| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Melvin Selim Atay, Suat Sari, Ebru Bodu. Molecular and Computational Analysis Identify Statins as Selective Inhibitors of Human Butyrylcholinesterase. The protein journal. 2023-01-17. PMID:36648628. |
cholinesterase enzyme family consists of acetylcholinesterase (ache, 3.1.1.7), the major enzyme responsible for hydrolysis of acetylcholine at cholinergic synapses, and butyrylcholinesterase (bche, 3.1.1.8) a detoxification enzyme of plasma. |
2023-01-17 |
2023-08-14 |
human |
| Saritha S L Silva, Luciane V Tureck, Leonardo C Souza, João V M Hortega, Ana Luiza Piumbini, Mayza D Teixeira, Lupe Furtado-Alle Writing-Reviewing, Maria A B F Vital, Ricardo L R Souz. Animal model of Alzheimer's disease induced by streptozotocin: new insights about cholinergic pathway. Brain research. 2022-11-27. PMID:36436686. |
disorders of the cholinergic system are well known to be involved in the pathogenesis of ad, characterized by increased acetylcholinesterase (ache) and butyrylcholinesterase (bche) and decreased acetyltransferase (chat) enzymatic activities. |
2022-11-27 |
2023-08-14 |
human |
| Saritha S L Silva, Luciane V Tureck, Leonardo C Souza, João V M Hortega, Ana Luiza Piumbini, Mayza D Teixeira, Lupe Furtado-Alle Writing-Reviewing, Maria A B F Vital, Ricardo L R Souz. Animal model of Alzheimer's disease induced by streptozotocin: new insights about cholinergic pathway. Brain research. 2022-11-27. PMID:36436686. |
thus, this study aimed to assess the long-term effects of icv-stz on the cholinergic system, through the measuring of ache and bche enzymatic activities in hippocampus, prefrontal cortex and liver of animals euthanized 30 and 120-days after the icv-stz. |
2022-11-27 |
2023-08-14 |
human |
| Saritha S L Silva, Luciane V Tureck, Leonardo C Souza, João V M Hortega, Ana Luiza Piumbini, Mayza D Teixeira, Lupe Furtado-Alle Writing-Reviewing, Maria A B F Vital, Ricardo L R Souz. Animal model of Alzheimer's disease induced by streptozotocin: new insights about cholinergic pathway. Brain research. 2022-11-27. PMID:36436686. |
regarding the cholinergic response to icv-stz, the 30-days and 120-days stz-induced rats exhibit decreased ache and bche activities only in the hippocampus. |
2022-11-27 |
2023-08-14 |
human |
| Saritha S L Silva, Luciane V Tureck, Leonardo C Souza, João V M Hortega, Ana Luiza Piumbini, Mayza D Teixeira, Lupe Furtado-Alle Writing-Reviewing, Maria A B F Vital, Ricardo L R Souz. Animal model of Alzheimer's disease induced by streptozotocin: new insights about cholinergic pathway. Brain research. 2022-11-27. PMID:36436686. |
this is the first study to investigate the long-term effects (more than 60 days) of the icv-stz on ache and bche activities, and our results, as well as those of a recent study, suggest that the cholinergic system may not be compromised by icv-stz, at least in the long term, which means that this model may not be the best model for studying the cholinergic system in ad or that it is informative only for a short period. |
2022-11-27 |
2023-08-14 |
human |
| Sani Muhammad Uzairu, Yahaya Tijani, Madu Adamu Gadaka, Babagana Modu, Miriam Watafua, Hadiza Ali Ahmad, Umar Abdullahi Zakariya, Aminu Ibrahim, Aliyu Daja, Hassan Zanna, Abdullahi Balarabe Salla. Kinetics and computational study of butyrylcholinesterase inhibition by methylrosmarinate: relevance to Alzheimer's disease treatment. Heliyon. vol 8. issue 9. 2022-09-23. PMID:36148271. |
experimental studies have shown that the function of bche in the attenuation of cholinergic neurotransmission is essentially altered in brains of advanced ad patients. |
2022-09-23 |
2023-08-14 |
Not clear |
