| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pedro Martínez-Moreno, Susana Nieto-Cerón, Juan Torres-Lanzas, Francisco Ruiz-Espejo, Isabel Tovar-Zapata, Pedro Martínez-Hernández, José N Rodríguez-López, Cecilio J Vidal, Juan Cabezas-Herrer. Cholinesterase activity of human lung tumours varies according to their histological classification. Carcinogenesis. vol 27. issue 3. 2006-04-04. PMID:16272577. |
the probable involvement of acetylcholinesterase (ache) and butyrylcholinesterase (bche) in cancer and the relevance of cholinergic responses for lung cancer growth prompted us to study whether cholinesterase activity of human lung is altered by malignancy. |
2006-04-04 |
2023-08-12 |
human |
| Nigel H Greig, Tadanobu Utsuki, Donald K Ingram, Yue Wang, Giancarlo Pepeu, Carla Scali, Qian-Sheng Yu, Jacek Mamczarz, Harold W Holloway, Tony Giordano, DeMao Chen, Katsutoshi Furukawa, Kumar Sambamurti, Arnold Brossi, Debomoy K Lahir. Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 47. 2006-01-12. PMID:16275899. |
like acetylcholinesterase, butyrylcholinesterase (bche) inactivates the neurotransmitter acetylcholine (ach) and is hence a viable therapeutic target in alzheimer's disease, which is characterized by a cholinergic deficit. |
2006-01-12 |
2023-08-12 |
mouse |
| Onofre Combarros, José A Riancho, Jon Infante, Carolina Sañudo, Javier Llorca, María T Zarrabeitia, José Bercian. Interaction between CYP19 aromatase and butyrylcholinesterase genes increases Alzheimer's disease risk. Dementia and geriatric cognitive disorders. vol 20. issue 2-3. 2005-10-13. PMID:16020944. |
biological evidence supports a role of aromatase and butyrilcholinesterase (bche) enzymes in the disruption of the cholinergic neurotransmission observed in alzheimer's disease (ad). |
2005-10-13 |
2023-08-12 |
human |
| Eliane Boudinot, Laurent Taysse, Sébastien Daulon, Arnaud Chatonnet, Jean Champagnat, Arthur S Fout. Effects of acetylcholinesterase and butyrylcholinesterase inhibition on breathing in mice adapted or not to reduced acetylcholinesterase. Pharmacology, biochemistry, and behavior. vol 80. issue 1. 2005-06-23. PMID:15652380. |
bche inhibition by bambuterol was ineffective in wild-type mice and heterozygotes, decreased v(t) in homozygotes adapted to null ache activity but increased v(t) in wild-type mice acutely treated with huperzine, also aggravating the cholinergic syndrome. |
2005-06-23 |
2023-08-12 |
mouse |
| Lynnette J Cook, Luk W Ho, Lin Wang, Edith Terrenoire, Carol Brayne, John Grimley Evans, John Xuereb, Nigel J Cairns, Dragana Turic, Paul Hollingworth, Pamela J Moore, Luke Jehu, Nicola Archer, Sarah Walter, Catherine Foy, Amanda Edmondson, John Powell, Simon Lovestone, Julie Williams, David C Rubinsztei. Candidate gene association studies of genes involved in neuronal cholinergic transmission in Alzheimer's disease suggests choline acetyltransferase as a candidate deserving further study. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 132B. issue 1. 2005-05-12. PMID:15690550. |
consistent deficits in the cholinergic system are evident in the brains of alzheimer's disease (ad) patients, including reductions in the activities of acetylcholine, acetylcholinesterase (ache), and choline acetyltransferase (chat), increased butyrylcholinesterase (bche) activity, and a selective loss of nicotinic acetylcholine receptors (nachrs). |
2005-05-12 |
2023-08-12 |
Not clear |
| Yoffi Segall, Gary B Quistad, Susan E Sparks, John E Casid. Major intermediates in organophosphate synthesis (PCl3, POCl3, PSCl3, and their diethyl esters) are anticholinesterase agents directly or on activation. Chemical research in toxicology. vol 16. issue 3. 2003-10-14. PMID:12641435. |
