| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Martha Cecilia Rosales Hernández, Marycruz Olvera-Valdez, Jazziel Velazquez Toledano, Jessica Elena Mendieta Wejebe, Leticia Guadalupe Fragoso Morales, Alejandro Cru. Exploring the Benzazoles Derivatives as Pharmacophores for AChE, BACE1, and as Anti-Aβ Aggregation to Find Multitarget Compounds against Alzheimer's Disease. Molecules (Basel, Switzerland). vol 29. issue 19. 2024-10-16. PMID:39407708. |
ad is a multifactorial disease in which several pharmacological targets have been identified-some are involved with amyloid beta (aβ) production, such as beta secretase (bace1) and beta amyloid aggregation, while others are involved with the cholinergic system as acetylcholinesterase (ache) and butirylcholinesterase (bche) and nicotinic and muscarinic receptors, as well as the hyperphosphorylation of microtubule-associated protein (tau). |
2024-10-16 |
2024-10-18 |
Not clear |
| Ivan Kong, Gary Ka-Wing Yuen, Qi-Yun Wu, Maggie Sui-Sui Guo, Jin Gao, Tina Ting-Xia Dong, Karl Wah-Keung Tsi. Acetylcholine regulates the melanogenesis of retinal pigment epithelia cells via a cAMP-dependent pathway: A non-neuronal function of cholinergic system in retina. Heliyon. vol 10. issue 16. 2024-09-10. PMID:39253121. |
the mrna and protein expressions of cholinergic molecules, e.g., acetylcholinesterase (ache), butyrylcholinesterase (bche), and melanogenic molecules i.e., tyrosinase (tyr), microphthalmia-associated transcription factor (mitf), and melanin pigment were measured during melanogenesis of cultured arpe-19 cells. |
2024-09-10 |
2024-09-13 |
human |
| Ivan Kong, Gary Ka-Wing Yuen, Qi-Yun Wu, Maggie Sui-Sui Guo, Jin Gao, Tina Ting-Xia Dong, Karl Wah-Keung Tsi. Acetylcholine regulates the melanogenesis of retinal pigment epithelia cells via a cAMP-dependent pathway: A non-neuronal function of cholinergic system in retina. Heliyon. vol 10. issue 16. 2024-09-10. PMID:39253121. |
during melanogenesis of arpe-19 cells, the mrna and protein expressions of cholinergic molecules, e.g., ache and bche, were increased along with melanogenic molecules, i.e., tyr, mitf and melanin pigment. |
2024-09-10 |
2024-09-13 |
human |
| Saurabh G Londhe, Vinayak Walhekar, Mangala Shenoy, Suvarna G Kini, Marcus T Scotti, Luciana Scotti, Dileep Kuma. Computational and ADMET Predictions of Novel Compounds as Dual Inhibitors of BuChE and GSK-3β to Combat Alzheimer's Disease. Pharmaceutics. vol 16. issue 8. 2024-08-29. PMID:39204336. |
co-targeting gsk3β and bche in alzheimer's disease helps to modify disease progression and enhance cognitive function by addressing both tau pathology and cholinergic deficits. |
2024-08-29 |
2024-09-04 |
Not clear |
| Abdelhamid Qara, Mohamed Ouabane, Chakib Sekkate, Samir Chtita, Tahar Lakhlifi, Mohammed Bouachrin. Design of New Aromatic Tertiary Amine-based as Butyrylcholinesterase Inhibitors Relying on Molecular Docking, ADME-Tox and Molecular Dynamics. Current computer-aided drug design. 2024-07-30. PMID:39076094. |
empirical research demonstrated a fundamental alteration in the role of bche concerning the reduction of cholinergic neurotransmission within the brains of individuals at advanced stages of alzheimer's. |
2024-07-30 |
2024-08-02 |
Not clear |
| Zuzana Kohoutova, Eliska Prchalova, Karolina Knittelova, Kamil Musilek, David Malina. Reactivators of butyrylcholinesterase inhibited by organophosphorus compounds. Bioorganic chemistry. vol 150. 2024-06-15. PMID:38878749. |
while ache inhibition can be life threatening due to cholinergic overstimulation and crisis, selective bche inhibition has presumably no adverse effects. |
2024-06-15 |
2024-06-18 |
human |
| Jun-Tao Guo, Han-Yu Li, Chao Cheng, Jia-Xue Shi, Hai-Nan Ruan, Jun Li, Chan-Min Li. Isochlorogenic acid A ameliorated lead-induced anxiety-like behaviors in mice by inhibiting ferroptosis-mediated neuroinflammation via the BDNF/Nrf2/GPX4 pathways. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2024-06-14. PMID:38876379. |
