| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Wurch, F C Colpaert, P J Pauwel. Mutation in a protein kinase C phosphorylation site of the 5-HT1A receptor preferentially attenuates Ca2+ responses to partial as opposed to higher-efficacy 5-HT1A agonists. Neuropharmacology. vol 44. issue 7. 2003-08-04. PMID:12726819. |
here, the ca(2+) responses for a series of 5-ht(1a) agonists were compared between the wild-type (wt) and mutant thr(149)ala 5-ht(1a) receptor as part of a fusion protein containing a g(alpha)(15) protein. |
2003-08-04 |
2023-08-12 |
Not clear |
| T Wurch, F C Colpaert, P J Pauwel. Mutation in a protein kinase C phosphorylation site of the 5-HT1A receptor preferentially attenuates Ca2+ responses to partial as opposed to higher-efficacy 5-HT1A agonists. Neuropharmacology. vol 44. issue 7. 2003-08-04. PMID:12726819. |
whereas at the wt 5-ht(1a) receptor, 5-ht induced a ca(2+) response in cho-k1 cells via endogenous g(i/o) proteins, the ca(2+) response to 5-ht at the mutant thr(149)ala 5-ht(1a) receptor was fully dependent on either the co-expression or the fusion to a recombinant g(alpha)(15) protein. |
2003-08-04 |
2023-08-12 |
Not clear |
| T Wurch, F C Colpaert, P J Pauwel. Mutation in a protein kinase C phosphorylation site of the 5-HT1A receptor preferentially attenuates Ca2+ responses to partial as opposed to higher-efficacy 5-HT1A agonists. Neuropharmacology. vol 44. issue 7. 2003-08-04. PMID:12726819. |
the maximal ca(2+) responses at the mutant thr(149)ala 5-ht(1a):g(alpha)(15) fusion protein were significantly attenuated for flesinoxan and 8-oh-dpat (-45 and -36%, respectively); the response to the other 5-ht agonists was not significantly affected. |
2003-08-04 |
2023-08-12 |
Not clear |
| T Wurch, F C Colpaert, P J Pauwel. Mutation in a protein kinase C phosphorylation site of the 5-HT1A receptor preferentially attenuates Ca2+ responses to partial as opposed to higher-efficacy 5-HT1A agonists. Neuropharmacology. vol 44. issue 7. 2003-08-04. PMID:12726819. |
a similar effect was observed upon treatment with phorbol 12-myristate 13-acetate at the thr(149)ala 5-ht(1a):g(alpha)(15) fusion protein. |
2003-08-04 |
2023-08-12 |
Not clear |
| T Wurch, F C Colpaert, P J Pauwel. Mutation in a protein kinase C phosphorylation site of the 5-HT1A receptor preferentially attenuates Ca2+ responses to partial as opposed to higher-efficacy 5-HT1A agonists. Neuropharmacology. vol 44. issue 7. 2003-08-04. PMID:12726819. |
in conclusion, the amplitude of the ca(2+) responses induced by partial, but not that to fuller 5-ht(1a) receptor agonists, is affected by the thr(149)ala mutation of the 5-ht(1a):g(alpha)(15) fusion protein. |
2003-08-04 |
2023-08-12 |
Not clear |
| Xiaolan Yao, Satoru Yamaguchi, Mei Hon. C(alpha) chemical shift tensors in helical peptides by dipolar-modulated chemical shift recoupling NMR. Journal of biomolecular NMR. vol 24. issue 1. 2003-08-01. PMID:12449418. |
we have determined the magnitude and orientation of the c(alpha) chemical shift tensors of two peptides with a-helical torsion angles: the ala residue in g*al (phi = -65.7 degrees, psi = -40 degrees), and the val residue in gg*v (phi = -81.5 degrees, psi = -50.7 degrees). |
2003-08-01 |
2023-08-12 |
Not clear |
| Xiaolan Yao, Satoru Yamaguchi, Mei Hon. C(alpha) chemical shift tensors in helical peptides by dipolar-modulated chemical shift recoupling NMR. Journal of biomolecular NMR. vol 24. issue 1. 2003-08-01. PMID:12449418. |
