| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Silvie Timmers, Johan de Vogel-van den Bosch, Mhairi C Towler, Gert Schaart, Esther Moonen-Kornips, Ronald P Mensink, Matthijs K Hesselink, D Grahame Hardie, Patrick Schrauwe. Prevention of high-fat diet-induced muscular lipid accumulation in rats by alpha lipoic acid is not mediated by AMPK activation. Journal of lipid research. vol 51. issue 2. 2010-03-19. PMID:19690335. |
recently, it has been suggested that alpha lipoic acid (ala) improves insulin sensitivity by lowering triglyceride accumulation in nonadipose tissues via activation of skeletal muscle amp-activated protein kinase (ampk). |
2010-03-19 |
2023-08-12 |
rat |
| G Zuliani, M Galvani, E Leitersdorf, S Volpato, M Cavalieri, R Felli. The role of polyunsaturated fatty acids (PUFA) in the treatment of dyslipidemias. Current pharmaceutical design. vol 15. issue 36. 2010-03-16. PMID:20041810. |
pufa n-3 include alpha linolenic acid (ala), eicosapentaenoic acid (epa), and docosahexaenoic acid (dha), while pufa n-6 include linoleic acid (la) and arachidonic acid (aa). |
2010-03-16 |
2023-08-12 |
human |
| E Yavin, E Himovichi, R Eila. Delayed cell migration in the developing rat brain following maternal omega 3 alpha linolenic acid dietary deficiency. Neuroscience. vol 162. issue 4. 2009-11-10. PMID:19447164. |
diminished levels of docosahexaenoic acid (dha, 22:6n-3), the major polyunsaturated fatty acid (fa) synthesized from alpha linolenic acid (ala, 18:3n-3), have been implicated in changes in neurotransmitter production, ion channel disruption and impairments of a variety of cognitive, behavioral and motor functions in the perinatal and adult mammal. |
2009-11-10 |
2023-08-12 |
rat |
| Santhrani Thaakur, G Himabindh. Effect of alpha lipoic acid on the tardive dyskinesia and oxidative stress induced by haloperidol in rats. Journal of neural transmission (Vienna, Austria : 1996). vol 116. issue 7. 2009-09-08. PMID:19444377. |
alpha lipoic acid (ala), a natural metabolic antioxidant, is effective in both prevention and treatment of numerous types of neurological disorders. |
2009-09-08 |
2023-08-12 |
rat |
| Y Angela Liou, Sheila M Inni. Dietary linoleic acid has no effect on arachidonic acid, but increases n-6 eicosadienoic acid, and lowers dihomo-gamma-linolenic and eicosapentaenoic acid in plasma of adult men. Prostaglandins, leukotrienes, and essential fatty acids. vol 80. issue 4. 2009-08-20. PMID:19356914. |
high intakes of linoleic acid (la,18:2n-6) have raised concern due to possible increase in arachidonic acid (ara, 20:4n-6) synthesis, and inhibition of alpha linolenic acid (ala, 18:3n-3) desaturation to eicosapentaenoic (epa, 20:5n-3) and docosahexaenoic acid (dha, 22:6n-3). |
2009-08-20 |
2023-08-12 |
Not clear |
| Zhonglin Xie, Yunzhou Dong, Junhua Zhang, Roland Scholz, Dietbert Neumann, Ming-Hui Zo. Identification of the serine 307 of LKB1 as a novel phosphorylation site essential for its nucleocytoplasmic transport and endothelial cell angiogenesis. Molecular and cellular biology. vol 29. issue 13. 2009-07-30. PMID:19414597. |
like the kinase-dead lkb1 d194a mutant (mutation of asp194 to ala), the constitutively nucleus-localized lkb1 sl26 mutant and the lkb1 s307a mutant (ser307 to ala) exhibit a decreased association with strad alpha. |
2009-07-30 |
2023-08-12 |
Not clear |
| Siti Balkis Budin, Faizah Othman, S R Louis, M Abu Bakar, M Radzi, K Osman, S Das, J Mohame. Effect of alpha lipoic acid on oxidative stress and vascular wall of diabetic rats. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 50. issue 1. 2009-07-15. PMID:19221642. |
