| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N Kaneda, Y Noro, T Nagats. Highly sensitive assay for acetylcholinesterase activity by high-performance liquid chromatography with electrochemical detection. Journal of chromatography. vol 344. 1986-03-10. PMID:4086572. |
it is based on the separation of acetylcholine and choline on an octadecylsilane reversed-phase column, followed by their enzymatic conversion into hydrogen peroxide through the post-column reaction with immobilized ache and choline oxidase. |
1986-03-10 |
2023-08-11 |
rat |
| S Brimijoin, K P Mintz, F G Prendergas. An inhibitory monoclonal antibody to rabbit brain acetylcholinesterase. Studies on interaction with the enzyme. Molecular pharmacology. vol 28. issue 6. 1986-01-29. PMID:4079910. |
a recently isolated monoclonal antibody was found to be a potent and powerful inhibitor of the catalytic activity of rabbit brain acetylcholinesterase (ache; acetylcholine acetylhydrolase, ec 3.1.1.7), with an ic50 of about 1 nm and a maximal inhibition of at least 90%. |
1986-01-29 |
2023-08-11 |
rabbit |
| b' I I Krivo\\xc4\\xad, V I Kuleshov, D P Matiushkin, V I Sanotski\\xc4\\xad, T P Se\\xc4\\xa. [Miniature currents of the endplates of the muscle fibers of the diaphragm of the rat after inhibition of acetylcholinesterase with galanthamine]. Neirofiziologiia = Neurophysiology. vol 17. issue 5. 1985-12-26. PMID:2999623.' |
it is supposed that the functional role of synaptic ache in limiting the postsynaptic effect of acetylcholine is not so significant as it is usually considered, therefore it is possible to use the parameters of mepc for the estimation of functional ache activity. |
1985-12-26 |
2023-08-11 |
rat |
| A H Futerman, M G Low, D M Michaelson, I Silma. Solubilization of membrane-bound acetylcholinesterase by a phosphatidylinositol-specific phospholipase C. Journal of neurochemistry. vol 45. issue 5. 1985-11-18. PMID:4045459. |
this selective removal of ache does not affect the amount of acetylcholine released from intact synaptosomes upon k+ depolarization. |
1985-11-18 |
2023-08-11 |
mouse |
| M F Bear, K M Carnes, F F Ebne. Postnatal changes in the distribution of acetylcholinesterase in kitten striate cortex. The Journal of comparative neurology. vol 237. issue 4. 1985-10-31. PMID:3900150. |
the possible contributions of acetylcholine and ache to the postnatal development of kitten striate cortex are discussed. |
1985-10-31 |
2023-08-11 |
cat |
| L Anglister, U J McMaha. Basal lamina directs acetylcholinesterase accumulation at synaptic sites in regenerating muscle. The Journal of cell biology. vol 101. issue 3. 1985-10-09. PMID:3875617. |
at the regenerated neuromuscular junctions, as at the original ones, the muscle fibers are characterized by junctional folds and accumulations of acetylcholine receptors and acetylcholinesterase (ache). |
1985-10-09 |
2023-08-11 |
Not clear |
| J de Belleroche, I M Gardiner, M H Hamilton, N J Birdsal. Analysis of muscarinic receptor concentration and subtypes following lesion of rat substantia innominata. Brain research. vol 340. issue 2. 1985-10-07. PMID:4027649. |
we have examined in rats the effect of lesion of si with kainate (1 microgram/0.5 microliter) on acetylcholine esterase (ache) activity, muscarinic receptor number and subtypes in cerebral cortex at 1, 2 and 4 weeks. |
1985-10-07 |
2023-08-11 |
rat |
| C C Chang, S J Hong, H L Lin, M J S. Acetylcholine hydrolysis during neuromuscular transmission in the synaptic cleft of skeletal muscle of mouse and chick. Neuropharmacology. vol 24. issue 6. 1985-09-24. PMID:2991804. |
on single stimulation, the relative peak concentrations of acetylcholine (ach) at the postsynaptic receptor site of the mouse diaphragm and chick biventer cervicis were estimated to be increased by about 110 and 120% respectively, after complete inhibition of ache. |
1985-09-24 |
2023-08-11 |
mouse |
| D L Kolson, R L Russel. A novel class of acetylcholinesterase, revealed by mutations, in the nematode Caenorhabditis elegans. Journal of neurogenetics. vol 2. issue 2. 1985-09-06. PMID:4020535. |
this residual activity differs markedly from ache classes a and b; its km for acetylcholine is 1000-5000-fold lower, its resistance to eserine is 3000-260,000-fold higher, it is markedly more thermolabile, and it can be separated from classes a and b by ion exchange chromatography. |
1985-09-06 |
2023-08-11 |
rat |
| K Akuzawa, K Wakabayash. A serum-free culture of the neurons in the septal, preoptic, and hypothalamic region. Effects of triiodothyronine and estradiol. Endocrinologia japonica. vol 32. issue 1. 1985-09-04. PMID:4017971. |
effects of triiodothyronine (t3) and estradiol (e2) on the activities of choline acetyltransferase (chat) and acetylcholinesterase (ache), synthetic and degradative enzymes for acetylcholine, respectively, were examined in this culture. |
1985-09-04 |
2023-08-11 |
rat |
| Y Take, S Narumi, E Kurihara, M Shibota, Y Saji, Y Nagaw. [Pharmacological study of the temporary cerebral ischemic rats produced by bilateral vertebral and carotid artery occlusion. Effects of DN-1417]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 85. issue 3. 1985-08-12. PMID:2861149. |
