| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sliha Awan, Aisha N Hashmi, Rizwan Taj, Sadaf Munir, Rabia Habib, Sajida Batool, Maleeha Azam, Raheel Qamar, Syed M Nurulai. Genetic Association of Butyrylcholinesterase with Major Depressive Disorder. Biochemical genetics. 2021-08-20. PMID:34414522. |
in the present study butyrylcholinesterase (bche), a co-regulatory cholinergic neurotransmitter enzyme implicated in several putative neuronal and non-neuronal physiological roles was investigated for its role in mdd. |
2021-08-20 |
2023-08-13 |
Not clear |
| b' Antonio Zandona, Gabriela Lihtar, Nikola Marakovi\\xc4\\x87, Katarina Mi\\xc5\\xa1, Valentina Bu\\xc5\\xa1i\\xc4\\x87, Dajana Ga\\xc5\\xa1o-Soka\\xc4\\x8d, Sergej Pirkmajer, Maja Katalini\\xc4\\x8. Vitamin B3-Based Biologically Active Compounds as Inhibitors of Human Cholinesterases. International journal of molecular sciences. vol 21. issue 21. 2021-03-29. PMID:33138280.' |
we evaluated the potential of nine vitamin b3 scaffold-based derivatives as acetylcholinesterase (ache) and butyrylcholinesterase (bche) inhibitors, as a starting point for the development of novel drugs for treating disorders with cholinergic neurotransmission-linked pathology. |
2021-03-29 |
2023-08-13 |
human |
| Janine Spieker, Johannes L Frieß, Laura Sperling, Gopenath Thangaraj, Astrid Vogel-Höpker, Paul G Laye. Cholinergic control of bone development and beyond. International immunopharmacology. vol 83. 2021-02-19. PMID:32208165. |
in results, we briefly summarize our in vivo and in vitro studies on bone development of chick and mouse [1,2], including (i) expressions of cholinergic components (ache, bche, chat) in chick embryo, (ii) characterisation of defects during skeletogenesis in prenatal che knockout mice, (iii) loss-of-function experiments with beads soaked in cholinergic components and implanted into chicken limb buds, and finally (iv) we use an in vitro mesenchymal 3d-micromass model that mimics cartilage and bone formation, which also had revealed complex crosstalks between cholinergic, radiation and inflammatory mechanisms [3]. |
2021-02-19 |
2023-08-13 |
mouse |
| Mbah Ntepe Leonel Javeres, Rabia Habib, Ngondi Judith, Moaz Iqbal, Eugenie Nepovimova, Kamil Kuca, Sajida Batool, Syed Muhammad Nurulai. Analysis of PON1 gene polymorphisms (rs662 and rs854560) and inflammatory markers in organophosphate pesticides exposed cohorts from two distinct populations. Environmental research. vol 191. 2021-01-11. PMID:32949615. |
the study was aimed to assess the cholinergic enzymes (ache and bche), pon1, and inflammatory markers (il1β, il6, tnfα, crp, apo ai, apo b) and determine the toxicogenetics association of pon1 gene (rs 662 and rs 85456) to chronically ops exposed groups from pakistan and cameroon. |
2021-01-11 |
2023-08-13 |
Not clear |
| Barbara Kaproń, Robert Czarnomysy, Mariusz Wysokiński, Rudolf Andrys, Kamil Musilek, Andrea Angeli, Claudiu T Supuran, Tomasz Plec. 1,2,4-Triazole-based anticonvulsant agents with additional ROS scavenging activity are effective in a model of pharmacoresistant epilepsy. Journal of enzyme inhibition and medicinal chemistry. vol 35. issue 1. 2020-12-21. PMID:32253957. |
based on the enzymatic studies on human carbonic anhydrases (cas), acetylcholinesterase (ache) and butyrylcholinesterase (bche), one can assume that the herein investigated drug candidates will not impair the cognitive processes mediated by cas and will have minimal off-target cholinergic effects. |
2020-12-21 |
2023-08-13 |
mouse |
| Jan Korabecny, Katarina Spilovska, Eva Mezeiova, Ondrej Benek, Radomir Juza, Daniel Kaping, Ondrej Souku. A Systematic Review on Donepezil-based Derivatives as Potential Cholinesterase Inhibitors for Alzheimer's Disease. Current medicinal chemistry. vol 26. issue 30. 2019-11-25. PMID:29768996. |
this review presents the overview of donepezilrelated compounds as potential anti-ad drugs developed on the basis of cholinergic hypothesis to act as solely ache and butyrylcholinesterase (bche) inhibitors. |
2019-11-25 |
2023-08-13 |
Not clear |
