| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Valérie Preud'homme, Sylvain Milla, Virginie Gillardin, Edwin De Pauw, Mathieu Denoël, Patrick Kestemon. Effects of low dose endosulfan exposure on brain neurotransmitter levels in the African clawed frog Xenopus laevis. Chemosphere. vol 120. 2015-12-18. PMID:25192837. |
endosulfan induced a significant increase of brain serotonin level at both concentrations and a significant increase of brain dopamine and gaba levels at the lower exposure but acetylcholinesterase activity was not modified by the treatment. |
2015-12-18 |
2023-08-13 |
xenopus_laevis |
| Elizabeth A Ennis, Jane Wright, Cassandra L Retzlaff, Owen B McManus, Zhinong Lin, Xiaofang Huang, Meng Wu, Min Li, J Scott Daniels, Craig W Lindsley, Corey R Hopkins, Randy D Blakel. Identification and characterization of ML352: a novel, noncompetitive inhibitor of the presynaptic choline transporter. ACS chemical neuroscience. vol 6. issue 3. 2015-12-08. PMID:25560927. |
at concentrations that fully antagonized cht in transfected cells and nerve terminal preparations, ml352 exhibited no inhibition of acetylcholinesterase (ache) or cholineacetyltransferase (chat) and also lacked activity at dopamine, serotonin, and norepinephrine transporters, as well as many receptors and ion channels. |
2015-12-08 |
2023-08-13 |
Not clear |
| Yi Xie, Binbin Wang, Fanchi Li, Lie Ma, Min Ni, Weide Shen, Fashui Hong, Bing L. Molecular mechanisms of reduced nerve toxicity by titanium dioxide nanoparticles in the phoxim-exposed brain of Bombyx mori. PloS one. vol 9. issue 6. 2015-10-28. PMID:24971466. |
the treatments also relieved the phoxim-induced increases in the contents of acetylcholine (ach), glutamate (glu) and nitric oxide (no) and the phoxim-induced decreases in the contents of norepinephrine (ne), dopamine (da), and 5-hydroxytryptamine (5-ht), and reduced the inhibition of acetylcholinesterase (ache), na+/k+-atpase, ca2+-atpase, and ca2+/mg2+-atpase activities and the activation of total nitric oxide synthase (tnos) in the brain. |
2015-10-28 |
2023-08-13 |
Not clear |
| Qiangwei Wang, James Chung-Wah Lam, Yin-Chung Man, Nelson Lok-Shun Lai, Karen Ying Kwok, Yong yong Guo, Paul Kwan-Sing Lam, Bingsheng Zho. Bioconcentration, metabolism and neurotoxicity of the organophorous flame retardant 1,3-dichloro 2-propyl phosphate (TDCPP) to zebrafish. Aquatic toxicology (Amsterdam, Netherlands). vol 158. 2015-04-10. PMID:25461749. |
there was no effect on locomotion, acetylcholinesterase activity, levels of the neurotransmitters dopamine and serotonin, and expression of mrnas and proteins related to central nervous system development (e.g., myelin basic protein, α1-tubulin) in any exposure group. |
2015-04-10 |
2023-08-13 |
zebrafish |
| Maria Nardell, Rajesh R Tamp. Pharmacological treatments for frontotemporal dementias: a systematic review of randomized controlled trials. American journal of Alzheimer's disease and other dementias. vol 29. issue 2. 2014-12-22. PMID:24164931. |
of these, 2 trials used the selective serotonin reuptake inhibitor (ssri), paroxetine; 1 trial used trazodone; 2 trials used stimulants (methylphenidate and dextroamphetamine); 1 trial used the acetylcholinesterase inhibitor, galantamine; 2 trials used the n-methyl-d-aspartate antagonist, memantine; and 1 trial used the neuropeptide oxytocin. |
2014-12-22 |
2023-08-12 |
Not clear |
| Mai A Abd-El-Fattah, Noha F Abdelakader, Hala F Zak. Pyrrolidine dithiocarbamate protects against scopolamine-induced cognitive impairment in rats. European journal of pharmacology. vol 723. 2014-10-07. PMID:24315930. |
rats were then sacrificed and homogenates of cortical and hippocampal tissues were used for the estimation of noradrenaline, dopamine, serotonin and heat shock protein 70 contents along with acetylcholinesterase activity. |
2014-10-07 |
2023-08-12 |
rat |
