| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Babar Ali, Qazi M S Jamal, Saiba Shams, Naser A Al-Wabel, Mughees U Siddiqui, Mohammad A Alzohairy, Mohammed A Al Karaawi, Kavindra Kumar Kesari, Gohar Mushtaq, Mohammad A Kama. In Silico Analysis of Green Tea Polyphenols as Inhibitors of AChE and BChE Enzymes in Alzheimer's Disease Treatment. CNS & neurological disorders drug targets. vol 15. issue 5. 2017-10-04. PMID:26996169. |
the present docking study suggests that tea polyphenols inhibit ache as well as bche and enhance the cholinergic neurotransmission by prolonging the time. |
2017-10-04 |
2023-08-13 |
Not clear |
| Urban Košak, Damijan Knez, Nicolas Coquelle, Boris Brus, Anja Pišlar, Florian Nachon, Xavier Brazzolotto, Janko Kos, Jacques-Philippe Colletier, Stanislav Gobe. N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer's agents. Bioorganic & medicinal chemistry. vol 25. issue 2. 2017-08-14. PMID:27908752. |
while bche is a viable therapeutic target for alleviation of symptoms caused by cholinergic hypofunction, mao-b is a potential therapeutic target for prevention of neurodegeneration in alzheimer's disease. |
2017-08-14 |
2023-08-13 |
human |
| Janine Spieker, Thomas Mudersbach, Astrid Vogel-Höpker, Paul G Laye. Endochondral Ossification Is Accelerated in Cholinesterase-Deficient Mice and in Avian Mesenchymal Micromass Cultures. PloS one. vol 12. issue 1. 2017-08-07. PMID:28118357. |
here, we analyzed endochondral ossification in mutant murine fetuses, in which genes of the rate-limiting cholinergic enzymes acetyl- (ache), or butyrylcholinesterase (bche), or both were deleted (called here a-b+, a+b-, a-b-, respectively). |
2017-08-07 |
2023-08-13 |
mouse |
| Maja Katalinić, Nikolina Maček Hrvat, Krešimir Baumann, Sara Morasi Piperčić, Sandro Makarić, Srđanka Tomić, Ozren Jović, Tomica Hrenar, Ante Miličević, Dubravko Jelić, Suzana Žunec, Ines Primožič, Zrinka Kovari. A comprehensive evaluation of novel oximes in creation of butyrylcholinesterase-based nerve agent bioscavengers. Toxicology and applied pharmacology. vol 310. 2017-05-31. PMID:27654152. |
a well-considered treatment of acute nerve agents poisoning involves the exogenous administration of butyrylcholinesterase (bche, ec 3.1.1.8) as a stoichiometric bioscavenger efficient in preventing cholinergic crises caused by acetylcholinesterase (ache, ec 3.1.1.7) inhibition. |
2017-05-31 |
2023-08-13 |
mouse |
| Ganiyu Oboh, Omodesola O Ogunruku, Sunday I Oyeleye, Tosin A Olasehinde, Ayokunle O Ademosun, Aline Augusti Boligo. Phenolic Extracts from Clerodendrum volubile Leaves Inhibit Cholinergic and Monoaminergic Enzymes Relevant to the Management of Some Neurodegenerative Diseases. Journal of dietary supplements. vol 14. issue 3. 2017-04-03. PMID:27753518. |
this study investigated the inhibitory effects of phenolic-rich extracts from clerodendrum volubile leaves on cholinergic [acetylcholinesterase (ache) and butyrylcholinesterase (bche)] and monoaminergic [monoamine oxidase (mao)] enzymes' activities and pro-oxidants [fe |
2017-04-03 |
2023-08-13 |
Not clear |
| Matheus D Baldissera, Carine F Souza, Pedro Henrique Doleski, Guerino B Júnior, Agueda C de Vargas, Bernardo Baldisserott. Involvement of cholinergic and purinergic systems during the inflammatory response caused by Aeromonas hydrophila in Rhamdia quelen. Microbial pathogenesis. vol 99. 2017-03-27. PMID:27521226. |
the aim of this study was to evaluate the cholinergic (acetylcholinesterase (ache) and butyrylcholinesterase (bche)) and purinergic (adenosine deaminase (ada)) systems in head kidney, spleen, total blood and serum samples in experimentally infected fish with a. hydrophila, and the involvement of these systems during the inflammatory process. |
2017-03-27 |
2023-08-13 |
Not clear |
| Matheus D Baldissera, Carine F Souza, Thirssa H Grando, Aleksandro S da Silva, Silvia G Monteir. Involvement of oxidative stress, cholinergic and adenosinergic systems on renal damage caused by Trypanosoma evansi infection: Relationship with lipid peroxidation. Microbial pathogenesis. vol 99. 2017-03-27. PMID:27565091. |
