receptor antagonism by enhancing BDNF/ERK/CREB signaling. Molecular medicine reports. vol 11. issue 4. 2015-09-28. PMID:25503442. |
western blot analysis demonstrated that the levels of bdnf expression in the hippocampus of rats without behavioral tests were elevated following 14 days of wsky treatment, and the effect of wsky treatment on hippocampal bdnf expression was presented in an inverted u‑shaped dose‑response pattern. |
2015-09-28 |
2023-08-13 |
rat |
| Jie Luo, Su Min, Ke Wei, Jun Cao, Bin Wang, Ping Li, Jun Dong, Yuanyuan Li. Behavioral and molecular responses to electroconvulsive shock differ between genetic and environmental rat models of depression. Psychiatry research. vol 226. issue 2-3. 2015-09-28. PMID:25708608. |
hippocampal bdnf, creb, and p-creb proteins were assayed with elisa or western blotting. |
2015-09-28 |
2023-08-13 |
rat |
| Jie Luo, Su Min, Ke Wei, Jun Cao, Bin Wang, Ping Li, Jun Dong, Yuanyuan Li. Behavioral and molecular responses to electroconvulsive shock differ between genetic and environmental rat models of depression. Psychiatry research. vol 226. issue 2-3. 2015-09-28. PMID:25708608. |
it elevated hippocampal bdnf and creb proteins only in cums rats, while it improved depressive behavior and hippocampal p-creb protein levels in both rats, with more effective regulations in the cums rats. |
2015-09-28 |
2023-08-13 |
rat |
| Jie Luo, Su Min, Ke Wei, Jun Cao, Bin Wang, Ping Li, Jun Dong, Yuanyuan Li. Behavioral and molecular responses to electroconvulsive shock differ between genetic and environmental rat models of depression. Psychiatry research. vol 226. issue 2-3. 2015-09-28. PMID:25708608. |
these findings suggest that ecs exerted up-regulating effects on hippocampal bdnf and creb (and its phosphorylation) in depressed rats, and the environmental model responded better. |
2015-09-28 |
2023-08-13 |
rat |
| Toshiyuki Mizui, Yasuyuki Ishikawa, Haruko Kumanogoh, Maria Lume, Tomoya Matsumoto, Tomoko Hara, Shigeto Yamawaki, Masami Takahashi, Sadao Shiosaka, Chiaki Itami, Koichi Uegaki, Mart Saarma, Masami Kojim. BDNF pro-peptide actions facilitate hippocampal LTD and are altered by the common BDNF polymorphism Val66Met. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 23. 2015-09-25. PMID:26015580. |
bdnf pro-peptide actions facilitate hippocampal ltd and are altered by the common bdnf polymorphism val66met. |
2015-09-25 |
2023-08-13 |
human |
| Toshiyuki Mizui, Yasuyuki Ishikawa, Haruko Kumanogoh, Maria Lume, Tomoya Matsumoto, Tomoko Hara, Shigeto Yamawaki, Masami Takahashi, Sadao Shiosaka, Chiaki Itami, Koichi Uegaki, Mart Saarma, Masami Kojim. BDNF pro-peptide actions facilitate hippocampal LTD and are altered by the common BDNF polymorphism Val66Met. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 23. 2015-09-25. PMID:26015580. |
here, we investigated the biological role of the pro-peptide of brain-derived neurotrophic factor (bdnf) and first showed that the pro-peptide is expressed and secreted in hippocampal tissues and cultures, respectively. |
2015-09-25 |
2023-08-13 |
human |
| Toshiyuki Mizui, Yasuyuki Ishikawa, Haruko Kumanogoh, Maria Lume, Tomoya Matsumoto, Tomoko Hara, Shigeto Yamawaki, Masami Takahashi, Sadao Shiosaka, Chiaki Itami, Koichi Uegaki, Mart Saarma, Masami Kojim. BDNF pro-peptide actions facilitate hippocampal LTD and are altered by the common BDNF polymorphism Val66Met. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 23. 2015-09-25. PMID:26015580. |
interestingly, we found that the bdnf pro-peptide directly facilitates hippocampal long-term depression (ltd), requiring the activation of glun2b-containing nmda receptors and the pan-neurotrophin receptor p75(ntr). |
2015-09-25 |
2023-08-13 |
human |
| Toshiyuki Mizui, Yasuyuki Ishikawa, Haruko Kumanogoh, Maria Lume, Tomoya Matsumoto, Tomoko Hara, Shigeto Yamawaki, Masami Takahashi, Sadao Shiosaka, Chiaki Itami, Koichi Uegaki, Mart Saarma, Masami Kojim. BDNF pro-peptide actions facilitate hippocampal LTD and are altered by the common BDNF polymorphism Val66Met. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 23. 2015-09-25. PMID:26015580. |
here, the bdnf pro-peptide with met mutation completely inhibits hippocampal ltd. |
2015-09-25 |
2023-08-13 |
human |
| Toshiyuki Mizui, Yasuyuki Ishikawa, Haruko Kumanogoh, Maria Lume, Tomoya Matsumoto, Tomoko Hara, Shigeto Yamawaki, Masami Takahashi, Sadao Shiosaka, Chiaki Itami, Koichi Uegaki, Mart Saarma, Masami Kojim. BDNF pro-peptide actions facilitate hippocampal LTD and are altered by the common BDNF polymorphism Val66Met. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 23. 2015-09-25. PMID:26015580. |
