| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F Gagné, C André, P Cejka, R Hausler, M Fournie. Evidence of neuroendocrine disruption in freshwater mussels exposed to municipal wastewaters. The Science of the total environment. vol 409. issue 19. 2012-07-18. PMID:21704357. |
neuroendocrinal effects were examined by tracking changes in acetylcholinesterase, glutamate, gamma-aminobutyrate, serotonin, dopamine and their respective adenylcyclase activities in synapse membranes, monoamine oxidase and vitellogenin-like proteins. |
2012-07-18 |
2023-08-12 |
Not clear |
| Alexis Ciro, Joon Park, Gary Burkhard, Nicole Yan, Changiz Geul. Biochemical differentiation of cholinesterases from normal and Alzheimer's disease cortex. Current Alzheimer research. vol 9. issue 1. 2012-06-14. PMID:21244353. |
using biochemical assays of acetylcholinesterase and butyrylcholinesterase activities, we demonstrate here that serotonin and bacitracin result in a significantly greater and dose-dependent inhibition of cholinesterases in alzheimer's disease cortex when compared with age-matched controls. |
2012-06-14 |
2023-08-12 |
Not clear |
| Gregory A Jich. Medical management of frontotemporal dementias: the importance of the caregiver in symptom assessment and guidance of treatment strategies. Journal of molecular neuroscience : MN. vol 45. issue 3. 2012-03-19. PMID:21647712. |
biologically, plausible treatment strategies include the use of antidepressants (selective serotonin reuptake inhibitors or serotonin-specific reuptake inhibitor and monoamine oxidase inhibitors), acetylcholinesterase inhibitors, n-methyl-d-aspartic acid antagonists, mood stabilizers, antipsychotics, stimulants, antihypertensives, and agents that may ameliorate the symptoms of parkinsonism, pseudobulbar affect, and motor neuron disease that can often coexist with ftd. |
2012-03-19 |
2023-08-12 |
Not clear |
| Aren van Waarde, Nisha K Ramakrishnan, Anna A Rybczynska, Philip H Elsinga, Kiichi Ishiwata, Ingrid M Nijholt, Paul G M Luiten, Rudi A Dierck. The cholinergic system, sigma-1 receptors and cognition. Behavioural brain research. vol 221. issue 2. 2011-09-09. PMID:20060423. |
several central nervous system (cns) drugs show high to moderate affinities for sigma-1 receptors, including acetylcholinesterase inhibitors (donepezil), antipsychotics (haloperidol, rimcazole), selective serotonin reuptake inhibitors (fluvoxamine, sertraline) and monoamine oxidase inhibitors (clorgyline). |
2011-09-09 |
2023-08-12 |
Not clear |
| Elena G Govorunova, Mustapha Moussaif, Andrey Kullyev, Ken C Q Nguyen, Thomas V McDonald, David H Hall, Ji Y Sz. A homolog of FHM2 is involved in modulation of excitatory neurotransmission by serotonin in C. elegans. PloS one. vol 5. issue 4. 2011-06-16. PMID:20442779. |
in c. elegans, exogenous 5-ht inhibits paralysis induced by the acetylcholinesterase inhibitor aldicarb. |
2011-06-16 |
2023-08-12 |
caenorhabditis_elegans |
| Qiong Wang, Li-Hua Sun, William Jia, Xin-Min Liu, Hai-Xia Dang, Wen-Li Mai, Ning Wang, Andre Steinmetz, Yu-Qin Wang, Chang-Jiang X. Comparison of ginsenosides Rg1 and Rb1 for their effects on improving scopolamine-induced learning and memory impairment in mice. Phytotherapy research : PTR. vol 24. issue 12. 2011-02-17. PMID:20564503. |
after 6 and 12 mg/kg of rg1 and rb1 intraperitoneal administration to mice for 7 days, their effects were assessed using the step-down passive avoidance (sd) and the morris water maze (mwm) tests, the acetylcholinesterase (ache) activity, acetylcholine (ach) content and serotonin (5-ht) level in the hippocampus were analysed after sd and mwm tests. |
2011-02-17 |
2023-08-12 |
mouse |