the aim of this study was to evaluate the oxidative stress variables, and enzymes of cholinergic (acetylcholinesterase (ache) and butyrylcholinesterase (bche)) and adenosinergic (adenosine deaminase (ada)) systems in renal tissue, as well as the relationship between these systems and lipid peroxidation. |
2017-03-27 |
2023-08-13 |
cat |
| Hyolanda M Grosskopf, Rhayana K Grosskopf, Angelisa H Biazus, Marta L R Leal, Nathieli B Bottari, Mariana S Alves, Maria Rosa C Schetinger, Vera M Morsch, Gustavo Machado, Matheus D Baldissera, Aleksandro S Da Silv. Supplementation with copper edetate in control of Haemonchus contortus of sheep, and its effect on cholinesterase's and superoxide dismutase activities. Experimental parasitology. vol 173. 2017-03-13. PMID:28007539. |
cholinergic system was evaluated to determine the acetylcholinesterase (ache) activity in total blood and butyrylcholinesterase (bche) activity in serum. |
2017-03-13 |
2023-08-13 |
cat |
| Katsuyoshi Mizukami, Hiroyasu Akatsu, Eric E Abrahamson, Zhiping Mi, Milos D Ikonomovi. Immunohistochemical analysis of hippocampal butyrylcholinesterase: Implications for regional vulnerability in Alzheimer's disease. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 36. issue 2. 2017-01-09. PMID:26293308. |
since ca2/3 is generally considered more resistant to ad pathology, bche upregulation could impact the cholinergic modulation of glutamate neurotransmission to prevent/reduce neuronal excitotoxicity in ad hippocampus. |
2017-01-09 |
2023-08-13 |
Not clear |
| Wen Luo, Ying Chen, Ting Wang, Chen Hong, Li-Ping Chang, Cong-Cong Chang, Ya-Cheng Yang, Song-Qiang Xie, Chao-Jie Wan. Design, synthesis and evaluation of novel 7-aminoalkyl-substituted flavonoid derivatives with improved cholinesterase inhibitory activities. Bioorganic & medicinal chemistry. vol 24. issue 4. 2016-10-14. PMID:26752094. |
compound 2-(naphthalen-1-yl)-7-(8-(pyrrolidin-1-yl)octyloxy)-4h-chromen-4-one (5q) showed the best inhibitory activity (ic50, 0.64μm for ache and 0.42μm for bche) which were better than our previously reported compounds and the commercially available cholinergic agent rivastigmine. |
2016-10-14 |
2023-08-13 |
Not clear |
| Franz Worek, Martina Schilha, Katharina Neumaier, Nadine Aurbek, Timo Wille, Horst Thiermann, Kai Keh. On-site analysis of acetylcholinesterase and butyrylcholinesterase activity with the ChE check mobile test kit-Determination of reference values and their relevance for diagnosis of exposure to organophosphorus compounds. Toxicology letters. vol 249. 2016-08-16. PMID:27033775. |
however, in case of unspecific signs and of delayed onset of cholinergic crisis a rapid, reliable and on-site analysis of acetylcholinesterase (ache) and butyrylcholinesterase (bche) activity would be of great value. |
2016-08-16 |
2023-08-13 |
human |
| Abdul Hameed, Syeda T Zehra, Syed J A Shah, Khalid M Khan, Rima D Alharthy, Norbert Furtmann, Jürgen Bajorath, Muhammad N Tahir, Jamshed Iqba. Syntheses, cholinesterases inhibition, and molecular docking studies of pyrido[2,3-b]pyrazine derivatives. Chemical biology & drug design. vol 86. issue 5. 2016-08-01. PMID:25951978. |
cholinesterases, acetylcholinesterase (ache) and butyrylcholinesterase (bche), have a role in cholinergic deficit which evidently leads to alzheimer's disease (ad). |
2016-08-01 |
2023-08-13 |
Not clear |
| Miroslav Pohanka, Petr Dobe. Caffeine inhibits acetylcholinesterase, but not butyrylcholinesterase. International journal of molecular sciences. vol 14. issue 5. 2016-05-26. PMID:23698772. |
in the present work, we focused on the question whether caffeine can inhibit acetylcholinesterase (ache) and/or, butyrylcholinesterase (bche), the two enzymes participating in cholinergic neurotransmission. |
2016-05-26 |
2023-08-12 |
human |
| G F Bono, D P Simão-Silva, M S Batistela, N D Josviak, P F R Dias, G A Nascimento, R L R Souza, M R Piovezan, R K M Souza, L Furtado-All. Butyrylcholinesterase: K variant, plasma activity, molecular forms and rivastigmine treatment in Alzheimer's disease in a Southern Brazilian population. Neurochemistry international. vol 81. 2015-12-03. PMID:25624079. |