the aim of the present study was to investigate the effect of alpha lipoic acid (ala) supplementation on plasma lipid, oxidative stress and vascular changes in diabetic rats. |
2009-07-15 |
2023-08-12 |
rat |
| Kamran Moradkhani, Jean Riou, Alain Francina, Henri Wajcman, Claude Preh. Hb Gerland [alpha 55(E4)Val-->Ala]: a mutation found on the alpha1-globin gene. Hemoglobin. vol 32. issue 5. 2009-07-10. PMID:18932073. |
hb gerland [alpha 55(e4)val-->ala]: a mutation found on the alpha1-globin gene. |
2009-07-10 |
2023-08-12 |
Not clear |
| Kamran Moradkhani, Jean Riou, Alain Francina, Henri Wajcman, Claude Preh. Hb Gerland [alpha 55(E4)Val-->Ala]: a mutation found on the alpha1-globin gene. Hemoglobin. vol 32. issue 5. 2009-07-10. PMID:18932073. |
the hb gerland [alpha 55(e4)val-->ala] mutation has been described in the alpha2-globin gene. |
2009-07-10 |
2023-08-12 |
Not clear |
| Gargi Bhattacharya, Anjali A Sarkar, Debasish Banerjee, Sarmila Chandra, Manikanchan Das, Uma B Dasgupt. Polymerase chain reaction-based search for two alpha-globin gene mutations in India. Hemoglobin. vol 32. issue 5. 2009-07-10. PMID:18932074. |
we have used restriction site-dependent polymerase chain reaction (pcr)-based methodology for detection of the alpha-globin polyadenylation (poly a) signal mutation, aataaa>aata- - and hb sun prairie [alpha 130(h13)ala-->pro, gct>cct (alpha2)] mutation. |
2009-07-10 |
2023-08-12 |
Not clear |
| Najmoutin G Abdulaev, Xiang Mao, Eva Ramon, Tony Ngo, Justyna Mysliwy, John P Marino, Kevin D Ridg. Designing point mutants to detect structural coupling in a heterotrimeric G protein alpha-subunit by NMR spectroscopy. Photochemistry and photobiology. vol 85. issue 2. 2009-07-02. PMID:19222798. |
to better understand the mechanism by which the activating signal is transmitted from the receptor-interacting regions on the g protein alpha-subunit (g(alpha)) to the guanine nucleotide-binding pocket, we generated and characterized mutant forms of g(alpha) with alterations in switch ii (trp-207-->phe) and the carboxyl-terminus (phe-350-->ala). |
2009-07-02 |
2023-08-12 |
Not clear |
| Najmoutin G Abdulaev, Xiang Mao, Eva Ramon, Tony Ngo, Justyna Mysliwy, John P Marino, Kevin D Ridg. Designing point mutants to detect structural coupling in a heterotrimeric G protein alpha-subunit by NMR spectroscopy. Photochemistry and photobiology. vol 85. issue 2. 2009-07-02. PMID:19222798. |
nmr analysis showed that while the gdp/mg(2+)-bound state of both mutants shared an overall conformation similar to that of the gdp/mg(2+)-bound state of chit, formation of the "transition/activated" state in the presence of aluminum fluoride (alf(4) (-)) revealed distinct differences between the wild-type and mutant g(alpha) subunits, particularly in the response of the (1)hn, (15)n cross-peak for the trp-254 indole in the trp-207-->phe mutant and the (1)hn, (15)n cross-peak for ala-350 in the phe-350-->ala mutant. |
2009-07-02 |
2023-08-12 |
Not clear |
| S Rajagopal, H Fang, C I A Oronce, S Jhaveri, S Taneja, E M Dehlin, S L Snyder, J J Sando, G L Kamatch. Site-specific regulation of CA(V)2.2 channels by protein kinase C isozymes betaII and epsilon. Neuroscience. vol 159. issue 2. 2009-06-17. PMID:19167461. |
the combination of isozyme specific inhibitors with previously generated ser/thr to ala mutants of alpha(1) 2.2 subunit revealed that pkc betaii or pkc epsilon isozymes (but not pkc alpha or delta) can provide full enhancement through the stimulatory site (thr-422) in the i-ii linker but that pkc epsilon is better at decreasing channel activity through the inhibitory site ser-425. |
