| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lanna Beatriz Neves Silva Corrêa, Carlos Alberto Soares da Costa, José Antônio Silva Ribas, Gilson Teles Boaventura, Mauricio Alves Chaga. Antioxidant action of alpha lipoic acid on the testis and epididymis of diabetic rats: morphological, sperm and immunohistochemical evaluation. International braz j urol : official journal of the Brazilian Society of Urology. vol 45. issue 4. 2019-09-23. PMID:31184457. |
alpha lipoic acid (ala) can prevent metabolic and morphological changes in diabetic individuals. |
2019-09-23 |
2023-08-13 |
rat |
| Eric N Ponnampalam, Vahid Vahedi, Khageswor Giri, Paul Lewandowski, Joe L Jacobs, Frank R Dunshe. Muscle Antioxidant Enzymes Activity and Gene Expression Are Altered by Diet-Induced Increase in Muscle Essential Fatty Acid (α-linolenic acid) Concentration in Sheep Used as a Model. Nutrients. vol 11. issue 4. 2019-08-07. PMID:30925775. |
this study investigated the effect of dietary manipulations on muscle fatty acid composition, the activities and relative mrna expressions of antioxidant enzymes and the relationship between muscle enzyme activity or mrna expression and alpha linolenic acid (ala) concentration in sheep. |
2019-08-07 |
2023-08-13 |
Not clear |
| Md Ahsanul Kabir Khan, Junhuan Yang, Syed Ammar Hussain, Huaiyuan Zhang, Victoriano Garre, Yuanda Son. Genetic Modification of International journal of molecular sciences. vol 20. issue 7. 2019-08-05. PMID:30987311. |
genetic modification of stearidonic acid (sda; 18:4, n-3) is the delta 15-desaturase product of gamma linolenic acid (gla; 18:3, n-6) and delta 6-desaturase product of alpha linolenic acid (ala; 18:3, n-3). |
2019-08-05 |
2023-08-13 |
Not clear |
| Małgorzata Szczuko, Małgorzata Kaczkan, Arleta Drozd, Dominika Maciejewska, Joanna Palma, Anna Owczarzak, Natalia Marczuk, Przemysław Rutkowski, Sylwia Małgorzewic. Comparison of Fatty Acid Profiles in a Group of Female Patients with Chronic Kidney Diseases (CKD) and Metabolic Syndrome (MetS)⁻Similar Trends of Changes, Different Pathophysiology. International journal of molecular sciences. vol 20. issue 7. 2019-07-26. PMID:30959940. |
in the mets group, auxiliary metabolic pathways of oleic acid were activated, which simultaneously inhibited the synthesis of eicosapentanoic acid (epa) and docosahexaenoic acid (dha) from alpha lipoic acid (ala). |
2019-07-26 |
2023-08-13 |
Not clear |
| Mahsa Kaveh, Akram Eidi, Ali Nemati, Mohammad Hossein Boskabad. The Extract of Portulaca oleracea and Its Constituent, Alpha Linolenic Acid Affects Serum Oxidant Levels and Inflammatory Cells in Sensitized Rats. Iranian journal of allergy, asthma, and immunology. vol 16. issue 3. 2019-07-09. PMID:28732439. |
eight groups of rats including control, sensitized, sensitized rats treated with 1, 2 and 4 mg/ml extract of p. oleracea, 0.2 and 0.4 mg/ml alpha linolenic acid (ala) and 1.25 μg/ml dexamethaswere studied serum levels of superoxide dismutase (sod), catalase (cat, thiol groups, no2, no3, and malondialdehyde (mda) as well as total and differential wbc in blood were measured. |
2019-07-09 |
2023-08-13 |
rat |
| Shweta Modgil, Sridhar Bammidi, Avijit Banik, Vijay Lakshmi Sharma, Akshay Anan. Alpha lipoic acid attenuates the long-term effects of lead exposure in retinal ischemic injury mouse model. Environmental science and pollution research international. vol 26. issue 15. 2019-07-02. PMID:30945075. |
further, alpha lipoic acid (ala) was administered to examine its neuroprotective effects against retinal damage. |
