| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Faiza Yaqub, Noreen Latief, Hira Butt, Nadia Naseer, Sheikh Riazuddi. Alpha lipoic acid priming enhances the hepatoprotective effect of adipose derived stem cells in CCl4 induced hepatic injury in-vitro. European journal of pharmacology. vol 906. 2021-07-16. PMID:34118221. |
alpha lipoic acid (ala) is a strong anti-oxidant which has been shown to ameliorate the adverse effects of fibrosis that otherwise can lead to severe liver problems like cirrhosis and liver failure. |
2021-07-16 |
2023-08-13 |
Not clear |
| Alexandros Tsoupras, Donal Moran, Thomas Byrne, James Ryan, Luke Barrett, Con Traas, Ioannis Zabetaki. Anti-Inflammatory and Anti-Platelet Properties of Lipid Bioactives from Apple Cider By-Products. Molecules (Basel, Switzerland). vol 26. issue 10. 2021-07-07. PMID:34066136. |
pls from all acbps and their pc bioactives were rich in polyunsaturated fatty acids (pufas) and especially in the essential omega-6 (n-6) linoleic acid (la) and omega-3 (n-3) alpha linolenic acid (ala), with favorably low values of the n-6/n-3 pufa ratio, thus providing a rationale for their higher anti-inflammatory bioactivities. |
2021-07-07 |
2023-08-13 |
human |
| Reyhaneh Darvish Damavandi, Farzad Shidfar, Mohammad Najafi, Leila Janani, Mohsen Masoodi, Maryam Akbari-Fakhrabadi, Afsaneh Dehna. Effect of Portulaca Oleracea (purslane) extract on liver enzymes, lipid profile, and glycemic status in nonalcoholic fatty liver disease: A randomized, double-blind clinical trial. Phytotherapy research : PTR. vol 35. issue 6. 2021-06-28. PMID:33880813. |
purslane (portulaca oleracea l.) is the richest green leafy vegetable source of omega-3, especially alpha linolenic acid (ala). |
2021-06-28 |
2023-08-13 |
Not clear |
| Khaled A Abdelrahman, Abdelrady S Ibrahim, Ayman M Osman, Mohamed G Aly, Abdelhady S Ali, Waleed S Farra. Alpha lipoic acid with pulsed radiofrequency in treatment of chronic lumbosacral radicular pain: A prospective, randomized study. Medicine. vol 100. issue 24. 2021-06-24. PMID:34128884. |
the effect of adding alpha lipoic acid (ala) to pulsed radiofrequency (prf) for treatment of lumbar-sacral pain was evaluated. |
2021-06-24 |
2023-08-13 |
Not clear |
| Marcella E O'Reilly, Yvonne M Lenighan, Eugene Dillon, Sarina Kajani, Sean Curley, Robyn Bruen, Rachel Byrne, Aoibhin Moore Heslin, Aidan P Moloney, Helen M Roche, Fiona C McGillicudd. Conjugated Linoleic Acid and Alpha Linolenic Acid Improve Cholesterol Homeostasis in Obesity by Modulating Distinct Hepatic Protein Pathways. Molecular nutrition & food research. vol 64. issue 7. 2021-06-14. PMID:31917888. |
it is hypothesized that dietary supplementation with the polyunsaturated fatty acids conjugated linoleic acid (cla) or alpha linolenic acid (ala) would prevent hfd-impaired rct by modulating hepatic protein pathways. |
2021-06-14 |
2023-08-13 |
Not clear |
| Chiara Di Tucci, Giulia Galati, Giulia Mattei, Valentina Bonanni, Oriana Capri, Renzo D'Amelio, Ludovico Muzii, Pierluigi Benedetti Panic. The role of alpha lipoic acid in female and male infertility: a systematic review. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. vol 37. issue 6. 2021-06-08. PMID:33345661. |
in this review, we examine if alpha lipoic acid (ala), among the oral supplements currently in use, has an evidence-based beneficial role in the context of female and male infertility. |
2021-06-08 |
2023-08-13 |
Not clear |
| Hatice Eser Faki, Bunyamin Tras, Kamil Une. Alpha lipoic acid and vitamin E improve atorvastatin-induced mitochondrial dysfunctions in rats. Mitochondrion. vol 52. 2021-06-07. PMID:32119925. |
