| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| LeAnne T Bloedon, Shilpa Balikai, Jesse Chittams, Stephen C Cunnane, Jesse A Berlin, Daniel J Rader, Philippe O Szapar. Flaxseed and cardiovascular risk factors: results from a double blind, randomized, controlled clinical trial. Journal of the American College of Nutrition. vol 27. issue 1. 2008-07-03. PMID:18460483. |
flaxseed is a rich source of alpha linolenic acid (ala), fiber and lignans, making it a potentially attractive functional food for modulating cardiovascular risk. |
2008-07-03 |
2023-08-12 |
Not clear |
| B T Diwakar, P K Dutta, B R Lokesh, K A Naid. Bio-availability and metabolism of n-3 fatty acid rich garden cress (Lepidium sativum) seed oil in albino rats. Prostaglandins, leukotrienes, and essential fatty acids. vol 78. issue 2. 2008-06-18. PMID:18249532. |
the ratio of fatty acids namely linoleic acid (la, 18:2, n-6) and alpha linolenic acid (ala, 18:3, n-3) in the diet plays an important role in enrichment of ala in tissues and further conversion to long-chain polyunsaturated fatty acids (lc-pufa) like eicosapentaenoic acid (epa, 20:5, n-3) and docosahexaenoic acid (dha, 22:6, n-3). |
2008-06-18 |
2023-08-12 |
rat |
| Richard E Jones, Nicole Moes, Heather Zwickey, Christopher L Cunningham, William L Gregory, Barry Oke. Treatment of experimental autoimmune encephalomyelitis with alpha lipoic acid and associative conditioning. Brain, behavior, and immunity. vol 22. issue 4. 2008-06-04. PMID:18162366. |
we have initiated studies to evaluate the suitability of performing therapeutic conditioning trials in experimental autoimmune encephalomyelitis (eae) mice treated with alpha lipoic acid (ala). |
2008-06-04 |
2023-08-12 |
mouse |
| Masaya Shimizu, Hiroyuki Nakamura, Tetsuya Hirabayashi, Akiko Suganami, Yutaka Tamura, Toshihiko Murayam. Ser515 phosphorylation-independent regulation of cytosolic phospholipase A2alpha (cPLA2alpha) by calmodulin-dependent protein kinase: possible interaction with catalytic domain A of cPLA2alpha. Cellular signalling. vol 20. issue 5. 2008-05-23. PMID:18280113. |
the mutation of ser515 to ala (s515a) did not change cpla(2)alpha activity, although s228a and s505a completely and partially decreased the activity, respectively. |
2008-05-23 |
2023-08-12 |
Not clear |
| K Simmer, S M Schulzke, S Patol. Long-chain polyunsaturated fatty acid supplementation in preterm infants. The Cochrane database of systematic reviews. issue 1. 2008-04-14. PMID:18253973. |
the n-3 and n-6 essential fatty acids alpha linolenic acid (ala) and linoleic acid (la) are the precursors of the n-3 and n-6 longchain polyunsaturated fatty acids (lcpufa). |
2008-04-14 |
2023-08-12 |
Not clear |
| Binu Tharakan, Juliet G Holder-Haynes, Felicia A Hunter, Ed W Child. Alpha lipoic acid attenuates microvascular endothelial cell hyperpermeability by inhibiting the intrinsic apoptotic signaling. American journal of surgery. vol 195. issue 2. 2008-02-05. PMID:18096126. |
this study examined whether alpha lipoic acid (ala), an antioxidant with anti-apoptotic properties, synthesized in mitochondria of endothelial cells, would inhibit intrinsic apoptotic signaling and microvascular endothelial cell hyperpermeability. |
2008-02-05 |
2023-08-12 |
Not clear |
| Mark Ambrose, Jimena V Goldstine, Richard A Gatt. Intrinsic mitochondrial dysfunction in ATM-deficient lymphoblastoid cells. Human molecular genetics. vol 16. issue 18. 2008-01-10. PMID:17606465. |
