| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D B Williams, M H Akaba. Gamma-aminobutyric acid increases the water accessibility of M3 membrane-spanning segment residues in gamma-aminobutyric acid type A receptors. Biophysical journal. vol 77. issue 5. 2010-12-03. PMID:10545357. |
cysteines substituted for alpha(1)phe(298), alpha(1)ala(300), alpha(1)leu(301), and alpha(1)glu(303) only reacted with pcmbs(-) applied in the presence of gaba. |
2010-12-03 |
2023-08-12 |
Not clear |
| D B Williams, M H Akaba. Gamma-aminobutyric acid increases the water accessibility of M3 membrane-spanning segment residues in gamma-aminobutyric acid type A receptors. Biophysical journal. vol 77. issue 5. 2010-12-03. PMID:10545357. |
others have shown that mutations of alpha(1)ala(291), a water-accessible residue, alter volatile anesthetic and ethanol potentiation of gaba-induced currents. |
2010-12-03 |
2023-08-12 |
Not clear |
| M Carmen Morán, M Rosa Infante, M Graça Miguel, Björn Lindman, Ramon Pon. Novel biocompatible DNA gel particles. Langmuir : the ACS journal of surfaces and colloids. vol 26. issue 13. 2010-09-30. PMID:20515037. |
we report here the formation of dna gel particles mixing dna (either single- (ssdna) or double-stranded (dsdna)) with two different single-chain amino acid-based surfactants: arginine-n-lauroyl amide dihydrochloride (ala) and n(alpha)-lauroyl-arginine-methyl ester hydrochloride (lam). |
2010-09-30 |
2023-08-12 |
Not clear |
| W C Tu, R J Cook-Johnson, M J James, B S Mühlhäusler, R A Gibso. Omega-3 long chain fatty acid synthesis is regulated more by substrate levels than gene expression. Prostaglandins, leukotrienes, and essential fatty acids. vol 83. issue 2. 2010-09-10. PMID:20573490. |
in this study, we tested the effect of increasing ala levels in diets of rats from 0.2% to 2.9% energy (en) against a constant la level (1%en) on plasma and liver phospholipid lcpufa content together with the expression of hepatic genes involved in pufa metabolism, the desaturases fads1 and fads2, the elongases elov2 and elov5, and the transcription factors sterol regulatory element-binding protein-1c (srebp-1c) and peroxisome proliferator-activated receptor alpha (pparalpha). |
2010-09-10 |
2023-08-12 |
rat |
| Senthilkumar Rajagopal, Hongyu Fang, Carl Lynch, Ganesan L Kamatch. Formalin-induced short- and long-term modulation of Cav currents expressed in Xenopus oocytes: an in vitro cellular model for formalin-induced pain. Basic & clinical pharmacology & toxicology. vol 106. issue 4. 2010-08-20. PMID:20030632. |
protein kinase c (pkc) may be involved in formalin-induced increase in ca(v) currents due to the (i) requirement for ca(v)beta(1)b sub-units; (ii) decreased phorbol-12-myristate,13-acetate potentiation of ca(v)2.3 currents; (iii) absence of potentiation of ca(v)2.3 currents following down-regulation of pkc; and (iv) absence of potentiation of ca(v)2.2 or 2.3 currents with ser-->ala mutation of ca(v)alpha(1)2.2 or 2.3 sub-units. |
2010-08-20 |
2023-08-12 |
xenopus_laevis |
| Mehmet Kanter, Saniye Sen, Salim Donmez, Cevat Aktas, Sedat Ustundag, Mustafa Erbog. Protective effects of irbesartan and alpha lipoic acid in STZ-induced diabetic nephropathy in rats. Renal failure. vol 32. issue 4. 2010-08-13. PMID:20446791. |
the aim of this study was designed to investigate the possible beneficial effects of the angiotensin (ang) ii t(1) (at(1)) receptor blocker, irbesartan (irb), and the alpha lipoic acid (ala) in streptozotocin (stz)-induced diabetic nephropathy (dnp) in rats. |
2010-08-13 |
2023-08-12 |
rat |