to determine the effects of alpha lipoic acid (ala) and vitamin e (vit e) on mitochondrial dysfunction caused by statins. |
2021-06-07 |
2023-08-13 |
rat |
| Leyla Bahar, Nehir Sucu, Nazan Eras, Ozlen Tubay Bagdatoglu, Metin Yildiri. Adrenomedullin expression in aortic artery wall of diabetic rats given alpha lipoic acid. Pharmacological reports : PR. vol 72. issue 4. 2021-05-28. PMID:32103464. |
the aim of this study was to investigate the effects of alpha lipoic acid (ala) on both the arterial wall of diabetic rats and the adrenomedullin (adm) gene expression. |
2021-05-28 |
2023-08-13 |
rat |
| Elham Sharifi-Zahabi, Hadi Abdollahzad, Seyed Mostafa Nachvak, Jalal Moloudi, Mohammad Reza Golpayegani, Sahar Asiaei, Laya Rezavand, Zeynab Iraji, Khadijeh Jamshid. Effects of alpha lipoic acid on iron overload, lipid profile and oxidative stress indices in β-thalassemia major patients: A cross-over randomised controlled clinical trial. International journal of clinical practice. vol 75. issue 6. 2021-05-18. PMID:33527721. |
alpha lipoic acid (ala) showed anti-oxidant and iron chelating properties, but its effect in β-tm patients is unclear. |
2021-05-18 |
2023-08-13 |
Not clear |
| Ji Wang, Daniel L Clark, Sheila K Jacobi, Sandra G Vellema. Effect of vitamin E and alpha lipoic acid on intestinal development associated with wooden breast myopathy in broilers. Poultry science. vol 100. issue 3. 2021-04-22. PMID:33652526. |
vitamin e (ve) and alpha lipoic acid (ala) with antioxidant and anti-inflammatory effects were used independently and in combination to evaluate their effects on intestinal developmental changes in ileal morphology and expression of genes related with gut nutrient transport, structure, and inflammation in broilers during the first 3 wk posthatch. |
2021-04-22 |
2023-08-13 |
chicken |
| Ji Wang, Daniel L Clark, Sheila K Jacobi, Sandra G Vellema. Effect of vitamin E and alpha lipoic acid on intestinal development associated with wooden breast myopathy in broilers. Poultry science. vol 100. issue 3. 2021-04-22. PMID:33652526. |
combination of ve and ala increased collagen type iv alpha 1 chain expression (p ≤ 0.05) and improved basement membrane structure indicating increased gut basement membrane integrity at 2 and 3 wk of age compared to the control. |
2021-04-22 |
2023-08-13 |
chicken |
| Farzan Mozaffarian, Mohammad Amin Dehghani, Atefeh Raesi Vanani, Masoud Mahdavini. Protective Effects of Alpha Lipoic Acid Against Arsenic Induced Oxidative Stress in Isolated Rat Liver Mitochondria. Biological trace element research. 2021-04-18. PMID:33866498. |
this study investigated alpha lipoic acid (ala) as an antioxidant could ameliorate against liver toxicity induced by arsenic in rat mitochondria. |
2021-04-18 |
2023-08-13 |
human |
| Fatma Ibrahim, Mahmoud A Nomier, Laila M E Sabik, Mohamed A Shahee. Manganese-induced neurotoxicity and the potential protective effects of lipoic acid and Toxicology mechanisms and methods. vol 30. issue 7. 2021-03-31. PMID:32441205. |
the aim of this study was to evaluate the neurotoxic effects of mn and the potential protective effects of alpha lipoic acid (ala) and |
2021-03-31 |
2023-08-13 |
Not clear |
| Jung Hwa Jung, Jin Hyun Kim, Myeong Hee Jung, Seung Won Kim, Bae Kwon Jeong, Seung Hoon Wo. Protective Effect of Alpha-Lipoic Acid on Salivary Dysfunction in a Mouse Model of Radioiodine Therapy-Induced Sialoadenitis. International journal of molecular sciences. vol 21. issue 11. 2021-03-25. PMID:32531940. |
this study was performed to investigate the radioprotective effects of alpha lipoic acid (ala) administered prior to ri therapy in a mouse model of ri-induced sialadenitis. |
2021-03-25 |