| Awanish Mishra, Rajesh Kumar Goe. Psychoneurochemical investigations to reveal neurobiology of memory deficit in epilepsy. Neurochemical research. vol 38. issue 12. 2014-07-21. PMID:24100926. |
neurochemical (glutamate, gaba, norepinephrine, dopamine and serotonin) changes and acetylcholinesterase activity and total nitrite level were estimated using hplc-fd methods and microplate reader method respectively, in discrete brain parts. |
2014-07-21 |
2023-08-12 |
Not clear |
| Sebastian Aguiar, Thomas Borowsk. Neuropharmacological review of the nootropic herb Bacopa monnieri. Rejuvenation research. vol 16. issue 4. 2014-05-05. PMID:23772955. |
current evidence suggests bm acts via the following mechanisms-anti-oxidant neuroprotection (via redox and enzyme induction), acetylcholinesterase inhibition and/or choline acetyltransferase activation, β-amyloid reduction, increased cerebral blood flow, and neurotransmitter modulation (acetylcholine [ach], 5-hydroxytryptamine [5-ht], dopamine [da]). |
2014-05-05 |
2023-08-12 |
Not clear |
| Sinikka Rahte, Richard Evans, Philippe J Eugster, Laurence Marcourt, Jean-Luc Wolfender, Andreas Kortenkamp, Deniz Tasdemi. Salvia officinalis for hot flushes: towards determination of mechanism of activity and active principles. Planta medica. vol 79. issue 9. 2014-01-27. PMID:23670626. |
no activity was observed in the selective serotonin reuptake inhibition or the acetylcholinesterase inhibition assays at the highest test concentrations. |
2014-01-27 |
2023-08-12 |
Not clear |
| Elena De Domenico, Angela Mauceri, Daniela Giordano, Maria Maisano, Alessia Giannetto, Vincenzo Parrino, Antonino Natalotto, Alessia D'Agata, Tiziana Cappello, Salvatore Fasul. Biological responses of juvenile European sea bass (Dicentrarchus labrax) exposed to contaminated sediments. Ecotoxicology and environmental safety. vol 97. 2013-11-27. PMID:23953925. |
apoptotic and proliferative activities [cell turnover: proliferating cell nuclear antigen (pcna) and fas ligand (fasl)], onset of hypoxic condition [hypoxia: hypoxia inducibile factor-1α (hif-1α)], and changes in the neuroendocrine control mechanisms [neurotransmission: tyrosine hydroxylase (th), choline acetyltransferase (chat), acetylcholinesterase (ache), 5-hydroxytryptamine (5-ht) and 5-hydroxytryptamine receptor 3 (5-ht3)] were investigated in sea bass gill tissues. |
2013-11-27 |
2023-08-12 |
Not clear |
| Kailash M Choudhary, Awanish Mishra, Vladimir V Poroikov, Rajesh Kumar Goe. Ameliorative effect of Curcumin on seizure severity, depression like behavior, learning and memory deficit in post-pentylenetetrazole-kindled mice. European journal of pharmacology. vol 704. issue 1-3. 2013-10-17. PMID:23461849. |
on 15th day, all the animals were sacrificed after behavioral evaluations and their brain was isolated and homogenized to estimate brain norepinephrine, serotonin, total nitrite level and acetylcholinesterase activity. |
2013-10-17 |
2023-08-12 |
mouse |
| K Witt, G Deuschl, T Bartsc. [Frontotemporal dementias]. Der Nervenarzt. vol 84. issue 1. 2013-06-26. PMID:22366755. |
different agents such as serotonin reuptake inhibitors, tricyclic antidepressants, atypical neuroleptics, carbamazepine, valproate, lamotrigine and when indicated also acetylcholinesterase inhibitors are potentially helpful. |
2013-06-26 |
2023-08-12 |
Not clear |
| Nobuo Tsuruoka, Yoshinori Beppu, Hirofumi Koda, Nobutaka Doe, Hiroshi Watanabe, Keiichi Ab. A DKP cyclo(L-Phe-L-Phe) found in chicken essence is a dual inhibitor of the serotonin transporter and acetylcholinesterase. PloS one. vol 7. issue 11. 2013-05-22. PMID:23209830. |
a dkp cyclo(l-phe-l-phe) found in chicken essence is a dual inhibitor of the serotonin transporter and acetylcholinesterase. |
2013-05-22 |
2023-08-12 |
mouse |
| Rachel E Seltman, Brandy R Matthew. Frontotemporal lobar degeneration: epidemiology, pathology, diagnosis and management. CNS drugs. vol 26. issue 10. 2013-02-14. PMID:22950490. |
