| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hiroshi Kogen, Narihiro Toda, Keiko Tago, Shinji Marumoto, Kazuko Takami, Mayuko Ori, Naho Yamada, Kazuo Koyama, Shunji Naruto, Kazumi Abe, Reina Yamazaki, Takao Hara, Atsushi Aoyagi, Yasuyuki Abe, Tsugio Kanek. Design and synthesis of dual inhibitors of acetylcholinesterase and serotonin transporter targeting potential agents for Alzheimer's disease. Organic letters. vol 4. issue 20. 2002-12-27. PMID:12323018. |
design and synthesis of dual inhibitors of acetylcholinesterase and serotonin transporter targeting potential agents for alzheimer's disease. |
2002-12-27 |
2023-08-12 |
Not clear |
| Hiroshi Kogen, Narihiro Toda, Keiko Tago, Shinji Marumoto, Kazuko Takami, Mayuko Ori, Naho Yamada, Kazuo Koyama, Shunji Naruto, Kazumi Abe, Reina Yamazaki, Takao Hara, Atsushi Aoyagi, Yasuyuki Abe, Tsugio Kanek. Design and synthesis of dual inhibitors of acetylcholinesterase and serotonin transporter targeting potential agents for Alzheimer's disease. Organic letters. vol 4. issue 20. 2002-12-27. PMID:12323018. |
highly efficient acetylcholinesterase (ache) and serotonin transporter (sert) dual inhibitors, (s)-4 and (r)-13 were designed and synthesized on the basis of the hypothetical model of ache active site. |
2002-12-27 |
2023-08-12 |
Not clear |
| L Lee, S A Kang, H O Lee, B H Lee, I K Jung, J E Lee, Y S Ho. Effect of supplementation of vitamin E and vitamin C on brain acetylcholinesterase activity and neurotransmitter levels in rats treated with scopolamine, an inducer of dementia. Journal of nutritional science and vitaminology. vol 47. issue 5. 2002-09-10. PMID:11814146. |
in conclusion, supplementation with vitamin e and/or vitamin c might be useful in maintaining brain acetylcholinesterase activity at the normal level and serotonin concentration for some extent under the condition to induce dementia by scopolamine administration. |
2002-09-10 |
2023-08-12 |
rat |
| Hans C Dringenberg, Peter Diavolitsi. Electroencephalographic activation by fluoxetine in rats: role of 5-HT(1A) receptors and enhancement of concurrent acetylcholinesterase inhibitor treatment. Neuropharmacology. vol 42. issue 2. 2002-04-29. PMID:11804611. |
electroencephalographic activation by fluoxetine in rats: role of 5-ht(1a) receptors and enhancement of concurrent acetylcholinesterase inhibitor treatment. |
2002-04-29 |
2023-08-12 |
rat |
| I R Whittle, P A Kell. Mechanisms of peritumoural brain dysfunction: metabolic and neuroreceptor findings in striatal C6 glioma. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 8. issue 5. 2001-12-07. PMID:11535011. |
acetylcholinesterase (ache) histochemistry and a range of ligand binding studies for dopamine type 1 and 2, and serotonergic 5-ht(2)receptors were negative in the tumour and normal in peritumoural brain. |
2001-12-07 |
2023-08-12 |
Not clear |
| A Ruiz-Torner, F Olucha-Bordonau, A A Valverde-Navarro, F Martínez-Sorian. The chemical architecture of the rat's periaqueductal gray based on acetylcholinesterase histochemistry: a quantitative and qualitative study. Journal of chemical neuroanatomy. vol 21. issue 4. 2001-08-23. PMID:11429271. |
however, the inner half of both lateral and ventrolateral columns displayed the same chemical properties including acetylcholinesterase, tyrosine hydroxilase and serotonin. |
2001-08-23 |
2023-08-12 |
rat |
| C Domeneghini, G Radaelli, S Arrighi, F Mascarello, A Veggett. Neurotransmitters and putative neuromodulators in the gut of Anguilla anguilla (L.). Localizations in the enteric nervous and endocrine systems. European journal of histochemistry : EJH. vol 44. issue 3. 2001-05-31. PMID:11095101. |