pcl(3) and pocl(3) produce cholinergic poisoning signs on ip administration to mice, and all three phosphotrichlorides give marked in vivo inhibition of serum bche but not brain ache activity. |
2003-10-14 |
2023-08-12 |
mouse |
| Marsel Mesulam, Angela Guillozet, Pamela Shaw, Bruce Quin. Widely spread butyrylcholinesterase can hydrolyze acetylcholine in the normal and Alzheimer brain. Neurobiology of disease. vol 9. issue 1. 2002-04-04. PMID:11848688. |
butyrylcholinesterase (bche), also known as the "pseudo" or "non-neuronal" cholinesterase, is traditionally thought to have a restricted cns distribution and to play little, if any, role in cholinergic transmission. |
2002-04-04 |
2023-08-12 |
Not clear |
| S Rossner, N Bakinde, U Zeitschel, R Schliebs, V Big. Cerebrospinal fluid cholinesterases--markers for loss of cholinergic basal forebrain neurons? International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 16. issue 7-8. 1999-07-07. PMID:10198815. |
to address this question enzyme activities of acetylcholinesterase (ache) and butyrylcholinesterase (bche) in both csf and parietal cortex were assayed following selective lesion of basal forebrain cholinergic neurons by a single intracerebroventricular application of the cholinergic immunotoxin 192igg-saporin. |
1999-07-07 |
2023-08-12 |
Not clear |
| S Rossner, N Bakinde, U Zeitschel, R Schliebs, V Big. Cerebrospinal fluid cholinesterases--markers for loss of cholinergic basal forebrain neurons? International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 16. issue 7-8. 1999-07-07. PMID:10198815. |
in contrast, the total enzyme activity of bche and its molecular forms were not affected by cholinergic lesion in both parietal cortex and csf. |
1999-07-07 |
2023-08-12 |
Not clear |
| E Weitnauer, A Robitzki, P G Laye. Aryl acylamidase activity exhibited by butyrylcholinesterase is higher in chick than in horse, but much lower than in fetal calf serum. Neuroscience letters. vol 254. issue 3. 1999-06-22. PMID:10214980. |
these data indicate that (1) aaa is a general feature of serum bche of vertebrates including avians, (2) aaa is effectively inhibited by cholinergic and serotonergic agents, and (3) aaa may have a developmental role, since it is much pronounced in a serum from fetal animals. |
1999-06-22 |
2023-08-12 |
chicken |
| M Koga, H Miyata, N Tsuno, K Nakayama, S Ushijima, Y Tanaka, Y Hiraga, N Kobayash. [Relationship between cholinergic symptoms caused by distigmine and the activities of serum AChE and BChE]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 17. issue 3. 1997-11-19. PMID:9278940. |
[relationship between cholinergic symptoms caused by distigmine and the activities of serum ache and bche]. |
1997-11-19 |
2023-08-12 |
Not clear |
| M Koga, H Miyata, N Tsuno, K Nakayama, S Ushijima, Y Tanaka, Y Hiraga, N Kobayash. [Relationship between cholinergic symptoms caused by distigmine and the activities of serum AChE and BChE]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 17. issue 3. 1997-11-19. PMID:9278940. |
we evaluated the possibility of using serum acetylcholinesterase (ache) and butyrylcholinesterase (bche) as specific clinical markers for the adverse cholinergic effects of distigmine. |
1997-11-19 |
2023-08-12 |
Not clear |
| M Koga, H Miyata, N Tsuno, K Nakayama, S Ushijima, Y Tanaka, Y Hiraga, N Kobayash. [Relationship between cholinergic symptoms caused by distigmine and the activities of serum AChE and BChE]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 17. issue 3. 1997-11-19. PMID:9278940. |
of the twelve patients treated with distigmine for dysuria caused by psychotropic drugs six patients presented both adverse cholinergic effects and decreased levels of serum ache and bche. |
