| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yasuhiro Kobayashi, Toshihide Mizoguchi, Ikuko Take, Saburo Kurihara, Nobuyuki Udagawa, Naoyuki Takahash. Prostaglandin E2 enhances osteoclastic differentiation of precursor cells through protein kinase A-dependent phosphorylation of TAK1. The Journal of biological chemistry. vol 280. issue 12. 2005-04-21. PMID:15647289. |
ser412 --> ala tak1 abolished the stimulatory effects of forskolin on those cellular events induced by tumor necrosis factor alpha. |
2005-04-21 |
2023-08-12 |
Not clear |
| Stacy A Overman, Priya Bondre, Nakul C Maiti, George J Thoma. Structural characterization of the filamentous bacteriophage PH75 from Thermus thermophilus by Raman and UV-resonance Raman spectroscopy. Biochemistry. vol 44. issue 8. 2005-04-18. PMID:15723554. |
the raman signature of ph75 also differs from those of fd, pf1, and pf3 by virtue of an unusual alanine marker (898 cm(-)(1) band), which is attributed to c(alpha)-h hydrogen-bond donation by subunit ala residues. |
2005-04-18 |
2023-08-12 |
Not clear |
| Stacy A Overman, Priya Bondre, Nakul C Maiti, George J Thoma. Structural characterization of the filamentous bacteriophage PH75 from Thermus thermophilus by Raman and UV-resonance Raman spectroscopy. Biochemistry. vol 44. issue 8. 2005-04-18. PMID:15723554. |
gly, ala, ser), and because the occurrence of such motifs in alpha-helices is believed to thermostabilize interhelix associations via c(alpha)-h...o interactions [g. kleiger et al. |
2005-04-18 |
2023-08-12 |
Not clear |
| Won Gu Jang, Hye Soon Kim, Keun-Gyu Park, Yong Bok Park, Kun-Ho Yoon, Seong-Wook Han, Seung-Ho Hur, Kyong Soo Park, In-Kyu Le. Analysis of proteome and transcriptome of tumor necrosis factor alpha stimulated vascular smooth muscle cells with or without alpha lipoic acid. Proteomics. vol 4. issue 11. 2005-04-13. PMID:15378733. |
alpha lipoic acid (ala), a well known antioxidant, acts as a pyruvate dehydrogenase cofactor in mitochondrial metabolism. |
2005-04-13 |
2023-08-12 |
Not clear |
| Won Gu Jang, Hye Soon Kim, Keun-Gyu Park, Yong Bok Park, Kun-Ho Yoon, Seong-Wook Han, Seung-Ho Hur, Kyong Soo Park, In-Kyu Le. Analysis of proteome and transcriptome of tumor necrosis factor alpha stimulated vascular smooth muscle cells with or without alpha lipoic acid. Proteomics. vol 4. issue 11. 2005-04-13. PMID:15378733. |
tnfalpha down-regulated proteins that were up-regulated in the presence of ala were keratin 19, eukaryotic translation elongation factor and rho gdp dissociation inhibitor alpha. |
2005-04-13 |
2023-08-12 |
Not clear |
| Björn Heitmann, Gabriel E Job, Robert J Kennedy, Sharon M Walker, Daniel S Kem. Water-solubilized, cap-stabilized, helical polyalanines: calibration standards for NMR and CD analyses. Journal of the American Chemical Society. vol 127. issue 6. 2005-03-28. PMID:15701003. |
these ala(n) calibration series, studied in water and lacking helix-stabilizing tertiary structure, yield the first (13)c nmr chemical shifts, (3)j(hnh)(alpha) coupling constants, and cd ellipticities [theta(molar)](lambda,n) characteristic of a fully helical alanine within an ala(n) context. |
2005-03-28 |
2023-08-12 |
Not clear |
| Yumiko Matsubara, Mitsuru Murata, Tomohiro Hayashi, Keijiro Suzuki, Yosuke Okamura, Makoto Handa, Hiroaki Ishihara, Toshiro Shibano, Yasuo Iked. Platelet glycoprotein Ib alpha polymorphisms affect the interaction with von Willebrand factor under flow conditions. British journal of haematology. vol 128. issue 4. 2005-03-22. PMID:15686464. |