these findings demonstrate functional roles for the bdnf pro-peptide and a naturally occurring human bdnf polymorphism in hippocampal synaptic depression. |
2015-09-25 |
2023-08-13 |
human |
| Qiong Wang, Feng Shao, Weiwen Wan. Maternal separation produces alterations of forebrain brain-derived neurotrophic factor expression in differently aged rats. Frontiers in molecular neuroscience. vol 8. 2015-09-21. PMID:26388728. |
in this study, we investigated the effects of repeated ms (4 h per day from postnatal day (pnd) 1-21) on the brain-derived neurotrophic factor (bdnf) expression in the medial prefrontal cortex (mpfc), the nucleus accumbens (nac) and the hippocampus of male and female juvenile (pnd 21), adolescent (pnd 35) and young adult (pnd 56) wistar rats. |
2015-09-21 |
2023-08-13 |
rat |
| Qiong Wang, Feng Shao, Weiwen Wan. Maternal separation produces alterations of forebrain brain-derived neurotrophic factor expression in differently aged rats. Frontiers in molecular neuroscience. vol 8. 2015-09-21. PMID:26388728. |
however, the expression of bdnf in the mpfc in the young adult rats was decreased by ms. additionally, in the hippocampus, there was decreased bdnf expression with age in both the ms and non separated rats. |
2015-09-21 |
2023-08-13 |
rat |
| Abigail Mariga, Jiri Zavadil, Stephen D Ginsberg, Moses V Cha. Withdrawal of BDNF from hippocampal cultures leads to changes in genes involved in synaptic function. Developmental neurobiology. vol 75. issue 2. 2015-09-16. PMID:25059794. |
withdrawal of bdnf from hippocampal cultures leads to changes in genes involved in synaptic function. |
2015-09-16 |
2023-08-13 |
rat |
| Milene Borsoi, Camila Boque Antonio, Liz Girardi Müller, Alice Fialho Viana, Vivian Hertzfeldt, Paula Santana Lunardi, Caroline Zanotto, Patrícia Nardin, Ana Paula Ravazzolo, Stela Maris Kuze Rates, Carlos-Alberto Gonçalve. Repeated forced swimming impairs prepulse inhibition and alters brain-derived neurotrophic factor and astroglial parameters in rats. Pharmacology, biochemistry, and behavior. vol 128. 2015-09-16. PMID:25444867. |
in addition, quantification of brain-derived neurotrophic factor (bdnf) mrna expression and protein levels, glutamate uptake, glutathione, s100b, glun1 subunit of n-methyl-d-aspartate receptor and calmodulin were evaluated in the frontal cortex and hippocampus after various swimming time points. |
2015-09-16 |
2023-08-13 |
rat |
| Milene Borsoi, Camila Boque Antonio, Liz Girardi Müller, Alice Fialho Viana, Vivian Hertzfeldt, Paula Santana Lunardi, Caroline Zanotto, Patrícia Nardin, Ana Paula Ravazzolo, Stela Maris Kuze Rates, Carlos-Alberto Gonçalve. Repeated forced swimming impairs prepulse inhibition and alters brain-derived neurotrophic factor and astroglial parameters in rats. Pharmacology, biochemistry, and behavior. vol 128. 2015-09-16. PMID:25444867. |
swimming stress altered the frontal cortical and hippocampal bdnf expression and the activity of hippocampal astrocytes by reducing hippocampal glutamate uptake and enhancing glutathione content in a time-dependent manner. |
2015-09-16 |
2023-08-13 |
rat |
| Marta M Nowacka, Monika Paul-Samojedny, Anna M Bielecka, Ewa Obuchowic. Chronic social instability stress enhances vulnerability of BDNF response to LPS in the limbic structures of female rats: a protective role of antidepressants. Neuroscience research. vol 88. 2015-09-14. PMID:25173454. |
the aim of the present study was to estimate the influence of antidepressants given chronically on brain-derived neurotrophic factor (bdnf) alterations induced by lipopolysaccharide (lps) in the amygdala and hippocampus of female rats subjected to chronic social instability stress (csis) for 29-30 days. |
2015-09-14 |
2023-08-13 |
rat |
| M H Galinato, L Orio, C D Mandya. Methamphetamine differentially affects BDNF and cell death factors in anatomically defined regions of the hippocampus. Neuroscience. vol 286. 2015-09-14. PMID:25463524. |
methamphetamine differentially affects bdnf and cell death factors in anatomically defined regions of the hippocampus. |
2015-09-14 |
2023-08-13 |
rat |
| M H Galinato, L Orio, C D Mandya. Methamphetamine differentially affects BDNF and cell death factors in anatomically defined regions of the hippocampus. Neuroscience. vol 286. 2015-09-14. PMID:25463524. |
expression of brain-derived neurotrophic factor (bdnf; a regulator of ltp and neurogenesis), and its receptor tropomyosin-related kinase b (trkb) were studied in the dorsal and ventral hippocampal tissue lysates in rats that intravenously self-administered methamphetamine in a limited access (1h/day) or extended access (6h/day) paradigm for 17days post baseline sessions. |
2015-09-14 |
2023-08-13 |
rat |