2023-08-13 |
mouse |
| Naglaa S El-Hansi, Abdelsattar M Sallam, Mona S Talaat, Hoda H Said, Mahmoud A Khalaf, Omar S Desouk. Biomechanical properties enhancement of gamma radiation-sterilized cortical bone using antioxidants. Radiation and environmental biophysics. vol 59. issue 3. 2021-03-24. PMID:32444954. |
the aim of this study is to examine the radioprotective role of hydroxytyrosol (ht) and alpha lipoic acid (ala) on the mechanical properties of gamma-sterilized cortical bone of bovine femur, using three-point bending and microhardness tests. |
2021-03-24 |
2023-08-13 |
cattle |
| Mehrazin Noshadian, Zahra Namvarpour, Abdollah Amini, Amir Raoofi, Hadi Atabati, Yousef Sadeghi, Abass Aliaghaei, Modammad-Amin Abdollahifa. Alpha lipoic acid ameliorates THIM-induced prefrontal cell loss and abnormal enzymatically contents in the developing rat. Journal of chemical neuroanatomy. vol 103. 2021-03-23. PMID:31740419. |
therefore, in this research, the protective effects of alpha lipoic acid (ala), against thim-induced brain cell loss, changes in neuroimmune cell and enzymatically contents were examined. |
2021-03-23 |
2023-08-13 |
rat |
| Waqar Ali, Muhammad Ikram, Hyun Young Park, Min Gi Jo, Rahat Ullah, Sareer Ahmad, Noman Bin Abid, Myeong Ok Ki. Oral Administration of Alpha Linoleic Acid Rescues Aβ-Induced Glia-Mediated Neuroinflammation and Cognitive Dysfunction in C57BL/6N Mice. Cells. vol 9. issue 3. 2021-03-16. PMID:32182943. |
in this work, we evaluated the effects of alpha linoleic acid (ala), an omega-3 polyunsaturated fatty acid, on amyloid-beta-induced glial-cell-mediated neuroinflammation, amyloidogenesis, and cognitive dysfunction in mice. |
2021-03-16 |
2023-08-13 |
mouse |
| Shedrach Benjamin Pewan, John Roger Otto, Roger Huerlimann, Alyssa Maree Budd, Felista Waithira Mwangi, Richard Crawford Edmunds, Benjamin William Behrens Holman, Michelle Lauren Elizabeth Henry, Robert Tumwesigye Kinobe, Oyelola Abdulwasiu Adegboye, Aduli Enoch Othniel Malau-Adul. Genetics of Omega-3 Long-Chain Polyunsaturated Fatty Acid Metabolism and Meat Eating Quality in Tattykeel Australian White Lambs. Genes. vol 11. issue 5. 2021-03-16. PMID:32466330. |
these health-beneficial n-3 lc-pufa play significant roles in optimal cardiovascular, retinal, maternal and childhood brain functions, and include alpha linolenic (ala), eicosapentaenoic (epa), docosahexaenoic (dha) and docosapentaenoic (dpa) acids. |
2021-03-16 |
2023-08-13 |
Not clear |
| Elham Asa, Rahim Ahmadi, Minoo Mahmoodi, Abdolreza Mohammadniy. Supplementation of freezing media with alpha lipoic acid preserves the structural and functional characteristics of sperm against cryodamage in infertile men with asthenoteratozoospermia. Cryobiology. vol 96. 2021-02-15. PMID:32652098. |
the aim of this study was to examine the effects of alpha lipoic acid (ala) supplementation during semen cryopreservation on the sperm quality, chromatin integrity, oxidative stress, and expression level of bax, bcl2, hsp70 and inos genes in semen samples obtained from infertile men with asthenoteratozoospermia. |
2021-02-15 |
2023-08-13 |
Not clear |
| Yong Dong, Ju Bai, Yimeng Zhang, Ya Zhou, Xu Pan, Xiaohong Li, Qiongxiu Zhou, Yijin Chen, Mowen Lai, Bin Mao, Guohui Bian, Jia Feng, Fangxin Xie, Bo Chen, Tatsutoshi Nakahata, Yonggang Zhang, Feng M. Alpha lipoic acid promotes development of hematopoietic progenitors derived from human embryonic stem cells by antagonizing ROS signals. Journal of leukocyte biology. vol 108. issue 6. 2021-02-09. PMID:32640500. |
alpha lipoic acid (ala), a small antioxidant molecule, affects cell apoptosis by lowering the ros level. |
2021-02-09 |
2023-08-13 |
human |