| Narihiro Toda, Tsugio Kaneko, Hiroshi Koge. Development of an efficient therapeutic agent for Alzheimer's disease: design and synthesis of dual inhibitors of acetylcholinesterase and serotonin transporter. Chemical & pharmaceutical bulletin. vol 58. issue 3. 2010-06-15. PMID:20190429. |
development of an efficient therapeutic agent for alzheimer's disease: design and synthesis of dual inhibitors of acetylcholinesterase and serotonin transporter. |
2010-06-15 |
2023-08-12 |
mouse |
| Jay P Overmyer, Paul F Smith, Kristen A Kellock, Jeong-Wook Kwon, Kevin L Armbrus. Assessment of the toxicological interaction of sertraline with cholinesterase inhibiting insecticides in aquatic insects using the black fly, Simulium vittatum IS-7. Environmental toxicology. vol 25. issue 1. 2010-05-04. PMID:19161234. |
although ssris are known to block serotonin reuptake sites on cell membranes, they also have been shown to inhibit acetylcholinesterase (ache) activity. |
2010-05-04 |
2023-08-12 |
Not clear |
| Amal A Kinaw. Impact of gasoline inhalation on some neurobehavioural characteristics of male rats. BMC physiology. vol 9. 2010-01-26. PMID:19930677. |
the impacts of gasoline exposure on na+, k+-atpase, superoxide dismutase (sod), acetylcholinesterase (ache), total protein, reduced glutathione (gsh), and lipid peroxidation (tbars) in the cerebral cortex, and monoamine neurotransmitters dopamine (da), norepinephrine (ne) and serotonin (5-ht) in the cerebral cortex, hippocampus, cerebellum and hypothalamus were evaluated. |
2010-01-26 |
2023-08-12 |
rat |
| K Campbell-Dittmeyer, G A Hicks, D L Earnest, B Greenwood-Van Meervel. Increased colonic transit in rats produced by a combination of a cholinesterase inhibitor with a 5-HT4 receptor agonist. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 21. issue 11. 2009-12-04. PMID:19210632. |
the acetylcholinesterase inhibitor, neostigmine, and the 5-ht(4) receptor partial agonist tegaserod, are two agents with known prokinetic activity which work by different mechanisms that result in increased levels of ach at cholinergic synapses innervating intestinal smooth muscle. |
2009-12-04 |
2023-08-12 |
rat |
| Nadine Gravett, Adhil Bhagwandin, Kjell Fuxe, Paul R Mange. Nuclear organization and morphology of cholinergic, putative catecholaminergic and serotonergic neurons in the brain of the rock hyrax, Procavia capensis. Journal of chemical neuroanatomy. vol 38. issue 1. 2009-09-18. PMID:19559986. |
the nuclear subdivisions of the cholinergic, putative catecholaminergic and serotonergic systems within the brain of the rock hyrax (procavia capensis) were identified following immunohistochemistry for acetylcholinesterase, tyrosine hydroxylase and serotonin. |
2009-09-18 |
2023-08-12 |
Not clear |
| H Kalonia, M Bishnoi, A Kuma. Possible mechanism involved in sleep deprivation-induced memory dysfunction. Methods and findings in experimental and clinical pharmacology. vol 30. issue 7. 2009-02-23. PMID:18985181. |
various electrophysiological (sleep-wake cycle), biochemical (lipid peroxidation, reduced glutathione, nitrite, catalase, acetylcholinesterase) and neurochemical parameters (norepinephrine, dopamine and serotonin) were also assessed. |
2009-02-23 |
2023-08-12 |
rat |
| Adriana Lourenço da Silva, Juliana G Ferreira, Bárbara da Silva Martins, Sabrina Oliveira, Nathalia Mai, Domingos S Nunes, Elaine Elisabetsk. Serotonin receptors contribute to the promnesic effects of P. olacoides (Marapuama). Physiology & behavior. vol 95. issue 1-2. 2008-12-18. PMID:18561960. |
the observed synergism between poee and spiperone can be interpreted as the combined effects of two subeffective doses of two 5ht antagonists, or the known synergism between an acetylcholinesterase inhibitor (poee) and a 5ht antagonist. |
