| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiao Chen, Zhen-zhen Wang, Wei Zuo, Shuai Zhang, Shi-feng Chu, Nai-hong Che. Effects of chronic mild stress on behavioral and neurobiological parameters - Role of glucocorticoid. Hormones and behavior. vol 78. 2016-09-15. PMID:26592454. |
molecular and cellular changes included the decreased bdnf in the hippocampus, astrocytic dysfunction with connexin43 (cx43) decreasing and abnormality in gap junction in prefrontal cortex (pfc). |
2016-09-15 |
2023-08-13 |
rat |
| Ying-pan Zhao, Min Su, Feng-yun Wang, Zhao-xiang Bian, Jian-qin Yang, Wei Wang, Xu-dong Tan. [Effect of Chang'an No. I Recipe on 5-hydroxytryptamine Signal System and mRNA Expression Levels of Hippocampal Brain Derived Neurotrophic Factor in Visceral Hypersensitivity Rats with Irritable Bowel Syndrome]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. vol 35. issue 10. 2016-09-15. PMID:26677676. |
i recipe (ca) on 5-hydroxytryptamine signal system and mrna expression levels of hippocampal brain derived neurotrophic factor (bdnf) in visceral hypersensitivity model rats with irritable bowel syndrome (ibs). |
2016-09-15 |
2023-08-13 |
rat |
| Yuefeng Li, Siyue Li, Jinchuan Yan, Dongqing Wang, Ruigen Yin, Liang Zhao, Yan Zhu, Xiaolan Zh. miR-182 (microRNA-182) suppression in the hippocampus evokes antidepressant-like effects in rats. Progress in neuro-psychopharmacology & biological psychiatry. vol 65. 2016-09-14. PMID:26368940. |
expression of mir-182 and bdnf in the hippocampus were analyzed in a chronic unpredictable mild stress (cums) model. |
2016-09-14 |
2023-08-13 |
rat |
| Yuefeng Li, Siyue Li, Jinchuan Yan, Dongqing Wang, Ruigen Yin, Liang Zhao, Yan Zhu, Xiaolan Zh. miR-182 (microRNA-182) suppression in the hippocampus evokes antidepressant-like effects in rats. Progress in neuro-psychopharmacology & biological psychiatry. vol 65. 2016-09-14. PMID:26368940. |
mir-182 upregulation was correlated with decreased bdnf expression in the hippocampus of a cums model. |
2016-09-14 |
2023-08-13 |
rat |
| Yuefeng Li, Siyue Li, Jinchuan Yan, Dongqing Wang, Ruigen Yin, Liang Zhao, Yan Zhu, Xiaolan Zh. miR-182 (microRNA-182) suppression in the hippocampus evokes antidepressant-like effects in rats. Progress in neuro-psychopharmacology & biological psychiatry. vol 65. 2016-09-14. PMID:26368940. |
moreover, bdnf and its target gene cyclic amp responsive element binding protein 1 (creb1) decreased following lv-mir-182 injection and increased upon lv-si-mir-182 injection in rat hippocampus and cultured neuronal cells. |
2016-09-14 |
2023-08-13 |
rat |
| N Zhang, M Xing, Y Wang, H Tao, Y Chen. Repetitive transcranial magnetic stimulation enhances spatial learning and synaptic plasticity via the VEGF and BDNF-NMDAR pathways in a rat model of vascular dementia. Neuroscience. vol 311. 2016-09-14. PMID:26518460. |
hippocampal expression of vascular endothelial growth factor (vegf), brain-derived neurotrophic factor (bdnf) and three subunits of the n-methyl-d-aspartic acid receptor (nmdar), nr1, nr2a and nr2b, was analyzed by western blotting. |
2016-09-14 |
2023-08-13 |
rat |
| Qiong Xiang, Jie Zhang, Chun-Yan Li, Yan Wang, Mao-Jun Zeng, Zhi-Xin Cai, Rong-Bo Tian, Wei Jia, Xian-Hui L. Insulin resistance-induced hyperglycemia decreased the activation of Akt/CREB in hippocampus neurons: Molecular evidence for mechanism of diabetes-induced cognitive dysfunction. Neuropeptides. vol 54. 2016-09-13. PMID:26344332. |
we found that the magnitude of escape latency time was significantly increased in such diabetic animals; the phosphorylated akt/creb; syp and bdnf as well as other downstream molecules in hippocampus neurons were also downregulated in both diabetic groups compared to the normal groups. |
2016-09-13 |
2023-08-13 |