| Olivier Mozziconacci, Bruce A Kerwin, Christian Schöneic. Reversible hydrogen transfer between cysteine thiyl radical and glycine and alanine in model peptides: covalent H/D exchange, radical-radical reactions, and L- to D-Ala conversion. The journal of physical chemistry. B. vol 114. issue 19. 2010-08-12. PMID:20415493. |
in addition, the reversible formation of (alpha)c(*) radicals on ala leads to the conversion of l-ala to d-ala, where the efficiency of this conversion depends on the primary sequence of the ala-containing peptide. |
2010-08-12 |
2023-08-12 |
Not clear |
| Ashwini V Rajwade, Ritu S Arora, Narendra Y Kadoo, Abhay M Harsulkar, Prakash B Ghorpade, Vidya S Gupt. Relatedness of Indian flax genotypes (Linum usitatissimum L.): an inter-simple sequence repeat (ISSR) primer assay. Molecular biotechnology. vol 45. issue 2. 2010-08-10. PMID:20195799. |
when the omega-3 alpha linolenic acid (ala) contents of the individual genotypes were correlated with the clusters in the dendrogram, the high ala containing genotypes were grouped in two clusters. |
2010-08-10 |
2023-08-12 |
Not clear |
| Laura M Mazer, Sarah H L Yi, Rani H Sing. Docosahexaenoic acid status in females of reproductive age with maple syrup urine disease. Journal of inherited metabolic disease. vol 33. issue 2. 2010-07-21. PMID:20217236. |
participants with msud had normal to increased concentrations of plasma and erythrocyte alpha linolenic acid (ala) but significantly lower concentrations of plasma and erythrocyte docosahexaenoic acid (dha) as percent of total lipid fatty acids compared with controls (plasma dha: msud 1.03 +/- 0.35, controls 2.87 +/- 1.08; p = 0.001; erythrocyte dha: msud 2.58 +/- 0.58, controls 3.66 +/- 0.80; p = 0.011). |
2010-07-21 |
2023-08-12 |
human |
| Shigenori Ito, Takashi Nakahari, Daisuke Yamamot. Relationship between impaired glycation and the N-terminal structure of the Hb Görwihl [beta5(A2)Pro-->Ala] variant. Hemoglobin. vol 34. issue 2. 2010-07-09. PMID:20353350. |
on the basis of the results, we predicted that the glycation site would have the following characteristics: 1) glycation of the beta-n-terminus of hb is probably accelerated by the neighboring histidine residue at beta2(na2), which acts as an acid-base catalyst via a phosphate-mediated proton transfer; and 2) the mutation beta5(a2)pro-->ala would bring about impaired glycation of the n-terminal residue by forming an electrostatic bond between the alpha amino group of beta1(na1)val and beta carboxyl group of beta79(ef3)asp. |
2010-07-09 |
2023-08-12 |
Not clear |
| Na Zhang, Rugang Zhon. Structural basis for decreased affinity of Emodin binding to Val66-mutated human CK2 alpha as determined by molecular dynamics. Journal of molecular modeling. vol 16. issue 4. 2010-07-06. PMID:19821123. |
the decreased affinity of emodin binding to human ck2 alpha resulting from single-point mutation of val66 to ala (v66a) has been demonstrated by experimental mutagenesis. |
2010-07-06 |
2023-08-12 |
human |
| L Huang, P A Castelfranc. Regulation of 5-Aminolevulinic Acid (ALA) Synthesis in Developing Chloroplasts : III. Evidence for Functional Heterogeneity of the ALA Pool. Plant physiology. vol 92. issue 1. 2010-06-29. PMID:16667243. |
gabaculine and 4-amino-5-hexynoic acid (aha) up to 3.0 millimolar concentration strongly inhibited 5-aminolevulinic acid (ala) synthesis in developing cucumber (cucumis sativus l. var beit alpha) chloroplasts, while they hardly affected protochlorophyllide (pchlide) synthesis. |
2010-06-29 |
2023-08-12 |
Not clear |
| Z X Poh, K P Go. A current update on the use of alpha lipoic acid in the management of type 2 diabetes mellitus. Endocrine, metabolic & immune disorders drug targets. vol 9. issue 4. 2010-06-14. PMID:19601918. |