2008-12-18 |
2023-08-12 |
mouse |
| S G Butler, M J Meega. Recent developments in the design of anti-depressive therapies: targeting the serotonin transporter. Current medicinal chemistry. vol 15. issue 17. 2008-09-26. PMID:18673223. |
recent advances in the design and synthesis of single molecular entities possessing 5-ht reuptake inhibition together with 5-ht(1a), 5-ht(1b), 5-ht(1d), 5-ht(2a), dat, net, alpha (2)-adrenoceptor and acetylcholinesterase antagonism are reviewed. |
2008-09-26 |
2023-08-12 |
Not clear |
| Adhil Bhagwandin, Kjell Fuxe, Nigel C Bennett, Paul R Mange. Nuclear organization and morphology of cholinergic, putative catecholaminergic and serotonergic neurons in the brains of two species of African mole-rat. Journal of chemical neuroanatomy. vol 35. issue 4. 2008-08-21. PMID:18407460. |
the distribution, morphology and nuclear subdivisions of the cholinergic, putative catecholaminergic and serotonergic systems within the brains of two species of african mole-rat (cape dune mole-rat -bathyergus suillus; highveld mole-rat -cryptomys hottentotuspretoriae) were identified following immunohistochemistry for acetylcholinesterase, tyrosine hydroxylase and serotonin. |
2008-08-21 |
2023-08-12 |
rat |
| S Cellek, R Thangiah, E M Jarvie, S Vivekanandan, O Lalude, G J Sange. Synergy between 5-HT4 receptor activation and acetylcholinesterase inhibition in human colon and rat forestomach. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 20. issue 5. 2008-08-06. PMID:18194150. |
5-hydroxytryptamine (5-ht4) receptor agonists increase gastrointestinal (gi) motility by enhancing enteric acetylcholine release which is then metabolized by acetylcholinesterase (ache) to inactive metabolites. |
2008-08-06 |
2023-08-12 |
human |
| M Cachard-Chastel, S Devers, S Sicsic, M Langlois, F Lezoualc'h, A M Gardier, C Belzun. Prucalopride and donepezil act synergistically to reverse scopolamine-induced memory deficit in C57Bl/6j mice. Behavioural brain research. vol 187. issue 2. 2008-04-07. PMID:18061284. |
before the probe test, they received an injection of either a 5-ht(4) receptor agonist (prucalopride or rs 67333), or an acetylcholinesterase inhibitor (donepezil), or both drugs. |
2008-04-07 |
2023-08-12 |
mouse |
| M Cachard-Chastel, S Devers, S Sicsic, M Langlois, F Lezoualc'h, A M Gardier, C Belzun. Prucalopride and donepezil act synergistically to reverse scopolamine-induced memory deficit in C57Bl/6j mice. Behavioural brain research. vol 187. issue 2. 2008-04-07. PMID:18061284. |
our results suggest that a combined treatment with a 5-ht(4) receptor agonist with an acetylcholinesterase inhibitor has beneficial effects on memory in mice. |
2008-04-07 |
2023-08-12 |
mouse |
| Punita Bhalla, Vijayta Dani Chadha, D K Dhawa. Effectiveness of zinc in modulating lithium induced biochemical and behavioral changes in rat brain. Cellular and molecular neurobiology. vol 27. issue 5. 2008-01-22. PMID:17458692. |
the effects of all the treatments were studied for a duration of 1, 2, and 4 months with regard to the parameters, which included estimation of serotonin and dopamine concentrations as well as the activity of acetylcholinesterase in cerebral cortex of rat brain. |
2008-01-22 |
2023-08-12 |
rat |
| Punita Bhalla, Vijayta Dani Chadha, D K Dhawa. Effectiveness of zinc in modulating lithium induced biochemical and behavioral changes in rat brain. Cellular and molecular neurobiology. vol 27. issue 5. 2008-01-22. PMID:17458692. |
zinc administration to the lithium-treated group significantly improved the acetylcholinesterase activity as well as the concentration of dopamine and serotonin. |
2008-01-22 |
2023-08-12 |
rat |