| Muslum Gok, Nimrod Madrer, Tamara Zorbaz, Estelle R Bennett, David Greenberg, David A Bennett, Hermona Sore. Altered levels of variant cholinesterase transcripts contribute to the imbalanced cholinergic signaling in Alzheimer's and Parkinson's disease. Frontiers in molecular neuroscience. vol 15. 2022-09-19. PMID:36117917. |
acetylcholinesterase and butyrylcholinesterase (ache and bche) are involved in modulating cholinergic signaling, but their roles in alzheimer's and parkinson's diseases (ad and pd) remain unclear. |
2022-09-19 |
2023-08-14 |
Not clear |
| Ilenia Severi, Silvia Abbatelli, Jessica Perugini, Eleonora Di Mercurio, Martina Senzacqua, Antonio Giordan. Butyrylcholinesterase distribution in the mouse gastrointestinal tract: An immunohistochemical study. Journal of anatomy. 2022-08-25. PMID:36004682. |
whereas ache has a well-established role in regulating cholinergic neurotransmission in central and peripheral synapses, the physiological role of bche remains elusive. |
2022-08-25 |
2023-08-14 |
mouse |
| Tess Puopolo, Chang Liu, Hang Ma, Navindra P Seera. Inhibitory Effects of Cannabinoids on Acetylcholinesterase and Butyrylcholinesterase Enzyme Activities. Medical cannabis and cannabinoids. vol 5. issue 1. 2022-06-15. PMID:35702400. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are two cholinergic enzymes catalyzing the reaction of cleaving acetylcholine into acetate and choline at the neuromuscular junction. |
2022-06-15 |
2023-08-14 |
Not clear |
| Tess Puopolo, Chang Liu, Hang Ma, Navindra P Seera. Inhibitory Effects of Cannabinoids on Acetylcholinesterase and Butyrylcholinesterase Enzyme Activities. Medical cannabis and cannabinoids. vol 5. issue 1. 2022-06-15. PMID:35702400. |
abnormal hyperactivity of ache and bche can lead to cholinergic deficiency, which is associated with several neurological disorders including cognitive decline and memory impairments. |
2022-06-15 |
2023-08-14 |
Not clear |
| Tess Puopolo, Chang Liu, Hang Ma, Navindra P Seera. Inhibitory Effects of Cannabinoids on Acetylcholinesterase and Butyrylcholinesterase Enzyme Activities. Medical cannabis and cannabinoids. vol 5. issue 1. 2022-06-15. PMID:35702400. |
preclinical studies support that some cannabinoids including cannabidiol (cbd) and tetrahydrocannabinol (thc) may exert pharmacological effects on the cholinergic system, but it remains unclear whether cannabinoids can inhibit ache and bche activities. |
2022-06-15 |
2023-08-14 |
Not clear |
| Khadija Boukholda, Brahim Gargouri, Bakhta Aouey, Abdelraheim Attaai, Mohamed Abd Elkodous, Mohamed Najimi, Bernd L Fiebich, Michèle Bouchard, Hamadi Fetou. Subacute silica nanoparticle exposure induced oxidative stress and inflammation in rat hippocampus combined with disruption of cholinergic system and behavioral functions. NanoImpact. vol 24. 2022-05-13. PMID:35559817. |
sinps affected the cholinergic system as reflected by reduced acetylcholinesterase (ache) and butyrylcholinesterase (bche) activity. |
2022-05-13 |
2023-08-13 |
rat |
| Carmel Therese Harrington, Naz Al Hafid, Karen Ann Water. Butyrylcholinesterase is a potential biomarker for Sudden Infant Death Syndrome. EBioMedicine. vol 80. 2022-05-09. PMID:35533499. |
butyrylcholinesterase (bche) is an enzyme of the cholinergic system, a major branch of the autonomic system, and may provide a measure of autonomic (dys)function. |
2022-05-09 |
2023-08-13 |
Not clear |
| b' Mehmet Koca, U\\xc4\\x9fur G\\xc3\\xbcller, P\\xc4\\xb1nar G\\xc3\\xbcller, Ziya Da\\xc4\\x9falan, Bilal Ni\\xc5\\x9fanc\\xc4\\xb. Design and Synthesis of Novel Dual Cholinesterase Inhibitors: In Vitro Inhibition Studies Supported with Molecular Docking. Chemistry & biodiversity. 2022-04-26. PMID:35470963.' |