rat |
| Y-C Li, L-L Wang, Y-Y Pei, J-D Shen, H-B Li, B-Y Wang, M Ba. Baicalin decreases SGK1 expression in the hippocampus and reverses depressive-like behaviors induced by corticosterone. Neuroscience. vol 311. 2016-09-13. PMID:26480816. |
after a 21-day treatment with baicalin (10 and 20 mg/kg), sucrose preference in the sucrose preference test (spt) and immobility time in forced swimming test (fst) were observed, serum corticosterone levels and brain-derived neurotrophic factor (bdnf) contents in the hippocampus were examined by enzyme-linked immunosorbent assay (elisa). |
2016-09-13 |
2023-08-13 |
mouse |
| Y-C Li, L-L Wang, Y-Y Pei, J-D Shen, H-B Li, B-Y Wang, M Ba. Baicalin decreases SGK1 expression in the hippocampus and reverses depressive-like behaviors induced by corticosterone. Neuroscience. vol 311. 2016-09-13. PMID:26480816. |
additionally, baicalin up-regulated the mrna and protein expression of glucocorticoid receptor (gr) and bdnf, accompanied with the down-regulation of serum- and glucocorticoid-regulated kinase 1 (sgk1) in the hippocampus. |
2016-09-13 |
2023-08-13 |
mouse |
| Y-C Li, L-L Wang, Y-Y Pei, J-D Shen, H-B Li, B-Y Wang, M Ba. Baicalin decreases SGK1 expression in the hippocampus and reverses depressive-like behaviors induced by corticosterone. Neuroscience. vol 311. 2016-09-13. PMID:26480816. |
the present results confirmed the antidepressant-like effects of baicalin in a mice model of depression induced by corticosterone and suggested that its mechanism was possibly involved in reducing serum corticosterone and thereby increasing bdnf in the hippocampus. |
2016-09-13 |
2023-08-13 |
mouse |
| Li Ge, Liwei Liu, Hansen Liu, Song Liu, Hao Xue, Xueer Wang, Lin Yuan, Zhen Wang, Dexiang Li. Resveratrol abrogates lipopolysaccharide-induced depressive-like behavior, neuroinflammatory response, and CREB/BDNF signaling in mice. European journal of pharmacology. vol 768. 2016-09-13. PMID:26485503. |
moreover, the antidepressant action of resveratrol was paralleled by significantly reducing the expression levels of pro-inflammatory cytokines, and up-regulating phosphorylated camp response-element-binding protein (pcreb)/brain-derived neurotrophic factor (bdnf) expression in prefrontal cortex (pfc) and hippocampus. |
2016-09-13 |
2023-08-13 |
mouse |
| Xing-Hua Zhen, Ying-Chun Quan, Hai-Ying Jiang, Zheng-Shun Wen, You-Le Qu, Li-Ping Gua. Fucosterol, a sterol extracted from Sargassum fusiforme, shows antidepressant and anticonvulsant effects. European journal of pharmacology. vol 768. 2016-09-13. PMID:26515446. |
a significant increase in hippocampal brain-derived neurotrophic factor (bdnf) levels was found in the fucosterol 20mg/kg group (p<0.05). |
2016-09-13 |
2023-08-13 |
mouse |
| Tiffany S Doherty, Amy Forster, Tania L Rot. Global and gene-specific DNA methylation alterations in the adolescent amygdala and hippocampus in an animal model of caregiver maltreatment. Behavioural brain research. vol 298. issue Pt A. 2016-09-01. PMID:26027495. |
previous work from our laboratory has demonstrated alterations in methylation of dna associated with the brain-derived neurotrophic factor (bdnf) gene within the amygdala and hippocampus of infant and adult rats that were repeatedly exposed to caregiver maltreatment outside the home cage during their first week of life. |
2016-09-01 |
2023-08-13 |
rat |
| Tiffany S Doherty, Amy Forster, Tania L Rot. Global and gene-specific DNA methylation alterations in the adolescent amygdala and hippocampus in an animal model of caregiver maltreatment. Behavioural brain research. vol 298. issue Pt A. 2016-09-01. PMID:26027495. |