treating a-t cells with the antioxidant, alpha lipoic acid (ala), restored mitochondrial respiration rates to levels approaching those of wild-type. |
2008-01-10 |
2023-08-12 |
Not clear |
| Piero C Giordano, R G H J Maatman, R W L M Niessen, Peter van Delft, Cornelis L Hartevel. Beta thalassemia IVS-I-5(G-->C) heterozygosity masked by the presence of HbJ-Meerut in a Dutch-Indian patient. Haematologica. vol 91. issue 12 Suppl. 2007-11-29. PMID:17194662. |
direct sequencing of the alpha globin genes revealed heterozygosity for hbj-meerut, a glu-->ala substitution at residue 120 not justifying the hematological parameters. |
2007-11-29 |
2023-08-12 |
Not clear |
| Kailee N Sutherland, Philippe C Mineau, Galina Orlov. Radical-cationic gaseous amino acids: a theoretical study. The journal of physical chemistry. A. vol 111. issue 32. 2007-10-18. PMID:17645316. |
an efficient spin delocalization along the n-c(alpha)-c(o-)o moiety occurs upon h-transfer from c(alpha) to the carboxylic group to yield the captodative enolic form, which is the lowest-energy isomer for ala(.+), pro(.+), ser(.+), cys(.+), tyr(.+), and phe(.+). |
2007-10-18 |
2023-08-12 |
Not clear |
| W Elaine Hardma. Dietary canola oil suppressed growth of implanted MDA-MB 231 human breast tumors in nude mice. Nutrition and cancer. vol 57. issue 2. 2007-09-11. PMID:17571951. |
in vivo, alpha linolenic acid (ala, 18:3n-3) can be converted to epa or dha. |
2007-09-11 |
2023-08-12 |
mouse |
| Franca Marangoni, Claudio Colombo, Antonella Martiello, Andrea Poli, Rodolfo Paoletti, Claudio Gall. Levels of the n-3 fatty acid eicosapentaenoic acid in addition to those of alpha linolenic acid are significantly raised in blood lipids by the intake of four walnuts a day in humans. Nutrition, metabolism, and cardiovascular diseases : NMCD. vol 17. issue 6. 2007-08-16. PMID:17008073. |
ingestion of alpha linolenic acid (ala), with the richest source among dry fruits such as walnuts, is associated with cardiovascular prevention. |
2007-08-16 |
2023-08-12 |
human |
| Marika Arduin, Barbara Spagnolo, Girolamo Calò, Remo Guerrini, Giacomo Carrà, Carmela Fischetti, Claudio Trapella, Erika Marzola, John McDonald, David G Lambert, Domenico Regoli, Severo Salvador. Synthesis and biological activity of nociceptin/orphanin FQ analogues substituted in position 7 or 11 with Calpha,alpha-dialkylated amino acids. Bioorganic & medicinal chemistry. vol 15. issue 13. 2007-08-13. PMID:17490886. |
previous structure-activity and nmr studies on nociceptin/orphanin fq (n/ofq) demonstrated that aib substitution of ala(7) and/or ala(11) increases the peptide potency through an alpha helix structure induction mechanism. |
2007-08-13 |
2023-08-12 |
mouse |
| Mónica Rosa, Maria Rosa Infante, Maria da G Miguel, Björn Lindma. Spontaneous formation of vesicles and dispersed cubic and hexagonal particles in amino acid-based catanionic surfactant systems. Langmuir : the ACS journal of surfaces and colloids. vol 22. issue 13. 2007-07-20. PMID:16768481. |
the surfactants used were arginine-n-lauroyl amide dihydrochloride (ala) and n(alpha)-lauroyl-arginine-methyl ester hydrochloride (lam), which are arginine-based cationic surfactants; sodium hydrogenated tallow glutamate (hs), a glutamic-based anionic surfactant; and the anionic surfactants sodium octyl sulfate (sos) and sodium cetyl sulfate (scs). |
2007-07-20 |
2023-08-12 |
Not clear |
