| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yvonne J Rosenberg, Beth Laube, Lingjun Mao, Xiaoming Jiang, Segundo Hernandez-Abanto, Keunmyoung D Lee, Robert Adam. Pulmonary delivery of an aerosolized recombinant human butyrylcholinesterase pretreatment protects against aerosolized paraoxon in macaques. Chemico-biological interactions. vol 203. issue 1. 2013-05-28. PMID:23178380. |
to address this, studies have been performed in mice and macaques using chinese hamster ovary cells (cho)-derived recombinant (r) bche delivered by the pulmonary route, to examine whether the deposition of both macaque (ma) and human (hu) rbche administered as aerosols (aer) favored the creation and retention of an efficient protective "pulmonary bioshield" that could scavenge incoming (inhaled) ops in situ thereby preventing entry into the circulation and inhibition of plasma bche and ache on red blood cells (rbc-ache) and in cholinergic synapses. |
2013-05-28 |
2023-08-12 |
mouse |
| Daniela Karlsson, Adyary Fallarero, Gerda Brunhofer, Claudia Mayer, Ohm Prakash, C Gopi Mohan, Pia Vuorela, Thomas Erke. The exploration of thienothiazines as selective butyrylcholinesterase inhibitors. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 47. issue 1. 2013-03-08. PMID:22683890. |
in the ad brain, selective bche inhibitors have been demonstrated to have a beneficial effect in vivo, probably by recovering cholinergic activity and/or by restoring ache:bche activity ratios to the levels observed in the healthy brain. |
2013-03-08 |
2023-08-12 |
human |
| I Erdogan Orhan, G Orhan, E Gurka. An overview on natural cholinesterase inhibitors--a multi-targeted drug class--and their mass production. Mini reviews in medicinal chemistry. vol 11. issue 10. 2012-02-15. PMID:21762104. |
cholinesterase enzyme family consisting of acetylcholinesterase (ache) and butrylcholinesterase (bche) is important in pathogenesis of alzheimer's disease (ad), explained by "cholinergic hypothesis". |
2012-02-15 |
2023-08-12 |
Not clear |
| Rita Romani, Roberta Galeazzi, Gabriella Rosi, Rosamaria Fiorini, Irene Pirisinu, Annarina Ambrosini, Giovanna Zoles. Anandamide and its congeners inhibit human plasma butyrylcholinesterase. Possible new roles for these endocannabinoids? Biochimie. vol 93. issue 9. 2012-02-03. PMID:21664223. |
butyrylcholinesterase (bche), a serine hydrolase biochemically related to the cholinergic enzyme acetylcholinesterase (ache), is found in many mammalian tissues, such as serum and central nervous system, but its physiological role is still unclear. |
2012-02-03 |
2023-08-12 |
human |
| Renato Scacchi, Maria Ruggeri, Rosa Maria Corb. Variation of the butyrylcholinesterase (BChE) and acetylcholinesterase (AChE) genes in coronary artery disease. Clinica chimica acta; international journal of clinical chemistry. vol 412. issue 15-16. 2011-09-30. PMID:21473860. |
butyrylcholinesterase (bche) and acetylcholinesterase (ache) are two enzymes of the cholinergic system putatively involved in coronary artery disease (cad). |
2011-09-30 |
2023-08-12 |
human |
| Marielle Wandhammer, Eugénie Carletti, Marcel Van der Schans, Emilie Gillon, Yvain Nicolet, Patrick Masson, Maurice Goeldner, Daan Noort, Florian Nacho. Structural study of the complex stereoselectivity of human butyrylcholinesterase for the neurotoxic V-agents. The Journal of biological chemistry. vol 286. issue 19. 2011-07-12. PMID:21454498. |
human butyrylcholinesterase (bche) functions as a bioscavenger, protecting the cholinergic system against ops. |
2011-07-12 |
2023-08-12 |
human |
| Manel Araoud, Fadoua Neffeti, Wahiba Douki, Hassen Ben Hfaiedh, Mohamed Akrout, Mohamed Fadhel Najjar, Abderraouf Kenan. Factors influencing plasma butyrylcholinesterase activity in agricultural workers. Annales de biologie clinique. vol 69. issue 2. 2011-06-06. PMID:21464008. |
