| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F Gagné, P Cejka, C André, R Hausler, C Blais. Neurotoxicological effects of a primary and ozonated treated wastewater on freshwater mussels exposed to an experimental flow-through system. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. vol 146. issue 4. 2007-12-11. PMID:17662667. |
a suite of biomarkers was used to assess the potential neurotoxic stress of the wastewaters on these benthic invertebrates: opiate binding sites, gamma-aminobutyric acid (gaba) metabolism, monoamines levels (serotonin, dopamine), monoamine oxidase, acetylcholinesterase and lipid peroxidation. |
2007-12-11 |
2023-08-12 |
Not clear |
| Hong Zhang, Ting Han, Cheng-Hao Yu, Khalid Rahman, Lu-Ping Qin, Cheng Pen. Ameliorating effects of essential oil from Acori graminei rhizoma on learning and memory in aged rats and mice. The Journal of pharmacy and pharmacology. vol 59. issue 2. 2007-05-18. PMID:17270083. |
the cerebral neurotransmitters in aged rats given the essential oil (0.02, 0.04, 0.08 g kg(-1)) for 30 days were also investigated, and increased levels of norepinephrine, dopamine and serotonin, and decreased levels of acetylcholinesterase activity were found. |
2007-05-18 |
2023-08-12 |
mouse |
| Hong Zhang, Ting Han, Cheng-Hao Yu, Khalid Rahman, Lu-Ping Qin, Cheng Pen. Ameliorating effects of essential oil from Acori graminei rhizoma on learning and memory in aged rats and mice. The Journal of pharmacy and pharmacology. vol 59. issue 2. 2007-05-18. PMID:17270083. |
the results suggest that the essential oil improves cognitive function in aged animals possibly by increasing norepinephrine, dopamine and serotonin relative levels, and by decreasing the activity of acetylcholinesterase in the cerebra. |
2007-05-18 |
2023-08-12 |
mouse |
| Wolf-Dieter Heiss, Karl Herhol. Brain receptor imaging. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 47. issue 2. 2006-11-24. PMID:16455637. |
the quantitative imaging for several receptors has gained clinical importance-for example, dopamine (d2)) receptors for differential diagnosis of movement disorders and for assessment of receptor occupancy by neuroleptics drugs; serotonin (5-hydroxytryptamine, 5-ht) receptors and the 5-ht transporter in affective disorders and for assessment of activity of antidepressants; nicotinic receptors and acetylcholinesterase as markers of cognitive and memory impairment; central benzodiazepine-binding sites at the gamma-aminobutyric acid a (gabaa) receptor complex as markers of neuronal integrity in neurodegenerative disorders, epilepsy, and stroke and as the site of action of benzodiazepines; peripheral benzodiazepine receptors as indicators of inflammatory changes; opioid receptors detecting increased cortical excitability in focal epilepsy but also affected in perception of and emotional response to pain; and several receptor systems affected in drug abuse and craving. |
2006-11-24 |
2023-08-12 |
Not clear |
| Geetu Saxena, S J S Flor. Changes in brain biogenic amines and haem biosynthesis and their response to combined administration of succimers and Centella asiatica in lead poisoned rats. The Journal of pharmacy and pharmacology. vol 58. issue 4. 2006-08-18. PMID:16597373. |
significant depletion of brain noradrenaline (norepinephrine, ne), 5-hydroxytryptamine (5-ht), dopamine (da) and acetylcholinesterase (ache) also were observed following lead exposure. |
2006-08-18 |
2023-08-12 |
rat |
| Nather Madjid, Elin Elvander Tottie, Maria Lüttgen, Björn Meister, Johan Sandin, Alexander Kuzmin, Oliver Stiedl, Sven Ove Ogre. 5-Hydroxytryptamine 1A receptor blockade facilitates aversive learning in mice: interactions with cholinergic and glutamatergic mechanisms. The Journal of pharmacology and experimental therapeutics. vol 316. issue 2. 2006-04-04. PMID:16223872. |
2) similar to the acetylcholinesterase inhibitor physostigmine, pretraining administration of the 5-ht(1a) receptor antagonists [(r)-3-n,n-dicyclobutylamino-8 fluoro-3,4-dihydro-3h-1-benzopyran-5-carboxamide hydrogen(2r,3r)-tartrate monohydrate] nad-299 (0.1-2 mg/kg) and [n-2-4-(2-methoxyphenyl)-1-piperazinylethyl-n-(2-pyridinyl)cyclohexane carboxamide trihydrochloride] way-100635 (0.3-3 mg/kg) enhanced pa retention. |
2006-04-04 |
2023-08-12 |
mouse |