in addition, dn-1417 (10 mg/kg) recovered the various changes such as decrease of 5-hydroxytryptamine (5-ht) levels, increase of cyclic amp (camp) levels, inhibition of [3h]-choline uptake, depression of choline acetyltransferase (cat) and acetylcholine esterase (ache) activities, and shortened the durations of hyperperfusion and hypoperfusion of rcbf. |
1985-08-12 |
2023-08-11 |
rat |
| P Kása, W Dames, Z Rakonczay, K Gulya, F Joó, J R Wolf. Modulation of the acetylcholine system in the superior cervical ganglion of rat: effects of GABA and hypoglossal nerve implantation after in vivo GABA treatment. Journal of neurochemistry. vol 44. issue 5. 1985-05-28. PMID:3989534. |
this treatment reduced the acetylcholinesterase (ache; ec 3.1.1.7) activity by 30% (p less than 0.01) and transiently increased the number of nicotinic acetylcholine receptors, but had no significant effect on the choline acetyltransferase (acetyl-coenzyme a:choline-o-acetyltransferase; ec 2.3.1.6) activity, the ach level, or the number of muscarinic acetylcholine receptors. |
1985-05-28 |
2023-08-11 |
rat |
| T G Mattio, J S Richardson, E Giacobin. Effects of DFP on iridic metabolism and release of acetylcholine and on pupillary function in the rat. Neuropharmacology. vol 23. issue 10. 1985-03-14. PMID:6521855. |
the time course of the effects of the topical administration of 1 microgram of diisopropylfluorophosphate (dfp) onto the cornea of the rat on the function of the iris and the biochemistry of acetylcholine (ach) was followed for 6 hr after the acute inhibition of acetylcholinesterase (ache) in the iris. |
1985-03-14 |
2023-08-12 |
rat |
| L G Magazanik, V V Fedorov, V A Snetko. [Factors determining the duration of a single postsynaptic response in neuromuscular junctions]. Neirofiziologiia = Neurophysiology. vol 16. issue 5. 1985-02-05. PMID:6096734. |
low activity of ache favours the prominent asynchrony of interaction between acetylcholine molecules and cholinoreceptors causing prolongation of the time course of synaptic response. |
1985-02-05 |
2023-08-12 |
rat |
| G V Prasad, W Rajendra, K Indir. Catalytic potential of field mouse Mus booduga brain acetylcholinesterase during repeated hexachlorophene treatment. Toxicology letters. vol 23. issue 2. 1985-01-23. PMID:6506093. |
fall in the activity potential of ache may account for the interference of hcp or its reactive metabolites with the acetylcholine (ach)-ache system and deserve consideration in contributing to the neurotoxicity. |
1985-01-23 |
2023-08-12 |
mouse |
| B S Narayana Reddy, L Maniraj Bhaskar, K S Bab. Impact of scorpion Heterometrus fulvipes venom on cholinesterase rhythmicity in the tropical mouse Mus booduga. Indian journal of physiology and pharmacology. vol 28. issue 1. 1984-12-11. PMID:6490130. |
rhythmicities of acetylcholine (ach) and acetylcholinesterase (ache) were studied in the mouse, mus booduga (gray), following intramuscular injection of scorpion, heterometrus fulvipes (c. koch) venom. |
1984-12-11 |
2023-08-12 |
mouse |
| K Siva Prasada Rao, K V Ramana Ra. Impact of methyl parathion toxicity and eserine inhibition on acetylcholinesterase activity in tissues of the teleost (Tilapia mossambica)--a correlative study. Toxicology letters. vol 22. issue 3. 1984-11-01. PMID:6485009. |
acetylcholinesterase (ache) activity and acetylcholine (ach) content of muscle, gill, liver and brain tissues of control and methyl parathion-exposed (mpe) fish were determined. |
1984-11-01 |
2023-08-12 |
Not clear |
| C G Caratsch, P G Wase. Effects of obidoxime chloride on native and sarin-poisoned frog neuromuscular junctions. Pflugers Archiv : European journal of physiology. vol 401. issue 1. 1984-10-12. PMID:6382149. |
the effect of the oxime reactivator obidoxime chloride (obidoxime) on single frog neuromuscular junctions has been studied in order to clarify its action on the acetylcholine receptor (achr) and on the acetylcholine esterase (ache), both before and after blocking its enzymatic activity with the organophosphorus compound sarin. |
1984-10-12 |
2023-08-12 |
Not clear |
| M Eco. The location of neuromuscular junctions on regenerating adult mouse muscle in culture. Journal of the neurological sciences. vol 64. issue 2. 1984-08-27. PMID:6747664. |
the position of the original motor end-plates on the explanted muscle fibres was determined by using either rhodamine-labelled alpha-bungarotoxin (r alpha bt) binding to the acetylcholine receptors, or by stains to demonstrate acetylcholinesterase (ache) also located at the end-plate. |
1984-08-27 |
2023-08-12 |
mouse |
| A L Acheson, K Naujoks, H Thoene. Nerve growth factor-mediated enzyme induction in primary cultures of bovine adrenal chromaffin cells: specificity and level of regulation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 4. issue 7. 1984-08-20. PMID:6145760. |
acetylcholinesterase (ache), an enzyme which catalyzes the breakdown of acetylcholine, is also induced by ngf. |
1984-08-20 |
2023-08-12 |
cattle |