2019-07-02 |
2023-08-13 |
mouse |
| Daiwu Lin, Xiao Liu, Renliang Huang, Wei Qi, Rongxin Su, Zhimin H. One-pot synthesis of mercapto functionalized Zr-MOFs for the enhanced removal of Hg Chemical communications (Cambridge, England). vol 55. issue 47. 2019-06-07. PMID:31120068. |
mercaptoacetic acid (maa) or alpha lipoic acid (ala) was used as the modulators and functionalized molecules to synthesize mercapto functionalized zr-mofs (zr-mofs-sh(o)). |
2019-06-07 |
2023-08-13 |
Not clear |
| Fahimeh Haghighatdoost, Mitra Harir. Does alpha-lipoic acid affect lipid profile? A meta-analysis and systematic review on randomized controlled trials. European journal of pharmacology. vol 847. 2019-06-04. PMID:30633888. |
randomized controlled trials (rcts) have demonstrated that alpha lipoic acid (ala) may change lipid profile, but their results are contradictory. |
2019-06-04 |
2023-08-13 |
Not clear |
| Kyung Ae Lee, Na Young Lee, Tae Sun Park, Heung Yong Ji. Comparison of peripheral nerve protection between insulin-based glucose control and alpha lipoic acid (ALA) in the streptozotocin (STZ)-induced diabetic rat. Endocrine. vol 61. issue 1. 2019-05-29. PMID:29736880. |
comparison of peripheral nerve protection between insulin-based glucose control and alpha lipoic acid (ala) in the streptozotocin (stz)-induced diabetic rat. |
2019-05-29 |
2023-08-13 |
rat |
| Kyung Ae Lee, Na Young Lee, Tae Sun Park, Heung Yong Ji. Comparison of peripheral nerve protection between insulin-based glucose control and alpha lipoic acid (ALA) in the streptozotocin (STZ)-induced diabetic rat. Endocrine. vol 61. issue 1. 2019-05-29. PMID:29736880. |
alpha lipoic acid (ala) has also been accepted as a therapeutic agent for diabetic peripheral neuropathy (dpn) in the respect of pathogenesis. |
2019-05-29 |
2023-08-13 |
rat |
| Duygu Ferek Emir, Ibrahim Ulas Ozturan, Serkan Yilma. Alpha lipoic acid intoxicatıon: An adult. The American journal of emergency medicine. vol 36. issue 6. 2019-05-08. PMID:29559356. |
alpha lipoic acid (ala) is a potent antioxidant used to treat a variety of disorders. |
2019-05-08 |
2023-08-13 |
Not clear |
| Carlos Cardoso, Joana Paiva Martinho, Paula A Lopes, Susana Martins, Jorge Correia, Cláudia Afonso, Francisco J Alarcón, María J González-Fernández, Rui M Pinto, José A Prates, Narcisa M Bandarra, José L Guil-Guerrer. Stearidonic acid combined with alpha-linolenic acid improves lipemic and neurological markers in a rat model subject to a hypercaloric diet. Prostaglandins, leukotrienes, and essential fatty acids. vol 135. 2019-04-03. PMID:30103925. |
in this study, we hypothesized that terrestrial plant oils, rich in alpha linolenic acid (ala) and stearidonic acid (sda) relative to fish oil, rich in eicosapentaenoic acid (epa) and docosahexaenoic acid (dha), prevent negative effects on cardiovascular and neurological function using a rat model fed a hypercaloric diet. |
2019-04-03 |
2023-08-13 |
human |
| Xiaotong Wang, Haixiong Lin, Shuai Xu, Yuanlin Jin, Ren Zhan. Alpha lipoic acid combined with epalrestat: a therapeutic option for patients with diabetic peripheral neuropathy. Drug design, development and therapy. vol 12. 2019-02-12. PMID:30233145. |
alpha lipoic acid (ala), a type of antioxidant, is used in combination with epalrestat in the treatment of diabetic peripheral neuropathy (dpn). |
2019-02-12 |
2023-08-13 |
Not clear |