the helical ala c(alpha) chemical shift tensor has a span of 36 ppm and an asymmetry parameter of 0.89. |
2003-08-01 |
2023-08-12 |
Not clear |
| F Femiano, C Scully, F Gombo. Idiopathic dysgeusia; an open trial of alpha lipoic acid (ALA) therapy. International journal of oral and maxillofacial surgery. vol 31. issue 6. 2003-04-15. PMID:12521319. |
idiopathic dysgeusia; an open trial of alpha lipoic acid (ala) therapy. |
2003-04-15 |
2023-08-12 |
Not clear |
| P Lacan, M Aubry, N Couprie, A Francin. Hb Gerland [alpha55(E4)Val-->Ala (alpha2)]: a new neutral alpha chain variant involving the alpha2 gene. Hemoglobin. vol 25. issue 4. 2003-04-14. PMID:11791875. |
hb gerland [alpha55(e4)val-->ala (alpha2)]: a new neutral alpha chain variant involving the alpha2 gene. |
2003-04-14 |
2023-08-12 |
Not clear |
| Okkeş Yilmaz, Yusuf Ozkan, Mehmet Yildirim, A Ihsan Oztürk, Yasemin Erşa. Effects of alpha lipoic acid, ascorbic acid-6-palmitate, and fish oil on the glutathione, malonaldehyde, and fatty acids levels in erythrocytes of streptozotocin induced diabetic male rats. Journal of cellular biochemistry. vol 86. issue 3. 2003-03-12. PMID:12210759. |
in this research, it has been aimed to evaluate the improvement effects of alpha lipoic acid (ala), ascorbic acid-6-palmitate (aa6p), fish oil (fo), and their combination (com) on some biochemical properties in erythrocytes of streptozotocin (stz)-induced diabetic male rats. |
2003-03-12 |
2023-08-12 |
rat |
| Thierry Wurch, Elisa A Boutet-Robinet, Christiane Palmier, Francis C Colpaert, Petrus J Pauwel. Constitutive coupling of a chimeric dopamine D2/alpha 1B receptor to the phospholipase C pathway: inverse agonism to silent antagonism by neuroleptic drugs. The Journal of pharmacology and experimental therapeutics. vol 304. issue 1. 2003-01-23. PMID:12490615. |
marked inverse agonist responses with a series of dopamine antagonists were obtained by: 1) exchange of the d 2short receptor's 3icl by that of the alpha 1b-adrenoceptor, 2) incorporation of an activating mutation (ala 279 glu) in the distal portion of its 3icl, and 3) coexpression with a g alpha11 protein. |
2003-01-23 |
2023-08-12 |
Not clear |
| Robert B Raff. Harmonic mean relationship between affinity for wild-type receptors and alanine-scan mutants. Journal of theoretical biology. vol 218. issue 2. 2002-12-27. PMID:12381293. |
the sequential process generates a discrete set of "mutant" proteins, each member of which differs from the native 'wild-type' receptor (r(wt)) or ligand by the single amino acid (alpha) substitution with alanine (r(ala)). |
2002-12-27 |
2023-08-12 |
Not clear |
| Robert B Raff. Harmonic mean relationship between affinity for wild-type receptors and alanine-scan mutants. Journal of theoretical biology. vol 218. issue 2. 2002-12-27. PMID:12381293. |
the ala mapsto alpha substitutions are made for amino acids suspected of being important for binding of ligand to receptor. |
2002-12-27 |
2023-08-12 |
Not clear |
| Gail H Marracci, Richard E Jones, Gabriel P McKeon, Dennis N Bourdett. Alpha lipoic acid inhibits T cell migration into the spinal cord and suppresses and treats experimental autoimmune encephalomyelitis. Journal of neuroimmunology. vol 131. issue 1-2. 2002-12-09. PMID:12458042. |
we tested the antioxidant alpha lipoic acid (ala) in an experimental murine model of ms, experimental autoimmune encephalomyelitis (eae). |
2002-12-09 |
2023-08-12 |
mouse |