histochemical reactions for the demonstration of nicotinamide adenine dinucleotide phosphate, reduced form-(nadph-)diaphorase and acetylcholinesterase (achease) were performed, as well as the immunohistochemical testing of tyrosine hydroxylase, met-enkephalin, substance p, calcitonin gene-related peptide (cgrp), bombesin, vasoactive intestinal peptide (vip), neuropeptide y (npy), somatostatin, cholecystokinin-octapeptide (cck-8), serotonin, cholineacetyl transferase. |
2001-05-31 |
2023-08-12 |
Not clear |
| H Mehta, B Thomas, K P Mohanakuma. Effects of p-chlorophenylalanine on striatal acetylcholinesterase activity and on biogenic amine levels in nuclei raphe and caudate-putamen during physostigmine-induced tremor in rats. Neuroscience letters. vol 299. issue 1-2. 2001-05-03. PMID:11166949. |
administration of pcpa caused significant decrease in da, norepinephrine (ne) and 5-ht levels in both the nuclei, without affecting striatal ne content and acetylcholinesterase activity. |
2001-05-03 |
2023-08-12 |
rat |
| Sunanda, B S Rao, T R Raj. Restraint stress-induced alterations in the levels of biogenic amines, amino acids, and AChE activity in the hippocampus. Neurochemical research. vol 25. issue 12. 2001-04-19. PMID:11152383. |
a significant (p < 0.001) decrease in the levels of noradrenaline, dopamine, 5-hydroxytryptamine and acetylcholinesterase activity in the stressed rats was observed compared to controls. |
2001-04-19 |
2023-08-12 |
rat |
| T Okumura, A Dobolyi, K Matsuyama, F Mori, S Mor. The cat neostriatum: relative distribution of cholinergic neurons versus serotonergic fibers. Brain & development. vol 22 Suppl 1. 2000-11-07. PMID:10984658. |
in the two main divisions of the striatum, the so-called 'patch' (acetylcholinesterase (ache)-poor) and 'matrix' (ache-rich) compartments, there was a near-even distribution of 5-ht fibers and terminals. |
2000-11-07 |
2023-08-12 |
cat |
| E KIVALO, U K RINNE, S MAKEL. Acetylcholinesterase, acid phosphatase, and succinic dehydrogenase in the hypothalamic magnocellular nuclei after serotonin administration. Experientia. vol 14. issue 11. 2000-07-01. PMID:13609607. |
acetylcholinesterase, acid phosphatase, and succinic dehydrogenase in the hypothalamic magnocellular nuclei after serotonin administration. |
2000-07-01 |
2023-08-12 |
Not clear |
| R Sarkar, K P Mohanakumar, M Chowdhur. Effects of an organophosphate pesticide, quinalphos, on the hypothalamo-pituitary-gonadal axis in adult male rats. Journal of reproduction and fertility. vol 118. issue 1. 2000-05-09. PMID:10793623. |
the effects of chronic sub-lethal doses (7-14 mg kg-1 a day for 15 days) of quinalphos were evaluated in adult male rats for changes in testicular morphology, circulatory concentrations of hormones (lh, fsh, prolactin and testosterone), activities of acetylcholinesterase (ache) and angiotensin converting enzyme (ace) as well as metabolism of biogenic amines (dopamine, noradrenaline and 5-hydroxytryptamine (5-ht)) in the hypothalamus and pituitary. |
2000-05-09 |
2023-08-12 |
rat |
| b' G Leposavi\\xc4\\x87, N Ugresi\\xc4\\x87, B Pejci\\xc4\\x87-Karapetrovi\\xc4\\x87, M Mi\\xc4\\x87i\\xc4\\x8. Castration of sexually immature rats affects sympathetic innervation of the adult thymus. Neuroimmunomodulation. vol 7. issue 2. 2000-03-31. PMID:10686514.' |
to test this hypothesis, in the thymi of adult rats orchidectomized (orx) at age of 1 (orx-1), 7 (orx-7) and 30 days (orx-30): (i) noradrenaline (na), dopamine (da) and serotonin (5-ht) contents and acetylcholinesterase (ache) activity were measured and (ii) the distribution of monoamine- and ache-containing nerves and cells was examined by a sucrose phosphate glyoxylic acid (spg) method and enzyme histochemistry, respectively. |
2000-03-31 |
2023-08-12 |
rat |
| b' G Leposavi\\xc4\\x87, B Pejci\\xc4\\x87-Karapetrovi\\xc4\\x87, M Mi\\xc4\\x87i\\xc4\\x87, N Ugresi\\xc4\\x8. Orchidectomy affects the innervation of the rat thymus. The International journal of neuroscience. vol 97. issue 1-2. 2000-03-08. PMID:10681121.' |
