| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H-L Sun, Z-Q Zhou, G-F Zhang, C Yang, X-M Wang, J-C Shen, K Hashimoto, J-J Yan. Role of hippocampal p11 in the sustained antidepressant effect of ketamine in the chronic unpredictable mild stress model. Translational psychiatry. vol 6. 2016-10-17. PMID:26905413. |
furthermore, ketamine significantly increased the reduced expression of brain-derived neurotrophic factor (bdnf) in the hippocampus of cums rats, whereas ketamine did not affect the expression of p11 in cums rats 0.5 h after administration. |
2016-10-17 |
2023-08-13 |
rat |
| H-L Sun, Z-Q Zhou, G-F Zhang, C Yang, X-M Wang, J-C Shen, K Hashimoto, J-J Yan. Role of hippocampal p11 in the sustained antidepressant effect of ketamine in the chronic unpredictable mild stress model. Translational psychiatry. vol 6. 2016-10-17. PMID:26905413. |
moreover, the reduced expression of bdnf and p11 in the hippocampus of cums rats was significantly recovered to control levels 72 h after ketamine administration. |
2016-10-17 |
2023-08-13 |
rat |
| Ling-sha Ju, Min Jia, Jie Sun, Xiao-ru Sun, Hui Zhang, Mu-huo Ji, Jian-jun Yang, Zhong-yun Wan. Hypermethylation of Hippocampal Synaptic Plasticity-Related genes is Involved in Neonatal Sevoflurane Exposure-Induced Cognitive Impairments in Rats. Neurotoxicity research. vol 29. issue 2. 2016-10-14. PMID:26678494. |
in conclusion, our results suggest that hypermethylation of hippocampal bdnf and reelin is involved in neonatal sevoflurane exposure-induced cognitive impairments. |
2016-10-14 |
2023-08-13 |
rat |
| R A Mohamed, A M Agha, A A Abdel-Rahman, N N Nassa. Role of adenosine A2A receptor in cerebral ischemia reperfusion injury: Signaling to phosphorylated extracellular signal-regulated protein kinase (pERK1/2). Neuroscience. vol 314. 2016-10-13. PMID:26642806. |
consequent to perk1/2 inhibition, reduced hippocampal microglial activation, glial tumor necrosis factor-alpha (tnf-α) and brain-derived neurotropic factor (bdnf) expression, glutamate (glu), inducible nitric oxide synthase (inos) and thiobarbituric acid reactive substances (tbars) were evident in animals receiving sch58261. |
2016-10-13 |
2023-08-13 |
rat |
| Ashok Jangra, Prajapati Kasbe, Surya Narayan Pandey, Shubham Dwivedi, Satendra S Gurjar, Mohit Kwatra, Murli Mishra, Athira K Venu, Kunjbihari Sulakhiya, Ranadeep Gogoi, Nitul Sarma, Babul K Bezbaruah, Mangala Lahka. Hesperidin and Silibinin Ameliorate Aluminum-Induced Neurotoxicity: Modulation of Antioxidants and Inflammatory Cytokines Level in Mice Hippocampus. Biological trace element research. vol 168. issue 2. 2016-10-12. PMID:26018497. |
moreover, the chronic alcl3 administration raised the proinflammatory cytokines (interleukin-1β and tumor necrosis factor-α) level and increased acetylcholinesterase activity and reduced the bdnf content in the hippocampus of alcl3-treated animals. |
2016-10-12 |
2023-08-13 |
mouse |
| ChengCheng Lin, Bei Shao, YuLei Zhou, XiaoTing Niu, YuanShao Li. Maternal high-fat diet influences stroke outcome in adult rat offspring. Journal of molecular endocrinology. vol 56. issue 2. 2016-10-11. PMID:26643911. |
furthermore, expression of brain-derived neurotrophic factor (bdnf) in the ipsilateral hippocampus was decreased in the hfd/c offspring (p<0.05), compared with the c/c offspring. |
2016-10-11 |