| Sergio G Peisajovich, Raquel F Epand, Richard M Epand, Yechiel Sha. Sendai virus N-terminal fusion peptide consists of two similar repeats, both of which contribute to membrane fusion. European journal of biochemistry. vol 269. issue 17. 2002-11-05. PMID:12199713. |
based on these experiments, we postulate that replacement of gly 7 and gly12 by ala increases the alpha helical content of the n-terminal region, with a concomitant increase in its fusogenic activity. |
2002-11-05 |
2023-08-12 |
Not clear |
| Youheng Shi, John T Ko. Functionally orthogonal ligand-receptor pairs for the selective regulation of gene expression generated by manipulation of charged residues at the ligand-receptor interface of ER alpha and ER beta. Journal of the American Chemical Society. vol 124. issue 24. 2002-08-12. PMID:12059215. |
carboxylate-functionalized e2 analogues can activate er alpha(glu353-->ala) and er beta(glu305-->ala) with very large selectivites, demonstrating that this design strategy is extendable to other members of the steroid hormone receptor family. |
2002-08-12 |
2023-08-12 |
Not clear |
| Shouchun Liu, William B Kiosses, David M Rose, Marina Slepak, Ravi Salgia, James D Griffin, Christopher E Turner, Martin A Schwartz, Mark H Ginsber. A fragment of paxillin binds the alpha 4 integrin cytoplasmic domain (tail) and selectively inhibits alpha 4-mediated cell migration. The Journal of biological chemistry. vol 277. issue 23. 2002-07-12. PMID:11919182. |
here we report that sequences between residues ala(176) and asp(275) of paxillin are sufficient for binding to the alpha(4) tail. |
2002-07-12 |
2023-08-12 |
Not clear |
| Shouchun Liu, William B Kiosses, David M Rose, Marina Slepak, Ravi Salgia, James D Griffin, Christopher E Turner, Martin A Schwartz, Mark H Ginsber. A fragment of paxillin binds the alpha 4 integrin cytoplasmic domain (tail) and selectively inhibits alpha 4-mediated cell migration. The Journal of biological chemistry. vol 277. issue 23. 2002-07-12. PMID:11919182. |
we found that the alpha(4) tail, paxillin, and fat, the focal adhesion targeting domain of pp125(fak), could form a ternary complex and that the alpha(4)-binding paxillin fragment, p(ala(176)-asp(275)), specifically blocked paxillin binding to the alpha(4) tail more efficiently than it blocked binding to fat. |
2002-07-12 |
2023-08-12 |
Not clear |
| Reto Bader, Gabriela Rytz, Mirjam Lerch, Annette G Beck-Sickinger, Oliver Zerb. Key motif to gain selectivity at the neuropeptide Y5-receptor: structure and dynamics of micelle-bound [Ala31, Pro32]-NPY. Biochemistry. vol 41. issue 25. 2002-07-12. PMID:12069594. |
the decreased density of medium-range noes for the c-terminal residues resulting in larger rmsd values for the backbone atoms of ala(31)-tyr(36) indicates that the alpha helix has become interrupted through the [ala(31), pro(32)] mutation. |
2002-07-12 |
2023-08-12 |
Not clear |
| Chantale Boisvert, Caroline Paré, Christelle Veyrat-Durebex, Alma Robert, Sophie Dubuisson, Gérard Morel, Pierrette Gaudrea. Localization and regulation of a functional GHRH receptor in the rat renal medulla. Endocrinology. vol 143. issue 4. 2002-04-29. PMID:11897706. |
as anti-ghrh-r- (392-404) immunoreactivity was demonstrated in hl cells, internalization of [n(alpha)-5-carboxyfluoresceinyl-d-ala(2),ala(8), ala(15),lys(22)]hghrh-(1-29)nh(2) in a time- and temperature-dependent manner and inhibition of this process by phenyl arsine oxide indicate that desensitization to ghrh involves both ghrh-r internalization and down-regulation of ghrh-r mrna levels. |
2002-04-29 |
2023-08-12 |
rat |