icaa successfully mitigated the pb-induced deficits in the cholinergic system in the brain through the reduction of ach levels and the enhancement of ache and bche activities. |
2024-06-14 |
2024-06-17 |
mouse |
| Juan David Villeda-González, José Luis Gómez-Olivares, Luis Arturo Baiza-Gutma. New paradigms in the study of the cholinergic system and metabolic diseases: Acetyl-and-butyrylcholinesterase. Journal of cellular physiology. 2024-04-12. PMID:38605655. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are enzymes that belong to the neuromuscular cholinergic system, their main function is to hydrolyze the neurotransmitter acetylcholine (ach), through their hydrolysis these enzymes regulate the neuronal and neuromuscular cholinergic system. |
2024-04-12 |
2024-04-14 |
Not clear |
| Dora Kolić, Vesna Pehar, Zrinka Kovari. Environmental exposure to glyphosate does not inhibit human acetylcholinesterase and butyrylcholinesterase. Arhiv za higijenu rada i toksikologiju. vol 75. issue 1. 2024-03-28. PMID:38548375. |
chemically, glyphosate belongs to a large family of organophosphorus pesticides, which exert a neurotoxic effect by inhibiting acetylcholinesterase (ache) and butyrylcholinesterase (bche), enzymes of the cholinergic system essential for maintaining neurotransmission. |
2024-03-28 |
2024-03-31 |
human |
| Asmaa E Kassab, Ehab M Gedawy, Alaa S Saye. Fused thiophene as a privileged scaffold: A review on anti-Alzheimer's disease potentials via targeting cholinesterases, monoamine oxidases, glycogen synthase kinase-3, and Aβ aggregation. International journal of biological macromolecules. 2024-03-22. PMID:38518928. |
consequently, a frequent therapy approach for ad is the suppression of ache and bche to improve cholinergic neurotransmission and reduce cognitive symptoms. |
2024-03-22 |
2024-03-25 |
Not clear |
| Charles Neu, Ricardo Esper Treml, Philipp Baumbach, Markus Engelmann, Claudius Gebhardt, Juliane Götze, Sina M Coldewe. Cholinesterase activities and sepsis-associated encephalopathy in viral versus nonviral sepsis. Canadian journal of anaesthesia = Journal canadien d'anesthesie. 2024-03-01. PMID:38429621. |
blood acetylcholinesterase (ache) and butyrylcholinesterase (bche) activities have been proposed as surrogate parameters for the cholinergic function of the central nervous system. |
2024-03-01 |
2024-03-04 |
Not clear |
| Ali Taghizadehghalehjoughi, Muhammet Emin Naldan, Yesim Yeni, Sidika Genc, Ahmet Hacimuftuoglu, Mesut Isik, Adem Necip, İsmail Bolat, Serkan Yildirim, Sukru Beydemir, Mahmut Bayka. Effect of fentanyl and remifentanil on neuron damage and oxidative stress during induction neurotoxicity. Journal of cellular and molecular medicine. vol 28. issue 4. 2024-02-09. PMID:38332529. |
mtt, pon1 activity and total thiol levels for its effect on oxidative stress, ache and bche activities for its effect on the cholinergic system, and tnf, il-8 and il-10 gene levels for its neuroinflammation effect were determined. |
2024-02-09 |
2024-02-11 |
Not clear |
| Ali Naderi, Akın Akıncıoğlu, Ahmet Çağan, Hilal Çelikkaleli, Hülya Akıncıoğlu, Süleyman Göks. Design, synthesis and anticholinergic properties of novel α-benzyl dopamine, tyramine, and phenethylamine derivatives. Bioorganic chemistry. vol 144. 2024-01-23. PMID:38262088. |
within the scope of this study, the inhibition effects of dopamine-derived carbamates and amine salts on the cholinergic enzymes ache and bche were examined. |
2024-01-23 |
2024-01-26 |
Not clear |
| b' Suzana \\xc5\\xbdunec, Donna Vadlja, Alma Rami\\xc4\\x87, Antonio Zandona, Nikola Marakovi\\xc4\\x87, Iva Brekalo, Ines Primo\\xc5\\xbei\\xc4\\x8d, Maja Katalini\\xc4\\x8. Profiling Novel Quinuclidine-Based Derivatives as Potential Anticholinesterase Drugs: Enzyme Inhibition and Effects on Cell Viability. International journal of molecular sciences. vol 25. issue 1. 2024-01-11. PMID:38203326.' |