the major cholinesterase enzymes, acetylcholinesterase (ache) and butyrylcholinesterase (bche), are important in the therapy of alzheimer's disease (ad) based on the cholinergic hypothesis. |
2022-04-26 |
2023-08-13 |
human |
| Hatice Esra Dura. Pyrimidines: Molecular docking and inhibition studies on carbonic anhydrase and cholinesterases. Biotechnology and applied biochemistry. 2022-02-03. PMID:35112394. |
cholinesterases (ches; ache, acetylcholinesterase and bche, butyrylcholinesterase) inhibitors and their benefits of cholinergic replacement in the treatment of ad have been researched and documented by scientists in various ways to date. |
2022-02-03 |
2023-08-13 |
human |
| Shuaizhang Li, Andrew J Li, Jameson Travers, Tuan Xu, Srilatha Sakamuru, Carleen Klumpp-Thomas, Ruili Huang, Menghang Xi. Identification of Compounds for Butyrylcholinesterase Inhibition. SLAS discovery : advancing life sciences R & D. vol 26. issue 10. 2021-12-04. PMID:34269114. |
bche plays a critical role in maintaining normal cholinergic function like acetylcholinesterase (ache) through hydrolyzing acetylcholine (ach). |
2021-12-04 |
2023-08-13 |
Not clear |
| b' Milena Mlaki\\xc4\\x87, Tena \\xc4\\x8cade\\xc5\\xbe, Danijela Bari\\xc4\\x87, Ivana Pu\\xc4\\x8dek, Ana Ratkovi\\xc4\\x87, \\xc5\\xbdeljko Marini\\xc4\\x87, Kornelija Lasi\\xc4\\x87, Zrinka Kovarik, Irena \\xc5\\xa0kori\\xc4\\x8. New Uncharged 2-Thienostilbene Oximes as Reactivators of Organophosphate-Inhibited Cholinesterases. Pharmaceuticals (Basel, Switzerland). vol 14. issue 11. 2021-11-30. PMID:34832929.' |
the inhibition of acetylcholinesterase (ache) and butyrylcholinesterase (bche) by organophosphates (ops) as nerve agents and pesticides compromises normal cholinergic nerve signal transduction in the peripheral and central nervous systems (cns) leading to cholinergic crisis. |
2021-11-30 |
2023-08-13 |
Not clear |
| Danish Iqbal, Md Tabish Rehman, Abdulaziz Bin Dukhyil, Syed Mohd Danish Rizvi, Mohamed F Al Ajmi, Bader Mohammed Alshehri, Saeed Banawas, M Salman Khan, Wael Alturaiki, Mohammed Alsawee. High-Throughput Screening and Molecular Dynamics Simulation of Natural Product-like Compounds against Alzheimer's Disease through Multitarget Approach. Pharmaceuticals (Basel, Switzerland). vol 14. issue 9. 2021-10-01. PMID:34577637. |
we have explored the library of 2029 natural product-like compounds for their multi-targeting potential against ad by inhibiting ache, bche (cholinergic pathway) mao-a, and moa-b (oxidative stress pathway) through in silico high-throughput screening and molecular dynamics simulation. |
2021-10-01 |
2023-08-13 |
Not clear |
| João Vitor Ferreira Rodrigues, Anna Paula Perin Vidigal, Vítor Sampaio Minassa, Thatiany Jardim Batista, Randriely Merscher Sobreira de Lima, Vinícius Rafael Funck, Leandro S Antero, Leonardo Barbosa Moraes Resstel, Juliana Barbosa Coitinho, Leandro Jose Bertoglio, Karla Nívea Sampaio, Vanessa Beijamin. A single dose of the organophosphate triazophos induces fear extinction deficits accompanied by hippocampal acetylcholinesterase inhibition. Neurotoxicology and teratology. vol 82. 2021-09-23. PMID:33031921. |
hippocampal and amygdalar ache activity and plasma butyrylcholinesterase (bche) were measured at the end of the experiment to confirm the cholinergic overstimulation. |
2021-09-23 |
2023-08-13 |
rat |
| M W D Thorne, M K Cash, G A Reid, D E Burley, D Luke, I R Pottie, S Darves. Imaging Butyrylcholinesterase in Multiple Sclerosis. Molecular imaging and biology. vol 23. issue 1. 2021-08-25. PMID:32926288. |
the purpose of this study was to further characterize changes in the cholinergic system in ms pathology, and to explore the utility of bche radioligands as potential diagnostic and treatment monitoring agents in ms. |
2021-08-25 |
2023-08-13 |
Not clear |