1997-11-19 |
2023-08-12 |
Not clear |
| M Koga, H Miyata, N Tsuno, K Nakayama, S Ushijima, Y Tanaka, Y Hiraga, N Kobayash. [Relationship between cholinergic symptoms caused by distigmine and the activities of serum AChE and BChE]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 17. issue 3. 1997-11-19. PMID:9278940. |
this study suggests that the values of serum ache and bche may be useful markers for the manifestation of adverse cholinergic effects caused by distigmine. |
1997-11-19 |
2023-08-12 |
Not clear |
| D H Small, S Michaelson, G Sbern. Non-classical actions of cholinesterases: role in cellular differentiation, tumorigenesis and Alzheimer's disease. Neurochemistry international. vol 28. issue 5-6. 1996-12-30. PMID:8792327. |
acetylcholine has been shown to influence cell proliferation and neurite outgrowth through nicotinic and muscarinic receptor-mediated mechanisms and thus, that the expression of ache and bche at non-synaptic sites may be associated with a cholinergic function. |
1996-12-30 |
2023-08-12 |
Not clear |
| T Arendt, M K Brückner, M Lange, V Big. Changes in acetylcholinesterase and butyrylcholinesterase in Alzheimer's disease resemble embryonic development--a study of molecular forms. Neurochemistry international. vol 21. issue 3. 1993-06-24. PMID:1303164. |
the pattern of molecular forms of acetylcholinesterase (ache, ec 3.1.1.7) and butyrylcholinesterase (bche, ec 3.1.1.8) separated by density gradient centrifugation was investigated in the brain and cerebrospinal fluid in alzheimer's disease (ad), in human embryonic brain and in rat brain after experimental cholinergic deafferentation of the cerebral cortex. |
1993-06-24 |
2023-08-11 |
human |
| P G Layer, T Weikert, E Willbol. Chicken retinospheroids as developmental and pharmacological in vitro models: acetylcholinesterase is regulated by its own and by butyrylcholinesterase activity. Cell and tissue research. vol 268. issue 3. 1992-08-20. PMID:1628298. |
thus, direct interaction with classical cholinergic systems is indicated for the seemingly redundant bche. |
1992-08-20 |
2023-08-11 |
chicken |
| H Soreq, Y Lapidot-Lifson, H Zaku. A role for cholinesterases in tumorigenesis? Cancer cells (Cold Spring Harbor, N.Y. : 1989). vol 3. issue 12. 1992-08-06. PMID:1820094. |
hydrolysis of the neurotransmitter acetylcholine by acetylcholinesterase (ache) and butyrylcholinesterase (bche) is the rate-limiting step in the termination of cholinergic signaling at neuromuscular junctions. |
1992-08-06 |
2023-08-11 |
human |
| L F Neville, A Gnatt, Y Loewenstein, S Seidman, G Ehrlich, H Sore. Intramolecular relationships in cholinesterases revealed by oocyte expression of site-directed and natural variants of human BCHE. The EMBO journal. vol 11. issue 4. 1992-05-15. PMID:1373381. |
gly70 bche variants also displayed lower binding as compared with asp70 bche to cholinergic drugs, certain choline esters and solanidine. |
1992-05-15 |
2023-08-11 |
human |
| M Ruberg, A Villageois, A M Bonnet, B Pillon, F Rieger, Y Agi. Acetylcholinesterase and butyrylcholinesterase activity in the cerebrospinal fluid of patients with neurodegenerative diseases involving cholinergic systems. Journal of neurology, neurosurgery, and psychiatry. vol 50. issue 5. 1987-07-07. PMID:2953866. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) were assayed in the cerebrospinal fluid (csf) of subjects with neurodegenerative diseases (dementing and non-dementing, with and without known cholinergic lesions), to determine whether csf ache is a valid marker of central cholinergic activity. |
1987-07-07 |
2023-08-11 |
human |