in the current study we examine changes in global levels of dna methylation (5-mc) and hydroxymethylation (5-hmc), as well as gene-specific changes in methylation patterns of the candidate gene bdnf (at exons i and iv) within the adolescent amygdala and hippocampus resulting from exposure to maltreatment. |
2016-09-01 |
2023-08-13 |
rat |
| Tiffany S Doherty, Amy Forster, Tania L Rot. Global and gene-specific DNA methylation alterations in the adolescent amygdala and hippocampus in an animal model of caregiver maltreatment. Behavioural brain research. vol 298. issue Pt A. 2016-09-01. PMID:26027495. |
while adolescent females exposed to maltreatment showed no significant alterations in global 5-mc or 5-hmc levels, examination of bdnf dna methylation revealed that maltreated females had greater methylation of exon iv dna in the amygdala and ventral hippocampus. |
2016-09-01 |
2023-08-13 |
rat |
| Tiffany S Doherty, Amy Forster, Tania L Rot. Global and gene-specific DNA methylation alterations in the adolescent amygdala and hippocampus in an animal model of caregiver maltreatment. Behavioural brain research. vol 298. issue Pt A. 2016-09-01. PMID:26027495. |
while adolescent males exposed to maltreatment showed no significant alterations in bdnf dna methylation, maltreated males had significantly higher 5-mc levels in the dorsal hippocampus and lower 5-hmc levels in the amygdala. |
2016-09-01 |
2023-08-13 |
rat |
| Qian Ren, Min Ma, Tamaki Ishima, Christophe Morisseau, Jun Yang, Karen M Wagner, Ji-Chun Zhang, Chun Yang, Wei Yao, Chao Dong, Mei Han, Bruce D Hammock, Kenji Hashimot. Gene deficiency and pharmacological inhibition of soluble epoxide hydrolase confers resilience to repeated social defeat stress. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 13. 2016-09-01. PMID:26976569. |
the seh ko mice showed increased brain-derived neurotrophic factor (bdnf) and phosphorylation of its receptor trkb in the prefrontal cortex, hippocampus, but not nucleus accumbens, suggesting that increased bdnf-trkb signaling in the prefrontal cortex and hippocampus confer stress resilience. |
2016-09-01 |
2023-08-13 |
mouse |
| Felix Badinter, Tamar Amit, Orit Bar-Am, Moussa B H Youdim, Orly Weinre. Beneficial behavioral, neurochemical and molecular effects of 1-(R)-aminoindan in aged mice. Neuropharmacology. vol 99. 2016-08-30. PMID:26087462. |
in addition, chronic ai treatment significantly enhanced expression levels of neurotrophins, including brain derived neurotrophic factor (bdnf) and nerve growth factor (ngf), tyrosine kinase- b (trk-b) receptor and synaptic plasticity markers, such as synapsin-1 and growth-associated protein-43 (gap-43) in the striatum and hippocampus in aged mice. |
2016-08-30 |
2023-08-13 |
mouse |
| Alessandro Ieraci, Alessandra Mallei, Laura Musazzi, Maurizio Popol. Physical exercise and acute restraint stress differentially modulate hippocampal brain-derived neurotrophic factor transcripts and epigenetic mechanisms in mice. Hippocampus. vol 25. issue 11. 2016-08-29. PMID:25820928. |
here, we show that total bdnf mrna levels and bdnf transcripts 1, 2, 3, 4, 6, and 7 were reduced immediately after acute restraint stress (rs) in the hippocampus of mice, and returned to control levels 24 h after the stress session. |
2016-08-29 |
2023-08-13 |
mouse |
| Giuseppe Musumeci, Paola Castrogiovanni, Sergio Castorina, Rosa Imbesi, Marta Anna Szychlinska, Soraya Scuderi, Carla Loreto, Salvatore Giunt. Changes in serotonin (5-HT) and brain-derived neurotrophic factor (BDFN) expression in frontal cortex and hippocampus of aged rat treated with high tryptophan diet. Brain research bulletin. vol 119. issue Pt A. 2016-08-29. PMID:26444078. |
since 5-ht is closely associated to bdnf, we aimed to investigate the effect of high trp diet on 5-ht levels and bdnf expression in frontal cortex (fc) and hippocampus (hp) of aged rats. |
2016-08-29 |
2023-08-13 |
rat |