| Jean-Marie Bourr. Dietary omega-3 fatty acids for women. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 61. issue 2-3. 2007-07-20. PMID:17254747. |
this review details the specific needs of women for omega-3 fatty acids, including alpha linoleic acid (ala) and the very long chain fatty acids eicosapentaenoic acid (epa) and docosahexaenoic acid (dha). |
2007-07-20 |
2023-08-12 |
human |
| Raj Kumar Singh, Vimal Chandra Srivastava, Udai P Sing. Copper (II) complexes with Ac-HXH-NHMe (X=Gly, Ala and Aib) peptide motifs: influence of increasing CH(3) groups at C(alpha) of residue X on the coordination in solution. Protein and peptide letters. vol 14. issue 4. 2007-07-18. PMID:17504086. |
copper (ii) complexes with ac-hxh-nhme (x=gly, ala and aib) peptide motifs: influence of increasing ch(3) groups at c(alpha) of residue x on the coordination in solution. |
2007-07-18 |
2023-08-12 |
human |
| Junko Arimochi, Ayako Ohashi-Kobayashi, Masatomo Maed. Interaction of Mat-8 (FXYD-3) with Na+/K+-ATPase in colorectal cancer cells. Biological & pharmaceutical bulletin. vol 30. issue 4. 2007-05-22. PMID:17409496. |
the gly41-->arg mutation in the transmembrane region of mat-8 inhibited its association with the na+/k+-atpase alpha subunit and localization on the plasma membrane, whereas the cys44-->ala or cys49-->ala substitution did not. |
2007-05-22 |
2023-08-12 |
Not clear |
| Yuichiro Takeuchi, Takahide Miyamoto, Tomoko Kakizawa, Satoshi Shigematsu, Kiyoshi Hashizum. Insulin Autoimmune Syndrome possibly caused by alpha lipoic acid. Internal medicine (Tokyo, Japan). vol 46. issue 5. 2007-04-09. PMID:17329919. |
here, we report a case of ias associated with alpha lipoic acid (ala). |
2007-04-09 |
2023-08-12 |
Not clear |
| Noboru Furukawa, Nobuhiro Miyamura, Kenro Nishida, Hiroyuki Motoshima, Kayo Taketa, Eiichi Arak. Possible relevance of alpha lipoic acid contained in a health supplement in a case of insulin autoimmune syndrome. Diabetes research and clinical practice. vol 75. issue 3. 2007-04-04. PMID:16963149. |
our patient have been taken alpha lipoic acid (ala) before onset. |
2007-04-04 |
2023-08-12 |
Not clear |
| Pu Liu, Gregory A Vot. Smart resolution replica exchange: an efficient algorithm for exploring complex energy landscapes. The Journal of chemical physics. vol 126. issue 4. 2007-03-27. PMID:17286516. |
the method is demonstrated for a two-dimensional model system, where the ideal population distribution can be recovered, and also for an alanine polypeptide (ala(15)) model with explicit water, where its native structure, an alpha helix, is obtained from the extended structure within 1 ns. |
2007-03-27 |
2023-08-12 |
Not clear |
| Natthiya Deeying, Kritsana Sagari. Effects of metal ion and solute conformation change on hydration of small amino acid. Biophysical chemistry. vol 125. issue 1. 2007-02-15. PMID:16889887. |
the theoretical investigations were started with construction of the test-particle model (t-model) potentials for all molecules involved and followed by molecular dynamics (md) simulations of [ala](aq) and [li(+)/ala](aq) at 298 k. the md results showed that the hydrogen bond (h-bond) networks of water at the functional groups of ala are strengthened by the metal ion binding, whereas the rotation of the n-c(alpha) bond from the angle phi=0 degrees to 180 degrees brings about smaller effects which cannot be generalized. |
2007-02-15 |
2023-08-12 |
Not clear |