| O Ozturk, M Saygin, O Ozmen, I Ilha. The effects of chronic smoking on lung tissue and the role of alpha lipoic acid. Biotechnic & histochemistry : official publication of the Biological Stain Commission. vol 93. issue 7. 2019-02-08. PMID:30056778. |
we investigated the effects of alpha lipoic acid (ala) on blood and lung tissue exposed chronically to cigarette smoke (cs). |
2019-02-08 |
2023-08-13 |
rat |
| Usama A Fahm. Augmentation of Fluvastatin Cytotoxicity Against Prostate Carcinoma PC3 Cell Line Utilizing Alpha Lipoic-Ellagic Acid Nanostructured Lipid Carrier Formula. AAPS PharmSciTech. vol 19. issue 8. 2019-02-04. PMID:30350252. |
both alpha lipoic acid (ala) and ellagic acid (ea) are natural antioxidants found in a normal diet. |
2019-02-04 |
2023-08-13 |
Not clear |
| Osama Aa Ahmed, Khalid M El-Say, Bader M Aljaeid, Shaimaa M Badr-Eldin, Tarek A Ahme. Optimized vinpocetine-loaded vitamin E D-α-tocopherol polyethylene glycol 1000 succinate-alpha lipoic acid micelles as a potential transdermal drug delivery system: in vitro and ex vivo studies. International journal of nanomedicine. vol 14. 2019-02-04. PMID:30587983. |
this work aimed at utilizing d-α-tocopherol polyethylene glycol 1000 succinate (tpgs) and alpha lipoic acid (ala) to develop efficient micellar system for transdermal delivery of vnp. |
2019-02-04 |
2023-08-13 |
Not clear |
| Asiye Sezgin, Cansu Altuntaş, Mehmet Demiralay, Salih Cinemre, Rabiye Terz. Exogenous alpha lipoic acid can stimulate photosystem II activity and the gene expressions of carbon fixation and chlorophyll metabolism enzymes in maize seedlings under drought. Journal of plant physiology. vol 232. 2019-01-22. PMID:30537614. |
however, there are not enough records about the response of plants to alpha lipoic acid (ala) application with antioxidant properties. |
2019-01-22 |
2023-08-13 |
Not clear |
| Nasrin Sadeghiyan Galeshkalami, Mohammad Abdollahi, Rezvan Najafi, Maryam Baeeri, Akram Jamshidzade, Reza Falak, Mohammad Davoodzadeh Gholami, Gholamreza Hassanzadeh, Tahmineh Mokhtari, Shokoufeh Hassani, Mahban Rahimifard, Asieh Hossein. Alpha-lipoic acid and coenzyme Q10 combination ameliorates experimental diabetic neuropathy by modulating oxidative stress and apoptosis. Life sciences. vol 216. 2019-01-07. PMID:30393023. |
neuroprotective effects of alpha lipoic acid (ala) and coenzyme q10 (coq10) has been previously shown in dn, but underlying mechanisms involved not been exactly found. |
2019-01-07 |
2023-08-13 |
Not clear |
| Irem Tasci, Caner Feyzi Demir, Tuncay Kulogl. Effects of Alpha Lipoic Acid on Loss of Myelin Sheath of Sciatic Nerve in Experimentally Induced Diabetic Rats. Medical archives (Sarajevo, Bosnia and Herzegovina). vol 72. issue 3. 2018-12-24. PMID:30061762. |
alpha lipoic acid (ala) is a potent lipophilic antioxidant in vitro and in vivo conditions, which plays a main role as cofactor in many mitochondrial reactions, easily absorbed from gastointestinal tract and can easily cross the blood brain barrier (bbb). |
2018-12-24 |
2023-08-13 |
rat |
| Ishit R Kothari, Kishan S Italiya, Saurabh Sharma, Anupama Mittal, Deepak Chitkar. A Rapid and Precise Liquid Chromatographic Method for Simultaneous Determination of Alpha Lipoic Acid and Docetaxel in Lipid-Based Nanoformulations. Journal of chromatographic science. vol 56. issue 10. 2018-12-14. PMID:29992274. |
a combination of conventional chemotherapeutic agent; docetaxel (dtx) and antioxidant agent; alpha lipoic acid (ala) which acts by preventing metastasis may fulfill idealness of control and targeted drug delivery against breast cancer. |
2018-12-14 |
2023-08-13 |
Not clear |