| Lucieli K F Müller, Aleksandro S DA Silva, Nathieli B Bottari, Janio M Santurio, Vera M Morsch, Manoela M Piva, Ricardo E Mendes, Eduardo M Gloria, Diovani Paian. Effects of fed mycotoxin contaminated diets supplemented with spray-dried porcine plasma on cholinergic response and behavior in piglets. Anais da Academia Brasileira de Ciencias. vol 91. issue 2. 2019-07-26. PMID:31269106. |
taken together, the data suggest changes in ache and bche activities may indicate alterations in cholinergic neurotransmission and consequently in the behavior of piglets. |
2019-07-26 |
2023-08-13 |
Not clear |
| Lorena R Braid, Catherine A Wood, Barry N For. Human umbilical cord perivascular cells: A novel source of the organophosphate antidote butyrylcholinesterase. Chemico-biological interactions. vol 305. 2019-05-10. PMID:30926319. |
however, bche secretion from hucpvcs is limited by innate feedback mechanisms that can be interrupted by addition of mir 186 oligonucleotide mimics or by competitive inhibition of muscarinic cholinergic signalling receptors by addition of atropine. |
2019-05-10 |
2023-08-13 |
human |
| Sadaf Munir, Rabia Habib, Sliha Awan, Nazia Bibi, Arooj Tanveer, Sajida Batool, Syed M Nurulai. Biochemical Analysis and Association of Butyrylcholinesterase SNPs rs3495 and rs1803274 with Substance Abuse Disorder. Journal of molecular neuroscience : MN. vol 67. issue 3. 2019-04-15. PMID:30707402. |
butyrylcholinesterase (bche), a cholinergic enzyme, has been implicated in the metabolism of various drugs, including cocaine, and an association between single-nucleotide polymorphisms (snps) of the butyrylcholinesterase gene (bche) and neuronal disorders has been reported. |
2019-04-15 |
2023-08-13 |
human |
| Marcella Reale, Erica Costantini, Marta Di Nicola, Chiara D'Angelo, Sara Franchi, Marco D'Aurora, Maria Di Bari, Viviana Orlando, Sabrina Galizia, Serena Ruggieri, Liborio Stuppia, Claudio Gasperini, Ada Maria Tata, Valentina Gatt. Butyrylcholinesterase and Acetylcholinesterase polymorphisms in Multiple Sclerosis patients: implication in peripheral inflammation. Scientific reports. vol 8. issue 1. 2018-11-21. PMID:29358722. |
the aim of the present research was to assess the associations between bche and ache genetic variations and serum cholinergic and inflammatory profiles in 102 relapsing remitting-ms patients and 117 healthy controls. |
2018-11-21 |
2023-08-13 |
Not clear |
| Marcella Reale, Erica Costantini, Marta Di Nicola, Chiara D'Angelo, Sara Franchi, Marco D'Aurora, Maria Di Bari, Viviana Orlando, Sabrina Galizia, Serena Ruggieri, Liborio Stuppia, Claudio Gasperini, Ada Maria Tata, Valentina Gatt. Butyrylcholinesterase and Acetylcholinesterase polymorphisms in Multiple Sclerosis patients: implication in peripheral inflammation. Scientific reports. vol 8. issue 1. 2018-11-21. PMID:29358722. |
we propose that serum bche and ache activity may be used as a secondary markers to assess the role of non-neuronal cholinergic system in regulating peripheral inflammation via ach regulation. |
2018-11-21 |
2023-08-13 |
Not clear |
| Aleksandar R Zivkovic, Sebastian O Decker, Anne C Zirnstein, Annette Sigl, Karsten Schmidt, Markus A Weigand, Stefan Hofer, Thorsten Brenne. A Sustained Reduction in Serum Cholinesterase Enzyme Activity Predicts Patient Outcome following Sepsis. Mediators of inflammation. vol 2018. 2018-10-01. PMID:29853783. |
serum cholinesterase (bche), an enzyme that hydrolyzes acetylcholine, plays an important role during inflammatory response and serves as an accurate index of cholinergic activity. |
2018-10-01 |
2023-08-13 |
Not clear |
| Oluwafemi Adeleke Ojo, Adebola Busola Ojo, Basiru Olaitan Ajiboye, Babatunji Emmanuel Oyinloye, Ayodele Jacob Akinyemi, Mary Abiola Okesola, Aline Augusti Boligon, Marli Matiko Anraku de Campo. Chromatographic fingerprint analysis, antioxidant properties, and inhibition of cholinergic enzymes (acetylcholinesterase and butyrylcholinesterase) of phenolic extracts from Irvingia gabonensis (Aubry-Lecomte ex O'Rorke) Baill bark. Journal of basic and clinical physiology and pharmacology. vol 29. issue 2. 2018-08-29. PMID:29381472. |