the dissociation constants of ristocetin-induced (125)i-labelled vwf binding to two forms of soluble recombinant gpib alpha [(1)his-(302)ala, either (145)thr (145t) or (145)met (145m)] were not different. |
2005-03-22 |
2023-08-12 |
Not clear |
| N Perricone, K Nagy, F Horváth, G Dajkó, I Uray, I Zs -Nag. Alpha lipoic acid (ALA) protects proteins against the hydroxyl free radical-induced alterations: rationale for its geriatric topical application. Archives of gerontology and geriatrics. vol 29. issue 1. 2005-03-14. PMID:15374076. |
alpha lipoic acid (ala) protects proteins against the hydroxyl free radical-induced alterations: rationale for its geriatric topical application. |
2005-03-14 |
2023-08-12 |
cattle |
| M S Bitar, S Wahid, C W Pilcher, E Al-Saleh, F Al-Mull. Alpha-lipoic acid mitigates insulin resistance in Goto-Kakizaki rats. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 36. issue 8. 2005-02-14. PMID:15326564. |
chronic administration of the hydrophobic/hydrophilic antioxidant alpha -lipoic-acid (ala, 100 mg/kg, i.p.) |
2005-02-14 |
2023-08-12 |
human |
| Gail H Marracci, Gabriel P McKeon, Whitney E Marquardt, Rolf W Winter, Michael K Riscoe, Dennis N Bourdett. Alpha lipoic acid inhibits human T-cell migration: implications for multiple sclerosis. Journal of neuroscience research. vol 78. issue 3. 2005-01-31. PMID:15389837. |
we have demonstrated previously the ability of the antioxidant alpha lipoic acid (ala) to suppress and treat a model of multiple sclerosis (ms), relapsing experimental autoimmune encephalomyelitis (eae). |
2005-01-31 |
2023-08-12 |
human |
| Philippe Lacan, Michel Becchi, Isabelle Zanella-Cleon, Martine Aubry, Philippe Renaudier, Alain Franci. Two new alpha chain variants: Hb Part-Dieu [alpha65(E14)Ala --> Thr (alpha2)] and Hb Decines-Charpieu [alpha69(E18)Ala --> Thr (alpha2)]. Hemoglobin. vol 28. issue 1. 2004-10-07. PMID:15008265. |
two new alpha chain variants: hb part-dieu [alpha65(e14)ala --> thr (alpha2)] and hb decines-charpieu [alpha69(e18)ala --> thr (alpha2)]. |
2004-10-07 |
2023-08-12 |
Not clear |
| Philippe Lacan, Martine Aubry, Nicole Couprie, Alain Francin. Two new alpha chain variants: Hb Die [alpha93(FG5)Val --> Ala (alpha1)] and Hb Beziers [alpha99(G6)Lys --> Asn (alpha1)]. Hemoglobin. vol 28. issue 1. 2004-10-07. PMID:15008266. |
two new alpha chain variants: hb die [alpha93(fg5)val --> ala (alpha1)] and hb beziers [alpha99(g6)lys --> asn (alpha1)]. |
2004-10-07 |
2023-08-12 |
Not clear |
| Hiroko Izumi-Nakaseko, Shinji Yamaguchi, Yukio Ohtsuka, Tatsuhiko Ebihara, Satomi Adachi-Akahane, Yasushi Okamur. DHP-insensitive L-type-like Ca channel of ascidian acquires sensitivity to DHP with single amino acid change in domain III P-region. FEBS letters. vol 549. issue 1-3. 2004-08-12. PMID:12914927. |
we have substituted ser for ala(1016) at the p-region of domain iii in tuca1 (tuca1/a1016s) and functionally expressed the channel in xenopus oocyte along with rabbit alpha(2)/delta and beta(2b). |
2004-08-12 |
2023-08-12 |
rabbit |
| Gurusamy Balakrishnan, Ching-Hsuan Tsai, Qiang Wu, Martin A Case, Alex Pevsner, George L McLendon, Chien Ho, Thomas G Spir. Hemoglobin site-mutants reveal dynamical role of interhelical H-bonds in the allosteric pathway: time-resolved UV resonance Raman evidence for intra-dimer coupling. Journal of molecular biology. vol 340. issue 4. 2004-08-03. PMID:15223326. |