to assess a putative role of the neural pathways in transfer of information from the gonads to the thymus, adult ao rats were orchidectomized (orx) or sham orx (controls); sacrificed 1, 3, 7, or 15 days later and their thymi were analyzed for: (a) the concentrations of noradrenaline (na), dopamine (da) and serotonin (5-ht) and distribution of monoamine-containing nerve profiles and (b) the acetylcholinesterase (ache) activity and distribution of ache-containing nerve profiles. |
2000-03-08 |
2023-08-12 |
rat |
| E L Dovedova, L M Gershteĭn, K A Nikol'skai. [The neurochemical and behavioral indices of an acquired alcohol craving in rats under conditions of information loading]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. vol 49. issue 2. 1999-10-19. PMID:10486902. |
the specific activities of neurotransmitter metabolizing enzymes (mao a and b, acetylcholinesterase, and acetylcholinetransferase) and the content of biogenic amines and their metabolites (serotonin, 5-hydroxyindoleacetic acid, noradrenaline, and dopamine) were measured in homogenates and subfractions of sensorimotor cortex and caudate nucleus. |
1999-10-19 |
2023-08-12 |
rat |
| P A Kelly, D E McBean, I M Ritchi. Intracerebral fetal raphé implants normalize hippocampal function but not cerebrovascular control in serotonin-depleted adult rat brain. Neuroscience. vol 85. issue 1. 1998-07-27. PMID:9607703. |
following the experiments, transplants were visualized by acetylcholinesterase histochemistry, and serotonergic reinnervation assessed using [3h]paroxetine binding to serotonin reuptake sites. |
1998-07-27 |
2023-08-12 |
rat |
| H R Aria. Topology of ligand binding sites on the nicotinic acetylcholine receptor. Brain research. Brain research reviews. vol 25. issue 2. 1998-01-15. PMID:9403137. |
the alpha subunits also carry the binding site for certain acetylcholinesterase inhibitors such as eserine and for the neurotransmitter 5-hydroxytryptamine which activate the receptor without interacting with the classical agonist binding sites. |
1998-01-15 |
2023-08-12 |
Not clear |
| M T McKenna, G R Proctor, L C Young, A L Harve. Novel tacrine analogues for potential use against Alzheimer's disease: potent and selective acetylcholinesterase inhibitors and 5-HT uptake inhibitors. Journal of medicinal chemistry. vol 40. issue 22. 1997-12-11. PMID:9357518. |
novel tacrine analogues for potential use against alzheimer's disease: potent and selective acetylcholinesterase inhibitors and 5-ht uptake inhibitors. |
1997-12-11 |
2023-08-12 |
Not clear |
| M T McKenna, G R Proctor, L C Young, A L Harve. Novel tacrine analogues for potential use against Alzheimer's disease: potent and selective acetylcholinesterase inhibitors and 5-HT uptake inhibitors. Journal of medicinal chemistry. vol 40. issue 22. 1997-12-11. PMID:9357518. |
several novel analogues of tacrine have been synthesized and tested for their ability to inhibit acetylcholinesterase, butyrylcholinesterase, and neuronal uptake of 5-ht (serotonin) and noradrenaline. |
1997-12-11 |
2023-08-12 |
Not clear |
| M Heider, R Schliebs, S Rossner, V Big. Basal forebrain cholinergic immunolesion by 192IgG-saporin: evidence for a presynaptic location of subpopulations of alpha 2- and beta-adrenergic as well as 5-HT2A receptors on cortical cholinergic terminals. Neurochemical research. vol 22. issue 8. 1997-10-22. PMID:9239751. |
to correlate the responses to cholinergic immunolesion in cholinoceptive cortical target regions with cholinergic hypoactivity, quantitative receptor autoradiography to measure adrenoceptors and 5-hydroxytryptamine (5-ht) receptor subtypes, and histochemistry to estimate acetylcholinesterase activity, were performed in adjacent brain sections. |
1997-10-22 |
2023-08-12 |
rat |