this work characterized the phenolic composition, evaluated the cholinergic enzymes (acetylcholinesterase, ache and butyrylcholinesterase, bche) inhibition, and assessed the antioxidant activity of phenolic extracts from i. gabonensis (aubry-lecomte ex o'rorke) baill bark. |
2018-08-29 |
2023-08-13 |
Not clear |
| Natalie Cortes, Karina Sierra, Fernando Alzate, Edison H Osorio, Edison Osori. Alkaloids of Amaryllidaceae as Inhibitors of Cholinesterases (AChEs and BChEs): An Integrated Bioguided Study. Phytochemical analysis : PCA. vol 29. issue 2. 2018-08-16. PMID:29044771. |
however, butyrylcholinesterase (bche), contributes critically to cholinergic dysfunction associated with ad. |
2018-08-16 |
2023-08-13 |
Not clear |
| Urban Košak, Boris Brus, Damijan Knez, Roman Šink, Simon Žakelj, Jurij Trontelj, Anja Pišlar, Jasna Šlenc, Martina Gobec, Marko Živin, Larisa Tratnjek, Martina Perše, Kinga Sałat, Adrian Podkowa, Barbara Filipek, Florian Nachon, Xavier Brazzolotto, Anna Więckowska, Barbara Malawska, Jure Stojan, Irena Mlinarič Raščan, Janko Kos, Nicolas Coquelle, Jacques-Philippe Colletier, Stanislav Gobe. Development of an in-vivo active reversible butyrylcholinesterase inhibitor. Scientific reports. vol 6. 2018-08-14. PMID:28000737. |
similar to acetylcholinesterase, butyrylcholinesterase (bche) contributes to the termination of cholinergic neurotransmission. |
2018-08-14 |
2023-08-13 |
mouse |
| Terrone L Rosenberry, Xavier Brazzolotto, Ian R Macdonald, Marielle Wandhammer, Marie Trovaslet-Leroy, Sultan Darvesh, Florian Nacho. Comparison of the Binding of Reversible Inhibitors to Human Butyrylcholinesterase and Acetylcholinesterase: A Crystallographic, Kinetic and Calorimetric Study. Molecules (Basel, Switzerland). vol 22. issue 12. 2018-07-17. PMID:29186056. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) hydrolyze the neurotransmitter acetylcholine and, thereby, function as coregulators of cholinergic neurotransmission. |
2018-07-17 |
2023-08-13 |
human |
| N D Josviak, M S Batistela, R K M Souza, N R Wegner, G F Bono, C D Sulzbach, D P Simão-Silva, M R Piovezan, R L R Souza, L Furtado-All. Plasma butyrylcholinesterase activity: a possible biomarker for differential diagnosis between Alzheimer's disease and dementia with Lewy bodies? The International journal of neuroscience. vol 127. issue 12. 2018-06-04. PMID:28504037. |
k and -116a bche variants were associated with decrease in plasma bche activity, and their influence has been investigated in diseases with a cholinergic deficit such as alzheimer's disease (ad) and dementia with lewy bodies (dlb). |
2018-06-04 |
2023-08-13 |
Not clear |
| Drew R DeBay, George A Reid, Ian R Macdonald, George Mawko, Steve Burrell, Earl Martin, Chris V Bowen, Sultan Darves. Butyrylcholinesterase-knockout reduces fibrillar β-amyloid and conserves Brain research. vol 1671. 2018-05-17. PMID:28729192. |
ad is also a state of cholinergic dysfunction and butyrylcholinesterase (bche) associates with aβ pathology. |
2018-05-17 |
2023-08-13 |
mouse |
| Danielle Hagstrom, Hideto Hirokawa, Limin Zhang, Zoran Radic, Palmer Taylor, Eva-Maria S Collin. Planarian cholinesterase: in vitro characterization of an evolutionarily ancient enzyme to study organophosphorus pesticide toxicity and reactivation. Archives of toxicology. vol 91. issue 8. 2018-04-12. PMID:27990564. |
while previous activity staining of d. japonica, which possess a discrete cholinergic nervous system, has shown acylthiocholine catalysis, it is unknown whether this is accomplished through an acetylcholinesterase (ache), butyrylcholinesterase (bche), or a hybrid esterase and how op exposure affects esterase activity. |
2018-04-12 |
2023-08-13 |
human |
| Aleksandar R Zivkovic, Kevin M Tourelle, Thorsten Brenner, Markus A Weigand, Stefan Hofer, Karsten Schmid. Reduced serum cholinesterase activity indicates splenic modulation of the sterile inflammation. The Journal of surgical research. vol 220. 2017-12-11. PMID:29180192. |
measuring the activity of the bche in blood might indicate the level of the nonneuronal cholinergic activity. |
2017-12-11 |
2023-08-13 |
Not clear |