mutation of the acceptor residues thr alpha 67 and ser beta 72 to val and ala eliminates the a-e h-bonds, but has been shown to have no significant effect on ligand-binding affinity or cooperativity, or on spectroscopic markers of the t-state quaternary interactions. |
2004-08-03 |
2023-08-12 |
Not clear |
| Renhao Li, Roman Gorelik, Vikas Nanda, Peter B Law, James D Lear, William F DeGrado, Joel S Bennet. Dimerization of the transmembrane domain of Integrin alphaIIb subunit in cell membranes. The Journal of biological chemistry. vol 279. issue 25. 2004-07-23. PMID:15067009. |
mutating each of the alpha(iib) tm domain residues to either ala, leu, ile, or val revealed that a gxxxg motif mediates oligomerization. |
2004-07-23 |
2023-08-12 |
Not clear |
| K Simmer, S Patol. Longchain polyunsaturated fatty acid supplementation in preterm infants. The Cochrane database of systematic reviews. issue 1. 2004-06-29. PMID:14973956. |
the n-3 and n-6 essential fatty acids alpha linolenic acid (ala) and linoleic acid (la) are the precursors of the n-3 and n-6 longchain polyunsaturated fatty acids (lcpufa). |
2004-06-29 |
2023-08-12 |
Not clear |
| J Sauer, N Tabet, R Howar. Alpha lipoic acid for dementia. The Cochrane database of systematic reviews. issue 1. 2004-06-29. PMID:14974062. |
alpha lipoic acid (ala) is an endogenous antioxidant that interrupts cellular oxidative processes in both its oxidized and reduced forms. |
2004-06-29 |
2023-08-12 |
Not clear |
| Isaac Rabinovitz, Lobsang Tsomo, Arthur M Mercuri. Protein kinase C-alpha phosphorylation of specific serines in the connecting segment of the beta 4 integrin regulates the dynamics of type II hemidesmosomes. Molecular and cellular biology. vol 24. issue 10. 2004-06-17. PMID:15121854. |
using cos-7 cells, which assemble hemidesmosomes type ii upon exogenous expression of the alpha 6 beta 4 integrin, we observed that expression of a beta 4 construct containing ser-->ala mutations of s(1356), s(1360), and s(1364) reduced the ability of egf to disrupt hemidesmosomes and that this effect appears to involve cooperation among these phosphorylation sites. |
2004-06-17 |
2023-08-12 |
Not clear |
| Felice Femiano, Fernando Gombos, Crispian Scull. Burning Mouth Syndrome: open trial of psychotherapy alone, medication with alpha-lipoic acid (thioctic acid), and combination therapy. Medicina oral : organo oficial de la Sociedad Espanola de Medicina Oral y de la Academia Iberoamericana de Patologia y Medicina Bucal. vol 9. issue 1. 2004-03-24. PMID:14704612. |
this open study of 192 otherwise healthy persons with burning mouth syndrome, examined the efficacy on control of symptoms of psychotherapy alone with two hour sessions weekly for two months; alpha lipoic acid (ala, tioctic acid; tiobec) 600 mg/day alone for two months; or combination therapy of psychoanalysis and 600 mg/day ala for two months. |
2004-03-24 |
2023-08-12 |
Not clear |
| Subrayashastry Aravinda, Narayanaswamy Shamala, Abhishek Bandyopadhyay, Padmanabhan Balara. Probing the role of the C-H...O hydrogen bond stabilized polypeptide chain reversal at the C-terminus of designed peptide helices. Structural characterization of three decapeptides. Journal of the American Chemical Society. vol 125. issue 49. 2004-02-26. PMID:14653741. |
peptides 3 and 4 provide examples of chiral residues occurring in the less favored sense of helical twist; (d)ala(4) in peptide 3 adopts an alpha(r) conformation, while (l)val(7) in 4 adopts an alpha(l) conformation. |
2004-02-26 |
2023-08-12 |
Not clear |