ancientness of exposure equal to 10 years or more, last exposure dates back to 60 days or less, exposure for 2 days or more per week, exposure exceeding 150 h per year and to organophosphorus-carbamates mixture were implicated in significant decreases of bche activity and can be considered as risk factors of cholinergic toxic effects. |
2011-06-06 |
2023-08-12 |
Not clear |
| Liu Xue, Mei-Chuan Ko, Min Tong, Wenchao Yang, Shurong Hou, Lei Fang, Junjun Liu, Fang Zheng, James H Woods, Hsin-Hsiung Tai, Chang-Guo Zha. Design, preparation, and characterization of high-activity mutants of human butyrylcholinesterase specific for detoxification of cocaine. Molecular pharmacology. vol 79. issue 2. 2011-02-22. PMID:20971807. |
an ideal, therapeutically valuable mutant of human bche should have not only a significantly improved catalytic activity against (-)-cocaine but also certain selectivity for (-)-cocaine over neurotransmitter acetylcholine (ach), such that one would not expect systemic administration of the bche mutant to interrupt cholinergic transmission. |
2011-02-22 |
2023-08-12 |
mouse |
| Anna Hrabovska, Véronique Bernard, Eric Krejc. A novel system for the efficient generation of antibodies following immunization of unique knockout mouse strains. PloS one. vol 5. issue 9. 2011-02-18. PMID:20886120. |
as a model we chose butyrylcholinesterase (bche), involved in termination of cholinergic signaling, and widely considered as a poor immunogen. |
2011-02-18 |
2023-08-12 |
mouse |
| Yvonne Rook, Kai-Uwe Schmidtke, Friedemann Gaube, Dirk Schepmann, Bernhard Wünsch, Jörg Heilmann, Jochen Lehmann, Thomas Winckle. Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents. Journal of medicinal chemistry. vol 53. issue 9. 2010-06-11. PMID:20361801. |
inhibitors of acetylcholinesterase (ache) and butyrylcholinesterase (bche) improve cholinergic signaling in the central nervous system and thus ache inhibitors are well established in the therapy of ad to improve memory disturbances and other cognitive symptoms. |
2010-06-11 |
2023-08-12 |
Not clear |
| Walter Maetzler, Stefanie Keller, Joan Michelis, Niklas Koehler, Elke Stransky, Clemens Becker, Claudia Schulte, Arthur Melms, Thomas Gasser, Daniela Ber. No differences of butyrylcholinesterase protein activity and allele frequency in Lewy body diseases. Neurobiology of disease. vol 35. issue 2. 2009-09-21. PMID:19481150. |
cholinergic deficits) aspects between ad and lewy body diseases (lbd), scarce data is obtainable about bche genotypes and buche activity in lbd. |
2009-09-21 |
2023-08-12 |
human |
| Julian R Haigh, Lee J Lefkowitz, Benedict R Capacio, Bhupendra P Doctor, Richard K Gordo. Advantages of the WRAIR whole blood cholinesterase assay: comparative analysis to the micro-Ellman, Test-mate ChE, and Michel (DeltapH) assays. Chemico-biological interactions. vol 175. issue 1-3. 2008-12-10. PMID:18555983. |
red blood cell ache (rbc-ache) and plasma bche can be used as sensitive biomarkers to detect exposure to op nerve agents, pesticides, and cholinergic drugs. |
2008-12-10 |
2023-08-12 |
human |
| Ilkay Orhan, Fatma Tosun, Bilge Sene. Coumarin, anthroquinone and stilbene derivatives with anticholinesterase activity. Zeitschrift fur Naturforschung. C, Journal of biosciences. vol 63. issue 5-6. 2008-08-26. PMID:18669022. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are the key enzymes in pathogenesis of alzheimer's disease (ad), which is characterized by a deficit in central cholinergic transmission. |
2008-08-26 |
2023-08-12 |
Not clear |