2023-08-13 |
rat |
| Dan Fan, Jun Li, Bin Zheng, Lei Hua, Zhiyi Zu. Enriched Environment Attenuates Surgery-Induced Impairment of Learning, Memory, and Neurogenesis Possibly by Preserving BDNF Expression. Molecular neurobiology. vol 53. issue 1. 2016-10-10. PMID:25432890. |
surgery also reduced the expression of brain-derived neurotrophic factor (bdnf) and neurogenesis in the hippocampus. |
2016-10-10 |
2023-08-13 |
mouse |
| Dan Fan, Jun Li, Bin Zheng, Lei Hua, Zhiyi Zu. Enriched Environment Attenuates Surgery-Induced Impairment of Learning, Memory, and Neurogenesis Possibly by Preserving BDNF Expression. Molecular neurobiology. vol 53. issue 1. 2016-10-10. PMID:25432890. |
these results provide initial evidence that surgery reduces bdnf expression and neurogenesis in the hippocampus. |
2016-10-10 |
2023-08-13 |
mouse |
| Carl Björkholm, Lisa M Monteggi. BDNF - a key transducer of antidepressant effects. Neuropharmacology. vol 102. 2016-10-07. PMID:26519901. |
an increase in hippocampal and cortical expression of bdnf mrna parallels the antidepressant-like response of conventional antidepressants such as ssris. |
2016-10-07 |
2023-08-13 |
mouse |
| Carl Björkholm, Lisa M Monteggi. BDNF - a key transducer of antidepressant effects. Neuropharmacology. vol 102. 2016-10-07. PMID:26519901. |
subsequent studies showed that a single bilateral infusion of bdnf into the ventricles or directly into the hippocampus is sufficient to induce a relatively rapid and sustained antidepressant-like effect. |
2016-10-07 |
2023-08-13 |
mouse |
| Carl Björkholm, Lisa M Monteggi. BDNF - a key transducer of antidepressant effects. Neuropharmacology. vol 102. 2016-10-07. PMID:26519901. |
ketamine transiently increases bdnf translation in hippocampus, leading to enhanced synaptic plasticity and synaptic strength. |
2016-10-07 |
2023-08-13 |
mouse |
| Carl Björkholm, Lisa M Monteggi. BDNF - a key transducer of antidepressant effects. Neuropharmacology. vol 102. 2016-10-07. PMID:26519901. |
in summary, current data suggests that conventional antidepressants and ketamine mediate their antidepressant-like effects by increasing bdnf in forebrain regions, in particular the hippocampus, making bdnf an essential determinant of antidepressant efficacy. |
2016-10-07 |
2023-08-13 |
mouse |
| S Cacioppo, J T Caciopp. Why may allopregnanolone help alleviate loneliness? Medical hypotheses. vol 85. issue 6. 2016-10-05. PMID:26365247. |
the similarities between animal and human research suggest that perceived social isolation (loneliness) may also be associated with a reduction in the synthesis of allo, potentially by reducing bdnf regulation and increasing hpa activity through the hippocampus, amygdala, and bed nucleus of the stria terminalis (bnst), especially during social threat processing. |
2016-10-05 |
2023-08-13 |
human |
| Yukihiko Shirayama, Chun Yang, Ji-chun Zhang, Qian Ren, Wei Yao, Kenji Hashimot. Alterations in brain-derived neurotrophic factor (BDNF) and its precursor proBDNF in the brain regions of a learned helplessness rat model and the antidepressant effects of a TrkB agonist and antagonist. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 12. 2016-10-05. PMID:26419294. |
lh rats showed a reduction of bdnf in the medial prefrontal cortex (mpfc), ca3, and dentate gyrus (dg) of the hippocampus, whereas lh rats showed an increase in bdnf in the nucleus accumbens (nac). |