| Cindy K J Lieben, Arjan Blokland, Ayhan Sik, Eric Sung, Petra van Nieuwenhuizen, Rudy Schreibe. The selective 5-HT6 receptor antagonist Ro4368554 restores memory performance in cholinergic and serotonergic models of memory deficiency in the rat. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 30. issue 12. 2006-01-24. PMID:15957009. |
the present study sought to characterize the cognitive-enhancing effects of the 5-ht(6) antagonist ro4368554 (3-benzenesulfonyl-7-(4-methyl-piperazin-1-yl)1h-indole) in a rat object recognition task employing a cholinergic (scopolamine pretreatment) and a serotonergic- (tryptophan (trp) depletion) deficient model, and compared its pattern of action with that of the acetylcholinesterase inhibitor metrifonate. |
2006-01-24 |
2023-08-12 |
rat |
| C Gómez, J G Briñón, M V Barbado, E Weruaga, J Valero, J R Alons. Heterogeneous targeting of centrifugal inputs to the glomerular layer of the main olfactory bulb. Journal of chemical neuroanatomy. vol 29. issue 4. 2005-08-24. PMID:15927786. |
thus, the morphology, distribution and density of positive axons were studied in the glomerular layer of the main olfactory bulb of the rat, using serotonin-, serotonin transporter- and dopamine-beta-hydroxylase-immunohistochemistry and acetylcholinesterase histochemistry in serial sections. |
2005-08-24 |
2023-08-12 |
rat |
| Sam Medhat Salah, Anna Katharina Jäge. Screening of traditionally used Lebanese herbs for neurological activities. Journal of ethnopharmacology. vol 97. issue 1. 2005-05-26. PMID:15652288. |
aqueous, ethanol and ethyl acetate extracts of seven lebanese plants that are used traditionally for neurological disorders as alzheimer's disease, epilepsy and affective disorders as depression were tested for inhibition of acetylcholinesterase and affinity to the gaba(a)-benzodiazepine site and to the serotonin transporter. |
2005-05-26 |
2023-08-12 |
Not clear |
| M Garcia-Alloza, F J Gil-Bea, M Diez-Ariza, C P L-H Chen, P T Francis, B Lasheras, M J Ramire. Cholinergic-serotonergic imbalance contributes to cognitive and behavioral symptoms in Alzheimer's disease. Neuropsychologia. vol 43. issue 3. 2005-04-12. PMID:15707619. |
the ratio of serotonin to acetylcholinesterase levels was also correlated with the psychotic factor at least in women. |
2005-04-12 |
2023-08-12 |
Not clear |
| Yasuyuki Abe, Atsushi Aoyagi, Takao Hara, Kazumi Abe, Reina Yamazaki, Yoshihiro Kumagae, Shunji Naruto, Kazuo Koyama, Shinji Marumoto, Keiko Tago, Narihiro Toda, Kazuko Takami, Naho Yamada, Mayuko Ori, Hiroshi Kogen, Tsugio Kanek. Pharmacological characterization of RS-1259, an orally active dual inhibitor of acetylcholinesterase and serotonin transporter, in rodents: possible treatment of Alzheimer's disease. Journal of pharmacological sciences. vol 93. issue 1. 2004-07-09. PMID:14501158. |
pharmacological characterization of rs-1259, an orally active dual inhibitor of acetylcholinesterase and serotonin transporter, in rodents: possible treatment of alzheimer's disease. |
2004-07-09 |
2023-08-12 |
mouse |
| Yasuyuki Abe, Atsushi Aoyagi, Takao Hara, Kazumi Abe, Reina Yamazaki, Yoshihiro Kumagae, Shunji Naruto, Kazuo Koyama, Shinji Marumoto, Keiko Tago, Narihiro Toda, Kazuko Takami, Naho Yamada, Mayuko Ori, Hiroshi Kogen, Tsugio Kanek. Pharmacological characterization of RS-1259, an orally active dual inhibitor of acetylcholinesterase and serotonin transporter, in rodents: possible treatment of Alzheimer's disease. Journal of pharmacological sciences. vol 93. issue 1. 2004-07-09. PMID:14501158. |
a dual inhibitor of acetylcholinesterase (ache) and serotonin transporter (sert), rs-1259 (4-[1s)-methylamino-3-(4-nitrophenoxy)]propylphenyl n,n-dimethylcarbamate (fumaric acid)(1/2)salt), was newly synthesized. |
2004-07-09 |
2023-08-12 |
mouse |
| Narihiro Toda, Keiko Tago, Shinji Marumoto, Kazuko Takami, Mayuko Ori, Naho Yamada, Kazuo Koyama, Shunji Naruto, Kazumi Abe, Reina Yamazaki, Takao Hara, Atsushi Aoyagi, Yasuyuki Abe, Tsugio Kaneko, Hiroshi Koge. A conformational restriction approach to the development of dual inhibitors of acetylcholinesterase and serotonin transporter as potential agents for Alzheimer's disease. Bioorganic & medicinal chemistry. vol 11. issue 20. 2004-06-01. PMID:13129577. |
a conformational restriction approach to the development of dual inhibitors of acetylcholinesterase and serotonin transporter as potential agents for alzheimer's disease. |
2004-06-01 |
2023-08-12 |
Not clear |
| Wieland Gsell, Gerd Jungkunz, Peter Riedere. Functional neurochemistry of Alzheimer's disease. Current pharmaceutical design. vol 10. issue 3. 2004-04-16. PMID:14754387. |