pharmacological strategies have focused on neurotransmitter replacement and modulation for the treatment of behavioural, motor and cognitive symptoms of ftd, and include selective serotonin reuptake inhibitors (ssris), atypical antipsychotics, acetylcholinesterase inhibitors and glutamate nmda receptor antagonists. |
2013-02-14 |
2023-08-12 |
Not clear |
| George Bartzoki. Neuroglialpharmacology: myelination as a shared mechanism of action of psychotropic treatments. Neuropharmacology. vol 62. issue 7. 2012-12-20. PMID:22306524. |
similarly, psychotropic treatments ranging from lithium and antipsychotics to serotonin reuptake inhibitors (ssris) and acetylcholinesterase inhibitors have been shown to be efficacious in a wide spectrum of psychiatric disorders ranging from autism, schizophrenia (sz), depression, and bipolar disorder (bd) to alzheimer's disease (ad). |
2012-12-20 |
2023-08-12 |
human |
| Ahmed E Abdel Monei. Flaxseed oil as a neuroprotective agent on lead acetate-induced monoamineric alterations and neurotoxicity in rats. Biological trace element research. vol 148. issue 3. 2012-11-28. PMID:22395955. |
the levels of lead, dopamine (da), norepinephrine (ne), serotonin (5-ht), lipid peroxidation, nitrite/nitrate (no), and glutathione (gsh) were determined; also, the activity of acetylcholinesterase (ache) and na(+)-k(+)-atpase were estimated on different brain regions of adult male albino rats. |
2012-11-28 |
2023-08-12 |
rat |
| Preeti Yadav, Sunil E Jadhav, Vinesh Kumar, Kirtee K Kaul, Satish C Pant, Swaran J S Flor. Protective efficacy of 2-PAMCl, atropine and curcumin against dichlorvos induced toxicity in rats. Interdisciplinary toxicology. vol 5. issue 1. 2012-10-02. PMID:22783142. |
we observed a significant increase in lipid peroxidation (lpo), reactive oxygen species (ros), oxidized glutathione (gssg), while there was a significant decrease in antioxidant enzymes, brain acetylcholinesterase (ache) and 5-hydroxy tryptamine (5-ht) activity on ddvp exposure of rats. |
2012-10-02 |
2023-08-12 |
rat |
| Mireille Basselin, Epolia Ramadan, Stanley I Rapopor. Imaging brain signal transduction and metabolism via arachidonic and docosahexaenoic acid in animals and humans. Brain research bulletin. vol 87. issue 2-3. 2012-08-01. PMID:22178644. |
we have employed our method to image and quantify effects of mood stabilizers on brain aa/dha incorporation during neurotransmission by muscarinic m(1,3,5), serotonergic 5-ht(2a/2c), dopaminergic d(2)-like (d(2), d(3), d(4)) or glutamatergic n-methyl-d-aspartic acid (nmda) receptors, and effects of inhibition of acetylcholinesterase, of selective serotonin and dopamine reuptake transporter inhibitors, of neuroinflammation (hiv-1 and lipopolysaccharide) and excitotoxicity, and in genetically modified rodents. |
2012-08-01 |
2023-08-12 |
human |
| Thomas Freret, Valentine Bouet, Anne Quiedeville, Gérald Nee, Patrick Dallemagne, Christophe Rochais, Michel Boulouar. Synergistic effect of acetylcholinesterase inhibition (donepezil) and 5-HT(4) receptor activation (RS67333) on object recognition in mice. Behavioural brain research. vol 230. issue 1. 2012-07-23. PMID:22348892. |
synergistic effect of acetylcholinesterase inhibition (donepezil) and 5-ht(4) receptor activation (rs67333) on object recognition in mice. |
2012-07-23 |
2023-08-12 |
mouse |
| Thomas Freret, Valentine Bouet, Anne Quiedeville, Gérald Nee, Patrick Dallemagne, Christophe Rochais, Michel Boulouar. Synergistic effect of acetylcholinesterase inhibition (donepezil) and 5-HT(4) receptor activation (RS67333) on object recognition in mice. Behavioural brain research. vol 230. issue 1. 2012-07-23. PMID:22348892. |
among potent molecules, rs67333, a reference 5-ht(4)r agonist and donepezil (dnpz), a reference acetylcholinesterase inhibitor, have been particularly chosen because of their close chemical structure. |
2012-07-23 |
2023-08-12 |
mouse |