2016-10-05 |
2023-08-13 |
rat |
| Anu Aonurm-Helm, Kaili Anier, Tamara Zharkovsky, Eero Castrén, Tomi Rantamäki, Vladimir Stepanov, Jaak Järv, Alexander Zharkovsk. NCAM-deficient mice show prominent abnormalities in serotonergic and BDNF systems in brain - Restoration by chronic amitriptyline. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 12. 2016-10-05. PMID:26499173. |
ncam(-)(/-) mice also showed a dramatic reduction in the bdnf protein levels in the hippocampus and prefrontal cortex. |
2016-10-05 |
2023-08-13 |
mouse |
| b' Marie Gajhede Gram, Elise Wogensen, Gitta W\\xc3\\xb6rtwein, Jesper Mogensen, Hana Mal\\xc3\\xa. Delayed restraint procedure enhances cognitive recovery of spatial function after\\xc2\\xa0fimbria-fornix transection. Restorative neurology and neuroscience. vol 34. issue 1. 2016-10-05. PMID:26518669.' |
to i) evaluate the effect of a restraint procedure (7 days, 2 h/day) on place learning after fimbria-fornix transection (ff), ii) investigate effects of early vs. late administration of restraint, and iii) establish effects of the restraint procedure on expression of brain derived neurotrophic factor (bdnf) in prefrontal cortex and hippocampus. |
2016-10-05 |
2023-08-13 |
Not clear |
| Chandra Shaker Sriram, Ashok Jangra, Satendra Singh Gurjar, Pritam Mohan, Babul Kumar Bezbarua. Edaravone abrogates LPS-induced behavioral anomalies, neuroinflammation and PARP-1. Physiology & behavior. vol 154. 2016-09-30. PMID:26522738. |
moreover, after 24h of lps administration serum corticosterone, hippocampal bdnf, oxido-nitrosative stress and pro-inflammatory cytokines were estimated by elisa. |
2016-09-30 |
2023-08-13 |
mouse |
| Chandra Shaker Sriram, Ashok Jangra, Satendra Singh Gurjar, Pritam Mohan, Babul Kumar Bezbarua. Edaravone abrogates LPS-induced behavioral anomalies, neuroinflammation and PARP-1. Physiology & behavior. vol 154. 2016-09-30. PMID:26522738. |
biochemical analyses revealed that lps significantly diminishes bdnf, increases pro-inflammatory cytokines and oxido-nitrosative stress in the hippocampus. |
2016-09-30 |
2023-08-13 |
mouse |
| Junhua Yang, Fangfang Qi, Huaiyu Gu, Juntao Zou, Yang Yang, Qunfang Yuan, Zhibin Ya. Neonatal BCG vaccination of mice improves neurogenesis and behavior in early life. Brain research bulletin. vol 120. 2016-09-30. PMID:26536170. |
the bcg-injected mice showed better behavioral performances at 4 w. we observed elevated neurogenesis, m2 microglial activation and a neurotrophic profile of neuroimmune molecules [more interferon (ifn)-γ, interleukin (il)-4, transforming growth factor (tgf)-β, brain-derived neurotrophic factor (bdnf) and insulin-like growth factor (igf)-1 and less tumor necrosis factor (tnf)-α and il-1β] in the hippocampus of the 2-w-old bcg-mice. |
2016-09-30 |
2023-08-13 |
mouse |
| Mari A Kondo, Laura J Gray, Gregory J Pelka, Sook-Kwan Leang, John Christodoulou, Patrick P L Tam, Anthony J Hanna. Affective dysfunction in a mouse model of Rett syndrome: Therapeutic effects of environmental stimulation and physical activity. Developmental neurobiology. vol 76. issue 2. 2016-09-29. PMID:26019053. |
ee of mecp2(+/-) mice normalized basal serum corticosterone and hippocampal bdnf protein levels. |
2016-09-29 |
2023-08-13 |
mouse |