besides therapy with acetylcholinesterase inhibitors, comedication to act on imbalances between serotonin and noradrenaline on the one site, and dopamine, glutamate and gaba on the other site should should be considered. |
2004-04-16 |
2023-08-12 |
human |
| L M Gerstein, E L Dovedova, N S Popov. [Mechanism of nootropic digam action in hypofunction of brain dopaminergic system]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 103. issue 7. 2003-12-29. PMID:12938655. |
using microchemical methods for detection of dopamine (da), noradrenaline (na), serotonin (s) and its metabolite--5'-hydroxyindolilacetic acid (5'-hiaa) as well as the activity of neuromediator-utilising enzymes--mao a and b and enzymes of acetylcholine metabolism--cholinacetyltranspherase (chat) and acetylcholinesterase (ache), we revealed that synthetic gaba-derivative compound diagram (250 mg/kg during 10 days) normalized functioning of dopaminergic and acetylcholinergic systems in sensormotor cortex and caudate nucleus of wistar rats with haloperidol-induced (0.5 mg/kg during 30 days) bradykinesia. |
2003-12-29 |
2023-08-12 |
rat |
| Narihiro Toda, Keiko Tago, Shinji Marumoto, Kazuko Takami, Mayuko Ori, Naho Yamada, Kazuo Koyama, Shunji Naruto, Kazumi Abe, Reina Yamazaki, Takao Hara, Atsushi Aoyagi, Yasuyuki Abe, Tsugio Kaneko, Hiroshi Koge. Design, synthesis and structure-activity relationships of dual inhibitors of acetylcholinesterase and serotonin transporter as potential agents for Alzheimer's disease. Bioorganic & medicinal chemistry. vol 11. issue 9. 2003-12-12. PMID:12670645. |
design, synthesis and structure-activity relationships of dual inhibitors of acetylcholinesterase and serotonin transporter as potential agents for alzheimer's disease. |
2003-12-12 |
2023-08-12 |
mouse |
| Narihiro Toda, Keiko Tago, Shinji Marumoto, Kazuko Takami, Mayuko Ori, Naho Yamada, Kazuo Koyama, Shunji Naruto, Kazumi Abe, Reina Yamazaki, Takao Hara, Atsushi Aoyagi, Yasuyuki Abe, Tsugio Kaneko, Hiroshi Koge. Design, synthesis and structure-activity relationships of dual inhibitors of acetylcholinesterase and serotonin transporter as potential agents for Alzheimer's disease. Bioorganic & medicinal chemistry. vol 11. issue 9. 2003-12-12. PMID:12670645. |
we have designed and synthesized a dual inhibitor of acetylcholinesterase (ache) and serotonin transporter (sert) as a novel class of treatment drugs for alzheimer's disease on the basis of a hypothetical model of the ache active site. |
2003-12-12 |
2023-08-12 |
mouse |
| Mária Sirot'áková, Katarína Schmidtová, Monika Kocisová, Milan Kucht. Adrenergic and acetylcholinesterase-positive innervation of palatine tonsils in mammals. Acta histochemica. vol 104. issue 4. 2003-06-11. PMID:12553700. |
adrenergic nerve components were visualized by formaldehyde-induced fluorescence of catecholamines and 5-ht, or by glyoxylic acid fluorescence, whereas acetylcholinesterase (ache)-positive nerve structures were demonstrated by the direct thiocholine method. |
2003-06-11 |
2023-08-12 |
human |
| Ilga Misane, Sven Ove Ogre. Selective 5-HT1A antagonists WAY 100635 and NAD-299 attenuate the impairment of passive avoidance caused by scopolamine in the rat. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 2. 2003-04-21. PMID:12589378. |
the present study examined the ability of two selective 5-ht(1a) receptor antagonists way 100635 and nad-299 (robalzotan) and two acetylcholinesterase (ache) inhibitors tacrine and donepezil to attenuate the impairment of pa retention caused by the nonselective muscarinic receptor antagonist scopolamine in the rat. |
2003-04-21 |
2023-08-12 |
rat |
| Laëtitia Lamirault, Catherine Guillou, Claude Thal, Hervé Simo. Combined treatment with galanthaminium bromide, a new cholinesterase inhibitor, and RS 67333, a partial agonist of 5-HT4 receptors, enhances place and object recognition in young adult and old rats. Progress in neuro-psychopharmacology & biological psychiatry. vol 27. issue 1. 2003-04-01. PMID:12551743. |
the present study was designed to investigate whether a combination of a new acetylcholinesterase inhibitor we have synthesized, galanthaminium bromide, and an agonist of 5-hydroxytryptamine(4) receptors, rs 67333, at doses ineffective alone, improves performance in tasks involving place and object recognition memory. |
2003-04-01 |
2023-08-12 |
rat |