| He Li, Lawrence M Schopfer, Patrick Masson, Oksana Lockridg. Lamellipodin proline rich peptides associated with native plasma butyrylcholinesterase tetramers. The Biochemical journal. vol 411. issue 2. 2008-04-24. PMID:18076380. |
bche (butyrylcholinesterase) protects the cholinergic nervous system from organophosphorus nerve agents by scavenging these toxins. |
2008-04-24 |
2023-08-12 |
human |
| Mariapaola Piccardi, Donatella Congiu, Alessio Squassina, Francesca Manconi, Paolo Francesco Putzu, Rosa Maria Mereu, Caterina Chillotti, Maria Del Zomp. Alzheimer's disease: case-control association study of polymorphisms in ACHE, CHAT, and BCHE genes in a Sardinian sample. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 144B. issue 7. 2007-12-06. PMID:17503475. |
the resulting reduction in cholinergic activity is associated with decreased levels of the neurotransmitter acetylcholine (ach), decreased activity of acetylcholinesterase (ache), choline acetyltransferase (chat), and increased butyrylcholinesterase (bche) activity. |
2007-12-06 |
2023-08-12 |
human |
| Ellen G Duysen, Bin Li, Sultan Darvesh, Oksana Lockridg. Sensitivity of butyrylcholinesterase knockout mice to (--)-huperzine A and donepezil suggests humans with butyrylcholinesterase deficiency may not tolerate these Alzheimer's disease drugs and indicates butyrylcholinesterase function in neurotransmission. Toxicology. vol 233. issue 1-3. 2007-05-29. PMID:17194517. |
ache-/- mice treated with chlorpyrifos oxon lost all bche activity, had severe cholinergic symptoms and died of convulsions. |
2007-05-29 |
2023-08-12 |
mouse |
| Joachim Hartmann, Cornelia Kiewert, Ellen G Duysen, Oksana Lockridge, Nigel H Greig, Jochen Klei. Excessive hippocampal acetylcholine levels in acetylcholinesterase-deficient mice are moderated by butyrylcholinesterase activity. Journal of neurochemistry. vol 100. issue 5. 2007-04-02. PMID:17212694. |
cholinergic dysfunction is treated with inhibitors of acetylcholinesterase (ache) while the role of butyrylcholinesterase (bche) for brain cholinergic function is unclear. |
2007-04-02 |
2023-08-12 |
mouse |
| Joachim Hartmann, Cornelia Kiewert, Ellen G Duysen, Oksana Lockridge, Nigel H Greig, Jochen Klei. Excessive hippocampal acetylcholine levels in acetylcholinesterase-deficient mice are moderated by butyrylcholinesterase activity. Journal of neurochemistry. vol 100. issue 5. 2007-04-02. PMID:17212694. |
these results point to a potential usefulness of bche inhibitors in the treatment of central cholinergic dysfunction in which brain ache activity is typically reduced. |
2007-04-02 |
2023-08-12 |
mouse |
| Karin U Schallreuter, Nicholas C J Gibbons, Carsten Zothner, Souna M Elwary, Hartmut Rokos, John M Woo. Butyrylcholinesterase is present in the human epidermis and is regulated by H2O2: more evidence for oxidative stress in vitiligo. Biochemical and biophysical research communications. vol 349. issue 3. 2006-11-07. PMID:16962996. |
the human epidermis holds the capacity for autocrine cholinergic signal transduction, but the presence of butyrylcholinesterase (bche) has not been shown so far. |
2006-11-07 |
2023-08-12 |
human |
| Karin U Schallreuter, Nicholas C J Gibbons, Carsten Zothner, Souna M Elwary, Hartmut Rokos, John M Woo. Butyrylcholinesterase is present in the human epidermis and is regulated by H2O2: more evidence for oxidative stress in vitiligo. Biochemical and biophysical research communications. vol 349. issue 3. 2006-11-07. PMID:16962996. |
based on our results we conclude that h(2)o(2) is a major player in the regulation of the cholinergic signal via both ache and bche and this signal is severely affected in the epidermis of patients with active vitiligo. |
2006-11-07 |
2023-08-12 |
human |