2009-06-17 |
2023-08-12 |
xenopus_laevis |
| T S Shanmugarajan, D Sivaraman, I Somasundaram, M Arunsundar, E Krishnakumar, R Balaji, V Ravichandira. Influence of alpha lipoic acid on antioxidant status in D-galactosamine-induced hepatic injury. Toxicology and industrial health. vol 24. issue 10. 2009-04-30. PMID:19141568. |
in the present study, we evaluated the effect of alpha lipoic acid (ala) supplementation on acute galn-induced oxidative liver injury. |
2009-04-30 |
2023-08-12 |
Not clear |
| Gian Luigi Russ. Dietary n-6 and n-3 polyunsaturated fatty acids: from biochemistry to clinical implications in cardiovascular prevention. Biochemical pharmacology. vol 77. issue 6. 2009-04-01. PMID:19022225. |
linoleic acid (la) and alpha linolenic acid (ala) belong to the n-6 (omega-6) and n-3 (omega-3) series of polyunsaturated fatty acids (pufa), respectively. |
2009-04-01 |
2023-08-12 |
human |
| Parag Mukhopadhyay, Gérard Zuber, David N Berata. Characterizing aqueous solution conformations of a peptide backbone using Raman optical activity computations. Biophysical journal. vol 95. issue 12. 2009-01-21. PMID:18805935. |
here we analyze raman optical activity (roa) spectra of n-acetylalanine-n'-methylamide (ala dipeptide) in h2o and d2o using density functional theory on monte carlo (mc) sampled geometries to examine the propensity of ala dipeptide to adopt compact right-handed (alpha(r)) and left-handed (alpha(l)) helical conformations. |
2009-01-21 |
2023-08-12 |
Not clear |
| Parag Mukhopadhyay, Gérard Zuber, David N Berata. Characterizing aqueous solution conformations of a peptide backbone using Raman optical activity computations. Biophysical journal. vol 95. issue 12. 2009-01-21. PMID:18805935. |
this analysis suggests that ala dipeptide populates the alpha(r) and ppii conformations but no substantial population of alpha(l)- or beta-structures, despite sampling alpha(l)- and beta-structures in our mc simulations. |
2009-01-21 |
2023-08-12 |
Not clear |
| A Zulkhairi, Z Zaiton, M Jamaluddin, F Sharida, T H B Mohd, B Hasnah, H M Nazmi, O Khairul, A Zanariya. Alpha lipoic acid possess dual antioxidant and lipid lowering properties in atherosclerotic-induced New Zealand White rabbit. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 62. issue 10. 2009-01-19. PMID:18538528. |
4.2 mg/body weight of alpha lipoic acid was supplemented daily to the ala group. |
2009-01-19 |
2023-08-12 |
rabbit |
| Philip E Graves, Douglas P Henderson, Molly J Horstman, Brian J Solomon, John S Olso. Enhancing stability and expression of recombinant human hemoglobin in E. coli: Progress in the development of a recombinant HBOC source. Biochimica et biophysica acta. vol 1784. issue 10. 2008-12-31. PMID:18489914. |
alpha gly15 to ala and beta gly16 to ala mutations have been constructed to increase the stability of the alpha helices of both subunits of hba, based on comparison with the sequences of the more stable sperm whale hemoglobin subunits. |
2008-12-31 |
2023-08-12 |
human |
| Jianmin Xu, Yunjia Chen, Roujian Lu, Christopher Cottingham, Kai Jiao, Qin Wan. Protein kinase A phosphorylation of spinophilin modulates its interaction with the alpha 2A-adrenergic receptor (AR) and alters temporal properties of alpha 2AAR internalization. The Journal of biological chemistry. vol 283. issue 21. 2008-07-18. PMID:18367453. |
activation of pka by forskolin abolishes the agonist-enhanced interaction between spinophilin and the alpha(2a)ar, and this event can be blocked by ser --> ala mutations at the pka phosphorylation sites of spinophilin. |
2008-07-18 |
2023-08-12 |
Not clear |