there is growing evidence that alpha lipoic acid (ala) has beneficial effects on the treatment of t2dm and some of its complications. |
2010-06-14 |
2023-08-12 |
Not clear |
| Autar K Mattoo, Subhash C Minocha, Rakesh Minocha, Avtar K Hand. Polyamines and cellular metabolism in plants: transgenic approaches reveal different responses to diamine putrescine versus higher polyamines spermidine and spermine. Amino acids. vol 38. issue 2. 2010-06-02. PMID:19956999. |
further, put levels were positively associated with ala (alpha and beta), ile and gaba and negatively correlated with gln and glu in both actively growing poplar cell cultures and non-dividing tomato pericarp tissue. |
2010-06-02 |
2023-08-12 |
mouse |
| Srinivasarao Raghothama, Subrayashastry Aravinda, Narayanaswamy Shamala, Padmanabhan Balara. Helical conformations of hexapeptides containing N-terminus diproline segments. Biopolymers. vol 94. issue 3. 2010-06-01. PMID:20108314. |
ala (2) adopts an alpha(l) conformation, resulting in a type ii beta-turn conformation followed by a stretch of 3(10)-helix. |
2010-06-01 |
2023-08-12 |
Not clear |
| Mikel Garcia-Marcos, Pradipta Ghosh, Jason Ear, Marilyn G Farquha. A structural determinant that renders G alpha(i) sensitive to activation by GIV/girdin is required to promote cell migration. The Journal of biological chemistry. vol 285. issue 17. 2010-05-20. PMID:20157114. |
activation of g alpha(i3) by giv was also dramatically reduced when trp-258 was replaced with tyr, leu, ser, his, asp, or ala, highlighting that trp is required for maximal activation. |
2010-05-20 |
2023-08-12 |
Not clear |
| Mehmet Erşahin, Hale Z Toklu, Sule Cetinel, Meral Yüksel, Can Erzik, M Zafer Berkman, Berrak C Yeğen, Göksel Sene. Alpha lipoic acid alleviates oxidative stress and preserves blood brain permeability in rats with subarachnoid hemorrhage. Neurochemical research. vol 35. issue 3. 2010-04-30. PMID:19823933. |
the neuroprotective effect of alpha lipoic acid (ala; 100 mg/kg, po), a dithiol antioxidant, on experimentally induced subarachnoid hemorrhage (sah) was assessed in wistar albino rats. |
2010-04-30 |
2023-08-12 |
rat |
| Thomas Arnesen, Kristian K Starheim, Petra Van Damme, Rune Evjenth, Huyen Dinh, Matthew J Betts, Anita Ryningen, Joël Vandekerckhove, Kris Gevaert, Dave Anderso. The chaperone-like protein HYPK acts together with NatA in cotranslational N-terminal acetylation and prevention of Huntingtin aggregation. Molecular and cellular biology. vol 30. issue 8. 2010-04-28. PMID:20154145. |
the human nata protein n(alpha)-terminal-acetyltransferase complex is responsible for cotranslational n-terminal acetylation of proteins with ser, ala, thr, gly, and val n termini. |
2010-04-28 |
2023-08-12 |
human |
| P López-Jornet, F Camacho-Alonso, S Leon-Espinos. Efficacy of alpha lipoic acid in burning mouth syndrome: a randomized, placebo-treatment study. Journal of oral rehabilitation. vol 36. issue 1. 2010-04-15. PMID:18976257. |
to study the efficacy of alpha lipoic acid (ala) in a group of patients with burning mouth syndrome (bms). |
2010-04-15 |
2023-08-12 |
Not clear |
| Ivan Birukou, Rachel L Schweers, John S Olso. Distal histidine stabilizes bound O2 and acts as a gate for ligand entry in both subunits of adult human hemoglobin. The Journal of biological chemistry. vol 285. issue 12. 2010-04-12. PMID:20080971. |
replacing his(e7) with gly, ala, leu, or phe causes 20-500-fold increases in the rates of o(2) dissociation from either hb subunit, demonstrating unambiguously that the native his(e7) imidazole side chain forms a strong hydrogen bond with bound o(2) in both the alpha and beta chains (deltag(his(e7)h-bond) approximately -8 kj/mol). |
2010-04-12 |
2023-08-12 |
human |