the enzymes acetylcholinesterase, ache, and butyrylcholinesterase, bche, responsible for hydrolyzing ach, can fine-tune the cholinergic system's activity and are, therefore, excellent pharmacological targets to address a range of medical conditions. |
2024-01-11 |
2024-01-13 |
Not clear |
| Musa Dirak, Jefferson Chan, Safacan Koleme. Optical imaging probes for selective detection of butyrylcholinesterase. Journal of materials chemistry. B. 2024-01-10. PMID:38196348. |
butyrylcholinesterase (bche), a member of the human serine hydrolase family, is an essential enzyme for cholinergic neurotransmission as it catalyzes the hydrolysis of acetylcholine. |
2024-01-10 |
2024-01-13 |
human |
| Banita Thakur, Laila Pamela Hasooni, Ruchi Gera, Sumonto Mitra, Lars Björndahl, Taher Darreh-Shor. Presence of key cholinergic enzymes in human spermatozoa and seminal fluid. Biology of reproduction. 2023-09-23. PMID:37741056. |
in conclusion, human spermatozoa exhibited a cholinergic phenotype and were one of the major sources of soluble chat and bche in ejaculate. |
2023-09-23 |
2023-10-07 |
human |
| Sara Bibi, Rabia Habib, Sania Shafiq, Syed Sayyam Abbas, Shaiza Khan, Syed Ali Musstjab Akber Shah Eqani, Eugenie Nepovimova, Mansoor Shaukat Khan, Kamil Kuca, Syed Muhammad Nurulai. Influence of the chronic groundwater fluoride consumption on cholinergic enzymes, ACHE and BCHE gene SNPs and pro-inflammatory cytokines: A study with Pakistani population groups. The Science of the total environment. 2023-04-08. PMID:37030382. |
influence of the chronic groundwater fluoride consumption on cholinergic enzymes, ache and bche gene snps and pro-inflammatory cytokines: a study with pakistani population groups. |
2023-04-08 |
2023-08-14 |
human |
| Sara Bibi, Rabia Habib, Sania Shafiq, Syed Sayyam Abbas, Shaiza Khan, Syed Ali Musstjab Akber Shah Eqani, Eugenie Nepovimova, Mansoor Shaukat Khan, Kamil Kuca, Syed Muhammad Nurulai. Influence of the chronic groundwater fluoride consumption on cholinergic enzymes, ACHE and BCHE gene SNPs and pro-inflammatory cytokines: A study with Pakistani population groups. The Science of the total environment. 2023-04-08. PMID:37030382. |
cholinergic enzymes (ache and bche) were significantly increased among different exposure groups. |
2023-04-08 |
2023-08-14 |
human |
| Yvonne J Rosenberg, Kelly Garcia, Justin Diener, Dennis Sullivan, Scott Donahue, Lingjun Mao, Jonathan Lees, Xiaoming Jiang, Lori A Urban, Jeremiah D Momper, Kwok-Yiu Ho, Palmer Taylo. A single post-exposure oxime RS194B treatment rapidly reactivates acetylcholinesterase and reverses acute symptoms in macaques exposed to diethylphosphorothioate parathion and chlorpyrifos insecticides. Journal of neurochemistry. 2023-02-14. PMID:36786545. |
thus, a single im injection of rs194b has been shown to rapidly restore blood ache and butyrylcholinesterase (bche) activity, reverse cholinergic symptoms and prevent death in macaques following lethal inhaled sarin and paraoxon exposure. |
2023-02-14 |
2023-08-14 |
mouse |
| Ignazio Schino, Mariangela Cantore, Modesto de Candia, Cosimo D Altomare, Catarina Maria, João Barros, Vasco Cachatra, Patrícia Calado, Karina Shimizu, Adilson A Freitas, Maria C Oliveira, Maria J Ferreira, José N C Lopes, Nicola A Colabufo, Amélia P Raute. Exploring Mannosylpurines as Copper Chelators and Cholinesterase Inhibitors with Potential for Alzheimer's Disease. Pharmaceuticals (Basel, Switzerland). vol 16. issue 1. 2023-01-21. PMID:36678552. |
alzheimer's disease (ad) is characterized by a progressive cholinergic neurotransmission imbalance, with a decrease of acetylcholinesterase (ache) activity followed by a significant increase of butyrylcholinesterase (bche) in the later ad stages. |
2023-01-21 |
2023-08-14 |
Not clear |