the human butyrylcholinesterase (bche) is an enzyme that has specific roles in cholinergic neurotransmission and it has been associated with ad. |
2015-12-03 |
2023-08-13 |
human |
| Vishakantha Murthy, Yang Gao, Liyi Geng, Nathan LeBrasseur, Thomas White, Stephen Brimijoi. Preclinical studies on neurobehavioral and neuromuscular effects of cocaine hydrolase gene therapy in mice. Journal of molecular neuroscience : MN. vol 53. issue 3. 2015-04-06. PMID:24085526. |
because mutated bche is approximately 70 % as efficient in hydrolyzing acetylcholine as wild-type enzyme, it is important to examine the impact on cholinergic function. |
2015-04-06 |
2023-08-12 |
mouse |
| Yaron Arbel, Shani Shenhar-Tsarfaty, Nir Waiskopf, Ariel Finkelstein, Amir Halkin, Miri Revivo, Shlomo Berliner, Itzhak Herz, Itzhak Shapira, Gad Keren, Hermona Soreq, Shmuel Bana. Decline in serum cholinesterase activities predicts 2-year major adverse cardiac events. Molecular medicine (Cambridge, Mass.). vol 20. 2014-10-28. PMID:24395570. |
cholinergic status was determined by measuring the cumulative capacity of serum acetylcholinesterase (ache) and butyrylcholinesterase (bche) to hydrolyze the ache substrate acetylthiocholine. |
2014-10-28 |
2023-08-12 |
Not clear |
| Alexandre A Tonin, Aleksandro S Da Silva, Gustavo R Thomé, Lizielle S Oliveira, Maria R C Schetinger, Vera M Morsch, Mariana M Flores, Rafael A Fighera, Gustavo Toscan, Fernanda F Vogel, Sonia T A Lope. Neospora caninum: Activity of cholinesterases during the acute and chronic phases of an experimental infection in gerbils. Experimental parasitology. vol 135. issue 4. 2014-01-17. PMID:24140613. |
since the participation of the cholinergic system in the immune response is well documented, the aim of this study was to evaluate the relationship between n. caninum infection and activities of acetylcholinesterase (ache) and butyrylcholinesterase (bche) during the acute and chronic phase of infection. |
2014-01-17 |
2023-08-12 |
cattle |
| Alexandre A Tonin, Aleksandro S Da Silva, Gustavo R Thomé, Lizielle S Oliveira, Maria R C Schetinger, Vera M Morsch, Mariana M Flores, Rafael A Fighera, Gustavo Toscan, Fernanda F Vogel, Sonia T A Lope. Neospora caninum: Activity of cholinesterases during the acute and chronic phases of an experimental infection in gerbils. Experimental parasitology. vol 135. issue 4. 2014-01-17. PMID:24140613. |
based on the results obtained, it was possible to observe a response of the cholinergic system, providing different grades of ache and bche activities, in response to the acute and chronic infection of gerbils experimentally infected with n. caninum. |
2014-01-17 |
2023-08-12 |
cattle |
| Eugénie Carletti, Jacques-Philippe Colletier, Lawrence M Schopfer, Gianluca Santoni, Patrick Masson, Oksana Lockridge, Florian Nachon, Martin Wei. Inhibition pathways of the potent organophosphate CBDP with cholinesterases revealed by X-ray crystallographic snapshots and mass spectrometry. Chemical research in toxicology. vol 26. issue 2. 2013-07-29. PMID:23339663. |
tocp is metabolized to cresyl saligenin phosphate (cbdp), a potent irreversible inhibitor of butyrylcholinesterase (bche), a natural bioscavenger present in the bloodstream, and acetylcholinesterase (ache), the off-switch at cholinergic synapses. |
2013-07-29 |
2023-08-12 |
mouse |
| Daiane Priscila Simão-Silva, Paulo Henrique Ferreira Bertolucci, Roger William de Labio, Spencer Luiz Marques Payão, Lupe Furtado-Alle, Ricardo Lehtonen Rodrigues Souz. Association analysis between K and -116A variants of butyrylcholinesterase and Alzheimer's disease in a Brazilian population. Chemico-biological interactions. vol 203. issue 1. 2013-05-28. PMID:23022600. |
the association of the k variant with ad in a controversial manner in different surveys is probably caused by its linkage disequilibrium with -116a that, by reducing bche activity, potentially increases cholinergic transmission in comparison with usual genotypes. |
2013-05-28 |
2023-08-12 |
human |